-
1
-
-
80053894087
-
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
-
COI: 1:CAS:528:DC%2BC3MXhtlSru7vK, PID: 21746863
-
Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K (2011) An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model. FASEB J 25:3720–3730
-
(2011)
FASEB J
, vol.25
, pp. 3720-3730
-
-
Asai, M.1
Yagishita, S.2
Iwata, N.3
Saido, T.C.4
Ishiura, S.5
Maruyama, K.6
-
2
-
-
84952985156
-
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease
-
PID: 26202697
-
Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S (2015) MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease. Cell Mol Life Sci 73:217–236
-
(2015)
Cell Mol Life Sci
, vol.73
, pp. 217-236
-
-
Baranger, K.1
Marchalant, Y.2
Bonnet, A.E.3
Crouzin, N.4
Carrete, A.5
Paumier, J.M.6
Py, N.A.7
Bernard, A.8
Bauer, C.9
Charrat, E.10
Moschke, K.11
Seiki, M.12
Vignes, M.13
Lichtenthaler, S.F.14
Checler, F.15
Khrestchatisky, M.16
Rivera, S.17
-
3
-
-
14444267540
-
Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer’s disease and cerebral amyloid angiopathy cases
-
COI: 1:CAS:528:DyaK2sXotFWgtbY%3D, PID: 9392006
-
Barelli H, Lebeau A, Vizzavona J, Delaere P, Chevallier N, Drouot C, Marambaud P, Ancolio K, Buxbaum JD, Khorkova O, Heroux J, Sahasrabudhe S, Martinez J, Warter JM, Mohr M, Checler F (1997) Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer’s disease and cerebral amyloid angiopathy cases. Mol Med 3:695–707
-
(1997)
Mol Med
, vol.3
, pp. 695-707
-
-
Barelli, H.1
Lebeau, A.2
Vizzavona, J.3
Delaere, P.4
Chevallier, N.5
Drouot, C.6
Marambaud, P.7
Ancolio, K.8
Buxbaum, J.D.9
Khorkova, O.10
Heroux, J.11
Sahasrabudhe, S.12
Martinez, J.13
Warter, J.M.14
Mohr, M.15
Checler, F.16
-
4
-
-
84873410199
-
Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice
-
COI: 1:CAS:528:DC%2BC3sXkt1Wntw%3D%3D, PID: 23295949
-
Benkhelifa-Ziyyat S, Besse A, Roda M, Duque S, Astord S, Carcenac R, Marais T, Barkats M (2013) Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice. Mol Ther 21:282–290
-
(2013)
Mol Ther
, vol.21
, pp. 282-290
-
-
Benkhelifa-Ziyyat, S.1
Besse, A.2
Roda, M.3
Duque, S.4
Astord, S.5
Carcenac, R.6
Marais, T.7
Barkats, M.8
-
5
-
-
69049091954
-
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway
-
COI: 1:CAS:528:DC%2BD1MXhtVKqt7fL, PID: 19692615
-
Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J (2009) Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. J Neurosci 29:10405–10409
-
(2009)
J Neurosci
, vol.29
, pp. 10405-10409
-
-
Bittner, T.1
Fuhrmann, M.2
Burgold, S.3
Jung, C.K.4
Volbracht, C.5
Steiner, H.6
Mitteregger, G.7
Kretzschmar, H.A.8
Haass, C.9
Herms, J.10
-
6
-
-
27944504351
-
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
PID: 16286508
-
Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171:603–614
-
(2005)
J Cell Biol
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
7
-
-
33746310315
-
Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD28XnsFymsbY%3D, PID: 16876668
-
Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer’s disease. Lancet 368:387–403
-
(2006)
Lancet
, vol.368
, pp. 387-403
-
-
Blennow, K.1
de Leon, M.J.2
Zetterberg, H.3
-
8
-
-
78549273390
-
Macroautophagy is not directly involved in the metabolism of amyloid precursor protein
-
COI: 1:CAS:528:DC%2BC3cXhsVCrt77F, PID: 20864542
-
Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM (2010) Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. J Biol Chem 285:37415–37426
-
(2010)
J Biol Chem
, vol.285
, pp. 37415-37426
-
-
Boland, B.1
Smith, D.A.2
Mooney, D.3
Jung, S.S.4
Walsh, D.M.5
Platt, F.M.6
-
9
-
-
85171202632
-
-
In, International Conference on Alzheimer’s Disease
-
Brigham E, Quinn K, Kwong G, Willits C, Goldbach E, Motter R, Lee M, Hu K, Wallace, Kholodenko D, Tanaka P, Ni H, Hemphill S, Chen X, Eichenbaum T, Ruslim L, Nguyen L, Santiago P, Liao A, Soriano F, Bova M, Probst G, Dappen M, Latimer L, Jagodzinski J, Konradi A, Garofalo A, Webb S, Sham H, Wehner N, Tonn G, Sauer J, Basi G, Ness D (2010) Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration. In: International Conference on Alzheimer’s Disease
-
(2010)
Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration
-
-
Brigham, E.1
Quinn, K.2
Kwong, G.3
Willits, C.4
Goldbach, E.5
Motter, R.6
Lee, M.7
Hu, K.8
Wallace, K.D.9
Tanaka, P.10
Ni, H.11
Hemphill, S.12
Chen, X.13
Eichenbaum, T.14
Ruslim, L.15
Nguyen, L.16
Santiago, P.17
Liao, A.18
Soriano, F.19
Bova, M.20
Probst, G.21
Dappen, M.22
Latimer, L.23
Jagodzinski, J.24
Konradi, A.25
Garofalo, A.26
Webb, S.27
Sham, H.28
Wehner, N.29
Tonn, G.30
Sauer, J.31
Basi, G.32
Ness, D.33
more..
