Human pre-implantation embryo development

Development

Volumn 139, Issue 5, 2012, Pages 829-841

  Niakan, Kathy K ^a   Han, Jinnuo ^b   Pedersen, Roger A ^a   Simon, Carlos ^c   Pera, Renee A Reijo ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUTO VALENCIANO DE INFERTILIDAD   (Spain)

Author keywords

Aneuploidy; Blastocyst; Cleavage division; Human embryo; Human embryonic stem cells; Oocyte to embryo transition; Zygote

Indexed keywords

GROWTH FACTOR;

ANEUPLOIDY; ARTICLE; CELL LINEAGE; DEVELOPMENTAL STAGE; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; HUMAN; HUMAN DEVELOPMENT; INFERTILITY THERAPY; MEDICAL LITERATURE; MOLECULAR BIOLOGY; NONHUMAN; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL;

ANEUPLOIDY; ANIMALS; BLASTOCYST; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; GENE REGULATORY NETWORKS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; REPRODUCTIVE TECHNIQUES, ASSISTED; TISSUE THERAPY;

HARNESS;

EID: 84856750425     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.060426     Document Type: Article

References (133)

1. Alfarawati, S., Fragouli, E., Colls, P., Stevens, J., Gutiérrez-Mateo, C., Katz-Jaffe, M. and Wells, D. (2011). The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertil. Steril. 95, 520-524
2. Amit, M., Carpenter, M., Inokuma, M., Chiu, C., Harris, C., Waknitz, M., Itskovitz-Eldor, J. and Thomson, J. (2000). Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev. Biol. 227, 271-278
3. Baart, E., Martini, E., van den Berg, I., Macklon, N., Galjaard, R., Fauser, B. and Opstal, D. V. (2006). Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Hum. Reprod. 21, 223-233
4. Baltaci, V., Satiroglu, H., Kabukçu, C., Unsal, E., Aydinuraz, B., Uner, O., Aktas, Y., Cetinkaya, E., Turhan, F. and Aktan, A. (2006). Relationship between embryo quality and aneuploidies. Reprod. Biomed. Online 12, 77-82
5. Beaujean, N., Taylor, J., Gardner, J., Wilmut, I., Meehan, R. and Young, L. (2004). Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer. Biol. Reprod. 71, 185-193
6. Bell, C. E., Calder, M. D. and Watson, A. J. (2008). Genomic RNA profiling and the programme controlling preimplantation mammalian development. Mol. Hum. Reprod. 14, 691-701
7. Benkhalifa, M., Kasakyan, S., Clement, P., Baldi, M., Tachdjian, G., Demirol, A., Gurgan, T., Fiorentino, F., Mohammed, M. and Qumsiyeh, M. (2005). Array comparative genomic hybridization profiling of first-trimester spontaneous abortions that fail to grow in vitro. Prenat. Diagn. 25, 894-900
8. Berg, D. K., Smith, C. S., Pearton, D. J., Wells, D. N., Broadhurst, R., Donnison, M. and Pfeffer, P. L. (2011). Trophectoderm lineage determination in cattle. Dev. Cell 20, 244-255
9. Bernardo, A. S., Faial, T., Gardner, L., Niakan, K. K., Ortmann, D., Senner, C. E., Callery, E. M., Trotter, M. W., Hemberger, M., Smith, J. C. et al. (2011). BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell 9, 144-155
10. Biggers, J. and Summers, M. (2008). Choosing a culture medium, making informed choices. Fertil. Steril. 90, 473-483
11. Bongso, A. and Tan, S. (2005). Human blastocyst culture and derivation of embryonic stem cell lines. Stem Cell Rev. 1, 87-98
12. Boumela, I., Assou, S., Aouacheria, A., Haouzi, D., Dechaud, H., Vos, J. D., Handyside, A. and Hamamah, S. (2011). Involvement of BCL2 family members in the regulation of human oocyte and early embryo survival and death, gene expression and beyond. Reproduction 141, 549-561
13. Braude, P., Bolton, V. and Moore, S. (1988). Human gene expression first occurs between the four-and eight-cell stages of preimplantation development. Nature 332, 459-461
