Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

Molecular Psychiatry

Volumn 21, Issue 5, 2016, Pages 707-716

  Kim, S ^a   Sato, Y ^b   Mohan, P S ^a,b   Peterhoff, C ^b   Pensalfini, A ^b   Rigoglioso, A ^a   Jiang, Y ^a,b   Nixon, R A ^a,b,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN CONTAINING PLECKSTRIN HOMOLOGY DOMAIN PHOSPHOTYROSINE BINDING DOMAIN AND LEUCINE ZIPPER MOTIF; AMYLOID PRECURSOR PROTEIN; BETA CLEAVED CARBOXY TERMINAL FRAGMENT OF BETA AMYLOID PRECURSOR PROTEIN; PROTEIN; PROTEIN RAB5; RAB PROTEIN; UNCLASSIFIED DRUG; APP PROTEIN, HUMAN; APPL1 PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATE; RAB5C PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; ENDOCYTOSIS; ENDOSOME; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; NERVE FIBER TRANSPORT; NEUROBLASTOMA CELL LINE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; AGED; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; FEMALE; GENE SILENCING; GENETICS; HEK293 CELL LINE; MALE; METABOLISM; MIDDLE AGED; NERVE CELL; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL LINE, TUMOR; CELLS, CULTURED; DOWN SYNDROME; ENDOSOMES; FEMALE; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HUMANS; MALE; MICE, INBRED C57BL; MIDDLE AGED; NEURONS; RAB5 GTP-BINDING PROTEINS;

EID: 84937605093     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.97     Document Type: Article

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