Stem Cells: A Renaissance in Human Biology Research

Cell

Volumn 165, Issue 7, 2016, Pages 1572-1585

  Wu, Jun ^a,b   Izpisua Belmonte, Juan Carlos ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b CATHOLIC UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM; EMBRYO DEVELOPMENT; HUMAN; HUMAN DEVELOPMENT; MONOLAYER CULTURE; PLURIPOTENT STEM CELL; PRENATAL DEVELOPMENT; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; REVIEW; STEM CELL RESEARCH; SURFACE PROPERTY; ANIMAL; CYTOLOGY; MAMMALIAN EMBRYO; METABOLISM; NIDATION;

ANIMALS; CYTOLOGICAL TECHNIQUES; EMBRYO IMPLANTATION; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; HUMANS; PLURIPOTENT STEM CELLS; STEM CELL RESEARCH;

EID: 84975282927     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.05.043     Document Type: Review

References (141)

1. T. Aasen, A. Raya, M.J. Barrero, E. Garreta, A. Consiglio, F. González, R. Vassena, J. Bilić, V. Pekarik, G. Tiscornia, and et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes Nat. Biotechnol. 26 2008 1276 1284
2. S. Aramaki, K. Hayashi, K. Kurimoto, H. Ohta, Y. Yabuta, H. Iwanari, Y. Mochizuki, T. Hamakubo, Y. Kato, K. Shirahige, and M. Saitou A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants Dev. Cell 27 2013 516 529
3. S. Bartfeld, T. Bayram, M. van de Wetering, M. Huch, H. Begthel, P. Kujala, R. Vries, P.J. Peters, and H. Clevers In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection Gastroenterology 148 2015 126 136.e6
4. S. Biechele, B.J. Cox, and J. Rossant Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos Dev. Biol. 355 2011 275 285
5. P. Blakeley, N.M.E. Fogarty, I. del Valle, S.E. Wamaitha, T.X. Hu, K. Elder, P. Snell, L. Christie, P. Robson, and K.K. Niakan Defining the three cell lineages of the human blastocyst by single-cell RNA-seq Development 142 2015 3151 3165
6. S.F. Boj, C.-I. Hwang, L.A. Baker, I.I.C. Chio, D.D. Engle, V. Corbo, M. Jager, M. Ponz-Sarvise, H. Tiriac, M.S. Spector, and et al. Organoid models of human and mouse ductal pancreatic cancer Cell 160 2015 324 338
7. T. Boroviak, R. Loos, P. Bertone, A. Smith, and J. Nichols The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification Nat. Cell Biol. 16 2014 516 528
8. T. Boroviak, R. Loos, P. Lombard, J. Okahara, R. Behr, E. Sasaki, J. Nichols, A. Smith, and P. Bertone Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis Dev. Cell 35 2015 366 382
9. M.A. Brehm, M.V. Wiles, D.L. Greiner, and L.D. Shultz Generation of improved humanized mouse models for human infectious diseases J. Immunol. Methods 410 2014 3 17
10. I.G.M. Brons, L.E. Smithers, M.W.B. Trotter, P. Rugg-Gunn, B. Sun, S.M. Chuva de Sousa Lopes, S.K. Howlett, A. Clarkson, L. Ährlund-Richter, R.A. Pedersen, and L. Vallier Derivation of pluripotent epiblast stem cells from mammalian embryos Nature 448 2007 191 195
11. A.M. Carter, A.C. Enders, and R. Pijnenborg The role of invasive trophoblast in implantation and placentation of primates Philos. Trans. R. Soc. Lond. B Biol. Sci. 370 2015 20140070-20140070
12. C. Chazaud, Y. Yamanaka, T. Pawson, and J. Rossant Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway Dev. Cell 10 2006 615 624