14. Brison, D. (2000). Apoptosis in mammalian preimplantation embryos: regulation by survival factors. Hum. Fertil. 3, 36-47
15. Brons, I., Smithers, L., Trotter, M., Rugg-Gunn, P., Sun, B., Chuva de Sousa Lopes, S. M., Howlett, S., Clarkson, A., Ahrlund-Richter, L., Pedersen, R. et al. (2007). Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448, 191-195
16. Cedars, M. (2005). Introduction to infertility. In Infertility (ed. M. Cedars). New York, NY: McGraw-Hill.
17. Chen, A. E., Egli, D., Niakan, K., Deng, J., Akutsu, H., Yamaki, M., Cowan, C., Fitz-Gerald, C., Zhang, K., Melton, D. A. et al. (2009). Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell 4, 103-106
18. Cheng, E. Y., Hunt, P. A., Naluai-Cecchini, T. A., Fligner, C. L., Fujimoto, V. Y., Pasternack, T. L., Schwartz, J. M., Steinauer, J. E., Woodruff, T. J., Cherry, S. M. et al. (2009). Meiotic recombination in human oocytes. PLoS Genet. 5, e1000661.
19. Chiang, T., Schultz, R. and Lampson, M. A. (2011). Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes. Biol. Reprod. 85, 1279-1283
20. Clarke, G. (2006). A.R.T. and history, 1678-1978 Hum. Reprod. 21, 1645-1650
21. Di Giorgio, F. P., Boulting, G. L., Bobrowicz, S. and Eggan, K. C. (2008). Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 3, 637-648
22. Dietrich, J. E. and Hiiragi, T. (2007). Stochastic patterning in the mouse preimplantation embryo. Development 134, 4219-4231
23. Dobson, A. T., Raja, R., Abeyta, M. J., Taylor, T., Shen, S., Haqq, C. and Reijo Pera, R. A. (2004). The unique transcriptome through day 3 of human preimplantation development. Hum. Mol. Genet. 13, 1461-1470
24. Duranthon, V., Watson, A. J. and Lonergan, P. (2008). Preimplantation embryo programming: transcription, epigenetics, and culture environment. Reproduction 135, 141-150
25. Edwards, R., Bavister, B. and Steptoe, P. (1969). Early stages of fertilization in vitro of human eggs matured in vitro. Nature 221, 632-635
26. Edwards, R., Steptoe, P. and Purdy, J. (1970). Fertilisation and cleavage in vitro of preovulatory human oocytes. Nature 227, 1307-1309
27. Edwards, R., Steptoe, P. and Purdy, J. (1980). Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br. J. Obstet. Gynaecol. 87, 737-756
28. Edwards, R. G. and Hansis, C. (2005). Initial differentiation of blastomeres in 4-cell human embryos and its significance for early embryogenesis and implantation. Reprod. Biomed. Online 11, 206-218
29. Enders, A. C. and Lopata, A. (1999). Implantation in the marmoset monkey: expansion of the early implantation site. Anat. Rec. 256, 279-299
30. Evers, J. L. (2002). Female subfertility. Lancet 360, 151-159
31. Fernández-González, R., de Dios Hourcade, J., López-Vidriero, I., Benguría, A., Fonseca, F. D. and Gutiérrez-Adán, A. (2009). Analysis of gene transcription alterations at the blastocyst stage related to the long-term consequences of in vitro culture in mice. Reproduction 137, 271-283
32. Flach, G., Johnson, M. H., Braude, P. R., Taylor, R. A. and Bolton, V. N. (1982). The transition from maternal to embryonic control in the 2-cell mouse embryo. EMBO J. 1, 681-686
33. French, D. B., Sabanegh, E. S., Jr, Goldfarb, J. and Desai, N. (2010). Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles? Fertil. Steril. 93, 1097-1103
34. Fritz, B., Hallermann, C., Olert, J., Fuchs, B., Bruns, M., Aslan, M., Schmidt, S., Coerdt, W., Müntefering, H. and Rehder, H. (2001). Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH)-Re-evaluation of chromosome aberration rates in early spontaneous abortions. Eur. J. Hum. Genet. 9, 539-547
