-
1
-
-
78149487692
-
Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues
-
Hanna, J. H., Saha, K. & Jaenisch, R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 143, 508-525 (2010).
-
(2010)
Cell
, vol.143
, pp. 508-525
-
-
Hanna, J.H.1
Saha, K.2
Jaenisch, R.3
-
3
-
-
84918528600
-
Regulatory principles of pluripotency: From the ground state up
-
Hackett, J. A. & Surani, M. A. Regulatory principles of pluripotency: from the ground state up. Cell Stem Cell 15, 416-430 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 416-430
-
-
Hackett, J.A.1
Surani, M.A.2
-
4
-
-
84940029964
-
Establishing the human naive pluripotent state
-
Manor, Y. S., Massarwa, R. & Hanna, J. H. Establishing the human naive pluripotent state. Curr. Opin. Genet. Dev. 34, 35-45 (2015).
-
(2015)
Curr. Opin. Genet. Dev.
, vol.34
, pp. 35-45
-
-
Manor, Y.S.1
Massarwa, R.2
Hanna, J.H.3
-
5
-
-
84898608302
-
iPS cells: A game changer for future medicine
-
Inoue, H., Nagata, N., Kurokawa, H. & Yamanaka, S. iPS cells: a game changer for future medicine. EMBO J. 33, 409-417 (2014).
-
(2014)
EMBO J
, vol.33
, pp. 409-417
-
-
Inoue, H.1
Nagata, N.2
Kurokawa, H.3
Yamanaka, S.4
-
6
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998).
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
-
7
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos
-
Evans, M. J. & Kaufman, M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156 (1981).
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
8
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
-
Martin, G. R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl Acad. Sci. USA 78, 7634-7638 (1981).
-
(1981)
Proc. Natl Acad. Sci. USA
, vol.78
, pp. 7634-7638
-
-
Martin, G.R.1
-
9
-
-
34447528757
-
New cell lines from mouse epiblast share defining features with human embryonic stem cells
-
Tesar, P. J. et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448, 196-199 (2007).
-
(2007)
Nature
, vol.448
, pp. 196-199
-
-
Tesar, P.J.1
-
10
-
-
34447527158
-
Derivation of pluripotent epiblast stem cells from mammalian embryos
-
Brons, I. G. et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448, 191-195 (2007).
-
(2007)
Nature
, vol.448
, pp. 191-195
-
-
Brons, I.G.1
-
11
-
-
77954649854
-
Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state
-
Leitch, H. G. et al. Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state. Development 137, 2279-2287 (2010).
-
(2010)
Development
, vol.137
, pp. 2279-2287
-
-
Leitch, H.G.1
-
12
-
-
0026699762
-
Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture
-
Matsui, Y., Zsebo, K. & Hogan, B. L. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 70, 841-847 (1992).
-
(1992)
Cell
, vol.70
, pp. 841-847
-
-
Matsui, Y.1
Zsebo, K.2
Hogan, B.L.3
-
13
-
-
19944385908
-
Generation of pluripotent stem cells from neonatal mouse testis
-
Kanatsu-Shinohara, M. et al. Generation of pluripotent stem cells from neonatal mouse testis. Cell 119, 1001-1012 (2004).
-
(2004)
Cell
, vol.119
, pp. 1001-1012
-
-
Kanatsu-Shinohara, M.1
-
14
-
-
84944632874
-
Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53
-
Tanaka, T., Kanatsu-Shinohara, M., Hirose, M., Ogura, A. & Shinohara, T. Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53. J. Reprod. Dev. 61, 473-484 (2015).
-
(2015)
J. Reprod. Dev.
, vol.61
, pp. 473-484
-
-
Tanaka, T.1
Kanatsu-Shinohara, M.2
Hirose, M.3
Ogura, A.4
Shinohara, T.5
-
15
-
-
67649215189
-
Induction of pluripotency in adult unipotent germline stem cells
-
Ko, K. et al. Induction of pluripotency in adult unipotent germline stem cells. Cell Stem Cell 5, 87-96 (2009).
