메뉴 건너뛰기




Volumn 17, Issue 6, 2012, Pages 6854-6868

Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation

Author keywords

Akt mTOR; Angiogenesis; Cancer; KDR Flk 1; Pristimerin

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; PRISTIMERIN; TRITERPENE; VASCULOTROPIN RECEPTOR 2;

EID: 84863000261     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17066869     Document Type: Article
Times cited : (52)

References (35)
  • 1
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: Molecular pathways and therapeutic targets
    • Weis, S. M.; Cheresh, D. A. Tumor angiogenesis: Molecular pathways and therapeutic targets. Nat. Med. 2011, 17, 1359-1370.
    • (2011) Nat. Med. , vol.17 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 2
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P.; Jain, R. K. Angiogenesis in cancer and other diseases. Nature 2000, 407, 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 3
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Kerbel, R. S. Tumor angiogenesis. N. Engl. J. Med. 2008, 358, 2039-2049. (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 4
    • 33749028188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling pathways: Therapeutic perspective
    • DOI 10.1158/1078-0432.CCR-06-1520
    • Kowanetz, M.; Ferrara, N. Vascular endothelial growth factor signaling pathways: Therapeutic perspective. Clin. Cancer Res. 2006, 12, 5018-5022. (Pubitemid 44453326)
    • (2006) Clinical Cancer Research , vol.12 , Issue.17 , pp. 5018-5022
    • Kowanetz, M.1    Ferrara, N.2
  • 5
    • 39149100314 scopus 로고    scopus 로고
    • Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity
    • DOI 10.1158/0008-5472.CAN-07-2799
    • Pyun, B. J.; Choi, S.; Lee, Y.; Kim, T. W.; Min, J. K.; Kim, Y.; Kim, B. D.; Kim, J. H.; Kim, T. Y.; Kim, Y. M.; et al. Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res. 2008, 68, 227-235. (Pubitemid 351380124)
    • (2008) Cancer Research , vol.68 , Issue.1 , pp. 227-235
    • Pyun, B.-J.1    Choi, S.2    Lee, Y.3    Kim, T.-W.4    Min, J.-K.5    Kim, Y.6    Kim, B.-D.7    Kim, J.-H.8    Kim, T.-Y.9    Kim, Y.-M.10    Kwon, Y.-G.11
  • 6
    • 79952216582 scopus 로고    scopus 로고
    • Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors
    • Falcon, B. L.; Barr, S.; Gokhale, P. C.; Chou, J.; Fogarty, J.; Depeille, P.; Miglarese, M.; Epstein, D. M.; McDonald, D. M. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 2011, 71, 1573-1583.
    • (2011) Cancer Res. , vol.71 , pp. 1573-1583
    • Falcon, B.L.1    Barr, S.2    Gokhale, P.C.3    Chou, J.4    Fogarty, J.5    Depeille, P.6    Miglarese, M.7    Epstein, D.M.8    McDonald, D.M.9
  • 9
    • 65449174330 scopus 로고    scopus 로고
    • Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo
    • Tiedemann, R. E.; Schmidt, J.; Keats, J. J.; Shi, C. X.; Zhu, Y. X.; Palmer, S. E.; Mao, X.; Schimmer, A. D.; Stewart, A. K. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood 2009, 113, 4027-4037.
    • (2009) Blood , vol.113 , pp. 4027-4037
    • Tiedemann, R.E.1    Schmidt, J.2    Keats, J.J.3    Shi, C.X.4    Zhu, Y.X.5    Palmer, S.E.6    Mao, X.7    Schimmer, A.D.8    Stewart, A.K.9
  • 10
    • 70349329993 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent activation of Bax and poly (ADPribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells
    • Byun, J. Y.; Kim, M. J.; Eum, D. Y.; Yoon, C. H.; Seo, W. D.; Park, K. H.; Hyun, J. W.; Lee, Y. S.; Lee, J. S.; Yoon, M. Y.; et al. Reactive oxygen species-dependent activation of Bax and poly (ADPribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Mol. Pharmacol. 2009, 76, 734-744.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 734-744
    • Byun, J.Y.1    Kim, M.J.2    Eum, D.Y.3    Yoon, C.H.4    Seo, W.D.5    Park, K.H.6    Hyun, J.W.7    Lee, Y.S.8    Lee, J.S.9    Yoon, M.Y.10
  • 12
    • 13544255506 scopus 로고    scopus 로고
    • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    • DOI 10.1016/j.cell.2004.12.018
    • Boire, A.; Covic, L.; Agarwal, A.; Jacques, S.; Sherifi, S.; Kuliopulos, A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 2005, 120, 303-313. (Pubitemid 40222426)
    • (2005) Cell , vol.120 , Issue.3 , pp. 303-313
    • Boire, A.1    Covic, L.2    Agarwal, A.3    Jacques, S.4    Sherifi, S.5    Kuliopulos, A.6
  • 13
    • 23844549870 scopus 로고    scopus 로고
    • Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria
