Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of alzheimer disease

Journal of Neuroscience

Volumn 32, Issue 34, 2012, Pages 11820-11834

  Oulès, Bénédicte ^a,b   Del Prete, Dolores ^c,d   Greco, Barbara ^c   Zhang, Xuexin ^e   Lauritzen, Inger ^d   Sevalle, Jean ^d   Moreno, Sebastien ^d   Paterlini Bréchot, Patrizia ^a,b   Trebak, Mohamed ^e   Checler, Frédéric ^d   Benfenati, Fabio ^c   Chami, Mounia ^d  

^a Institut National de la Santé et de la Recherche Médicale U807   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN [1-40]; AMYLOID BETA PROTEIN [1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; DANTROLENE; GAMMA SECRETASE; POSTSYNAPTIC DENSITY PROTEIN 95; RYANODINE RECEPTOR; RYANODINE RECEPTOR 1; RYANODINE RECEPTOR 2; RYANODINE RECEPTOR 3; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RECOGNITION; SENILE PLAQUE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMINOPHENOLS; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; CAFFEINE; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CYTOSOL; DANTROLENE; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MALEIMIDES; MAZE LEARNING; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MUSCLE RELAXANTS, CENTRAL; MUTATION; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PLAQUE, AMYLOID; PURINES; REACTION TIME; RECOGNITION (PSYCHOLOGY); RNA, MESSENGER; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TRANSFECTION;

EID: 84865254936     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0875-12.2012     Document Type: Article

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