-
(2009)
Cell Stem Cell
, vol.5
, pp. 87-96
-
-
Ko, K.1
-
16
-
-
77953938497
-
Human adult germline stem cells in question
-
discussion E3
-
Ko, K. et al. Human adult germline stem cells in question. Nature 465, E1; discussion E3 (2010).
-
(2010)
Nature
, vol.465
, pp. E1
-
-
Ko, K.1
-
17
-
-
0032506231
-
Derivation of pluripotent stem cells from cultured human primordial germ cells
-
Shamblott, M. J. et al. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc. Natl Acad. Sci. USA 95, 13726-13731 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13726-13731
-
-
Shamblott, M.J.1
-
18
-
-
84903535623
-
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells
-
Yamada, M. et al. Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature 510, 533-536 (2014).
-
(2014)
Nature
, vol.510
, pp. 533-536
-
-
Yamada, M.1
-
19
-
-
84878838747
-
Human embryonic stem cells derived by somatic cell nuclear transfer
-
Tachibana, M. et al. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell 153, 1228-1238 (2013).
-
(2013)
Cell
, vol.153
, pp. 1228-1238
-
-
Tachibana, M.1
-
20
-
-
0035957754
-
Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer
-
Wakayama, T. et al. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science 292, 740-743 (2001).
-
(2001)
Science
, vol.292
, pp. 740-743
-
-
Wakayama, T.1
-
21
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
22
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
-
23
-
-
34249908901
-
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
-
Wernig, M. et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324 (2007).
-
(2007)
Nature
, vol.448
, pp. 318-324
-
-
Wernig, M.1
-
24
-
-
65649116572
-
Human induced pluripotent stem cells free of vector and transgene sequences
-
Yu, J. et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797-801 (2009).
-
(2009)
Science
, vol.324
, pp. 797-801
-
-
Yu, J.1
-
25
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
-
26
-
-
84920749824
-
SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts
-
Deuse, T. et al. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell 16, 33-38 (2015).
-
(2015)
Cell Stem Cell
, vol.16
, pp. 33-38
-
-
Deuse, T.1
-
27
-
-
84939553386
-
Metabolic rescue in pluripotent cells from patients with mtDNA disease
-
Ma, H. et al. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature 524, 234-238 (2015).
-
(2015)
Nature
, vol.524
, pp. 234-238
-
-
Ma, H.1
-
28
-
-
70349284435
-
Mitochondrial gene replacement in primate offspring and embryonic stem cells
-
Tachibana, M. et al. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature 461, 367-372 (2009).
-
(2009)
Nature
, vol.461
, pp. 367-372
-
-
Tachibana, M.1
-
29
-
-
84873099821
-
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
-
Paull, D. et al. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature 493, 632-637 (2013).
-
(2013)
Nature
, vol.493
, pp. 632-637
-
-
Paull, D.1
-
30
-
-
67349183976
-
Metastable pluripotent states in NOD-mouse-derived ESCs
-
Hanna, J. et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 4, 513-524 (2009).
-
(2009)
Cell Stem Cell
, vol.4
, pp. 513-524
-
-
Hanna, J.1
-
31
-
-
66049117813
-
Naive and primed pluripotent states
-
Nichols, J. & Smith, A. Naive and primed pluripotent states. Cell Stem Cell 4, 487-492 (2009).
-
(2009)
Cell Stem Cell
, vol.4
, pp. 487-492
-
-
Nichols, J.1
Smith, A.2
-
32
-
-
78650515020
-
Direct reprogramming of fibroblasts into epiblast stem cells
-
Han, D. W. et al. Direct reprogramming of fibroblasts into epiblast stem cells. Nat. Cell Biol. 13, 66-71 (2011).