13. A.E. Chen, D. Egli, K. Niakan, J. Deng, H. Akutsu, M. Yamaki, C. Cowan, C. Fitz-Gerald, K. Zhang, D.A. Melton, and K. Eggan Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines Cell Stem Cell 4 2009 103 106
14. J.G. Chenoweth, R.D.G. McKay, and P.J. Tesar Epiblast stem cells contribute new insight into pluripotency and gastrulation Dev. Growth Differ. 52 2010 293 301
15. Y. Chung, I. Klimanskaya, S. Becker, J. Marh, S.-J. Lu, J. Johnson, L. Meisner, and R. Lanza Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres Nature 439 2006 216 219
16. R.L. Clarke, A.D. Yzaguirre, Y. Yashiro-Ohtani, A. Bondue, C. Blanpain, W.S. Pear, N.A. Speck, and G. Keller The expression of Sox17 identifies and regulates haemogenic endothelium Nat. Cell Biol. 15 2013 502 510
17. I.M. Conboy, M.J. Conboy, G.M. Smythe, and T.A. Rando Notch-mediated restoration of regenerative potential to aged muscle Science 302 2003 1575 1577
18. L. Cong, F.A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib, P.D. Hsu, X. Wu, W. Jiang, L.A. Marraffini, and F. Zhang Multiplex genome engineering using CRISPR/Cas systems Science 339 2013 819 823
19. L. Dahéron, S.L. Opitz, H. Zaehres, M.W. Lensch, P.W. Andrews, J. Itskovitz-Eldor, and G.Q. Daley LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells Stem Cells 22 2004 770 778
20. C. De Paepe, M. Krivega, G. Cauffman, M. Geens, and H. Van de Velde Totipotency and lineage segregation in the human embryo Mol. Hum. Reprod. 20 2014 599 618
21. A. Deglincerti, G.F. Croft, L.N. Pietila, M. Zernicka-Goetz, E.D. Siggia, and A.H. Brivanlou Self-organization of the in vitro attached human embryo Nature 533 2016 251 254 10.1038/nature17948
22. J.F. Dekkers, C.L. Wiegerinck, H.R. de Jonge, I. Bronsveld, H.M. Janssens, K.M. de Winter-de Groot, A.M. Brandsma, N.W.M. de Jong, M.J.C. Bijvelds, B.J. Scholte, and et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids Nat. Med. 19 2013 939 945
23. B.R. Dye, D.R. Hill, M.A. Ferguson, Y.-H. Tsai, M.S. Nagy, R. Dyal, J.M. Wells, C.N. Mayhew, R. Nattiv, O.D. Klein, and et al. In vitro generation of human pluripotent stem cell derived lung organoids Elife 4 2015 10.7554/eLife.05098
24. M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotential cells from mouse embryos Nature 292 1981 154 156
25. A. Fatehullah, S.H. Tan, and N. Barker Organoids as an in vitro model of human development and disease Nat. Cell Biol. 18 2016 246 254
26. S.R. Finkbeiner, D.R. Hill, C.H. Altheim, P.H. Dedhia, M.J. Taylor, Y.-H. Tsai, A.M. Chin, M.M. Mahe, C.L. Watson, J.J. Freeman, and et al. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo Stem Cell Reports 4 2015 1140 1155
27. L.F. Franchini, and K.S. Pollard Genomic approaches to studying human-specific developmental traits Development 142 2015 3100 3112
28. O. Gafni, L. Weinberger, A.A. Mansour, Y.S. Manor, E. Chomsky, D. Ben-Yosef, Y. Kalma, S. Viukov, I. Maza, A. Zviran, and et al. Derivation of novel human ground state naive pluripotent stem cells Nature 504 2013 282 286
29. D. Gao, I. Vela, A. Sboner, P.J. Iaquinta, W.R. Karthaus, A. Gopalan, C. Dowling, J.N. Wanjala, E.A. Undvall, V.K. Arora, and et al. Organoid cultures derived from patients with advanced prostate cancer Cell 159 2014 176 187