-
10
-
-
84901745843
-
Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer’s disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature
-
COI: 1:CAS:528:DC%2BC2cXps12qtr8%3D, PID: 24899720
-
Caccamo A, De Pinto V, Messina A, Branca C, Oddo S (2014) Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer’s disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature. J Neurosci 34:7988–7998
-
(2014)
J Neurosci
, vol.34
, pp. 7988-7998
-
-
Caccamo, A.1
De Pinto, V.2
Messina, A.3
Branca, C.4
Oddo, S.5
-
11
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
-
COI: 1:CAS:528:DC%2BC3cXkvVGisLw%3D, PID: 20178983
-
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem 285:13107–13120
-
(2010)
J Biol Chem
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
12
-
-
4644319713
-
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
-
COI: 1:CAS:528:DC%2BD2cXotFCmuro%3D, PID: 15465622
-
Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA (2004) Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging 25:1263–1272
-
(2004)
Neurobiol Aging
, vol.25
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Mehta, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
13
-
-
3843114301
-
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
-
COI: 1:CAS:528:DC%2BD2cXntlWitbo%3D, PID: 15330337
-
Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA (2004) Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol 63:821–830
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 821-830
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Schmidt, S.D.3
Terio, N.B.4
Duff, K.5
Beard, M.6
Mathews, P.M.7
Nixon, R.A.8
-
14
-
-
0034711207
-
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
-
COI: 1:CAS:528:DC%2BD3cXoslWlsrk%3D, PID: 10962005
-
Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE (2000) Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. J Biol Chem 275:36794–36802
-
(2000)
J Biol Chem
, vol.275
, pp. 36794-36802
-
-
Chen, F.1
Yang, D.S.2
Petanceska, S.3
Yang, A.4
Tandon, A.5
Yu, G.6
Rozmahel, R.7
Ghiso, J.8
Nishimura, M.9
Zhang, D.M.10
Kawarai, T.11
Levesque, G.12
Mills, J.13
Levesque, L.14
Song, Y.Q.15
Rogaeva, E.16
Westaway, D.17
Mount, H.18
Gandy, S.19
St George-Hyslop, P.20
Fraser, P.E.21
more..