35. Fujioka, T., Yasuchika, K., Nakamura, Y., Nakatsuji, N. and Suemori, H. (2004). A simple and efficient cryopreservation method for primate embryonic stem cells. Int. J. Dev. Biol. 48, 1149-1154
36. Fulka, H., Mrazek, M., Tepla, O. and Fulka, J., Jr (2004). DNA methylation pattern in human zygotes and developing embryos. Reproduction 128, 703-708
37. Galan, A., Montaner, D., Poo, M., Valbuena, D., Ruiz, V., Aguilar, C., Dopazo, J. and Simon, C. (2010). Functional genomics of 5-to 8-cell stage human embryos by blastomere single-cell cDNA analysis. PLoS ONE 5, e13615.
38. Gardner, D., Lane, M. (2000). Culture and transfer of viable blastocysts, a feasible proposition for human IVF. Hum. Reprod. 6 Suppl., 9-23
39. Gardner, R. (2001). Specification of embryonic axes begins before cleavage in normal mouse development. Development 128, 839-847
40. Ghosh, S., Hong, C., Feingold, E., Ghosh, P., Bhaumik, P. and Dey, S. (2011). Epidemiology of down syndrome, new insight into the multidimensional interactions among genetic and environmental risk factors in the oocyte. Am. J. Epidemiol. 174, 1009-1016
41. Greber, B., Wu, G., Bernemann, C., Joo, J. Y., Han, D. W., Ko, K., Tapia, N., Sabour, D., Sterneckert, J., Tesar, P. and Schöler, H. R. (2010). Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 6, 215-226
42. Hamatani, T., Daikoku, T., Wang, H., Matsumoto, H., Carter, M. G., Ko, M. S. and Dey, S. K. (2004). Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc. Natl. Acad. Sci. USA 101, 10326-10331
43. Hamatani, T., Ko, M., Yamada, M., Kuji, N., Mizusawa, Y., Shoji, M., Hada, T., Asada, H., Maruyama, T. and Yoshimura, Y. (2006). Global gene expression profiling of preimplantation embryos. Hum. Cell 19, 98-117
44. Hansis, C., Grifo, J. A., Tang, Y. and Krey, L. C. (2002). Assessment of beta-HCG, beta-LH mRNA and ploidy in individual human blastomeres. Reprod. Biomed. Online 5, 156-161
45. Hardarson, T., Caisander, G., Sjögren, A., Hanson, C., Hamberger, L. and Lundin, K. (2003). A morphological and chromosomal study of blastocysts developing from morphologically suboptimal human pre-embryos compared with control blastocysts. Hum. Reprod. 18, 399-407
46. Hardy, K., Wright, C. S., Franks, S. and Winston, R. M. (2000). In vitro maturation of oocytes. Br. Med. Bull. 56, 588-602
47. Harton, G., Rycke, M. D., Fiorentino, F., Moutou, C., SenGupta, S., Traeger-Synodinos, J., Harper, J. C. and the European Society for Human Reproduction and Embryology (ESHRE) PGD Consortium (2011). ESHRE PGD consortium best practice guidelines for amplification-based PGD. Hum. Reprod. 26, 33-40
48. Hasegawa, K., Fujioka, T., Nakamura, Y., Nakatsuji, N. and Suemori, H. (2006). A method for the selection of human embryonic stem cell sublines with high replating efficiency after single-cell dissociation. Stem Cells 24, 2649-2660
49. Hassold, T. and Hunt, P. (2001). To err (meiotically) is human: the genesis of human aneuploidy. Nat. Rev. Genet. 2, 280-291
50. Hassold, T. and Hunt, P. (2009). Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew. Curr. Opin. Pediatr. 21, 703-708
51. Hassold, T., Abruzzo, M., Adkins, K., Griffin, D., Merrill, M., Millie, E., Saker, D., Shen, J. and Zaragoza, M. (1996). Human aneuploidy: incidence, origin, and etiology. Environ. Mol. Mutagen. 28, 167-175
52. Hertig, A., Rock, J., Adams, E. and Mulligan, W. (1954). On the preimplantation stages of the human ovum: a description of four normal and four abnormal specimens ranging from the second to the fifth day of development. Contrib. Embryol. Carnegie Instn. 35, 119-220
