Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Cell Stem Cell

Volumn 17, Issue 2, 2015, Pages 178-194

  Sasaki, Kotaro ^a,b   Yokobayashi, Shihori ^a,b,c   Nakamura, Tomonori ^a,b   Okamoto, Ikuhiro ^a,b   Yabuta, Yukihiro ^a,b   Kurimoto, Kazuki ^a,b   Ohta, Hiroshi ^a,b   Moritoki, Yoshinobu ^a,b,d   Iwatani, Chizuru ^e   Tsuchiya, Hideaki ^e   Nakamura, Shinichiro ^e   Sekiguchi, Kiyotoshi ^f   Sakuma, Tetsushi ^g   Yamamoto, Takashi ^g   Mori, Takahide ^h   Woltjen, Knut ^c,i   Nakagawa, Masato ^c   Yamamoto, Takuya ^b,c,j   Takahashi, Kazutoshi ^c   Yamanaka, Shinya ^c   Saitou, Mitinori ^a,b,c,j   more..

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^f OSAKA UNIVERSITY   (Japan)

^g HIROSHIMA UNIVERSITY   (Japan)

^h Academia for Repro regenerative Medicine   (Japan)

ⁱ KYOTO UNIVERSITY   (Japan)

^j KYOTO UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BONE MORPHOGENETIC PROTEIN 4; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELL ADHESION MOLECULE; FIBROBLAST GROWTH FACTOR 2; LEUKEMIA INHIBITORY FACTOR; STEM CELL FACTOR; BIOLOGICAL MARKER; PRDM1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; DOWN REGULATION; EPIGENETICS; FLUORESCENCE ACTIVATED CELL SORTING; GERM LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MESODERM; NERVE CELL DIFFERENTIATION; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SOMATIC CELL; UPREGULATION; ANIMAL; CELL LINEAGE; CYTOLOGY; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GERM CELL; GONAD; INDUCED PLURIPOTENT STEM CELL; MACACA FASCICULARIS; METABOLISM; MOLECULAR GENETICS; MOUSE; NERVE CELL; NUCLEOTIDE SEQUENCE; REPORTER GENE;

MUS; PRIMATES;

ANIMALS; BASE SEQUENCE; BIOMARKERS; CELL DIFFERENTIATION; CELL LINEAGE; EPIGENESIS, GENETIC; GENES, REPORTER; GERM CELLS; GONADS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MACACA FASCICULARIS; MESODERM; MICE; MOLECULAR SEQUENCE DATA; NEURONS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84938738204     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.06.014     Document Type: Article

References (35)