30. S. Gkountela, K.X. Zhang, T.A. Shafiq, W.-W. Liao, J. Hargan-Calvopiña, P.-Y. Chen, and A.T. Clark DNA Demethylation Dynamics in the Human Prenatal Germline Cell 161 2015 1425 1436
31. S.J. Graham, and M. Zernicka-Goetz The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous? Curr. Top. Dev. Biol. 117 2016 671 695
32. G. Guo, F. von Meyenn, F. Santos, Y. Chen, and W. Reik Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass Stem Cell Reports 6 2016 437 446
33. H. Guo, P. Zhu, L. Yan, R. Li, B. Hu, Y. Lian, J. Yan, X. Ren, S. Lin, J. Li, and et al. The DNA methylation landscape of human early embryos Nature 511 2014 606 610
34. F. Guo, L. Yan, H. Guo, L. Li, B. Hu, Y. Zhao, J. Yong, Y. Hu, X. Wang, Y. Wei, and et al. The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells Cell 161 2015 1437 1452
35. P. Guye, M.R. Ebrahimkhani, N. Kipniss, J.J. Velazquez, E. Schoenfeld, S. Kiani, L.G. Griffith, and R. Weiss Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 Nat. Commun. 7 2016 10243
36. J.A. Hackett, and M.A. Surani Regulatory principles of pluripotency: from the ground state up Cell Stem Cell 15 2014 416 430
37. J.A. Hackett, R. Sengupta, J.J. Zylicz, K. Murakami, C. Lee, T.A. Down, and M.A. Surani Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine Science 339 2013 448 452
38. P. Hajkova, S. Erhardt, N. Lane, T. Haaf, O. El-Maarri, W. Reik, J. Walter, and M.A. Surani Epigenetic reprogramming in mouse primordial germ cells Mechanisms of Development 117 2002 15 23
39. K. Hara, M. Kanai-Azuma, M. Uemura, H. Shitara, C. Taya, H. Yonekawa, H. Kawakami, N. Tsunekawa, M. Kurohmaru, and Y. Kanai Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis Dev. Biol. 330 2009 427 439
40. K. Hayashi, H. Ohta, K. Kurimoto, S. Aramaki, and M. Saitou Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells Cell 146 2011 519 532
41. K. Hayashi, S. Ogushi, K. Kurimoto, S. Shimamoto, H. Ohta, and M. Saitou Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice Science 338 2012 971 975
42. J.W. Haycock 3D Cell Culture: A Review of Current Approaches and Techniques. In 3D Cell Culture 2010 Humana Press Totowa, NJ 1 15
43. E. Heard, and R.A. Martienssen Transgenerational epigenetic inheritance: myths and mechanisms Cell 157 2014 95 109
44. S. Hrvatin, C.W. O'Donnell, F. Deng, J.R. Millman, F.W. Pagliuca, P. DiIorio, A. Rezania, D.K. Gifford, and D.A. Melton Differentiated human stem cells resemble fetal, not adult, β cells Proc. Natl. Acad. Sci. USA 111 2014 3038 3043
45. Y. Huang, R. Osorno, A. Tsakiridis, and V. Wilson In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation Cell Rep. 2 2012 1571 1578
46. K. Huang, T. Maruyama, and G. Fan The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses Cell Stem Cell 15 2014 410 415
47. M. Huch, and B.-K. Koo Modeling mouse and human development using organoid cultures Development 142 2015 3113 3125
48. M. Huch, H. Gehart, R. van Boxtel, K. Hamer, F. Blokzijl, M.M.A. Verstegen, E. Ellis, M. van Wenum, S.A. Fuchs, J. de Ligt, and et al. Long-term culture of genome-stable bipotent stem cells from adult human liver Cell 160 2015 299 312