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 66-71
-
-
Han, D.W.1
-
33
-
-
79952174848
-
Isolation of epiblast stem cells from preimplantation mouse embryos
-
Najm, F. J. et al. Isolation of epiblast stem cells from preimplantation mouse embryos. Cell Stem Cell 8, 318-325 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 318-325
-
-
Najm, F.J.1
-
34
-
-
0016489816
-
Differentiation of clonal lines of teratocarcinoma cells: Formation of embryoid bodies in vitro
-
Martin, G. R. & Evans, M. J. Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. Proc. Natl Acad. Sci. USA 72, 1441-1445 (1975).
-
(1975)
Proc. Natl Acad. Sci. USA
, vol.72
, pp. 1441-1445
-
-
Martin, G.R.1
Evans, M.J.2
-
35
-
-
0024245022
-
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
-
Smith, A. G. et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688-690 (1988).
-
(1988)
Nature
, vol.336
, pp. 688-690
-
-
Smith, A.G.1
-
36
-
-
0024205842
-
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
-
Williams, R. L. et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336, 684-687 (1988).
-
(1988)
Nature
, vol.336
, pp. 684-687
-
-
Williams, R.L.1
-
37
-
-
79958252915
-
Chromatin connections to pluripotency and cellular reprogramming
-
Orkin, S. H. & Hochedlinger, K. Chromatin connections to pluripotency and cellular reprogramming. Cell 145, 835-850 (2011).
-
(2011)
Cell
, vol.145
, pp. 835-850
-
-
Orkin, S.H.1
Hochedlinger, K.2
-
38
-
-
0344845415
-
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self renewal in collaboration with STAT3
-
Ying, Q. L., Nichols, J., Chambers, I. & Smith, A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self renewal in collaboration with STAT3. Cell 115, 281-292 (2003).
-
(2003)
Cell
, vol.115
, pp. 281-292
-
-
Ying, Q.L.1
Nichols, J.2
Chambers, I.3
Smith, A.4
-
39
-
-
0033152966
-
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
-
Burdon, T., Stracey, C., Chambers, I., Nichols, J. & Smith, A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 210, 30-43 (1999).
-
(1999)
Dev. Biol.
, Issue.210
, pp. 30-43
-
-
Burdon, T.1
Stracey, C.2
Chambers, I.3
Nichols, J.4
Smith, A.5
-
40
-
-
44349170450
-
The ground state of embryonic stem cell self-renewal
-
Ying, Q. L. et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519-523 (2008).
-
(2008)
Nature
, vol.453
, pp. 519-523
-
-
Ying, Q.L.1
-
41
-
-
57649181379
-
Capture of authentic embryonic stem cells from rat blastocysts
-
Buehr, M. et al. Capture of authentic embryonic stem cells from rat blastocysts. Cell 135, 1287-1298 (2008).
-
(2008)
Cell
, vol.135
, pp. 1287-1298
-
-
Buehr, M.1
-
42
-
-
67650432118
-
Validated germline-competent embryonic stem cell lines from nonobese diabetic mice
-
Nichols, J. et al. Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat. Med. 15, 814-818 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 814-818
-
-
Nichols, J.1
-
43
-
-
84946550104
-
Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells
-
Chen, H. et al. Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc. Natl Acad. Sci. USA 112, E5936-E5943 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E5936-E5943
-
-
Chen, H.1
-
44
-
-
84862897338
-
Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling
-
Shimizu, T. et al. Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling. Stem Cells 30, 1394-1404 (2012).
-
(2012)
Stem Cells
, vol.30
, pp. 1394-1404
-
-
Shimizu, T.1
-
45
-
-
79953786094
-
Self-renewal versus lineage commitment of embryonic stem cells: Protein kinase C signaling shifts the balance
-
Dutta, D. et al. Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells 29, 618-628 (2011).
-
(2011)
Stem Cells
, vol.29
, pp. 618-628
-
-
Dutta, D.1
-
46
-
-
84947748539
-
Single cell RNAsequencing of pluripotent states unlocks modular transcriptional variation
-
Kolodziejczyk, A. A. et al. Single cell RNAsequencing of pluripotent states unlocks modular transcriptional variation. Cell Stem Cell 17, 471-485 (2015).