1. S. Aramaki, K. Hayashi, K. Kurimoto, H. Ohta, Y. Yabuta, H. Iwanari, Y. Mochizuki, T. Hamakubo, Y. Kato, K. Shirahige, and M. Saitou A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants Dev. Cell 27 2013 516 529
2. I.G. Brons, L.E. Smithers, M.W. Trotter, P. Rugg-Gunn, B. Sun, S.M. Chuva de Sousa Lopes, S.K. Howlett, A. Clarkson, L. Ahrlund-Richter, R.A. Pedersen, and L. Vallier Derivation of pluripotent epiblast stem cells from mammalian embryos Nature 448 2007 191 195
3. N.Y. Chia, Y.S. Chan, B. Feng, X. Lu, Y.L. Orlov, D. Moreau, P. Kumar, L. Yang, J. Jiang, M.S. Lau, and et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity Nature 468 2010 316 320
4. J. de Jong, H. Stoop, A.J. Gillis, R.J. van Gurp, G.J. van de Geijn, Md. Boer, R. Hersmus, P.T. Saunders, R.A. Anderson, J.W. Oosterhuis, and L.H. Looijenga Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications J. Pathol. 215 2008 21 30
5. D. Eckert, K. Biermann, D. Nettersheim, A.J. Gillis, K. Steger, H.M. Jäck, A.M. Müller, L.H. Looijenga, and H. Schorle Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors BMC Dev. Biol. 8 2008 106
6. K. Hayashi, H. Ohta, K. Kurimoto, S. Aramaki, and M. Saitou Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells Cell 146 2011 519 532
7. K. Hayashi, S. Ogushi, K. Kurimoto, S. Shimamoto, H. Ohta, and M. Saitou Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice Science 338 2012 971 975
8. Y. Hayashi, M. Saitou, and S. Yamanaka Germline development from human pluripotent stem cells toward disease modeling of infertility Fertil. Steril. 97 2012 1250 1259
9. N. Irie, L. Weinberger, W.W. Tang, T. Kobayashi, S. Viukov, Y.S. Manor, S. Dietmann, J.H. Hanna, and M.A. Surani SOX17 is a critical specifier of human primordial germ cell fate Cell 160 2015 253 268
10. K. Kurimoto, Y. Yabuta, Y. Ohinata, M. Shigeta, K. Yamanaka, and M. Saitou Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice Genes Dev. 22 2008 1617 1635
11. K. Kurimoto, Y. Yabuta, K. Hayashi, H. Ohta, H. Kiyonari, T. Mitani, Y. Moritoki, K. Kohri, H. Kimura, T. Yamamoto, and et al. Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells Cell Stem Cell 16 2015 517 532
12. I.Y. Lin, F.L. Chiu, C.H. Yeang, H.F. Chen, C.Y. Chuang, S.Y. Yang, P.S. Hou, N. Sintupisut, H.N. Ho, H.C. Kuo, and K.I. Lin Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells Stem Cell Reports 2 2014 189 204
13. M. Nakagawa, Y. Taniguchi, S. Senda, N. Takizawa, T. Ichisaka, K. Asano, A. Morizane, D. Doi, J. Takahashi, M. Nishizawa, and et al. A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells Sci. Rep. 4 2014 3594
14. F. Nakaki, and M. Saitou PRDM14: a unique regulator for pluripotency and epigenetic reprogramming Trends Biochem. Sci. 39 2014 289 298
15. F. Nakaki, K. Hayashi, H. Ohta, K. Kurimoto, Y. Yabuta, and M. Saitou Induction of mouse germ-cell fate by transcription factors in vitro Nature 501 2013 222 226
16. T. Nakamura, Y. Yabuta, I. Okamoto, S. Aramaki, S. Yokobayashi, K. Kurimoto, K. Sekiguchi, M. Nakagawa, T. Yamamoto, and M. Saitou SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression Nucleic Acids Res. 43 2015 e60
17. Y. Ohinata, B. Payer, D. O'Carroll, K. Ancelin, Y. Ono, M. Sano, S.C. Barton, T. Obukhanych, M. Nussenzweig, A. Tarakhovsky, and et al. Blimp1 is a critical determinant of the germ cell lineage in mice Nature 436 2005 207 213
18. K. Okita, T. Yamakawa, Y. Matsumura, Y. Sato, N. Amano, A. Watanabe, N. Goshima, and S. Yamanaka An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells Stem Cells 31 2013 458 466
19. K. Pauls, R. Jager, S. Weber, E. Wardelmann, A. Koch, R. Buttner, and H. Schorle Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors Int. J. Cancer 115 2005 470 477
20. R.M. Perrett, L. Turnpenny, J.J. Eckert, M. O'Shea, S.B. Sonne, I.T. Cameron, D.I. Wilson, E. Rajpert-De Meyts, and N.A. Hanley The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture Biol. Reprod. 78 2008 852 858
21. M. Saitou, and M. Yamaji Germ cell specification in mice: signaling, transcription regulation, and epigenetic consequences Reproduction 139 2010 931 942
22. M. Saitou, S.C. Barton, and M.A. Surani A molecular programme for the specification of germ cell fate in mice Nature 418 2002 293 300
23. T. Sakuma, S. Hosoi, K. Woltjen, K. Suzuki, K. Kashiwagi, H. Wada, H. Ochiai, T. Miyamoto, N. Kawai, Y. Sasakura, and et al. Efficient TALEN construction and evaluation methods for human cell and animal applications Genes Cells 18 2013 315 326
24. H. Suemori, T. Tada, R. Torii, Y. Hosoi, K. Kobayashi, H. Imahie, Y. Kondo, A. Iritani, and N. Nakatsuji Establishment of embryonic stem cell lines from cynomolgus monkey blastocysts produced by IVF or ICSI Dev. Dyn. 222 2001 273 279
25. F. Sugawa, M.J. Araúzo-Bravo, J. Yoon, K.P. Kim, S. Aramaki, G. Wu, M. Stehling, O.E. Psathaki, K. Hübner, and H.R. Schöler Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile EMBO J. 34 2015 1009 1024
26. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
27. P.J. Tesar, J.G. Chenoweth, F.A. Brook, T.J. Davies, E.P. Evans, D.L. Mack, R.L. Gardner, and R.D. McKay New cell lines from mouse epiblast share defining features with human embryonic stem cells Nature 448 2007 196 199
28. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147
29. K. Watanabe, M. Ueno, D. Kamiya, A. Nishiyama, M. Matsumura, T. Wataya, J.B. Takahashi, S. Nishikawa, S. Nishikawa, K. Muguruma, and Y. Sasai A ROCK inhibitor permits survival of dissociated human embryonic stem cells Nat. Biotechnol. 25 2007 681 686
30. S. Weber, D. Eckert, D. Nettersheim, A.J. Gillis, S. Schäfer, P. Kuckenberg, J. Ehlermann, U. Werling, K. Biermann, L.H. Looijenga, and H. Schorle Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance Biol. Reprod. 82 2010 214 223
31. J.F. Wilson, and R. Erlandsson Sexing of human and other primate DNA Biol. Chem. 379 1998 1287 1288
32. Y. Yabuta, K. Kurimoto, Y. Ohinata, Y. Seki, and M. Saitou Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling Biol. Reprod. 75 2006 705 716
33. M. Yamaji, Y. Seki, K. Kurimoto, Y. Yabuta, M. Yuasa, M. Shigeta, K. Yamanaka, Y. Ohinata, and M. Saitou Critical function of Prdm14 for the establishment of the germ cell lineage in mice Nat. Genet. 40 2008 1016 1022
34. J. Yamasaki, C. Iwatani, H. Tsuchiya, J. Okahara, T. Sankai, and R. Torii Vitrification and transfer of cynomolgus monkey (Macaca fascicularis) embryos fertilized by intracytoplasmic sperm injection Theriogenology 76 2011 33 38
35. Q.L. Ying, J. Wray, J. Nichols, L. Batlle-Morera, B. Doble, J. Woodgett, P. Cohen, and A. Smith The ground state of embryonic stem cell self-renewal Nature 453 2008 519 523