49. N. Irie, L. Weinberger, W.W.C. Tang, T. Kobayashi, S. Viukov, Y.S. Manor, S. Dietmann, J.H. Hanna, and M.A. Surani SOX17 is a critical specifier of human primordial germ cell fate Cell 160 2015 253 268
50. R. Ito, T. Takahashi, I. Katano, and M. Ito Current advances in humanized mouse models Cell. Mol. Immunol. 9 2012 208 214
51. V. Janzen, R. Forkert, H.E. Fleming, Y. Saito, M.T. Waring, D.M. Dombkowski, T. Cheng, R.A. DePinho, N.E. Sharpless, and D.T. Scadden Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a Nature 443 2006 421 426
52. W.R. Karthaus, P.J. Iaquinta, J. Drost, A. Gracanin, R. van Boxtel, J. Wongvipat, C.M. Dowling, D. Gao, H. Begthel, N. Sachs, and et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures Cell 159 2014 163 175
53. T.B.L. Kirkwood Understanding the odd science of aging Cell 120 2005 437 447
54. H. Kobayashi, T. Sakurai, F. Miura, M. Imai, K. Mochiduki, E. Yanagisawa, A. Sakashita, T. Wakai, Y. Suzuki, T. Ito, and et al. High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice Genome Res. 23 2013 616 627
55. M. Krivega, W. Essahib, and H. Van de Velde WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts Mol. Hum. Reprod. 21 2015 711 722
56. E.W. Kuijk, L.T.A. van Tol, H. Van de Velde, R. Wubbolts, M. Welling, N. Geijsen, and B.A.J. Roelen The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos Development 139 2012 871 882
57. T. Kunath, Y. Yamanaka, J. Detmar, D. MacPhee, I. Caniggia, J. Rossant, and A. Jurisicova Developmental differences in the expression of FGF receptors between human and mouse embryos Placenta 35 2014 1079 1088
58. K. Kurimoto, Y. Yabuta, Y. Ohinata, M. Shigeta, K. Yamanaka, and M. Saitou Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice Genes Dev. 22 2008 1617 1635
59. M.A. Lancaster, and J.A. Knoblich Organogenesis in a dish: modeling development and disease using organoid technologies Science 345 2014 1247125-1247125
60. M.A. Lancaster, M. Renner, C.-A. Martin, D. Wenzel, L.S. Bicknell, M.E. Hurles, T. Homfray, J.M. Penninger, A.P. Jackson, and J.A. Knoblich Cerebral organoids model human brain development and microcephaly Nature 501 2013 373 379
61. M.T. Lee, A.R. Bonneau, and A.J. Giraldez Zygotic genome activation during the maternal-to-zygotic transition Annu. Rev. Cell Dev. Biol. 30 2014 581 613
62. C. López-Otín, M.A. Blasco, L. Partridge, M. Serrano, and G. Kroemer The hallmarks of aging Cell 153 2013 1194 1217
63. P. Mali, L. Yang, K.M. Esvelt, J. Aach, M. Guell, J.E. DiCarlo, J.E. Norville, and G.M. Church RNA-guided human genome engineering via Cas9 Science 339 2013 823 826
64. J. Mariani, G. Coppola, P. Zhang, A. Abyzov, L. Provini, L. Tomasini, M. Amenduni, A. Szekely, D. Palejev, M. Wilson, and et al. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders Cell 162 2015 375 390
65. G.R. Martin Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proc. Natl. Acad. Sci. USA 78 1981 7634 7638
66. V.L. Mascetti, and R.A. Pedersen Human-Mouse Chimerism Validates Human Stem Cell Pluripotency Cell Stem Cell 18 2016 67 72
67. M. Matano, S. Date, M. Shimokawa, A. Takano, M. Fujii, Y. Ohta, T. Watanabe, T. Kanai, and T. Sato Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids Nat. Med. 21 2015 256 262