-
(2015)
Cell Stem Cell
, vol.17
, pp. 471-485
-
-
Kolodziejczyk, A.A.1
-
47
-
-
84883867435
-
Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition
-
Chen, Y., Blair, K. & Smith, A. Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Rep. 1, 209-217 (2013).
-
(2013)
Stem Cell Rep.
, vol.1
, pp. 209-217
-
-
Chen, Y.1
Blair, K.2
Smith, A.3
-
48
-
-
84887949248
-
Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells
-
Meek, S. et al. Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells. Stem Cells 31, 2104-2115 (2013).
-
(2013)
Stem Cells
, vol.31
, pp. 2104-2115
-
-
Meek, S.1
-
49
-
-
84883141564
-
Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency
-
Rajendran, G. et al. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J. Biol. Chem. 288, 24351-24362 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 24351-24362
-
-
Rajendran, G.1
-
50
-
-
78650972892
-
Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos
-
Li, X. et al. Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos. Cell Stem Cell 8, 46-58 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 46-58
-
-
Li, X.1
-
51
-
-
61749092595
-
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
-
Nishioka, N. et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev. Cell 16, 398-410 (2009).
-
(2009)
Dev. Cell
, vol.16
, pp. 398-410
-
-
Nishioka, N.1
-
52
-
-
84904043132
-
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
-
Azzolin, L. et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell 158, 157-170 (2014).
-
(2014)
Cell
, vol.158
, pp. 157-170
-
-
Azzolin, L.1
-
53
-
-
77953040994
-
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
-
Lian, I. et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 24, 1106-1118 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 1106-1118
-
-
Lian, I.1
-
54
-
-
79959950773
-
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
-
Wray, J. et al. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat. Cell Biol. 13, 838-845 (2011).
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 838-845
-
-
Wray, J.1
-
55
-
-
84874512754
-
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells
-
Faunes, F. et al. A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells. Development 140, 1171-1183 (2013).
-
(2013)
Development
, vol.140
, pp. 1171-1183
-
-
Faunes, F.1
-
56
-
-
84944754959
-
LIF supports primitive endoderm expansion during preimplantation development
-
Morgani, S. M. & Brickman, J. M. LIF supports primitive endoderm expansion during preimplantation development. Development 142, 3488-3499 (2015).
-
(2015)
Development
, vol.142
, pp. 3488-3499
-
-
Morgani, S.M.1
Brickman, J.M.2
-
57
-
-
68749110887
-
Nanog is the gateway to the pluripotent ground state
-
Silva, J. et al. Nanog is the gateway to the pluripotent ground state. Cell 138, 722-737 (2009).
-
(2009)
Cell
, vol.138
, pp. 722-737
-
-
Silva, J.1
-
58
-
-
84938400166
-
Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors
-
Maza, I. et al. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat. Biotechnol. 33, 769-774 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 769-774
-
-
Maza, I.1
-
59
-
-
84893759004
-
Nanog-independent reprogramming to iPSCs with canonical factors
-
Carter, A. C., Davis-Dusenbery, B. N., Koszka, K., Ichida, J. K. & Eggan, K. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Rep. 2, 119-126 (2014).
-
(2014)
Stem Cell Rep.
, vol.2
, pp. 119-126
-
-
Carter, A.C.1
Davis-Dusenbery, B.N.2
Koszka, K.3
Ichida, J.K.4
Eggan, K.5
-
60
-
-
84895068666
-
Nanog is dispensable for the generation of induced pluripotent stem cells
-
Schwartz, B. A. et al. Nanog is dispensable for the generation of induced pluripotent stem cells. Curr. Biol. 24, 347-350 (2014).
-
(2014)
Curr. Biol.
, vol.24
, pp. 347-350
-
-
Schwartz, B.A.1
-
61
-
-
84867381511
-
Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells
-
Festuccia, N. et al. Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell 11, 477-490 (2012).