-
15
-
-
84880712325
-
A phase 3 trial of semagacestat for treatment of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3sXhtF2nur7L, PID: 23883379
-
Doody RS, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas RG, Aisen PS, Siemers E, Sethuraman G, Mohs R (2013) A phase 3 trial of semagacestat for treatment of Alzheimer’s disease. N Engl J Med 369:341–350
-
(2013)
N Engl J Med
, vol.369
, pp. 341-350
-
-
Doody, R.S.1
Raman, R.2
Farlow, M.3
Iwatsubo, T.4
Vellas, B.5
Joffe, S.6
Kieburtz, K.7
He, F.8
Sun, X.9
Thomas, R.G.10
Aisen, P.S.11
Siemers, E.12
Sethuraman, G.13
Mohs, R.14
-
16
-
-
84861497482
-
Evidence that the amyloid-beta protein precursor intracellular domain, AICD, derives from beta-secretase-generated C-terminal fragment
-
COI: 1:CAS:528:DC%2BC38XmsF2mt74%3D, PID: 22406447
-
Flammang B, Pardossi-Piquard R, Sevalle J, Debayle D, Dabert-Gay AS, Thevenet A, Lauritzen I, Checler F (2012) Evidence that the amyloid-beta protein precursor intracellular domain, AICD, derives from beta-secretase-generated C-terminal fragment. J Alzheimers Dis 30:145–153
-
(2012)
J Alzheimers Dis
, vol.30
, pp. 145-153
-
-
Flammang, B.1
Pardossi-Piquard, R.2
Sevalle, J.3
Debayle, D.4
Dabert-Gay, A.S.5
Thevenet, A.6
Lauritzen, I.7
Checler, F.8
-
17
-
-
0035159785
-
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD3MXosVKitrc%3D, PID: 11816787
-
Glabe C (2001) Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer’s disease. J Mol Neurosci 17:137–145
-
(2001)
J Mol Neurosci
, vol.17
, pp. 137-145
-
-
Glabe, C.1
-
18
-
-
44049108170
-
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression
-
COI: 1:CAS:528:DC%2BD1cXlsFGktrw%3D, PID: 18434550
-
Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B (2008) Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA 105:6415–6420
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6415-6420
-
-
Hebert, S.S.1
Horre, K.2
Nicolai, L.3
Papadopoulou, A.S.4
Mandemakers, W.5
Silahtaroglu, A.N.6
Kauppinen, S.7
Delacourte, A.8
De Strooper, B.9
-
19
-
-
2942525573
-
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant
-
COI: 1:CAS:528:DC%2BD2cXkslWnu7w%3D, PID: 15184044
-
Horikoshi Y, Sakaguchi G, Becker AG, Gray AJ, Duff K, Aisen PS, Yamaguchi H, Maeda M, Kinoshita N, Matsuoka Y (2004) Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun 319:733–737
-
(2004)
Biochem Biophys Res Commun
, vol.319
, pp. 733-737
-
-
Horikoshi, Y.1
Sakaguchi, G.2
Becker, A.G.3
Gray, A.J.4
Duff, K.5
Aisen, P.S.6
Yamaguchi, H.7
Maeda, M.8
Kinoshita, N.9
Matsuoka, Y.10
-
20
-
-
76549096350
-
Alzheimer’s-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
-
COI: 1:CAS:528:DC%2BC3cXhslGgt74%3D, PID: 20080541
-
Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA (2010) Alzheimer’s-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci USA 107:1630–1635
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 1630-1635
-
-
Jiang, Y.1
Mullaney, K.A.2
Peterhoff, C.M.3
Che, S.4
Schmidt, S.D.5
Boyer-Boiteau, A.6
Ginsberg, S.D.7
Cataldo, A.M.8
Mathews, P.M.9
Nixon, R.A.10
-
21
-
-
84876301199
-
Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo
-
PID: 23347239
-
Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL (2013) Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. Eur J Neurosci 37:1203–1220
-
(2013)
Eur J Neurosci
, vol.37
, pp. 1203-1220
-
-
Kim, J.Y.1
Ash, R.T.2
Ceballos-Diaz, C.3
Levites, Y.4
Golde, T.E.5
Smirnakis, S.M.6
Jankowsky, J.L.7
-
22
-
-
84937605093
-
Evidence that the rab5 effector APPL1 mediates APP-betaCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC2MXht1Wqt7%2FL, PID: 26194181
-
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA (2016) Evidence that the rab5 effector APPL1 mediates APP-betaCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease. Mol Psychiatry 21:707–716
-
(2016)
Mol Psychiatry
, vol.21
, pp. 707-716
-
-
Kim, S.1
Sato, Y.2
Mohan, P.S.3
Peterhoff, C.4
Pensalfini, A.5
Rigoglioso, A.6
Jiang, Y.7
Nixon, R.A.8
-
23
-
-
33846135452
-
Monoclonal antibodies that target pathological assemblies of Abeta
-
COI: 1:CAS:528:DC%2BD2sXptlyqtg%3D%3D, PID: 17116235
-
Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL (2007) Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem 100:23–35
-
(2007)
J Neurochem