68. K.W. McCracken, E.M. Catá, C.M. Crawford, K.L. Sinagoga, M. Schumacher, B.E. Rockich, Y.-H. Tsai, C.N. Mayhew, J.R. Spence, Y. Zavros, and J.M. Wells Modelling human development and disease in pluripotent stem-cell-derived gastric organoids Nature 516 2014 400 404
69. F. von Meyenn, and W. Reik Forget the Parents: Epigenetic Reprogramming in Human Germ Cells Cell 161 2015 1248 1251
70. R. Morizane, A.Q. Lam, B.S. Freedman, S. Kishi, M.T. Valerius, and J.V. Bonventre Nephron organoids derived from human pluripotent stem cells model kidney development and injury Nat. Biotechnol. 33 2015 1193 1200
71. S.J. Morrison, A.M. Wandycz, K. Akashi, A. Globerson, and I.L. Weissman The aging of hematopoietic stem cells Nat. Med. 2 1996 1011 1016
72. L. Morsut, K.T. Roybal, X. Xiong, R.M. Gordley, S.M. Coyle, M. Thomson, and W.A. Lim Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors Cell 164 2016 780 791
73. K. Muguruma, A. Nishiyama, H. Kawakami, K. Hashimoto, and Y. Sasai Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells Cell Rep. 10 2015 537 550
74. F. Nakaki, K. Hayashi, H. Ohta, K. Kurimoto, Y. Yabuta, and M. Saitou Induction of mouse germ-cell fate by transcription factors in vitro Nature 501 2013 222 226
75. T. Nakano, S. Ando, N. Takata, M. Kawada, K. Muguruma, K. Sekiguchi, K. Saito, S. Yonemura, M. Eiraku, and Y. Sasai Self-formation of optic cups and storable stratified neural retina from human ESCs Cell Stem Cell 10 2012 771 785
76. K.K. Niakan, and K. Eggan Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse Dev. Biol. 375 2013 54 64
77. K.K. Niakan, J. Han, R.A. Pedersen, C. Simon, and R.A.R. Pera Human pre-implantation embryo development Development 139 2012 829 841
78. J. Nichols, and A. Smith Naive and primed pluripotent states Cell Stem Cell 4 2009 487 492
79. J. Nichols, I. Chambers, T. Taga, and A. Smith Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines Development 128 2001 2333 2339
80. T.K. Noguchi, N. Ninomiya, M. Sekine, S. Komazaki, P.-C. Wang, M. Asashima, and A. Kurisaki Generation of stomach tissue from mouse embryonic stem cells Nat. Cell Biol. 17 2015 984 993
81. J. Oh, Y.D. Lee, and A.J. Wagers Stem cell aging: mechanisms, regulators and therapeutic opportunities Nat. Med. 20 2014 870 880
82. Y. Ohinata, B. Payer, D. O'Carroll, K. Ancelin, Y. Ono, M. Sano, S.C. Barton, T. Obukhanych, M. Nussenzweig, A. Tarakhovsky, and et al. Blimp1 is a critical determinant of the germ cell lineage in mice Nature 436 2005 207 213
83. Y. Ohinata, H. Ohta, M. Shigeta, K. Yamanaka, T. Wakayama, and M. Saitou A signaling principle for the specification of the germ cell lineage in mice Cell 137 2009 571 584
84. H. Okae, H. Chiba, H. Hiura, H. Hamada, A. Sato, T. Utsunomiya, H. Kikuchi, H. Yoshida, A. Tanaka, M. Suyama, and T. Arima Genome-wide analysis of DNA methylation dynamics during early human development PLoS Genet. 10 2014 e1004868
85. I.H. Park, R. Zhao, J.A. West, A. Yabuuchi, H. Huo, T.A. Ince, P.H. Lerou, M.W. Lensch, and G.Q. Daley Reprogramming of human somatic cells to pluripotency with defined factors Nature 451 2008 141 146
86. R. Passier, V. Orlova, and C. Mummery Complex Tissue and Disease Modeling using hiPSCs Cell Stem Cell 18 2016 309 321