-
(2012)
Cell Stem Cell
, vol.11
, pp. 477-490
-
-
Festuccia, N.1
-
62
-
-
84902130309
-
Klf2 is an essential factor that sustains ground state pluripotency
-
Yeo, J. C. et al. Klf2 is an essential factor that sustains ground state pluripotency. Cell Stem Cell 14, 864-872 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 864-872
-
-
Yeo, J.C.1
-
63
-
-
84860647928
-
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment
-
Reynolds, N. et al. NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell 10, 583-594 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 583-594
-
-
Reynolds, N.1
-
64
-
-
84885619736
-
Deterministic direct reprogramming of somatic cells to pluripotency
-
Rais, Y. et al. Deterministic direct reprogramming of somatic cells to pluripotency. Nature 502, 65-70 (2013).
-
(2013)
Nature
, vol.502
, pp. 65-70
-
-
Rais, Y.1
-
65
-
-
79953847687
-
A precarious balance: Pluripotency factors as lineage specifiers
-
Loh, K. M. & Lim, B. A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell 8, 363-369 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 363-369
-
-
Loh, K.M.1
Lim, B.2
-
66
-
-
84922342926
-
6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
-
6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 347, 1002-1006 (2015).
-
(2015)
Science
, vol.347
, pp. 1002-1006
-
-
Geula, S.1
-
67
-
-
84871677729
-
In vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation
-
Huang, Y. et al. In vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. Cell Rep. 2, 1571-1578 (2012).
-
(2012)
Cell Rep.
, vol.2
, pp. 1571-1578
-
-
Huang, Y.1
-
68
-
-
84902184462
-
Reorganization of enhancer patterns in transition from naive to primed pluripotency
-
Buecker, C. et al. Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell 14, 838-853 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 838-853
-
-
Buecker, C.1
-
69
-
-
84860351082
-
The transcriptional and epigenomic foundations of ground state pluripotency
-
Marks, H. et al. The transcriptional and epigenomic foundations of ground state pluripotency. Cell 149, 590-604 (2012).
-
(2012)
Cell
, vol.149
, pp. 590-604
-
-
Marks, H.1
-
70
-
-
84890439421
-
Derivation of novel human ground state naive pluripotent stem cells
-
Gafni, O. et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 504, 282-286 (2013).
-
(2013)
Nature
, vol.504
, pp. 282-286
-
-
Gafni, O.1
-
71
-
-
84902160341
-
Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency
-
Factor, D. C. et al. Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. Cell Stem Cell 14, 854-863 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 854-863
-
-
Factor, D.C.1
-
72
-
-
84923188586
-
Deconstructing transcriptional heterogeneity in pluripotent stem cells
-
Kumar, R. M. et al. Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature 516, 56-61 (2014).
-
(2014)
Nature
, vol.516
, pp. 56-61
-
-
Kumar, R.M.1
-
73
-
-
84892178502
-
Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal
-
Kim, H. et al. Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat. Commun. 4, 2403 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2403
-
-
Kim, H.1
-
74
-
-
84891747616
-
The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak
-
Kojima, Y. et al. The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak. Cell Stem Cell 14, 107-120 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 107-120
-
-
Kojima, Y.1
-
75
-
-
84930195552
-
An alternative pluripotent state confers interspecies chimaeric competency
-
Wu, J. et al. An alternative pluripotent state confers interspecies chimaeric competency. Nature 521, 316-321 (2015).
-
(2015)
Nature
, vol.521
, pp. 316-321
-
-
Wu, J.1
-
76
-
-
78149500053
-
Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
-
Han, D. W. et al. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell 143, 617-627 (2010).
-
(2010)
Cell
, vol.143
, pp. 617-627
-
-
Han, D.W.1
-
77
-
-
80052022935
-
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells
-
Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S. & Saitou, M. Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell 146, 519-532 (2011).
-
(2011)
Cell
, vol.146
, pp. 519-532
-
-
Hayashi, K.1
Ohta, H.2
Kurimoto, K.3
Aramaki, S.4
Saitou, M.5
-
78
-
-
66049136895
-
Klf4 reverts developmentally programmed restriction of ground state pluripotency
-
Guo, G. et al. Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development 136, 1063-1069 (2009).
