-
1
-
-
84901828078
-
Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids
-
J. Averous, S. Lambert-Langlais, V. Carraro, O. Gourbeyre, L. Parry, W. B'Chir, Y. Muranishi, C. Jousse, A. Bruhat, A.C. Maurin, and et al. Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids Cell. Signal. 26 2014 1918 1927
-
(2014)
Cell. Signal.
, vol.26
, pp. 1918-1927
-
-
Averous, J.1
Lambert-Langlais, S.2
Carraro, V.3
Gourbeyre, O.4
Parry, L.5
B'Chir, W.6
Muranishi, Y.7
Jousse, C.8
Bruhat, A.9
Maurin, A.C.10
-
3
-
-
84878357685
-
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
-
L. Bar-Peled, L. Chantranupong, A.D. Cherniack, W.W. Chen, K.A. Ottina, B.C. Grabiner, E.D. Spear, S.L. Carter, M. Meyerson, and D.M. Sabatini A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 Science 340 2013 1100 1106
-
(2013)
Science
, vol.340
, pp. 1100-1106
-
-
Bar-Peled, L.1
Chantranupong, L.2
Cherniack, A.D.3
Chen, W.W.4
Ottina, K.A.5
Grabiner, B.C.6
Spear, E.D.7
Carter, S.L.8
Meyerson, M.9
Sabatini, D.M.10
-
4
-
-
84885138286
-
TSC on the peroxisome controls mTORC1
-
D. Benjamin, and M.N. Hall TSC on the peroxisome controls mTORC1 Nat. Cell Biol. 15 2013 1135 1136
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 1135-1136
-
-
Benjamin, D.1
Hall, M.N.2
-
5
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
A. Beugnet, A.R. Tee, P.M. Taylor, and C.G. Proud Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability Biochem. J. 372 2003 555 566
-
(2003)
Biochem. J.
, vol.372
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
6
-
-
0037151112
-
Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
-
M. Boll, M. Foltz, I. Rubio-Aliaga, G. Kottra, and H. Daniel Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters J. Biol. Chem. 277 2002 22966 22973
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22966-22973
-
-
Boll, M.1
Foltz, M.2
Rubio-Aliaga, I.3
Kottra, G.4
Daniel, H.5
-
7
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
J. Brugarolas, K. Lei, R.L. Hurley, B.D. Manning, J.H. Reiling, E. Hafen, L.A. Witters, L.W. Ellisen, and W.G. Kaelin Jr. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex Genes Dev. 18 2004 2893 2904
-
(2004)
Genes Dev.
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin, W.G.9
-
8
-
-
77955055166
-
MAP4K3 regulates body size and metabolism in Drosophila
-
B. Bryk, K. Hahn, S.M. Cohen, and A.A. Teleman MAP4K3 regulates body size and metabolism in Drosophila Dev. Biol. 344 2010 150 157
-
(2010)
Dev. Biol.
, vol.344
, pp. 150-157
-
-
Bryk, B.1
Hahn, K.2
Cohen, S.M.3
Teleman, A.A.4
-
9
-
-
25444457577
-
HVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
M.P. Byfield, J.T. Murray, and J.M. Backer hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase J. Biol. Chem. 280 2005 33076 33082
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
10
-
-
84942503512
-
Amino acids and autophagy: Cross-talk and co-operation to control cellular homeostasis
-
B. Carroll, V.I. Korolchuk, and S. Sarkar Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis Amino Acids 47 2015 2065 2088
-
(2015)
Amino Acids
, vol.47
, pp. 2065-2088
-
-
Carroll, B.1
Korolchuk, V.I.2
Sarkar, S.3
-
11
-
-
84958580792
-
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
-
B. Carroll, D. Maetzel, O.D. Maddocks, G. Otten, M. Ratcliff, G.R. Smith, E.A. Dunlop, J.F. Passos, O.R. Davies, R. Jaenisch, and et al. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity eLife 5 2016 e11058 10.7554/eLife.11058
-
(2016)
ELife
, vol.5
, pp. e11058
-
-
Carroll, B.1
Maetzel, D.2
Maddocks, O.D.3
Otten, G.4
Ratcliff, M.5
Smith, G.R.6
Dunlop, E.A.7
Passos, J.F.8
Davies, O.R.9
Jaenisch, R.10
-
12
-
-
84925873653
-
Nutrient-sensing mechanisms across evolution
-
L. Chantranupong, R.L. Wolfson, and D.M. Sabatini Nutrient-sensing mechanisms across evolution Cell 161 2015 67 83
-
(2015)
Cell
, vol.161
, pp. 67-83
-
-
Chantranupong, L.1
Wolfson, R.L.2
Sabatini, D.M.3
-
13
-
-
84959880781
-
The CASTOR proteins are arginine sensors for the mTORC1 pathway
-
L. Chantranupong, S.M. Scaria, R.A. Saxton, M.P. Gygi, K. Shen, G.A. Wyant, T. Wang, J.W. Harper, S.P. Gygi, and D.M. Sabatini The CASTOR proteins are arginine sensors for the mTORC1 pathway Cell 165 2016 153 164 10.1016/j.cell.2016.02.035