, vol.100
, pp. 23-35
-
-
Lambert, M.P.1
Velasco, P.T.2
Chang, L.3
Viola, K.L.4
Fernandez, S.5
Lacor, P.N.6
Khuon, D.7
Gong, Y.8
Bigio, E.H.9
Shaw, P.10
De Felice, F.G.11
Krafft, G.A.12
Klein, W.L.13
-
24
-
-
84869014029
-
The beta-secretase-derived C-terminal fragment of betaAPP, C99, but not Abeta, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus
-
COI: 1:CAS:528:DC%2BC38XhslagurzF, PID: 23152608
-
Lauritzen I, Pardossi-Piquard R, Bauer C, Brigham E, Abraham JD, Ranaldi S, Fraser P, St-George-Hyslop P, Le Thuc O, Espin V, Chami L, Dunys J, Checler F (2012) The beta-secretase-derived C-terminal fragment of betaAPP, C99, but not Abeta, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci 32:16243–16255
-
(2012)
J Neurosci
, vol.32
, pp. 16243-16255
-
-
Lauritzen, I.1
Pardossi-Piquard, R.2
Bauer, C.3
Brigham, E.4
Abraham, J.D.5
Ranaldi, S.6
Fraser, P.7
St-George-Hyslop, P.8
Le Thuc, O.9
Espin, V.10
Chami, L.11
Dunys, J.12
Checler, F.13
-
25
-
-
34347353311
-
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer’s disease-linked mutant presenilin 1
-
COI: 1:CAS:528:DC%2BD2sXnsVyjt7g%3D, PID: 17596450
-
Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS (2007) Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer’s disease-linked mutant presenilin 1. J Neurosci 27:7011–7020
-
(2007)
J Neurosci
, vol.27
, pp. 7011-7020
-
-
Lazarov, O.1
Morfini, G.A.2
Pigino, G.3
Gadadhar, A.4
Chen, X.5
Robinson, J.6
Ho, H.7
Brady, S.T.8
Sisodia, S.S.9
-
26
-
-
84896301845
-
Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis
-
Ling D, Magallanes M, Salvaterra PM (2014) Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis. ASN Neuro 6(2). doi:10.1042/AN20130044
-
(2014)
ASN Neuro
, vol.6
, Issue.2
-
-
Ling, D.1
Magallanes, M.2
Salvaterra, P.M.3
-
27
-
-
79451471809
-
Brain aging and Abeta(1)(-)(4)(2) neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging
-
PID: 21076961
-
Ling D, Salvaterra PM (2011) Brain aging and Abeta(1)(-)(4)(2) neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging. Acta Neuropathol 121:183–191
-
(2011)
Acta Neuropathol
, vol.121
, pp. 183-191
-
-
Ling, D.1
Salvaterra, P.M.2
-
28
-
-
58449101589
-
Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
-
PID: 19145255
-
Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM (2009) Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 4:e4201. doi:10.1371/journal.pone.0004201
-
(2009)
PLoS One
, vol.4
-
-
Ling, D.1
Song, H.J.2
Garza, D.3
Neufeld, T.P.4
Salvaterra, P.M.5
-
29
-
-
0028172238
-
Metabolism of the “Swedish” amyloid precursor protein variant in Madin-Darby canine kidney cells
-
COI: 1:CAS:528:DyaK2cXmslyjt74%3D, PID: 7983032
-
Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS (1994) Metabolism of the “Swedish” amyloid precursor protein variant in Madin-Darby canine kidney cells. J Biol Chem 269:30966–30973
-
(1994)
J Biol Chem
, vol.269
, pp. 30966-30973
-
-
Lo, A.C.1
Haass, C.2
Wagner, S.L.3
Teplow, D.B.4
Sisodia, S.S.5
-
30
-
-
0025133329
-
Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor
-
COI: 1:CAS:528:DyaK3cXmtV2gs74%3D, PID: 1977086
-
Maruyama K, Terakado K, Usami M, Yoshikawa K (1990) Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature 347:566–569
-
(1990)
Nature
, vol.347
, pp. 566-569
-
-
Maruyama, K.1
Terakado, K.2
Usami, M.3
Yoshikawa, K.4
-
31
-
-
84857020179
-
Differential effects between gamma-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice
-
COI: 1:CAS:528:DC%2BC38XisFantbw%3D, PID: 22323718
-
Mitani Y, Yarimizu J, Saita K, Uchino H, Akashiba H, Shitaka Y, Ni K, Matsuoka N (2012) Differential effects between gamma-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice. J Neurosci 32:2037–2050
-
(2012)
J Neurosci
, vol.32
, pp. 2037-2050
-
-
Mitani, Y.1
Yarimizu, J.2
Saita, K.3
Uchino, H.4
Akashiba, H.5
Shitaka, Y.6
Ni, K.7
Matsuoka, N.8
-
32
-
-
33748524564
-
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD28XhtVGls7%2FK, PID: 16982417
-
Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L (2006) Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer’s disease. Neuron 51:703–714
-
(2006)
Neuron
, vol.51
, pp. 703-714
-
-
Mueller-Steiner, S.1
Zhou, Y.2
Arai, H.3
Roberson, E.D.4
Sun, B.5
Chen, J.6
Wang, X.7
Yu, G.8
Esposito, L.9
Mucke, L.10