-
(2009)
Development
, vol.136
, pp. 1063-1069
-
-
Guo, G.1
-
79
-
-
70350627509
-
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells
-
Bao, S. et al. Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells. Nature 461, 1292-1295 (2009).
-
(2009)
Nature
, vol.461
, pp. 1292-1295
-
-
Bao, S.1
-
80
-
-
84859541725
-
Epiblast stem cell-based system reveals reprogramming synergy of germline factors
-
Gillich, A. et al. Epiblast stem cell-based system reveals reprogramming synergy of germline factors. Cell Stem Cell 10, 425-439 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 425-439
-
-
Gillich, A.1
-
81
-
-
77449161605
-
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells
-
Greber, B. et al. Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 6, 215-226 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 215-226
-
-
Greber, B.1
-
82
-
-
84875201183
-
Naive pluripotency is associated with global DNA hypomethylation
-
Leitch, H. G. et al. Naive pluripotency is associated with global DNA hypomethylation. Nat. Struct. Mol. Biol. 20, 311-316 (2013).
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 311-316
-
-
Leitch, H.G.1
-
83
-
-
84884164554
-
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency
-
Ficz, G. et al. FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell 13, 351-359 (2013).
-
(2013)
Cell Stem Cell
, vol.13
, pp. 351-359
-
-
Ficz, G.1
-
84
-
-
84890963403
-
Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency
-
Hackett, J. A. et al. Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency. Stem Cell Rep. 1, 518-531 (2013).
-
(2013)
Stem Cell Rep.
, vol.1
, pp. 518-531
-
-
Hackett, J.A.1
-
85
-
-
84952315751
-
Ground state conditions induce rapid reorganization of core pluripotency factor binding before global epigenetic reprogramming
-
Galonska, C., Ziller, M. J., Karnik, R. & Meissner, A. Ground state conditions induce rapid reorganization of core pluripotency factor binding before global epigenetic reprogramming. Cell Stem Cell 17, 462-470 (2015).
-
(2015)
Cell Stem Cell
, vol.17
, pp. 462-470
-
-
Galonska, C.1
Ziller, M.J.2
Karnik, R.3
Meissner, A.4
-
86
-
-
84929134273
-
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
-
Liao, J. et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat. Genet. 47, 469-478 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 469-478
-
-
Liao, J.1
-
87
-
-
84894118496
-
Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs
-
Tee, W. W., Shen, S. S., Oksuz, O., Narendra, V. & Reinberg, D. Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs. Cell 156, 678-690 (2014).
-
(2014)
Cell
, vol.156
, pp. 678-690
-
-
Tee, W.W.1
Shen, S.S.2
Oksuz, O.3
Narendra, V.4
Reinberg, D.5
-
88
-
-
84926314123
-
Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark
-
Bertero, A. et al. Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes Dev. 29, 702-717 (2015).
-
(2015)
Genes Dev.
, vol.29
, pp. 702-717
-
-
Bertero, A.1
-
89
-
-
84905052378
-
DNA methylation dynamics of the human preimplantation embryo
-
Smith, Z. D. et al. DNA methylation dynamics of the human preimplantation embryo. Nature 511, 611-615 (2014).
-
(2014)
Nature
, vol.511
, pp. 611-615
-
-
Smith, Z.D.1
-
90
-
-
84860640679
-
Erosion of dosage compensation impacts human iPSC disease modeling
-
Mekhoubad, S. et al. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell 10, 595-609 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 595-609
-
-
Mekhoubad, S.1
-
91
-
-
78149465975
-
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
-
Chia, N. Y. et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468, 316-320 (2010).
-
(2010)
Nature
, vol.468
, pp. 316-320
-
-
Chia, N.Y.1
-
92
-
-
84907207898
-
Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
-
Shipony, Z. et al. Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells. Nature 513, 115-119 (2014).
-
(2014)
Nature
, vol.513
, pp. 115-119
-
-
Shipony, Z.1
-
93
-
-
84876261517
-
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3
-
Betschinger, J. et al. Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell 153, 335-347 (2013).