53. Hertig, A. T., Rock, J. and Adams, E. C. (1956). A description of 34 human ova within the first 17 days of development. Am. J. Anat. 98, 435-493
54. Hoffman, D., Zellman, G., Fair, C., Mayer, J., Zeitz, J., Gibbons, W. and Turner, T. G., Jr (2003). Cryopreserved embryos in the United States and their availability for research. Fertil. Steril. 79, 1063-1069
55. Hunt, C. J. and Timmons, P. M. (2007). Cryopreservation of human embryonic stem cell lines. Methods Mol. Biol. 368, 261-270
56. Hunt, P. A. and Hassold, T. J. (2002). Sex matters in meiosis. Science 296, 2181-2183
57. Hunt, P. and Hassold, T. (2008). Human female meiosis: what makes a good egg go bad? Trends Genet. 24, 86-93
58. Hunt, P. and Hassold, T. (2010). Female meiosis: coming unglued with age. Curr. Biol. 20, R699-R702.
59. Ilic, D., Genbacev, O. and Krtolica, A. (2007). Derivation of hESC from intact blastocysts. Curr. Protoc. Stem Cell Biol. 1:1A.2.1-1A.2.18.
60. Inge, G., Brinsden, P. and Elder, K. (2005). Oocyte number per live birth in IVF, were Steptoe and Edwards less wasteful? Hum. Reprod. 20, 588-592
61. James, D., Noggle, S. A., Swigut, T. and Brivanlou, A. H. (2006). Contribution of human embryonic stem cells to mouse blastocysts. Dev. Biol. 295, 90-102
62. Jedrusik, A., Parfitt, D. E., Guo, G., Skamagki, M., Grabarek, J. B., Johnson, M. H., Robson, P. and Zernicka-Goetz, M. (2008). Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22, 2692-2706
63. Jones, H. (2003). IVF, past and future. Reprod. Biomed. Online 6, 375-381
64. Kalista, T., Freeman, H. A., Behr, B., Reijo Pera, R. A. and Scott, C. T. (2011). Donation of embryos for human development and stem cell research. Cell Stem Cell 8, 360-362
65. Katari, S., Turan, N., Bibikova, M., Erinle, O., Chalian, R., Foster, M., Gaughan, J., Coutifaris, C. and Sapienza, C. (2009). DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum. Mol. Genet. 18, 3769-3778
66. Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J. and Keller, G. (2011). Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8, 228-240
67. Khosla, S., Dean, W., Reik, W. and Feil, R. (2001). Preimplantation embryos and its long-term effects on gene expression and phenotype. Hum. Reprod. Update 7, 419-427
68. Koo, J.-J., Choi, S.-Y., Jeong, H.-J. and Roh, S.-I. (2011). Fragmentation of embryos is associated with both necrosis and apoptosis. Fertil. Steril. 96, 187-192
69. Kuijk, E. W., van Tol, L. T. A., Van de Velde, H., Wubbolts, R., Welling, M., Geijsen, N. and Roelen, B. A. J. (2012). The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos. Development 139, 871-882
70. Kuo, H., Ogilvie, C. and Handyside, A. (1998). Chromosomal mosaicism in cleavage-stage human embryos and the accuracy of single-cell genetic analysis. J. Assist. Reprod. Genet. 15, 276-280
71. Lanner, F. and Rossant, J. (2010). The role of FGF/Erk signaling in pluripotent cells. Development 137, 3351-3360
72. Lazzari, G., Wrenzycki, C., Herrmann, D., Duchi, R., Kruip, T., Niemann, H. and Galli, C. (2002). Cellular and molecular deviations in bovine in vitroproduced embryos are related to the large offspring syndrome. Biol. Reprod. 67, 767-775
73. Leese, H. (2002). Quiet please, do not disturb: a hypothesis of embryo metabolism and viability. BioEssays 24, 845-849
74. Lim, D., Bowdin, S., Tee, L., Kirby, G., Blair, E., Fryer, A., Lam, W., Oley, C., Cole, T., Brueton, L. et al. (2009). Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies. Hum. Reprod. 24, 741-747
75. Lin, T., Yen, J., Gong, K., Hsu, T. and Chen, L. (2003). IGF-1/IGFBP-1 increases blastocyst formation and total blastocyst cell number in mouse embryo culture and facilitates the establishment of a stem-cell line. BMC Cell Biol. 4, 14.