Gan, L.11
-
33
-
-
38349046973
-
Autophagy, amyloidogenesis and Alzheimer disease
-
COI: 1:CAS:528:DC%2BD1cXmtFeisg%3D%3D, PID: 18032783
-
Nixon RA (2007) Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 120:4081–4091
-
(2007)
J Cell Sci
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
34
-
-
0034304390
-
The endosomal-lysosomal system of neurons in Alzheimer’s disease pathogenesis: a review
-
COI: 1:CAS:528:DC%2BD3cXns1eit7c%3D, PID: 11059790
-
Nixon RA, Cataldo AM, Mathews PM (2000) The endosomal-lysosomal system of neurons in Alzheimer’s disease pathogenesis: a review. Neurochem Res 25:1161–1172
-
(2000)
Neurochem Res
, vol.25
, pp. 1161-1172
-
-
Nixon, R.A.1
Cataldo, A.M.2
Mathews, P.M.3
-
35
-
-
79955969705
-
Autophagy failure in Alzheimer’s disease–locating the primary defect
-
COI: 1:CAS:528:DC%2BC3MXmtFCktbw%3D, PID: 21296668
-
Nixon RA, Yang DS (2011) Autophagy failure in Alzheimer’s disease–locating the primary defect. Neurobiol Dis 43:38–45
-
(2011)
Neurobiol Dis
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
36
-
-
84863890450
-
Autophagy and neuronal cell death in neurological disorders
-
Nixon RA, Yang DS (2012) Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol 4(10). doi:10.1101/cshperspect.a008839
-
(2012)
Cold Spring Harb Perspect Biol
, vol.4
, Issue.10
-
-
Nixon, R.A.1
Yang, D.S.2
-
37
-
-
0042697305
-
Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
-
COI: 1:CAS:528:DC%2BD3sXmsFOksro%3D, PID: 12895417
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409–421
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
38
-
-
58149388879
-
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology
-
COI: 1:CAS:528:DC%2BD1cXhsVGmtLvM, PID: 19020010
-
Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH, LaFerla FM (2008) Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci 28:12163–12175
-
(2008)
J Neurosci
, vol.28
, pp. 12163-12175
-
-
Oddo, S.1
Caccamo, A.2
Tseng, B.3
Cheng, D.4
Vasilevko, V.5
Cribbs, D.H.6
LaFerla, F.M.7
-
39
-
-
84887909793
-
Autophagic/lysosomal dysfunction in Alzheimer’s disease
-
PID: 24171818
-
Orr ME, Oddo S (2013) Autophagic/lysosomal dysfunction in Alzheimer’s disease. Alzheimers Res Ther 5:53
-
(2013)
Alzheimers Res Ther
, vol.5
, pp. 53
-
-
Orr, M.E.1
Oddo, S.2
-
40
-
-
84865254936
-
Ryanodine receptor blockade reduces amyloid-beta load and memory impairments in Tg2576 mouse model of Alzheimer disease
-
COI: 1:CAS:528:DC%2BC38Xht1OrtrzN, PID: 22915123
-
Oules B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Brechot P, Trebak M, Checler F, Benfenati F, Chami M (2012) Ryanodine receptor blockade reduces amyloid-beta load and memory impairments in Tg2576 mouse model of Alzheimer disease. J Neurosci 32:11820–11834
-
(2012)
J Neurosci
, vol.32
, pp. 11820-11834
-
-
Oules, B.1
Del Prete, D.2
Greco, B.3
Zhang, X.4
Lauritzen, I.5
Sevalle, J.6
Moreno, S.7
Paterlini-Brechot, P.8
Trebak, M.9
Checler, F.10
Benfenati, F.11
Chami, M.12
-
41
-
-
84975699587
-
Influence of genetic background on apathy-like behavior in triple transgenic AD mice
-
Pardossi-Piquard R, Lauritzen I, Bauer C, Sacco G, Robert P, Checler F (2016) Influence of genetic background on apathy-like behavior in triple transgenic AD mice. Curr Alzheimer Res 13:1–8. doi:10.2174/1567205013666160404120106
-
(2016)
Curr Alzheimer Res
, vol.13
, pp. 1-8
-
-
Pardossi-Piquard, R.1
Lauritzen, I.2
Bauer, C.3
Sacco, G.4
Robert, P.5
Checler, F.6
-
42
-
-
84878840263
-
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
-
COI: 1:CAS:528:DC%2BC3sXhtlGnsLY%3D, PID: 23224319
-
Pera M, Alcolea D, Sanchez-Valle R, Guardia-Laguarta C, Colom-Cadena M, Badiola N, Suarez-Calvet M, Llado A, Barrera-Ocampo AA, Sepulveda-Falla D, Blesa R, Molinuevo JL, Clarimon J, Ferrer I, Gelpi E, Lleo A (2013) Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease. Acta Neuropathol 125:201–213
-
(2013)
Acta Neuropathol
, vol.125
, pp. 201-213
-
-
Pera, M.1
Alcolea, D.2
Sanchez-Valle, R.3
Guardia-Laguarta, C.4
Colom-Cadena, M.5
Badiola, N.6
Suarez-Calvet, M.7
Llado, A.8
Barrera-Ocampo, A.A.9
Sepulveda-Falla, D.10
Blesa, R.11
Molinuevo, J.L.12
Clarimon, J.13
Ferrer, I.14
Gelpi, E.15
Lleo, A.16
-
43
-
-
84925511980
-
Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?