-
(2013)
Cell
, vol.153
, pp. 335-347
-
-
Betschinger, J.1
-
94
-
-
77952699848
-
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
-
Hanna, J. et al. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc. Natl Acad. Sci. USA 107, 9222-9227 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 9222-9227
-
-
Hanna, J.1
-
95
-
-
84922637623
-
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
-
Theunissen, T. W. et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 15, 471-487 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 471-487
-
-
Theunissen, T.W.1
-
96
-
-
84908074395
-
Resetting transcription factor control circuitry toward ground-state pluripotency in human
-
Takashima, Y. et al. Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell 158, 1254-1269 (2014).
-
(2014)
Cell
, vol.158
, pp. 1254-1269
-
-
Takashima, Y.1
-
97
-
-
84942163495
-
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq
-
Blakeley, P. et al. Defining the three cell lineages of the human blastocyst by single-cell RNA-seq. Development 142, 3151-3165 (2015).
-
(2015)
Development
, vol.142
, pp. 3151-3165
-
-
Blakeley, P.1
-
98
-
-
84930476912
-
DNA demethylation dynamics in the human prenatal germline
-
Gkountela, S. et al. DNA demethylation dynamics in the human prenatal germline. Cell 161, 1425-1436 (2015).
-
(2015)
Cell
, vol.161
, pp. 1425-1436
-
-
Gkountela, S.1
-
99
-
-
84935840469
-
CD24 tracks divergent pluripotent states in mouse and human cells
-
Shakiba, N. et al. CD24 tracks divergent pluripotent states in mouse and human cells. Nat. Commun. 6, 7329 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7329
-
-
Shakiba, N.1
-
100
-
-
84922505286
-
Stable X chromosome reactivation in female human induced pluripotent stem cells
-
Barakat, T. S. et al. Stable X chromosome reactivation in female human induced pluripotent stem cells. Stem Cell Rep. 4, 199-208 (2015).
-
(2015)
Stem Cell Rep.
, vol.4
, pp. 199-208
-
-
Barakat, T.S.1
-
101
-
-
84890079514
-
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast
-
Chan, Y. S. et al. Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell 13, 663-675 (2013).
-
(2013)
Cell Stem Cell
, vol.13
, pp. 663-675
-
-
Chan, Y.S.1
-
102
-
-
84940467025
-
Alternative routes to induce naive pluripotency in human embryonic stem cells
-
Duggal, G. et al. Alternative routes to induce naive pluripotency in human embryonic stem cells. Stem Cells 33, 2686-2698 (2015).
-
(2015)
Stem Cells
, vol.33
, pp. 2686-2698
-
-
Duggal, G.1
-
103
-
-
84929359290
-
Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency
-
Chen, H. et al. Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. Nat. Commun. 6, 7095 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7095
-
-
Chen, H.1
-
104
-
-
84952628235
-
Rho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells
-
Ohgushi, M., Minaguchi, M. & Sasai, Y. Rho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells. Cell Stem Cell 17, 448-461 (2015).
-
(2015)
Cell Stem Cell
, vol.17
, pp. 448-461
-
-
Ohgushi, M.1
Minaguchi, M.2
Sasai, Y.3
-
105
-
-
28444431537
-
Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript
-
Kameda, T. & Thomson, J. A. Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript. Stem Cells 23, 1535-1540 (2005).
-
(2005)
Stem Cells
, vol.23
, pp. 1535-1540
-
-
Kameda, T.1
Thomson, J.A.2
-
106
-
-
84946711375
-
Lineage-specific profiling delineates the emergence and progression of naive pluripotency in mammalian embryogenesis
-
Boroviak, T. et al. Lineage-specific profiling delineates the emergence and progression of naive pluripotency in mammalian embryogenesis. Dev. Cell 35, 366-382 (2015).
