Differentiated human stem cells resemble fetal, not adult, β cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 3038-3043

  Hrvatin, Siniša ^a   O'Donnell, Charles W ^a,c   Deng, Francis ^a   Millman, Jeffrey R ^a   Pagliuca, Felicia Walton ^a   DiIorio, Philip ^d   Rezania, Alireza ^e   Gifford, David K ^c   Melton, Douglas A ^a,b  

^a Harvard University   (United States)

^b HARVARD UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Beta cells; Differentiation; MARIS; Transcriptional profiling

Indexed keywords

ARISTALESS RELATED HOMEOBOX PROTEIN; CHROMOGRANIN B; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; INSULIN; IROQUOIS HOMEOBOX 2 PROTEIN; MNX1 PROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNK1; POTASSIUM CHANNEL KCNK3; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; FETUS; FETUS CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; MICROARRAY ANALYSIS; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE;

BETA CELLS; DIFFERENTIATION; MARIS; TRANSCRIPTIONAL PROFILING;

ADULT; CELL DIFFERENTIATION; FETUS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; INSULIN-SECRETING CELLS; MICROARRAY ANALYSIS; PANCREAS; PLURIPOTENT STEM CELLS;

EID: 84896889356     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400709111     Document Type: Article

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