Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus

Acta Neuropathologica

Volumn 123, Issue 1, 2012, Pages 53-70

  Sanchez Varo, Raquel ^a,d   Trujillo Estrada, Laura ^a,d   Sanchez Mejias, Elisabeth ^a,d   Torres, Manuel ^b,d,e   Baglietto Vargas, David ^a,d   Moreno Gonzalez, Ines ^a,d   De Castro, Vanessa ^a,d   Jimenez, Sebastian ^b,d,e   Ruano, Diego ^b,d,e   Vizuete, Marisa ^b,d,e   Davila, Jose Carlos ^a,d   Garcia Verdugo, Jose Manuel ^c,d   Jimenez, Antonio Jesus ^a   Vitorica, Javier ^b,d,e   Gutierrez, Antonia ^a,d  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Amyloid plaques; Dystrophic neurites; Electron microscopy; LC3; Presynaptic terminals; PS1 APP transgenic mice

Indexed keywords

ACTIN; AMYLOID BETA PROTEIN; CELL PROTEIN; COFILIN; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN 1; LC3 PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN SYNAPTOSOME; CELL ULTRASTRUCTURE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; HIPPOCAMPUS; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AUTOPHAGY; AXONS; CYTOPLASMIC VESICLES; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MICE; MICE, TRANSGENIC; MICROSCOPY, IMMUNOELECTRON; NEURITES; NEURONS; PLAQUE, AMYLOID; PRESYNAPTIC TERMINALS;

EID: 84857029592     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-011-0896-x     Document Type: Article

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