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Volumn 67, Issue 10, 2007, Pages 1348-1361

PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

Author keywords

Adult neural hippocampal progenitor; CREB; Differentiation; PI3K Akt; Proliferation

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BETA TUBULIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGENIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETROVIRUS VECTOR; SOMATOMEDIN C; SONIC HEDGEHOG PROTEIN;

EID: 34547793039     PISSN: 19328451     EISSN: 1932846X     Source Type: Journal    
DOI: 10.1002/dneu.20506     Document Type: Article
Times cited : (377)

References (89)
  • 3
    • 0000853121 scopus 로고
    • Autoradiographic study of degenerative and regenerative proliferation of neuroglia cells with tritiated thymidine
    • Altman J. 1962. Autoradiographic study of degenerative and regenerative proliferation of neuroglia cells with tritiated thymidine. Exp Neurol 5:302-318.
    • (1962) Exp Neurol , vol.5 , pp. 302-318
    • Altman, J.1
  • 5
    • 0034909799 scopus 로고    scopus 로고
    • N-methyl-d-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke
    • Arvidsson A, Kokaia Z, Lindvall O. 2001. N-methyl-d-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke. Eur J Neurosci 14:10-18.
    • (2001) Eur J Neurosci , vol.14 , pp. 10-18
    • Arvidsson, A.1    Kokaia, Z.2    Lindvall, O.3
  • 7
    • 0037109761 scopus 로고    scopus 로고
    • Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: A new route to cAMP response element-binding protein phosphorylation
    • Brami-Cherrier K, Valjent E, Garcia M, Pages C, Hipskind RA, Caboche J. 2002. Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: A new route to cAMP response element-binding protein phosphorylation. J Neurosci 22:8911-8921.
    • (2002) J Neurosci , vol.22 , pp. 8911-8921
    • Brami-Cherrier, K.1    Valjent, E.2    Garcia, M.3    Pages, C.4    Hipskind, R.A.5    Caboche, J.6
  • 8
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, et al. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6    Anderson, M.J.7
  • 9
    • 0033152966 scopus 로고    scopus 로고
    • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
    • Burdon T, Stracey C, Chambers I, Nichols J, Smith A. 1999. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 210:30-43.
    • (1999) Dev Biol , vol.210 , pp. 30-43
    • Burdon, T.1    Stracey, C.2    Chambers, I.3    Nichols, J.4    Smith, A.5
  • 11
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 12
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. 2006. Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 13
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. 1999. Cellular survival: A play in three Akts. Genes Dev 13:2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 14
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 15
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • Downward J. 2004. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15:177-182.
    • (2004) Semin Cell Dev Biol , vol.15 , pp. 177-182
    • Downward, J.1
  • 16
    • 0032484019 scopus 로고    scopus 로고
    • CREB is a regulatory target for the protein kinase Akt/PKB
    • Du K, Montminy M. 1998. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273:32377-32379.
    • (1998) J Biol Chem , vol.273 , pp. 32377-32379
    • Du, K.1    Montminy, M.2
  • 17
    • 0031053586 scopus 로고    scopus 로고
    • Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, et al. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
    • Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, et al. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
  • 22
    • 0028670773 scopus 로고
    • A secondary phosphorylation of CREB341 at Serl29 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression
    • Fiol CJ, Williams JS, Chou CH, Wang QM, Roach PJ, Andrisani OM. 1994. A secondary phosphorylation of CREB341 at Serl29 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem 269:32187-32193.
    • (1994) J Biol Chem , vol.269 , pp. 32187-32193
    • Fiol, C.J.1    Williams, J.S.2    Chou, C.H.3    Wang, Q.M.4    Roach, P.J.5    Andrisani, O.M.6
  • 23
    • 0037166258 scopus 로고    scopus 로고
    • Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells
    • Funakoshi Y, Ichiki T, Takeda K, Tokuno T, Iino N, Takeshita A. 2002. Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem 277:18710-18717.
    • (2002) J Biol Chem , vol.277 , pp. 18710-18717
    • Funakoshi, Y.1    Ichiki, T.2    Takeda, K.3    Tokuno, T.4    Iino, N.5    Takeshita, A.6
  • 24
    • 0027501690 scopus 로고
    • Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements
    • Gossen M, Bonin AL, Bujard H. 1993. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci 18:471-475.