-
COI: 1:CAS:528:DC%2BC2MXht12kt7Y%3D, PID: 25556159
-
Peric A, Annaert W (2015) Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction? Acta Neuropathol 129:363–381
-
(2015)
Acta Neuropathol
, vol.129
, pp. 363-381
-
-
Peric, A.1
Annaert, W.2
-
44
-
-
84956583677
-
Immune dysfunction in Niemann-Pick disease type C
-
COI: 1:CAS:528:DC%2BC2MXpsFemt7Y%3D, PID: 25946402
-
Platt N, Speak AO, Colaco A, Gray J, Smith DA, Williams IM, Wallom KL, Platt FM (2016) Immune dysfunction in Niemann-Pick disease type C. J Neurochem 136(Suppl 1):74–80
-
(2016)
J Neurochem
, vol.136
, pp. 74-80
-
-
Platt, N.1
Speak, A.O.2
Colaco, A.3
Gray, J.4
Smith, D.A.5
Williams, I.M.6
Wallom, K.L.7
Platt, F.M.8
-
45
-
-
84880171733
-
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydr o-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable gamma-secretase Inhibitors that selectively inhibit the production of amyloid-beta over Notch
-
COI: 1:CAS:528:DC%2BC3sXosVejurg%3D, PID: 23713656
-
Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS (2013) Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydr o-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable gamma-secretase Inhibitors that selectively inhibit the production of amyloid-beta over Notch. J Med Chem 56:5261–5274
-
(2013)
J Med Chem
, vol.56
, pp. 5261-5274
-
-
Probst, G.1
Aubele, D.L.2
Bowers, S.3
Dressen, D.4
Garofalo, A.W.5
Hom, R.K.6
Konradi, A.W.7
Marugg, J.L.8
Mattson, M.N.9
Neitzel, M.L.10
Semko, C.M.11
Sham, H.L.12
Smith, J.13
Sun, M.14
Truong, A.P.15
Ye, X.M.16
Xu, Y.Z.17
Dappen, M.S.18
Jagodzinski, J.J.19
Keim, P.S.20
Peterson, B.21
Latimer, L.H.22
Quincy, D.23
Wu, J.24
Goldbach, E.25
Ness, D.K.26
Quinn, K.P.27
Sauer, J.M.28
Wong, K.29
Zhang, H.30
Zmolek, W.31
Brigham, E.F.32
Kholodenko, D.33
Hu, K.34
Kwong, G.T.35
Lee, M.36
Liao, A.37
Motter, R.N.38
Sacayon, P.39
Santiago, P.40
Willits, C.41
Bard, F.42
Bova, M.P.43
Hemphill, S.S.44
Nguyen, L.45
Ruslim, L.46
Tanaka, K.47
Tanaka, P.48
Wallace, W.49
Yednock, T.A.50
Basi, G.S.51
more..