87. S. Petropoulos, D. Edsgard, B. Reinius, and Q. Deng Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos Cell 165 2016 1012 1026
88. E.A. Pollina, and A. Brunet Epigenetic regulation of aging stem cells Oncogene 30 2011 3105 3126
89. R.S. Prather, M. Lorson, J.W. Ross, J.J. Whyte, and E. Walters Genetically engineered pig models for human diseases Annu. Rev. Anim. Biosci. 1 2013 203 219
90. M. Roode, K. Blair, P. Snell, K. Elder, S. Marchant, A. Smith, and J. Nichols Human hypoblast formation is not dependent on FGF signalling Dev. Biol. 361 2012 358 363
91. J. Rossant Mouse and human blastocyst-derived stem cells: vive les differences Development 142 2015 9 12
92. J. Rossant Human embryology: Implantation barrier overcome Nature 533 2016 182 183 10.1038/nature17894
93. D.J. Rossi, J. Seita, A. Czechowicz, D. Bhattacharya, D. Bryder, and I.L. Weissman Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging Cell Cycle 6 2007 2371 2376
94. K.T. Roybal, L.J. Rupp, L. Morsut, W.J. Walker, K.A. McNally, J.S. Park, and W.A. Lim Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits Cell 164 2016 770 779
95. Y. Sasai Cytosystems dynamics in self-organization of tissue architecture Nature 493 2013 318 326
96. Y. Sasai Next-generation regenerative medicine: organogenesis from stem cells in 3D culture Cell Stem Cell 12 2013 520 530
97. K. Sasaki, S. Yokobayashi, T. Nakamura, I. Okamoto, Y. Yabuta, K. Kurimoto, H. Ohta, Y. Moritoki, C. Iwatani, H. Tsuchiya, and et al. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells Cell Stem Cell 17 2015 178 194
98. T. Sato, D.E. Stange, M. Ferrante, R.G.J. Vries, J.H. Van Es, S. Van den Brink, W.J. Van Houdt, A. Pronk, J. Van Gorp, P.D. Siersema, and H. Clevers Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium Gastroenterology 141 2011 1762 1772
99. P. Schlaermann, B. Toelle, H. Berger, S.C. Schmidt, M. Glanemann, J. Ordemann, S. Bartfeld, H.J. Mollenkopf, and T.F. Meyer A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro Gut 65 2016 202 213
100. G. Schwank, B.-K. Koo, V. Sasselli, J.F. Dekkers, I. Heo, T. Demircan, N. Sasaki, S. Boymans, E. Cuppen, C.K. van der Ent, and et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients Cell Stem Cell 13 2013 653 658
101. S. Seisenberger, S. Andrews, F. Krueger, J. Arand, J. Walter, F. Santos, C. Popp, B. Thienpont, W. Dean, and W. Reik The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells Mol. Cell 48 2012 849 862
102. M.N. Shahbazi, A. Jedrusik, S. Vuoristo, G. Recher, A. Hupalowska, V. Bolton, N.M. Fogarty, A. Campbell, L.G. Devito, D. Ilic, and et al. Self-organization of the human embryo in the absence of maternal tissues Nat. Cell Biol. 2016 10.1038/ncb3347
103. E.R. Shamir, and A.J. Ewald Three-dimensional organotypic culture: experimental models of mammalian biology and disease Nat. Rev. Mol. Cell Biol. 15 2014 647 664
104. A.C. Shaw, S. Joshi, H. Greenwood, A. Panda, and J.M. Lord Aging of the innate immune system Curr. Opin. Immunol. 22 2010 507 513
105. Z.D. Smith, M.M. Chan, K.C. Humm, R. Karnik, S. Mekhoubad, A. Regev, K. Eggan, and A. Meissner DNA methylation dynamics of the human preimplantation embryo Nature 511 2014 611 615
