Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells

Development (Cambridge)

Volumn 142, Issue 18, 2015, Pages 3231-3238

  Van Den Berg, Cathelijne W ^a   Okawa, Satoshi ^b   Chuva De Sousa Lopes, Susana M ^a   Van Iperen, Liesbeth ^a   Passier, Robert ^a   Braam, Stefan R ^c   Tertoolen, Leon G ^a   Del Sol, Antonio ^b   Davis, Richard P ^a   Mummery, Christine L ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^c Pluriomics BV   (Germany)

Author keywords

Gene expression profiling; Human heart development; Human pluripotent stem cells

Indexed keywords

RNA; TRANSCRIPTOME;

ADULT; AGE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; COMPARATIVE STUDY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; FETUS; FETUS HEART; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GENETIC TRANSCRIPTION; GESTATIONAL AGE; HEART ATRIUM; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART VENTRICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RNA EXTRACTION; SECOND TRIMESTER PREGNANCY; TRANSCRIPTOMICS; UPREGULATION; CYTOLOGY; GENE EXPRESSION REGULATION; HEART MUSCLE; METABOLISM; PHYSIOLOGY;

CELL DIFFERENTIATION; FETUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MYOCARDIUM; MYOCYTES, CARDIAC; PLURIPOTENT STEM CELLS; TRANSCRIPTOME;

EID: 84942100201     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.123810     Document Type: Article

References (32)

