High β-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-β levels: Implications for the treatment of Alzheimer disease

Journal of Biological Chemistry

Volumn 280, Issue 38, 2005, Pages 32957-32967

  Rockenstein, Edward ^a   Mante, Michael ^a   Alford, Michael ^a   Adame, Anthony ^a   Crews, Leslie ^a   Hashimoto, Makoto ^a   Esposito, Luke ^c,d   Mucke, Lennart ^c,d   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BRAIN; DISEASES; MOLECULAR BIOLOGY; NEUROLOGY;

ALZHEIMER DISEASE; NEURODEGENERATION; PATHOGENIC PATHWAYS; PROTEOLYSIS;

ENZYMES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1; ENZYME; MYELIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; IN VIVO STUDY; MOUSE; NEOCORTEX; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; BRAIN; DNA, COMPLEMENTARY; ENDOPEPTIDASES; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MIDDLE AGED; NEURODEGENERATIVE DISEASES; NEURONS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RNA; RNA, MESSENGER; TIME FACTORS;

MURINAE; MUS MUSCULUS;

EID: 25444479179     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M507016200     Document Type: Article

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