76. Macklon, N., Geraedts, J. and Fauser, B. (2002). Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Hum. Reprod. Update 8, 333-343
77. Memili, E. and First, N. L. (2000). Zygotic and embryonic expression in cow: a review of timing and mechanisms of early gene expression as compared with other species. Zygote 8, 87-96
78. Mercader, A., Valbuena, D. and Simón, C. (2006). Human embryo culture. Methods Enzymol. 420, 3-18
79. Mitalipov, S., Kuo, H., Hennebold, J. and Wolf, D. (2003). Oct-4 expression in pluripotent cells of the rhesus monkey. Biol. Reprod. 69, 1785-1792
80. Moffett, A. and Loke, C. (2006). Immunology of placentation in eutherian mammals. Nat. Rev. Immunol. 6, 584-594
81. Morris, S. A., Teo, R. T., Li, H., Robson, P., Glover, D. M. and Zernicka-Goetz, M. (2010). Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc. Natl. Acad. Sci. USA 107, 6364-6369
82. Motosugi, N., Bauer, T., Polanski, Z., Solter, D. and Hiiragi, T. (2005). Polarity of the mouse embryo is established at blastocyst and is not prepatterned. Genes Dev. 19, 1081-1092
83. Munné, S., Lee, A., Rosenwaks, Z., Grifo, J. and Cohen, J. (1993). Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum. Reprod. 8, 2185-2191
84. Munné, S., Tomkin, G. and Cohen, J. (2009). Selection of embryos by morphology is less effective than by a combination of aneuploidy testing and morphology observations. Fertil. Steril. 91, 943-945
85. Niakan, K. K., Ji, H., Maehr, R., Vokes, S. A., Rodolfa, K. T., Sherwood, R. I., Yamaki, M., Dimos, J. T., Chen, A. E., Melton, D. A. et al. (2010). Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24, 312-326
86. Norwitz, E. R., Schust, D. J. and Fisher, S. J. (2001). Implantation and the survival of early pregnancy. N. Engl. J. Med. 345, 1400-1408
87. Ohgushi, M., Matsumura, M., Eiraku, M., Murakami, K., Aramaki, T., Nishiyama, A., Muguruma, K., Nakano, T., Suga, H., Ueno, M. et al. (2010). Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell 7, 225-239
88. Osafune, K., Caron, L., Borowiak, M., Martinez, R. J., Fitz-Gerald, C. S., Sato, Y., Cowan, C. A., Chien, K. R. and Melton, D. A. (2008). Marked differences in differentiation propensity among human embryonic stem cell lines. Nat. Biotechnol. 26, 313-315
89. Palermo, G., Joris, H., Devroey, P. and Van Steirteghem, A. C. (1992). Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 340, 17-18
90. Piotrowska, K., Wianny, F., Pedersen, R. and Zernicka-Goetz, M. (2001). Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development. Development 128, 3739-3748
91. Plachta, N., Bollenbach, T., Pease, S., Fraser, S. and Pantazis, P. (2011). Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat. Cell Biol. 13, 117-123
92. Plusa, B., Piliszek, A., Frankenberg, S., Artus, J. and Hadjantonakis, A. K. (2008). Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development 135, 3081-3091
93. Racowsky, C. (2002). High rates of embryonic loss, yet high incidence of multiple births in human ART: Is this paradoxical? Theriogenol. 57, 87-96
94. Ralston, A. and Rossant, J. (2008). Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev. Biol. 313, 614-629
95. Reijo Pera, R. A., DeJonge, C., Bossert, N., Yao, M., Hwa Yang, J. Y., Asadi, N. B., Wong, W., Wong, C. and Firpo, M. T. (2009). Gene expression profiles of human inner cell mass cells and embryonic stem cells. Differentiation 78, 18-23
96. Reubinoff, B. E., Pera, M. F., Vajta, G. and Trounson, A. O. (2001). Effective cryopreservation of human embryonic stem cells by the open pulled straw vitrification method. Hum. Reprod. 16, 2187-2194