106. J.R. Spence, C.N. Mayhew, S.A. Rankin, M.F. Kuhar, J.E. Vallance, K. Tolle, E.E. Hoskins, V.V. Kalinichenko, S.I. Wells, A.M. Zorn, and et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro Nature 470 2011 105 109
107. H. Sperber, J. Mathieu, Y. Wang, A. Ferreccio, J. Hesson, Z. Xu, K.A. Fischer, A. Devi, D. Detraux, H. Gu, and et al. The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition Nat. Cell Biol. 17 2015 1523 1535
108. M.A. Surani Human Germline: A New Research Frontier Stem Cell Reports 4 2015 955 960
109. V. Tabar, and L. Studer Pluripotent stem cells in regenerative medicine: challenges and recent progress Nat. Rev. Genet. 15 2014 82 92
110. M. Tachibana, P. Amato, M. Sparman, N.M. Gutierrez, R. Tippner-Hedges, H. Ma, E. Kang, A. Fulati, H.-S. Lee, H. Sritanaudomchai, and et al. Human embryonic stem cells derived by somatic cell nuclear transfer Cell 153 2013 1228 1238
111. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
112. M. Takasato, P.X. Er, H.S. Chiu, B. Maier, G.J. Baillie, C. Ferguson, R.G. Parton, E.J. Wolvetang, M.S. Roost, S.M. Chuva de Sousa Lopes, and M.H. Little Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis Nature 526 2015 564 568
113. Y. Takashima, G. Guo, R. Loos, J. Nichols, G. Ficz, F. Krueger, D. Oxley, F. Santos, J. Clarke, W. Mansfield, and et al. Resetting transcription factor control circuitry toward ground-state pluripotency in human Cell 158 2014 1254 1269
114. P.P.L. Tam, and J. Rossant Mouse embryonic chimeras: tools for studying mammalian development Development 130 2003 6155 6163
115. W.W.C. Tang, S. Dietmann, N. Irie, H.G. Leitch, V.I. Floros, C.R. Bradshaw, J.A. Hackett, P.F. Chinnery, and M.A. Surani A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development Cell 161 2015 1453 1467
116. P.J. Tesar Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos Proc. Natl. Acad. Sci. USA 102 2005 8239 8244
117. P.J. Tesar, J.G. Chenoweth, F.A. Brook, T.J. Davies, E.P. Evans, D.L. Mack, R.L. Gardner, and R.D.G. McKay New cell lines from mouse epiblast share defining features with human embryonic stem cells Nature 448 2007 196 199
118. T.W. Theunissen, B.E. Powell, H. Wang, M. Mitalipova, D.A. Faddah, J. Reddy, Z.P. Fan, D. Maetzel, K. Ganz, L. Shi, and et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency Cell Stem Cell 15 2014 471 487
119. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147
120. C.W. van den Berg, S. Okawa, S.M. Chuva de Sousa Lopes, L. van Iperen, R. Passier, S.R. Braam, L.G. Tertoolen, A. del Sol, R.P. Davis, and C.L. Mummery Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells Development 142 2015 3231 3238
121. M. Van der Jeught, T. O'Leary, S. Ghimire, S. Lierman, G. Duggal, K. Versieren, D. Deforce, S. Chuva de Sousa Lopes, B. Heindryckx, and P. De Sutter The combination of inhibitors of FGF/MEK/Erk and GSK3β signaling increases the number of OCT3/4- and NANOG-positive cells in the human inner cell mass, but does not improve stem cell derivation Stem Cells Dev. 22 2013 296 306
122. M. Van der Jeught, B. Heindryckx, T. O'Leary, G. Duggal, S. Ghimire, S. Lierman, N. Van Roy, S.M. Chuva de Sousa Lopes, T. Deroo, D. Deforce, and et al. Treatment of human embryos with the TGFbeta inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation Hum. Reprod. 29 2014 41 48