    • Wu, C. C.; Chan, M. L.; Chen, W. Y.; Tsai, C. Y.; Chang, F. R.; Wu, Y. C. Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria. Mol. Cancer Ther. 2005, 4, 1277-1285.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1277-1285
    • Wu, C.C.1    Chan, M.L.2    Chen, W.Y.3    Tsai, C.Y.4    Chang, F.R.5    Wu, Y.C.6
  • 14
    • 75749150162 scopus 로고    scopus 로고
    • LYG-202, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo
    • Chen, Y.; Lu, N.; Ling, Y.; Wang, L.; You, Q.; Li, Z.; Guo, Q. LYG-202, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo. J. Pharmacol. Sci. 2010, 112, 37-45.
    • (2010) J. Pharmacol. Sci. , vol.112 , pp. 37-45
    • Chen, Y.1    Lu, N.2    Ling, Y.3    Wang, L.4    You, Q.5    Li, Z.6    Guo, Q.7
  • 15
    • 1942486863 scopus 로고    scopus 로고
    • Modelling approaches for angiogenesis
    • DOI 10.1016/j.ejca.2004.01.002, PII S0959804904000528
    • Taraboletti, G.; Giavazzi, R. Modelling approaches for angiogenesis. Eur. J. Cancer 2004, 40, 881-889. (Pubitemid 38519766)
    • (2004) European Journal of Cancer , vol.40 , Issue.6 , pp. 881-889
    • Taraboletti, G.1    Giavazzi, R.2
  • 16
    • 79952026605 scopus 로고    scopus 로고
    • Synthesis, biology and clinical significance of pentacyclic triterpenes: A multi-target approach to prevention and treatment of metabolic and vascular diseases
    • Sheng, H.; Sun, H. Synthesis, biology and clinical significance of pentacyclic triterpenes: A multi-target approach to prevention and treatment of metabolic and vascular diseases. Nat. Prod. Rep. 2011, 28, 543-593.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 543-593
    • Sheng, H.1    Sun, H.2
  • 17
    • 53049107046 scopus 로고    scopus 로고
    • Terpenoids: Natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
    • Salminen, A.; Lehtonen, M.; Suuronen, T.; Kaarniranta, K.; Huuskonen, J. Terpenoids: Natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential. Cell Mol. Life Sci. 2008, 65, 2979-2999.
    • (2008) Cell Mol. Life Sci. , vol.65 , pp. 2979-2999
    • Salminen, A.1    Lehtonen, M.2    Suuronen, T.3    Kaarniranta, K.4    Huuskonen, J.5
  • 18
    • 77950234271 scopus 로고    scopus 로고
    • Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
    • Pang, X.; Yi, Z.; Zhang, J.; Lu, B.; Sung, B.; Qu, W.; Aggarwal, B. B.; Liu, M. Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res. 2010, 70, 1951-1959.
    • (2010) Cancer Res. , vol.70 , pp. 1951-1959
    • Pang, X.1    Yi, Z.2    Zhang, J.3    Lu, B.4    Sung, B.5    Qu, W.6    Aggarwal, B.B.7    Liu, M.8
  • 19
    • 79952084572 scopus 로고    scopus 로고
    • Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer
    • Yadav, V. R.; Prasad, S.; Sung, B.; Kannappan, R.; Aggarwal, B. B. Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins (Basel) 2010, 2, 2428-2466.
    • (2010) Toxins (Basel) , vol.2 , pp. 2428-2466
    • Yadav, V.R.1    Prasad, S.2    Sung, B.3    Kannappan, R.4    Aggarwal, B.B.5
  • 20
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Napoleone Ferrara, R. S. K. Angiogenesis as a therapeutic target. Nature 2005, 438, 967-974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Napoleone Ferrara, R.S.K.1
  • 21
    • 34548443831 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition
    • DOI 10.1016/j.cellsig.2007.05.013, PII S0898656807001532
    • Holmes, K.; Roberts, O. L.; Thomas, A. M.; Cross, M. J. Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition. Cell. Signal. 2007, 19, 2003-2012. (Pubitemid 47354167)
    • (2007) Cellular Signalling , vol.19 , Issue.10 , pp. 2003-2012
    • Holmes, K.1    Roberts, O.L.2    Thomas, A.M.3    Cross, M.J.4
  • 23
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers, I.; Vincent, E. E.; Tavare, J. M. Akt signalling in health and disease. Cell Signal. 2011, 23, 1515-1527.
    • (2011) Cell Signal. , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 24
    • 77957242580 scopus 로고    scopus 로고
    • Methyl 2-cyano-3, 11-dioxo-18-olean-1, 12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor
    • Pang, X.; Zhang, L.; Wu, Y.; Lin, L.; Li, J.; Qu, W.; Safe, S.; Liu, M. Methyl 2-cyano-3, 11-dioxo-18-olean-1, 12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor. J. Pharmacol. Exp. Ther. 2010, 335, 172-179.
    • (2010) J. Pharmacol. Exp. Ther. , vol.335 , pp. 172-179