-
(2016)
Cell
, vol.165
, pp. 153-164
-
-
Chantranupong, L.1
Scaria, S.M.2
Saxton, R.A.3
Gygi, M.P.4
Shen, K.5
Wyant, G.A.6
Wang, T.7
Harper, J.W.8
Gygi, S.P.9
Sabatini, D.M.10
-
14
-
-
84896629473
-
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
-
C. Chauvin, V. Koka, A. Nouschi, V. Mieulet, C. Hoareau-Aveilla, A. Dreazen, N. Cagnard, W. Carpentier, T. Kiss, O. Meyuhas, and M. Pende Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program Oncogene 33 2014 474 483
-
(2014)
Oncogene
, vol.33
, pp. 474-483
-
-
Chauvin, C.1
Koka, V.2
Nouschi, A.3
Mieulet, V.4
Hoareau-Aveilla, C.5
Dreazen, A.6
Cagnard, N.7
Carpentier, W.8
Kiss, T.9
Meyuhas, O.10
Pende, M.11
-
15
-
-
0242585370
-
Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2
-
Z. Chen, D.J. Kennedy, K.A. Wake, L. Zhuang, V. Ganapathy, and D.T. Thwaites Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2 Biochem. Biophys. Res. Commun. 304 2003 747 754
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.304
, pp. 747-754
-
-
Chen, Z.1
Kennedy, D.J.2
Wake, K.A.3
Zhuang, L.4
Ganapathy, V.5
Thwaites, D.T.6
-
16
-
-
0037155888
-
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner
-
G.R. Christie, E. Hajduch, H.S. Hundal, C.G. Proud, and P.M. Taylor Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner J. Biol. Chem. 277 2002 9952 9957
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 9952-9957
-
-
Christie, G.R.1
Hajduch, E.2
Hundal, H.S.3
Proud, C.G.4
Taylor, P.M.5
-
17
-
-
0141733277
-
A nutrient sensor mechanism controls Drosophila growth
-
J. Colombani, S. Raisin, S. Pantalacci, T. Radimerski, J. Montagne, and P. Léopold A nutrient sensor mechanism controls Drosophila growth Cell 114 2003 739 749
-
(2003)
Cell
, vol.114
, pp. 739-749
-
-
Colombani, J.1
Raisin, S.2
Pantalacci, S.3
Radimerski, T.4
Montagne, J.5
Léopold, P.6
-
18
-
-
84894212463
-
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
-
C. Demetriades, N. Doumpas, and A.A. Teleman Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2 Cell 156 2014 786 799
-
(2014)
Cell
, vol.156
, pp. 786-799
-
-
Demetriades, C.1
Doumpas, N.2
Teleman, A.A.3
-
19
-
-
84958092655
-
Lysosomal recruitment of TSC2 is a universal response to cellular stress
-
C. Demetriades, M. Plescher, and A.A. Teleman Lysosomal recruitment of TSC2 is a universal response to cellular stress Nat. Commun. 7 2016 10662 10.1038/ncomms10662
-
(2016)
Nat. Commun.
, vol.7
, pp. 10662
-
-
Demetriades, C.1
Plescher, M.2
Teleman, A.A.3
-
20
-
-
84878532557
-
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
-
C.C. Dibble, and B.D. Manning Signal integration by mTORC1 coordinates nutrient input with biosynthetic output Nat. Cell Biol. 15 2013 555 564
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 555-564
-
-
Dibble, C.C.1
Manning, B.D.2
-
21
-
-
21244448694
-
The TOR and EGO protein complexes orchestrate microautophagy in yeast
-
F. Dubouloz, O. Deloche, V. Wanke, E. Cameroni, and C. De Virgilio The TOR and EGO protein complexes orchestrate microautophagy in yeast Mol. Cell 19 2005 15 26
-
(2005)
Mol. Cell
, vol.19
, pp. 15-26
-
-
Dubouloz, F.1
Deloche, O.2
Wanke, V.3
Cameroni, E.4
De Virgilio, C.5
-
22
-
-
84900405146
-
RagA, but not RagB, is essential for embryonic development and adult mice
-
A. Efeyan, L.D. Schweitzer, A.M. Bilate, S. Chang, O. Kirak, D.W. Lamming, and D.M. Sabatini RagA, but not RagB, is essential for embryonic development and adult mice Dev. Cell 29 2014 321 329
-
(2014)
Dev. Cell
, vol.29
, pp. 321-329
-
-
Efeyan, A.1
Schweitzer, L.D.2
Bilate, A.M.3
Chang, S.4
Kirak, O.5
Lamming, D.W.6
Sabatini, D.M.7
-
23
-
-
84973610952
-
PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
-
S.J. Fan, C. Snell, H. Turley, J.L. Li, R. McCormick, S.M. Perera, S. Heublein, S. Kazi, A. Azad, C. Wilson, and et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer Oncogene 2015 10.1038/onc.2015.363
-
(2015)
Oncogene
-
-
Fan, S.J.1
Snell, C.2
Turley, H.3
Li, J.L.4
McCormick, R.5
Perera, S.M.6
Heublein, S.7
Kazi, S.8
Azad, A.9
Wilson, C.10
-
24
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
G.M. Findlay, L. Yan, J. Procter, V. Mieulet, and R.F. Lamb A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling Biochem. J. 403 2007 13 20
-
(2007)
Biochem. J.