-
(2015)
Dev. Cell
, vol.35
, pp. 366-382
-
-
Boroviak, T.1
-
107
-
-
84861529303
-
Enhancers as information integration hubs in development: Lessons from genomics
-
Buecker, C. & Wysocka, J. Enhancers as information integration hubs in development: lessons from genomics. Trends Genet. 28, 276-284 (2012).
-
(2012)
Trends Genet.
, vol.28
, pp. 276-284
-
-
Buecker, C.1
Wysocka, J.2
-
108
-
-
84877297850
-
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog
-
Karwacki-Neisius, V. et al. Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell 12, 531-545 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 531-545
-
-
Karwacki-Neisius, V.1
-
109
-
-
84901758151
-
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
-
Boroviak, T., Loos, R., Bertone, P., Smith, A. & Nichols, J. The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat. Cell Biol. 16, 516-528 (2014).
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 516-528
-
-
Boroviak, T.1
Loos, R.2
Bertone, P.3
Smith, A.4
Nichols, J.5
-
110
-
-
40449141341
-
Marked differences in differentiation propensity among human embryonic stem cell lines
-
Osafune, K. et al. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat. Biotechnol. 26, 313-315 (2008).
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 313-315
-
-
Osafune, K.1
-
111
-
-
84920989095
-
SOX17 is a critical specifier of human primordial germ cell fate
-
Irie, N. et al. SOX17 is a critical specifier of human primordial germ cell fate. Cell 160, 253-268 (2015).
-
(2015)
Cell
, vol.160
, pp. 253-268
-
-
Irie, N.1
-
112
-
-
79551677421
-
Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
-
Bock, C. et al. Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell 144, 439-452 (2011).
-
(2011)
Cell
, vol.144
, pp. 439-452
-
-
Bock, C.1
-
113
-
-
77956163474
-
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells
-
Kobayashi, T. et al. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell 142, 787-799 (2010).
-
(2010)
Cell
, vol.142
, pp. 787-799
-
-
Kobayashi, T.1
-
114
-
-
84937023145
-
Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells
-
Chen, Y. et al. Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell 17, 116-124 (2015).
-
(2015)
Cell Stem Cell
, vol.17
, pp. 116-124
-
-
Chen, Y.1
-
115
-
-
84918491608
-
Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts
-
Fang, R. et al. Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts. Cell Stem Cell 15, 488-496 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 488-496
-
-
Fang, R.1
-
116
-
-
84904472782
-
Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells
-
Bock, A. S., Leigh, N. D. & Bryda, E. C. Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. In Vitro Cell Dev. Biol. Anim. 50, 572-579 (2014).
-
(2014)
In Vitro Cell Dev. Biol. Anim.
, vol.50
, pp. 572-579
-
-
Bock, A.S.1
Leigh, N.D.2
Bryda, E.C.3
-
117
-
-
84904559751
-
Systematic identification of barriers to human iPSC generation
-
Qin, H. et al. Systematic identification of barriers to human iPSC generation. Cell 158, 449-461 (2014).
-
(2014)
Cell
, vol.158
, pp. 449-461
-
-
Qin, H.1
-
118
-
-
83255177149
-
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells
-
Kim, K. et al. Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat. Biotechnol. 29, 1117-1119 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 1117-1119
-
-
Kim, K.1
-
119
-
-
84947252379
-
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
-
Choi, J. et al. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nat. Biotechnol. 33, 1173-1181 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 1173-1181
-
-
Choi, J.1
-
120
-
-
84904214305
-
Abnormalities in human pluripotent cells due to reprogramming mechanisms
-
Ma, H. et al. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature 511, 177-183 (2014).
-
(2014)
Nature
, vol.511
, pp. 177-183
-
-
Ma, H.1
-
121
-
-
84959542835
-
Naive human pluripotent cells feature a methylation landscape devoid of blastocyst or germline memory
-
Pastor, W. A. et al. Naive human pluripotent cells feature a methylation landscape devoid of blastocyst or germline memory. Cell Stem Cell http://dx.doi.org/10.1016/j.stem.2016.01.019 (2016).
-
(2016)
Cell Stem Cell
-
-
Pastor, W.A.1
|