    • (1993) Trends Biochem Sci , vol.18 , pp. 471-475
    • Gossen, M.1    Bonin, A.L.2    Bujard, H.3
  • 25
    • 0033363319 scopus 로고    scopus 로고
    • Learning enhances adult neurogenesis in the hippocampal formation
    • Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. 1999a. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 2:260-265.
    • (1999) Nat Neurosci , vol.2 , pp. 260-265
    • Gould, E.1    Beylin, A.2    Tanapat, P.3    Reeves, A.4    Shors, T.J.5
  • 26
    • 0030992982 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation
    • Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. 1997. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 17:2492-2498.
    • (1997) J Neurosci , vol.17 , pp. 2492-2498
    • Gould, E.1    McEwen, B.S.2    Tanapat, P.3    Galea, L.A.4    Fuchs, E.5
  • 28
    • 0034806590 scopus 로고    scopus 로고
    • CREB DNA binding activity is inhibited by glycogen synthase kinase-3β and facilitated by lithium
    • Grimes CA, Jope RS. 2001. CREB DNA binding activity is inhibited by glycogen synthase kinase-3β and facilitated by lithium. J Neurochem 78:1219-1232.
    • (2001) J Neurochem , vol.78 , pp. 1219-1232
    • Grimes, C.A.1    Jope, R.S.2
  • 30
    • 30444455577 scopus 로고    scopus 로고
    • PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci USA 103:111-116.
    • PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci USA 103:111-116.
  • 31
    • 0034665975 scopus 로고    scopus 로고
    • Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    • Hahn H, Wojnowski L, Specht K, Kappler R, Calzada-Wack J, Potter D, Zimmer A, et al. 2000. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J Biol Chem 275:28341-28344.
    • (2000) J Biol Chem , vol.275 , pp. 28341-28344
    • Hahn, H.1    Wojnowski, L.2    Specht, K.3    Kappler, R.4    Calzada-Wack, J.5    Potter, D.6    Zimmer, A.7
  • 34
    • 0037206890 scopus 로고    scopus 로고
    • N-CoR controls differentiation of neural stem cells into astrocytes
    • Hermanson O, Jepsen K, Rosenfeld MG. 2002. N-CoR controls differentiation of neural stem cells into astrocytes. Nature 419:934-939.
    • (2002) Nature , vol.419 , pp. 934-939
    • Hermanson, O.1    Jepsen, K.2    Rosenfeld, M.G.3
  • 35
    • 0037424249 scopus 로고    scopus 로고
    • Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
    • Kanda S, Mochizuki Y, Suematsu T, Miyata Y, Nomata K, Kanetake H. 2003. Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J Biol Chem 278:8244-8249.
    • (2003) J Biol Chem , vol.278 , pp. 8244-8249
    • Kanda, S.1    Mochizuki, Y.2    Suematsu, T.3    Miyata, Y.4    Nomata, K.5    Kanetake, H.6
  • 37
    • 0017701702 scopus 로고
    • Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs
    • Kaplan MS, Hinds JW. 1977. Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs. Science 197:1092-1094.
    • (1977) Science , vol.197 , pp. 1092-1094
    • Kaplan, M.S.1    Hinds, J.W.2
  • 38
    • 0032531881 scopus 로고    scopus 로고
    • Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
    • Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD. 1998. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 395:713-716.
    • (1998) Nature , vol.395 , pp. 713-716
    • Kato, Y.1    Tapping, R.I.2    Huang, S.3    Watson, M.H.4    Ulevitch, R.J.5    Lee, J.D.6
  • 39
    • 0032972245 scopus 로고    scopus 로고
    • Experience-dependent regulation of adult hippocampal neurogenesis: Effects of long-term stimulation and stimulus withdrawal
    • Kempermann G, Gage FH. 1999. Experience-dependent regulation of adult hippocampal neurogenesis: Effects of long-term stimulation and stimulus withdrawal. Hippocampus 9:321-332.
    • (1999) Hippocampus , vol.9 , pp. 321-332
    • Kempermann, G.1    Gage, F.H.2
  • 40
    • 0037262305 scopus 로고    scopus 로고
    • Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    • Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH. 2003. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130:391-399.