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
25
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
X. Gao, Y. Zhang, P. Arrazola, O. Hino, T. Kobayashi, R.S. Yeung, B. Ru, and D. Pan Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling Nat. Cell Biol. 4 2002 699 704
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
26
-
-
79952774855
-
Intracellular amino acid sensing and mTORC1-regulated growth: New ways to block an old target?
-
D.C. Goberdhan Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target? Curr. Opin. Investig. Drugs 11 2010 1360 1367
-
(2010)
Curr. Opin. Investig. Drugs
, vol.11
, pp. 1360-1367
-
-
Goberdhan, D.C.1
-
27
-
-
0141922962
-
The functions of insulin signaling: Size isn't everything, even in Drosophila
-
D.C. Goberdhan, and C. Wilson The functions of insulin signaling: size isn't everything, even in Drosophila Differentiation 71 2003 375 397
-
(2003)
Differentiation
, vol.71
, pp. 375-397
-
-
Goberdhan, D.C.1
Wilson, C.2
-
28
-
-
21044440310
-
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
-
D.C. Goberdhan, D. Meredith, C.A. Boyd, and C. Wilson PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids Development 132 2005 2365 2375
-
(2005)
Development
, vol.132
, pp. 2365-2375
-
-
Goberdhan, D.C.1
Meredith, D.2
Boyd, C.A.3
Wilson, C.4
-
29
-
-
84897988069
-
Loss of TSC2 confers resistance to ceramide and nutrient deprivation
-
G.G. Guenther, G. Liu, M.U. Ramirez, R.J. McMonigle, S.M. Kim, A.N. McCracken, Y. Joo, I. Ushach, N.L. Nguyen, and A.L. Edinger Loss of TSC2 confers resistance to ceramide and nutrient deprivation Oncogene 33 2014 1776 1787
-
(2014)
Oncogene
, vol.33
, pp. 1776-1787
-
-
Guenther, G.G.1
Liu, G.2
Ramirez, M.U.3
McMonigle, R.J.4
Kim, S.M.5
McCracken, A.N.6
Joo, Y.7
Ushach, I.8
Nguyen, N.L.9
Edinger, A.L.10
-
30
-
-
84880523573
-
Talks about TORCs: Recent advancesin target of rapamycin signalling. on mTOR nomenclature
-
M.N. Hall Talks about TORCs: recent advancesin target of rapamycin signalling. On mTOR nomenclature Biochem. Soc. Trans. 41 2013 887 888
-
(2013)
Biochem. Soc. Trans.
, vol.41
, pp. 887-888
-
-
Hall, M.N.1
-
31
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
J.M. Han, S.J. Jeong, M.C. Park, G. Kim, N.H. Kwon, H.K. Kim, S.H. Ha, S.H. Ryu, and S. Kim Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway Cell 149 2012 410 424
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
32
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
K. Hara, K. Yonezawa, Q.P. Weng, M.T. Kozlowski, C. Belham, and J. Avruch Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism J. Biol. Chem. 273 1998 14484 14494
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
33
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
J. Heitman, N.R. Movva, and M.N. Hall Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast Science 253 1991 905 909
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
34
-
-
77954757143
-
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
-
S. Heublein, S. Kazi, M.H. Ogmundsdóttir, E.V. Attwood, S. Kala, C.A. Boyd, C. Wilson, and D.C. Goberdhan Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation Oncogene 29 2010 4068 4079
-
(2010)
Oncogene
, vol.29
, pp. 4068-4079
-
-
Heublein, S.1
Kazi, S.2
Ogmundsdóttir, M.H.3
Attwood, E.V.4
Kala, S.5
Boyd, C.A.6
Wilson, C.7
Goberdhan, D.C.8
-
35
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
K. Inoki, Y. Li, T. Zhu, J. Wu, and K.L. Guan TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat. Cell Biol. 4 2002 648 657
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
36
-
-
84884676252
-
Nutrient signaling to mTOR and cell growth
-
J.L. Jewell, and K.L. Guan Nutrient signaling to mTOR and cell growth Trends Biochem. Sci. 38 2013 233 242
-
(2013)
Trends Biochem. Sci.