97. Robertson, S., Sjöblom, C., Jasper, M., Norman, R. and Seamark, R. (2001). Granulocyte-macrophage colony-stimulating factor promotes glucose transport and blastomere viability in murine preimplantation embryos. Biol. Reprod. 64, 1206-1215
98. Robinson, W., Christian, S., Kuchinka, B., Peñaherrera, M., Das, S., Schuffenhauer, S., Malcolm, S., Schinzel, A., Hassold, T. and Ledbetter, D. (2000). Somatic segregation errors predominantly contribute to the gain or loss of a paternal chromosome leading to uniparental disomy for chromosome 15. Clin. Genet. 57, 349-358
99. Roode, M., Blair, K., Snell, P., Elder, K., Marchant, S., Smith, A. and Nichols, J. (2012). Human hypoblast formation is not dependent on FGF signalling. Dev. Biol. 361, 358-363
100. Rother, F., Shmidt, T., Popova, E., Krivokharchenko, A., Hügel, S., Vilianovich, L., Ridders, M., Tenner, K., Alenina, N., Köhler, M. et al. (2011). Importin 7 is essential for zygotic genome activation and early mouse development. PLoS ONE 6, e18310.
101. Sathananthan, A. and Osianlis, T. (2010). Human embryo culture and assessment for the derivation of embryonic stem cells (ESC). Methods Mol. Biol. 584, 1-20
102. Treff, N. R., Stevens, J. M., Ferry, K., Katz-Jaffe, M. and Scott, R. T., Jr (2011). Live birth outcome with trophectoderm biopsy, blastocyst vitrification, and single-nucleotide polymorphism microarray-based comprehensive chromosome screening in infertile patients. Fertil. Steril. 96, 638-640
103. Selesniemi, K., Lee, H., Muhlhauser, A. and Tilly, J. (2011). Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc. Natl. Acad. Sci. USA 108, 12319-12324
104. Simmons, D., Fortier, A. and Cross, J. (2007). Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Dev. Biol. 304, 567-578
105. Sjöblom, C., Wikland, M. and Robertson, S. (1999). Granulocyte-macrophage colony-stimulating factor promotes human blastocyst development in vitro. Hum. Reprod. 14, 3069-3076
106. Sjöblom, C., Wikland, M. and Robertson, S. (2002). Granulocyte-macrophage colony-stimulating factor (GM-CSF). acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol. Reprod. 67, 1817-1823
107. Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G., Moreau, J., Stahl, M. and Rogers, D. (1988). Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688-690
108. Spallanzani, L. (1785). Esperimenti che servono nella storio della genera-zione di animali e piante. Geneva: Barthelmi Ciro.
109. Spanos, S., Becker, D., Winston, R. and Hardy, K. (2000). Anti-apoptotic action of insulin-like growth factor-I during human preimplantation embryo development. Biol. Reprod. 63, 1413-1420
110. Steptoe, P. C. and Edwards, R. G. (1978). Birth after the reimplantation of a human embryo. Lancet 2, 366.
111. Ström, S., Inzunza, J., Grinnemo, K., Holmberg, K., Matilainen, E., Strömberg, A. M., Blennow, E. and Hovatta, O. (2007). Mechanical isolation of the inner cell mass is effective in derivation of new human embryonic stem cell lines. Hum. Reprod. 22, 3051-3058
112. Tarkowski, A. K., Suwinska, A., Czolowska, R. and Ozdzenski, W. (2010). Individual blastomeres of 16-and 32-cell mouse embryos are able to develop into foetuses and mice. Dev. Biol. 348, 190-198
113. Taylor, D. M., Ray, P. F., Ao, A., Winston, R. M. and Handyside, A. H. (1997). Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the threeto-four-cell stage. Mol. Reprod. Dev. 48, 442-448
114. Tesar, P., Chenoweth, J., Brook, F., Davies, T., Evans, E., Mack, D., Gardner, R. and McKay, R. (2007). New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448, 196-199