    • (2003) Development , vol.130 , pp. 391-399
    • Kempermann, G.1    Gast, D.2    Kronenberg, G.3    Yamaguchi, M.4    Gage, F.H.5
  • 41
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • Kempermann G, Kuhn HG, Gage FH. 1997. More hippocampal neurons in adult mice living in an enriched environment. Nature 386:493-495.
    • (1997) Nature , vol.386 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 42
    • 1642474000 scopus 로고    scopus 로고
    • Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    • Kenney AM, Widlund HR, Rowitch DH. 2004. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 131:217-228.
    • (2004) Development , vol.131 , pp. 217-228
    • Kenney, A.M.1    Widlund, H.R.2    Rowitch, D.H.3
  • 44
    • 1642603947 scopus 로고    scopus 로고
    • A small modulatory dsRNA specifies the fate of adult neural stem cells
    • Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH. 2004. A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell 116:779-793.
    • (2004) Cell , vol.116 , pp. 779-793
    • Kuwabara, T.1    Hsieh, J.2    Nakashima, K.3    Taira, K.4    Gage, F.H.5
  • 45
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • Lai K, Kaspar BK, Gage FH, Schaffer DV. 2003. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 6:21-27.
    • (2003) Nat Neurosci , vol.6 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 46
    • 0025325391 scopus 로고
    • Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation
    • Lamph WW, Dwarki VJ, Ofir R, Montminy M, Verma IM. 1990. Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. Proc Natl Acad Sci USA 87:4320-4324.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4320-4324
    • Lamph, W.W.1    Dwarki, V.J.2    Ofir, R.3    Montminy, M.4    Verma, I.M.5
  • 48
    • 0030953874 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells
    • Lin X, Bulleit RF. 1997. Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells. Brain Res Dev Brain Res 99:234-242.
    • (1997) Brain Res Dev Brain Res , vol.99 , pp. 234-242
    • Lin, X.1    Bulleit, R.F.2
  • 49
    • 0032189609 scopus 로고    scopus 로고
    • Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
    • Liu J, Solway K, Messing RO, Sharp FR. 1998. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18:7768-7778.
    • (1998) J Neurosci , vol.18 , pp. 7768-7778
    • Liu, J.1    Solway, K.2    Messing, R.O.3    Sharp, F.R.4
  • 50
    • 0034884911 scopus 로고    scopus 로고
    • Cross-talk between PKA and PKC in human fibroblasts: What are the pharmacotherapeutic implications?
    • Manier DH, Shelton RC, Sulser F. 2001. Cross-talk between PKA and PKC in human fibroblasts: What are the pharmacotherapeutic implications? J Affect Disord 65:275-279.
    • (2001) J Affect Disord , vol.65 , pp. 275-279
    • Manier, D.H.1    Shelton, R.C.2    Sulser, F.3
  • 52
    • 22944481525 scopus 로고    scopus 로고
    • A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation
    • Mao Y, Lee AW. 2005. A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation. J Cell Biol 170:305-316.
    • (2005) J Cell Biol , vol.170 , pp. 305-316
    • Mao, Y.1    Lee, A.W.2
  • 53
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation-dependent factor CREB
    • Mayr B, Montminy M. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 54
    • 0035940387 scopus 로고    scopus 로고
    • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein
    • Mehrhof FB, Muller FU, Bergmann MW, Li P, Wang Y, Schmitz W, Dietz R, et al. 2001. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 104:2088-2094.
    • (2001) Circulation , vol.104 , pp. 2088-2094
    • Mehrhof, F.B.1    Muller, F.U.2    Bergmann, M.W.3    Li, P.4    Wang, Y.5    Schmitz, W.6    Dietz, R.7
  • 55
    • 0036581252 scopus 로고    scopus 로고
    • Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
    • Nakagawa S, Kim JE, Lee R, Malberg JE, Chen J, Steffen C, Zhang YJ, et al. 2002. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22:3673-3682.
    • (2002) J Neurosci , vol.22 , pp. 3673-3682
    • Nakagawa, S.1    Kim, J.E.2    Lee, R.3    Malberg, J.E.4    Chen, J.5    Steffen, C.6    Zhang, Y.J.7
  • 56
    • 20044362580 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
    • Nyberg J, Anderson MF, Meister B, Alborn AM, Strom AK, Brederlau A, Illerskog AC, et al. 2005. Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation. J Neurosci 25:1816-1825.