    • Pang, X.1    Zhang, L.2    Wu, Y.3    Lin, L.4    Li, J.5    Qu, W.6    Safe, S.7    Liu, M.8
  • 26
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
    • LoPiccolo, J.; Blumenthal, G. M.; Bernstein, W. B.; Dennis, P. A. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist. Updat. 2008, 11, 32-50.
    • (2008) Drug Resist. Updat. , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 27
    • 2442459672 scopus 로고    scopus 로고
    • S6K pathway in regulating the actin cytoskeleton and cell migration
    • DOI 10.1016/j.yexcr.2003.12.032, PII S001448270300689X
    • Berven, L. A.; Willard, F. S.; Crouch, M. F. Role of the p70 (S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp. Cell Res. 2004, 296, 183-195. (Pubitemid 38624640)
    • (2004) Experimental Cell Research , vol.296 , Issue.2 , pp. 183-195
    • Berven, L.A.1    Willard, F.S.2    Crouch, M.F.3
  • 28
    • 77952316523 scopus 로고    scopus 로고
    • Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl
    • Lu, Z.; Jin, Y.; Chen, C.; Li, J.; Cao, Q.; Pan, J. Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl. Mol. Cancer 2010, 9, 112.
    • (2010) Mol. Cancer , vol.9 , pp. 112
    • Lu, Z.1    Jin, Y.2    Chen, C.3    Li, J.4    Cao, Q.5    Pan, J.6
  • 29
    • 59549107896 scopus 로고    scopus 로고
    • Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: Implications for anticancer therapy
    • Garcia-Maceira, P.; Mateo, J. Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy. Oncogene 2009, 28, 313-324.
    • (2009) Oncogene , vol.28 , pp. 313-324
    • Garcia-Maceira, P.1    Mateo, J.2
  • 30
    • 84856064603 scopus 로고    scopus 로고
    • Q39, a quinoxaline 1, 4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1alpha expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells
    • Weng, Q.; Zhang, J.; Cao, J.; Xia, Q.; Wang, D.; Hu, Y.; Sheng, R.; Wu, H.; Zhu, D.; Zhu, H.; He, Q.; Yang, B. Q39, a quinoxaline 1, 4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1alpha expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells. Invest. New Drugs 2011, 29, 1177-1187.
    • (2011) Invest. New Drugs , vol.29 , pp. 1177-1187
    • Weng, Q.1    Zhang, J.2    Cao, J.3    Xia, Q.4    Wang, D.5    Hu, Y.6    Sheng, R.7    Wu, H.8    Zhu, D.9    Zhu, H.10    He, Q.11    Yang, B.12
  • 31
    • 68049137608 scopus 로고    scopus 로고
    • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
    • Yu, K.; Toral-Barza, L.; Shi, C.; Zhang, W. G.; Lucas, J.; Shor, B.; Kim, J.; Verheijen, J.; Curran, K.; Malwitz, D. J.; et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009, 69, 6232-6240.
    • (2009) Cancer Res. , vol.69 , pp. 6232-6240
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3    Zhang, W.G.4    Lucas, J.5    Shor, B.6    Kim, J.7    Verheijen, J.8    Curran, K.9    Malwitz, D.J.10
  • 32
    • 58349092759 scopus 로고    scopus 로고
    • Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signalregulated kinase signaling pathways
    • Pang, X.; Yi, T.; Yi, Z.; Cho, S. G.; Qu, W.; Pinkaew, D.; Fujise, K.; Liu, M. Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signalregulated kinase signaling pathways. Cancer Res. 2009, 69, 518-525.
    • (2009) Cancer Res. , vol.69 , pp. 518-525
    • Pang, X.1    Yi, T.2    Yi, Z.3    Cho, S.G.4    Qu, W.5    Pinkaew, D.6    Fujise, K.7    Liu, M.8
  • 33
    • 84863989201 scopus 로고    scopus 로고
    • Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly (I:C), on human breast cancer
    • doi:10.1007/s10549-011-1930-3
    • Inao, T.; Harashima, N.; Monma, H.; Okano, S.; Itakura, M.; Tanaka, T.; Tajima, Y.; Harada, M. Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly (I:C), on human breast cancer. Breast Cancer Res. Treat. 2011, doi:10.1007/s10549-011-1930-3.
    • (2011) Breast Cancer Res. Treat.
    • Inao, T.1    Harashima, N.2    Monma, H.3    Okano, S.4    Itakura, M.5    Tanaka, T.6    Tajima, Y.7    Harada, M.8
  • 34
    • 59449086815 scopus 로고    scopus 로고
    • Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation
    • Abdel-Malak, N. A.; Mofarrahi, M.; Mayaki, D.; Khachigian, L. M.; Hussain, S. N. Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation. Arterioscler. Thromb. Vasc. Biol. 2009, 29, 209-216.
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 209-216
    • Abdel-Malak, N.A.1    Mofarrahi, M.2    Mayaki, D.3    Khachigian, L.M.4    Hussain, S.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.