-
46
-
-
25444479179
-
High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease
-
COI: 1:CAS:528:DC%2BD2MXhtVWiurrJ, PID: 16027115
-
Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E (2005) High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. J Biol Chem 280:32957–32967
-
(2005)
J Biol Chem
, vol.280
, pp. 32957-32967
-
-
Rockenstein, E.1
Mante, M.2
Alford, M.3
Adame, A.4
Crews, L.5
Hashimoto, M.6
Esposito, L.7
Mucke, L.8
Masliah, E.9
-
47
-
-
84857029592
-
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
-
PID: 22020633
-
Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A (2011) Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus. Acta Neuropathol 123:53–70
-
(2011)
Acta Neuropathol
, vol.123
, pp. 53-70
-
-
Sanchez-Varo, R.1
Trujillo-Estrada, L.2
Sanchez-Mejias, E.3
Torres, M.4
Baglietto-Vargas, D.5
Moreno-Gonzalez, I.6
De Castro, V.7
Jimenez, S.8
Ruano, D.9
Vizuete, M.10
Davila, J.C.11
Garcia-Verdugo, J.M.12
Jimenez, A.J.13
Vitorica, J.14
Gutierrez, A.15
-
48
-
-
22544434621
-
Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice
-
COI: 1:CAS:528:DC%2BD2MXmslClsbY%3D, PID: 16033885
-
Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J (2005) Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci 25:6755–6764
-
(2005)
J Neurosci
, vol.25
, pp. 6755-6764
-
-
Saura, C.A.1
Chen, G.2
Malkani, S.3
Choi, S.Y.4
Takahashi, R.H.5
Zhang, D.6
Gouras, G.K.7
Kirkwood, A.8
Morris, R.G.9
Shen, J.10
-
49
-
-
61849084232
-
Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide
-
COI: 1:CAS:528:DC%2BD1MXktVWht70%3D, PID: 19187443
-
Sevalle J, Amoyel A, Robert P, Fournie-Zaluski MC, Roques B, Checler F (2009) Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide. J Neurochem 109:248–256
-
(2009)
J Neurochem
, vol.109
, pp. 248-256
-
-
Sevalle, J.1
Amoyel, A.2
Robert, P.3
Fournie-Zaluski, M.C.4
Roques, B.5
Checler, F.6
-
50
-
-
38449091923
-
The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy
-
COI: 1:CAS:528:DC%2BD1cXhs1Cht7c%3D, PID: 17981582
-
Shacka JJ, Roth KA, Zhang J (2008) The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Front Biosci 13:718–736
-
(2008)
Front Biosci
, vol.13
, pp. 718-736
-
-
Shacka, J.J.1
Roth, K.A.2
Zhang, J.3
-
51
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer’s disease
-
PID: 20376313
-
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer’s disease. PLoS One 5:e9979. doi:10.1371/journal.pone.0009979
-
(2010)
PLoS One
, vol.5
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
Richardson, A.7
Strong, R.8
Galvan, V.9
-
52
-
-
84862161020
-
Inhibition of gamma-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
-
COI: 1:CAS:528:DC%2BC38XhvVSiurnI, PID: 22537414
-
Tamayev R, D’Adamio L (2012) Inhibition of gamma-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia. Mol Neurodegener 7:19
-
(2012)
Mol Neurodegener
, vol.7
, pp. 19
-
-
Tamayev, R.1
D’Adamio, L.2
-
53
-
-
84858123000
-
beta- but not gamma-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
-
COI: 1:CAS:528:DC%2BC38XjsVSqs7g%3D, PID: 22170863
-
Tamayev R, Matsuda S, Arancio O, D’Adamio L (2012) beta- but not gamma-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. EMBO Mol Med 4:171–179
-
(2012)
EMBO Mol Med
, vol.4
, pp. 171-179
-
-
Tamayev, R.1
Matsuda, S.2
Arancio, O.3
D’Adamio, L.4
-
54
-
-
79957917512
-
A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway
-
COI: 1:CAS:528:DC%2BC3MXnsFyqt70%3D, PID: 21368103
-
Tian Y, Bustos V, Flajolet M, Greengard P (2011) A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J 25:1934–1942
-
(2011)
FASEB J
, vol.25
, pp. 1934-1942
-
-
Tian, Y.1
Bustos, V.2
Flajolet, M.3
Greengard, P.4
-
55
-
-
84869861910
-
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
-
COI: 1:CAS:528:DC%2BC3sXjsFyqt7w%3D, PID: 23173743
-
Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J (2012) Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener 7:59
-
(2012)
Mol Neurodegener
, vol.7
, pp. 59
-
-
Torres, M.1
Jimenez, S.2
Sanchez-Varo, R.3
Navarro, V.4
Trujillo-Estrada, L.5
Sanchez-Mejias, E.6
Carmona, I.7
Davila, J.C.8
Vizuete, M.9
Gutierrez, A.10
Vitorica, J.11
-
56
-
-
33847322057
-
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
-
COI: 1:CAS:528:DC%2BD2sXisVWiu7g%3D, PID: 17207630