    • (2005) J Neurosci , vol.25 , pp. 1816-1825
    • Nyberg, J.1    Anderson, M.F.2    Meister, B.3    Alborn, A.M.4    Strom, A.K.5    Brederlau, A.6    Illerskog, A.C.7
  • 57
    • 9144239955 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
    • Paling NR, Wheadon H, Bone HK, Welham MJ. 2004. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279:48063-48070.
    • (2004) J Biol Chem , vol.279 , pp. 48063-48070
    • Paling, N.R.1    Wheadon, H.2    Bone, H.K.3    Welham, M.J.4
  • 58
    • 0033216122 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS
    • Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH. 1999. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 19:8487-8497.
    • (1999) J Neurosci , vol.19 , pp. 8487-8497
    • Palmer, T.D.1    Markakis, E.A.2    Willhoite, A.R.3    Safar, F.4    Gage, F.H.5
  • 60
    • 0030438734 scopus 로고    scopus 로고
    • The adult rat hippocampus contains primordial neural stem cells
    • Palmer TD, Takahashi J, Gage FH. 1997. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8:389-404.
    • (1997) Mol Cell Neurosci , vol.8 , pp. 389-404
    • Palmer, T.D.1    Takahashi, J.2    Gage, F.H.3
  • 61
    • 0141733263 scopus 로고    scopus 로고
    • Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts
    • Park CS, Schneider IC, Haugh JM. 2003. Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts. J Biol Chem 278:37064-37072.
    • (2003) J Biol Chem , vol.278 , pp. 37064-37072
    • Park, C.S.1    Schneider, I.C.2    Haugh, J.M.3
  • 62
    • 0038692926 scopus 로고    scopus 로고
    • Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors
    • Persson AI, Thorlin T, Bull C, Eriksson PS. 2003. Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol Cell Neurosci 23:360-372.
    • (2003) Mol Cell Neurosci , vol.23 , pp. 360-372
    • Persson, A.I.1    Thorlin, T.2    Bull, C.3    Eriksson, P.S.4
  • 64
    • 0035793574 scopus 로고    scopus 로고
    • p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
    • Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, et al. 2001. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem 276:3517-3523.
    • (2001) J Biol Chem , vol.276 , pp. 3517-3523
    • Rane, M.J.1    Coxon, P.Y.2    Powell, D.W.3    Webster, R.4    Klein, J.B.5    Pierce, W.6    Ping, P.7
  • 65
    • 0027538182 scopus 로고
    • Proliferation, differentiation, and long-term culture of primary hippocampal neurons
    • Ray J, Peterson DA, Schinstine M, Gage FH. 1993. Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc Natl Acad Sci USA 90: 3602-3606.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3602-3606
    • Ray, J.1    Peterson, D.A.2    Schinstine, M.3    Gage, F.H.4
  • 66
  • 68
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. 1999. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401:86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 69
    • 0033214994 scopus 로고    scopus 로고
    • Aberrant expression of cAMP-response-element-binding protein ('CREB') induces apoptosis
    • Saeki K, Yuo A, Suzuki E, Yazaki Y, Takaku F. 1999. Aberrant expression of cAMP-response-element-binding protein ('CREB') induces apoptosis. Biochem J 343 (Part 1):249-255.
    • (1999) Biochem J , vol.343 , Issue.PART 1 , pp. 249-255
    • Saeki, K.1    Yuo, A.2    Suzuki, E.3    Yazaki, Y.4    Takaku, F.5
  • 70
  • 71
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, et al. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7
  • 72
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
    • Schaeffer HJ, Weber MJ. 1999. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol 19:2435-2444.
    • (1999) Mol Cell Biol , vol.19 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 73
    • 0032560521 scopus 로고    scopus 로고
    • Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
    • Scott PH, Brunn GJ, Kohn AD, Roth RA, Lawrence JC Jr. 1998. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci USA 95:7772-7777.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7772-7777
    • Scott, P.H.1    Brunn, G.J.2    Kohn, A.D.3    Roth, R.A.4    Lawrence Jr., J.C.5
  • 74
    • 0032852479 scopus 로고    scopus 로고
    • CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
    • Shaywitz AJ, Greenberg ME. 1999. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861.
