Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature

Journal of Neuroscience

Volumn 34, Issue 23, 2014, Pages 7988-7998

  Caccamo, Antonella ^a,b   De Pinto, Vito ^b   Messina, Angela ^b   Branca, Caterina ^a,c   Oddo, Salvatore ^a,d  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Amyloid ; Autophagy; A ; Plaques; Tangles; Tau

Indexed keywords

AMYLOID BETA PROTEIN [1-42]; MAMMALIAN TARGET OF RAPAMYCIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENOTYPE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; SIGNAL TRANSDUCTION; TASK PERFORMANCE; WESTERN BLOTTING;

AMYLOID-Β; AUTOPHAGY; AΒ; PLAQUES; TANGLES; TAU;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84901745843     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0777-14.2014     Document Type: Article

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