115. Tesarík, J., Kopecný, V., Plachot, M. and Mandelbaum, J. (1987). High-resolution autoradiographic localization of DNA-containing sites and RNA synthesis in developing nucleoli of human preimplantation embryos: a new concept of embryonic nucleologenesis. Development 101, 777-791
116. Thomson, J., Itskovitz-Eldor, J., Shapiro, S., Waknitz, M., Swiergiel, J., Marshall, V. and Jones, J. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147
117. Torres-Padilla, M., Parfitt, D., Kouzarides, T. and Zernicka-Goetz, M. (2007). Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 445, 214-218
118. Troncoso, C., Bosch, E., Rubio, C., Remohí, J., Simón, C. and Pellicer, A. (2003). The origin of biochemical pregnancies: lessons learned from preimplantation genetic diagnosis. Fertil. Steril. 79, 449-450
119. Vallier, L. (2011). Serum-free and feeder-free culture conditions for human embryonic stem cells. Methods Mol. Biol. 690, 57-66
120. Vallier, L., Alexander, M. and Pedersen, R. A. (2005). Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J. Cell Sci. 118, 4495-4509
121. Vanneste, E., Voet, T., Caignec, C. L., Ampe, M., Konings, P., Melotte, C., Debrock, S., Amyere, M., Vikkula, M., Schuit, F. et al. (2009). Chromosome instability is common in human cleavage-stage embryos. Nat. Med. 15, 577-583
122. Vanneste, E., Melotte, C., Voet, T., Robberecht, C., Debrock, S., Pexsters, A., Staessen, C., Tomassetti, C., Legius, E., D'Hooghe, T. et al. (2011). PGD for a complex chromosomal rearrangement by array comparative genomic hybridization. Hum. Reprod. 26, 941-949
123. Vassena, R., Boué, S., González-Roca, E., Aran, B., Auer, H., Veiga, A. and Belmonte, J. (2011). Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development 138, 3699-3709
124. Vijayaragavan, K., Szabo, E., Bosse, M., Ramos-Mejia, V., Moon, R. T. and Bhatia, M. (2009). Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell 4, 248-262
125. Wang, Q., Piotrowska, K., Ciemerych, M. A., Milenkovic, L., Scott, M. P., Davis, R. W. and Zernicka-Goetz, M. (2004). A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev. Cell 6, 133-144
126. Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J., Nishikawa, S., Nishikawa, S., Muguruma, K. et al. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25, 681-686
127. Williams, R. L., Hilton, D. J., Pease, S., Willson, T. A., Stewart, C. L., Gearing, D. P., Wagner, E. F., Metcalf, D., Nicola, N. A. and Gough, N. M. (1988). Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336, 684-687
128. Wilton, L., Williamson, R., McBain, J., Edgar, D. and Voullaire, L. (2002). Birth of a healthy infant after preimplantation confirmation of euploidy by comparative genomic hybridization. N. Engl. J. Med. 345, 1537-1541
129. Wong, C., Loewke, K., Bossert, N., Behr, B., DeJonge, C., Baer, T. and Reijo Pera, R. R. (2010). Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat. Biotechnol. 28, 1115-1121
130. Ying, Q. L., Nichols, J., Chambers, I. and Smith, A. (2003). BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281-292
131. Ying, Q. L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P. and Smith, A. (2008). The ground state of embryonic stem cell selfrenewal. Nature 453, 519-523
132. Zeng, F. and Schultz, R. (2005). RNA transcript profiling during zygotic gene activation in the preimplantation mouse embryo. Dev. Biol. 283, 40-57
133. Zhang, P., Zucchelli, M., Bruce, S., Hambiliki, F., Stavreus-Evers, A., Levkov, L., Skottman, H., Kerkela, E., Kere, J. and Hovatta, O. (2009). Transcriptome profiling of human preimplantation development. PLoS ONE 4, e7844.