123. S.D. Vincent, N.R. Dunn, R. Sciammas, M. Shapiro-Shalef, M.M. Davis, K. Calame, E.K. Bikoff, and E.J. Robertson The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse Development 132 2005 1315 1325
124. D. Wang, and S. Bodovitz Single cell analysis: the new frontier in 'omics' Trends in Biotechnology 28 2010 281 290
125. P. Wang, R.T. Rodriguez, J. Wang, A. Ghodasara, and S.K. Kim Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm Cell Stem Cell 8 2011 335 346
126. C.B. Ware, A.M. Nelson, B. Mecham, J. Hesson, W. Zhou, E.C. Jonlin, A.J. Jimenez-Caliani, X. Deng, C. Cavanaugh, S. Cook, and et al. Derivation of naive human embryonic stem cells Proc. Natl. Acad. Sci. USA 111 2014 4484 4489
127. L. Weinberger, M. Ayyash, N. Novershtern, and J.H. Hanna Dynamic stem cell states: naive to primed pluripotency in rodents and humans Nat. Rev. Mol. Cell Biol. 17 2016 155 169
128. M. Wernig, A. Meissner, R. Foreman, T. Brambrink, M. Ku, K. Hochedlinger, B.E. Bernstein, and R. Jaenisch In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 448 2007 318 324
129. J. Wu, and J.C.I. Belmonte Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts Transgenic Res. 2016 10.1007/s11248-016-9930-z Published online January 28, 2016
130. J. Wu, and J.C. Izpisua Belmonte Stem cells: A designer's guide to pluripotency Nature 516 2014 172 173
131. J. Wu, and J.C. Izpisua Belmonte Dynamic Pluripotent Stem Cell States and Their Applications Cell Stem Cell 17 2015 509 525
132. J. Wu, and J.C. Izpisua Belmonte Metabolic exit from naive pluripotency Nat. Cell Biol. 17 2015 1519 1521
133. J. Wu, and J.C. Izpisua Belmonte The Molecular Harbingers of Early Mammalian Embryo Patterning Cell 165 2016 13 15
134. J. Wu, D. Okamura, M. Li, K. Suzuki, C. Luo, L. Ma, Y. He, Z. Li, C. Benner, I. Tamura, and et al. An alternative pluripotent state confers interspecies chimaeric competency Nature 521 2015 316 321
135. Z. Xue, K. Huang, C. Cai, L. Cai, C.-Y. Jiang, Y. Feng, Z. Liu, Q. Zeng, L. Cheng, Y.E. Sun, and et al. Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing Nature 500 2013 593 597
136. Y. Yamanaka, A. Ralston, R.O. Stephenson, and J. Rossant Cell and molecular regulation of the mouse blastocyst Dev. Dyn. 235 2006 2301 2314
137. L. Yan, M. Yang, H. Guo, L. Yang, J. Wu, R. Li, P. Liu, Y. Lian, X. Zheng, J. Yan, and et al. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells Nat. Struct. Mol. Biol. 20 2013 1131 1139
138. K. Yanger, and B.Z. Stanger Facultative stem cells in liver and pancreas: fact and fancy Dev. Dyn. 240 2011 521 529
139. J. Yu, M.A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J.L. Frane, S. Tian, J. Nie, G.A. Jonsdottir, V. Ruotti, R. Stewart, and et al. Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
140. J.G. Zalatan, M.E. Lee, R. Almeida, L.A. Gilbert, E.H. Whitehead, M. La Russa, J.C. Tsai, J.S. Weissman, J.E. Dueber, L.S. Qi, and W.A. Lim Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds Cell 160 2015 339 350
141. Q. Zhou, M. Wang, Y. Yuan, X. Wang, R. Fu, H. Wan, M. Xie, M. Liu, X. Guo, Y. Zheng, and et al. Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro Cell Stem Cell 18 2016 330 340