-
Vingtdeux V, Hamdane M, Begard S, Loyens A, Delacourte A, Beauvillain JC, Buee L, Marambaud P, Sergeant N (2007) Intracellular pH regulates amyloid precursor protein intracellular domain accumulation. Neurobiol Dis 25:686–696
-
(2007)
Neurobiol Dis
, vol.25
, pp. 686-696
-
-
Vingtdeux, V.1
Hamdane, M.2
Begard, S.3
Loyens, A.4
Delacourte, A.5
Beauvillain, J.C.6
Buee, L.7
Marambaud, P.8
Sergeant, N.9
-
57
-
-
34547093203
-
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies
-
COI: 1:CAS:528:DC%2BD2sXmsVOlu74%3D, PID: 17468104
-
Vingtdeux V, Hamdane M, Loyens A, Gele P, Drobeck H, Begard S, Galas MC, Delacourte A, Beauvillain JC, Buee L, Sergeant N (2007) Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. J Biol Chem 282:18197–18205
-
(2007)
J Biol Chem
, vol.282
, pp. 18197-18205
-
-
Vingtdeux, V.1
Hamdane, M.2
Loyens, A.3
Gele, P.4
Drobeck, H.5
Begard, S.6
Galas, M.C.7
Delacourte, A.8
Beauvillain, J.C.9
Buee, L.10
Sergeant, N.11
-
58
-
-
0037930851
-
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors
-
COI: 1:CAS:528:DC%2BD3sXjsVKnsL4%3D, PID: 12621027
-
Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors. J Biol Chem 278:16528–16533
-
(2003)
J Biol Chem
, vol.278
, pp. 16528-16533
-
-
Weihofen, A.1
Lemberg, M.K.2
Friedmann, E.3
Rueeger, H.4
Schmitz, A.5
Paganetti, P.6
Rovelli, G.7
Martoglio, B.8
-
59
-
-
84944324335
-
eta-Secretase processing of APP inhibits neuronal activity in the hippocampus
-
COI: 1:CAS:528:DC%2BC2MXhsVCis7%2FN, PID: 26322584
-
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Muller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Muller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C (2015) eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526:443–447
-
(2015)
Nature
, vol.526
, pp. 443-447
-
-
Willem, M.1
Tahirovic, S.2
Busche, M.A.3
Ovsepian, S.V.4
Chafai, M.5
Kootar, S.6
Hornburg, D.7
Evans, L.D.8
Moore, S.9
Daria, A.10
Hampel, H.11
Muller, V.12
Giudici, C.13
Nuscher, B.14
Wenninger-Weinzierl, A.15
Kremmer, E.16
Heneka, M.T.17
Thal, D.R.18
Giedraitis, V.19
Lannfelt, L.20
Muller, U.21
Livesey, F.J.22
Meissner, F.23
Herms, J.24
Konnerth, A.25
Marie, H.26
Haass, C.27
more..
-
60
-
-
0025316164
-
Identification and characterization of C-terminal fragments of the beta-amyloid precursor produced in cell culture
-
COI: 1:CAS:528:DyaK3cXkvFGltrk%3D, PID: 1694126
-
Wolf D, Quon D, Wang Y, Cordell B (1990) Identification and characterization of C-terminal fragments of the beta-amyloid precursor produced in cell culture. EMBO J 9:2079–2084
-
(1990)
EMBO J
, vol.9
, pp. 2079-2084
-
-
Wolf, D.1
Quon, D.2
Wang, Y.3
Cordell, B.4
-
61
-
-
78650716872
-
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits
-
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA (2010) Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits. Brain 134:258–277
-
(2010)
Brain
, vol.134
, pp. 258-277
-
-
Yang, D.S.1
Stavrides, P.2
Mohan, P.S.3
Kaushik, S.4
Kumar, A.5
Ohno, M.6
Schmidt, S.D.7
Wesson, D.8
Bandyopadhyay, U.9
Jiang, Y.10
Pawlik, M.11
Peterhoff, C.M.12
Yang, A.J.13
Wilson, D.A.14
St George-Hyslop, P.15
Westaway, D.16
Mathews, P.M.17
Levy, E.18
Cuervo, A.M.19
Nixon, R.A.20
more..
-
62
-
-
26444587508
-
Macroautophagy—a novel Beta-amyloid peptide-generating pathway activated in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2MXhtFWitrjI, PID: 16203860
-
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA (2005) Macroautophagy—a novel Beta-amyloid peptide-generating pathway activated in Alzheimer’s disease. J Cell Biol 171:87–98
-
(2005)
J Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
Jiang, Y.11
Duff, K.12
Uchiyama, Y.13
Naslund, J.14
Mathews, P.M.15
Cataldo, A.M.16
Nixon, R.A.17
-
63
-
-
2442642836
-
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
-
COI: 1:CAS:528:DC%2BD2cXksFCqurk%3D, PID: 15140937
-
Zhang B, Higuchi M, Yoshiyama Y, Ishihara T, Forman MS, Martinez D, Joyce S, Trojanowski JQ, Lee VM (2004) Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J Neurosci 24:4657–4667
-
(2004)
J Neurosci
, vol.24
, pp. 4657-4667
-
-
Zhang, B.1
Higuchi, M.2
Yoshiyama, Y.3
Ishihara, T.4
Forman, M.S.5
Martinez, D.6
Joyce, S.7
Trojanowski, J.Q.8
Lee, V.M.9
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