    • (1999) Annu Rev Biochem , vol.68 , pp. 821-861
    • Shaywitz, A.J.1    Greenberg, M.E.2
  • 75
    • 4744355621 scopus 로고    scopus 로고
    • Akt-1 expression level regulates CNS precursors
    • Sinor AD, Lillien L. 2004. Akt-1 expression level regulates CNS precursors. J Neurosci 24:8531-8541.
    • (2004) J Neurosci , vol.24 , pp. 8531-8541
    • Sinor, A.D.1    Lillien, L.2
  • 76
    • 0033549246 scopus 로고    scopus 로고
    • Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice
    • Takagi Y, Nozaki K, Takahashi J, Yodoi J, Ishikawa M, Hashimoto N. 1999. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Res 831:283-287.
    • (1999) Brain Res , vol.831 , pp. 283-287
    • Takagi, Y.1    Nozaki, K.2    Takahashi, J.3    Yodoi, J.4    Ishikawa, M.5    Hashimoto, N.6
  • 77
    • 0032906070 scopus 로고    scopus 로고
    • Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures
    • Takahashi J, Palmer TD, Gage FH. 1999. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol 38:65-81.
    • (1999) J Neurobiol , vol.38 , pp. 65-81
    • Takahashi, J.1    Palmer, T.D.2    Gage, F.H.3
  • 78
    • 23144449547 scopus 로고    scopus 로고
    • Essential role of protein kinase B γ (PKB γ /Akt3) in post-natal brain development but not in glucose homeostasis
    • Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T, Michaelis T, et al. 2005. Essential role of protein kinase B γ (PKB γ /Akt3) in post-natal brain development but not in glucose homeostasis. Development 132:2943-2954.
    • (2005) Development , vol.132 , pp. 2943-2954
    • Tschopp, O.1    Yang, Z.Z.2    Brodbeck, D.3    Dummler, B.A.4    Hemmings-Mieszczak, M.5    Watanabe, T.6    Michaelis, T.7
  • 79
  • 80
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag H, Kempermann G, Gage FH. 1999b. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2:266-270.
    • (1999) Nat Neurosci , vol.2 , pp. 266-270
    • van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 81
    • 0038383066 scopus 로고    scopus 로고
    • Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation
    • Vojtek AB, Taylor J, DeRuiter SL, Yu JY, Figueroa C, Kwok RP, Turner DL. 2003. Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation. Mol Cell Biol 23:4417-4427.
    • (2003) Mol Cell Biol , vol.23 , pp. 4417-4427
    • Vojtek, A.B.1    Taylor, J.2    DeRuiter, S.L.3    Yu, J.Y.4    Figueroa, C.5    Kwok, R.P.6    Turner, D.L.7
  • 82
    • 0033049422 scopus 로고    scopus 로고
    • Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
    • Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, Klip A. 1999. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19:4008-4018.
    • (1999) Mol Cell Biol , vol.19 , pp. 4008-4018
    • Wang, Q.1    Somwar, R.2    Bilan, P.J.3    Liu, Z.4    Jin, J.5    Woodgett, J.R.6    Klip, A.7
  • 83
    • 33646549601 scopus 로고    scopus 로고
    • Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
    • Watanabe S, Umehara H, Murayama K, Okabe M, Kimura T, Nakano T. 2006. Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene 25:2697-2707.
    • (2006) Oncogene , vol.25 , pp. 2697-2707
    • Watanabe, S.1    Umehara, H.2    Murayama, K.3    Okabe, M.4    Kimura, T.5    Nakano, T.6
  • 85
    • 0031594573 scopus 로고    scopus 로고
    • Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
    • Xing J, Kornhauser JM, Xia Z, Thiele EA, Greenberg ME. 1998. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol 18:1946-1955.
    • (1998) Mol Cell Biol , vol.18 , pp. 1946-1955
    • Xing, J.1    Kornhauser, J.M.2    Xia, Z.3    Thiele, E.A.4    Greenberg, M.E.5
  • 87
    • 33645217805 scopus 로고    scopus 로고
    • Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectors
    • Yu JH, Schaffer DV. 2006. Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectors. J Virol 80:3285-3292.
    • (2006) J Virol , vol.80 , pp. 3285-3292
    • Yu, J.H.1    Schaffer, D.V.2
  • 88
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3:973-982.
    • (2001) Nat Cell Biol , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6
  • 89
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • Zimmermann S, Moelling K. 1999. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286: 1741-1744.
    • (1999) Science , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2


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