1. Alfano, C., Magrinelli, E., Harb, K. and Studer, M. (2014). The nuclear receptors COUP-TF: a long-lasting experience in forebrain assembly. Cell. Mol. Life Sci. 71, 43-62.
2. Asp, J., Synnergren, J., Jonsson, M., Dellgren, G. and Jeppsson, A. (2012). Comparison of human cardiac gene expression profiles in paired samples of right atrium and left ventricle collected in vivo. Physiol. Genomics 44, 89-98.
3. Bellin, M., Casini, S., Davis, R. P., D’Aniello, C., Haas, J., Ward-van Oostwaard, D., Tertoolen, L. G. J., Jung, C. B., Elliott, D. A., Welling, A. et al. (2013). Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J. 32, 3161-3175.
4. Bergmann, O., Zdunek, S., Felker, A., Salehpour, M., Alkass, K., Bernard, S., Sjostrom, S. L., Szewczykowska, M., Jackowska, T., dos Remedios, C. et al. (2015). Dynamics of cell generation and turnover in the human heart. Cell 161, 1566-1575.
5. Birket, M. J., Ribeiro, M. C., Verkerk, A. O., Ward, D., Leitoguinho, A. R., den Hartogh, S. C., Orlova, V. V., Devalla, H. D., Schwach, V., Bellin, M. et al. (2015). Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat. Biotechnol. doi:10.1038/nbt.3271.
6. Chang, C.-P. and Bruneau, B. G. (2012). Epigenetics and cardiovascular development. Annu. Rev. Physiol. 74, 41-68.
7. Chen, H., Shi, S., Acosta, L., Li, W., Lu, J., Bao, S., Chen, Z., Yang, Z., Schneider, M. D., Chien, K. R. et al. (2004). BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development 131, 2219-2231.
8. Christophersen, I. E., Olesen, M. S., Liang, B., Andersen, M. N., Larsen, A. P., Nielsen, J. B., Haunso, S., Olesen, S.-P., Tveit, A., Svendsen, J. H. et al. (2013). Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation. Eur. Heart J. 34, 1517-1525.
9. Davis, R. P., van den Berg, C. W., Casini, S., Braam, S. R. and Mummery, C. L. (2011). Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol. Med. 17, 475-484.
10. Davis, R. P., Casini, S., van den Berg, C. W., Hoekstra, M., Remme, C. A., Dambrot, C., Salvatori, D., Oostwaard, D.W.-V.,Wilde, A. A. M., Bezzina, C. R. et al. (2012). Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation 125, 3079-3091.
11. Devalla, H. D., Schwach, V., Ford, J. W., Milnes, J. T., El-Haou, S., Jackson, C., Gkatzis, K., Elliott, D. A., Chuva dezousa Lopes, S. M., Mummery, C. L. et al. (2015). Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology. EMBO Mol. Med. 7, 394-410.
12. Elliott, D. A., Braam, S. R., Koutsis, K., Ng, E. S., Jenny, R., Lagerqvist, E. L., Biben, C., Hatzistavrou, T., Hirst, C. E., Yu, Q. C. et al. (2011). NKX2–5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat. Methods 8, 1037-1040.
13. Gidh-Jain, M., Huang, B., Jain, P., Gick, G. and El-Sherif, N. (1998). Alterations in cardiac gene expression during ventricular remodeling following experimental myocardial infarction. J. Mol. Cell Cardiol. 30, 627-637.
14. Han, P., Hang, C. T., Yang, J. and Chang, C.-P. (2011). Chromatin remodeling in cardiovascular development and physiology. Circ. Res. 108, 378-396.
15. Harvey, R. P. (2002). Patterning the vertebrate heart. Nat. Rev. Genet. 3, 544-556.
16. Huber, W., von Heydebreck, A., Sultmann, H., Poustka, A. and Vingron, M. (2002). Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18 Suppl. 1, S96-S104.
17. Kaab, S., Barth, A. S., Margerie, D., Dugas, M., Gebauer, M., Zwermann, L., Merk, S., Pfeufer, A., Steinmeyer, K., Bleich, M. et al. (2004). Global gene expression in human myocardium-oligonucleotide microarray analysis of regional diversity and transcriptional regulation in heart failure. J. Mol. Med. 82, 308-316.
18. Kimura, K., Ieda, M. and Fukuda, K. (2012). Development, maturation, and transdifferentiation of cardiac sympathetic nerves. Circ. Rses. 110, 325-336.
19. Lu, Z. Q., Sinha, A., Sharma, P., Kislinger, T. and Gramolini, A. O. (2014). Proteomic analysis of human fetal atria and ventricle. J. Proteome Res. 13, 5869-5878.
20. Moorman, A., Webb, S., Brown, N. A., Lamers, W. and Anderson, R. H. (2003). Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart 89, 806-814.
21. Nanni, L., Romualdi, C., Maseri, A. and Lanfranchi, G. (2006). Differential gene expression profiling in genetic and multifactorial cardiovascular diseases. J. Mol. Cell. Cardiol. 41, 934-948.
22. Ng, S. Y., Wong, C. K. and Tsang, S. Y. (2010). Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies. Am. J. Physiol. Cell Physiol. 299, C1234-C1249.
23. Ribeiro, M. C., Tertoolen, L. G., Guadix, J. A., Bellin, M., Kosmidis, G., D’Aniello, C., Monshouwer-Kloots, J., Goumans, M.-J., Wang, Y.-L., Feinberg, A. W. et al. (2015). Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro–correlation between contraction force and electrophysiology. Biomaterials 51, 138-150.
24. Sanoudou, D., Vafiadaki, E., Arvanitis, D. A., Kranias, E. and Kontrogianni- Konstantopoulos, A. (2005). Array lessons from the heart: focus on the genome and transcriptome of cardiomyopathies. Physiol. Genomics 21, 131-143.
25. Small, E. M. and Krieg, P. A. (2004). Molecular regulation of cardiac chamberspecific gene expression. Trends Cardiovasc. Med. 14, 13-18.
26. Smyth, G. K. (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, 1-25.
27. Synnergren, J., Ameen, C., Jansson, A. and Sartipy, P. (2012). Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue. Physiol. Genomics 44, 245-258.
28. Taegtmeyer, H., Sen, S. and Vela, D. (2010). Return to the fetal gene program: a suggested metabolic link to gene expression in the heart. Ann. N. Y. Acad. Sci. 1188, 191-198.
29. Tissir, F. and Goffinet, A. M. (2003). Reelin and brain development. Nat. Rev. Neurosci. 4, 496-505.
30. van den Berg, C.W., Elliott, D. A., Braam, S. R., Mummery, C. L. and Davis, R. P. (2015). Differentiation of human pluripotent stem cells to cardiomyocytes under defined conditions. Methods Mol. Biol. doi:10.1007/7651_2014_178.
31. Yang, X., Pabon, L. and Murry, C. E. (2014). Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes. Circ. Res. 114, 511-523.
32. Zgheib, C., Allukian, M. W., Xu, J., Morris, M. W., Jr., Caskey, R. C., Herdrich, B. J., Hu, J., Gorman, J. H., III, Gorman, R. C. and Liechty, K. W. (2014). Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult. Ann. Thorac. Surg. 97, 1643-1650.