, vol.38
, pp. 233-242
-
-
Jewell, J.L.1
Guan, K.L.2
-
37
-
-
84922727084
-
Metabolism. Differential regulation of mTORC1 by leucine and glutamine
-
J.L. Jewell, Y.C. Kim, R.C. Russell, F.X. Yu, H.W. Park, S.W. Plouffe, V.S. Tagliabracci, and K.L. Guan Metabolism. Differential regulation of mTORC1 by leucine and glutamine Science 347 2015 194 198
-
(2015)
Science
, vol.347
, pp. 194-198
-
-
Jewell, J.L.1
Kim, Y.C.2
Russell, R.C.3
Yu, F.X.4
Park, H.W.5
Plouffe, S.W.6
Tagliabracci, V.S.7
Guan, K.L.8
-
38
-
-
44149127993
-
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
-
G. Juhász, J.H. Hill, Y. Yan, M. Sass, E.H. Baehrecke, J.M. Backer, and T.P. Neufeld The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila J. Cell Biol. 181 2008 655 666
-
(2008)
J. Cell Biol.
, vol.181
, pp. 655-666
-
-
Juhász, G.1
Hill, J.H.2
Yan, Y.3
Sass, M.4
Baehrecke, E.H.5
Backer, J.M.6
Neufeld, T.P.7
-
39
-
-
84932638310
-
Amino acid-dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9
-
J. Jung, H.M. Genau, and C. Behrends Amino acid-dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9 Mol. Cell. Biol. 35 2015 2479 2494
-
(2015)
Mol. Cell. Biol.
, vol.35
, pp. 2479-2494
-
-
Jung, J.1
Genau, H.M.2
Behrends, C.3
-
40
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
E. Kim, P. Goraksha-Hicks, L. Li, T.P. Neufeld, and K.L. Guan Regulation of TORC1 by Rag GTPases in nutrient response Nat. Cell Biol. 10 2008 935 945
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
41
-
-
0037276069
-
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
-
N. Kimura, C. Tokunaga, S. Dalal, C. Richardson, K. Yoshino, K. Hara, B.E. Kemp, L.A. Witters, O. Mimura, and K. Yonezawa A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway Genes Cells 8 2003 65 79
-
(2003)
Genes Cells
, vol.8
, pp. 65-79
-
-
Kimura, N.1
Tokunaga, C.2
Dalal, S.3
Richardson, C.4
Yoshino, K.5
Hara, K.6
Kemp, B.E.7
Witters, L.A.8
Mimura, O.9
Yonezawa, K.10
-
42
-
-
84954467884
-
Dynamic relocation of the TORC1-Gtr1/2-Ego1/2/3 complex is regulated by Gtr1 and Gtr2
-
S. Kira, Y. Kumano, H. Ukai, E. Takeda, A. Matsuura, and T. Noda Dynamic relocation of the TORC1-Gtr1/2-Ego1/2/3 complex is regulated by Gtr1 and Gtr2 Mol. Biol. Cell 27 2016 382 396
-
(2016)
Mol. Biol. Cell
, vol.27
, pp. 382-396
-
-
Kira, S.1
Kumano, Y.2
Ukai, H.3
Takeda, E.4
Matsuura, A.5
Noda, T.6
-
43
-
-
84901263663
-
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
-
C.F. Labuschagne, N.J. van den Broek, G.M. Mackay, K.H. Vousden, and O.D. Maddocks Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells Cell Rep. 7 2014 1248 1258
-
(2014)
Cell Rep.
, vol.7
, pp. 1248-1258
-
-
Labuschagne, C.F.1
Van Den Broek, N.J.2
Mackay, G.M.3
Vousden, K.H.4
Maddocks, O.D.5
-
44
-
-
84954044571
-
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
-
Z. Li, and H. Zhang Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression Cell. Mol. Life Sci. 73 2015 377 392
-
(2015)
Cell. Mol. Life Sci.
, vol.73
, pp. 377-392
-
-
Li, Z.1
Zhang, H.2
-
45
-
-
84896692038
-
Rapamycin: One drug, many effects
-
J. Li, S.G. Kim, and J. Blenis Rapamycin: one drug, many effects Cell Metab. 19 2014 373 379
-
(2014)
Cell Metab.
, vol.19
, pp. 373-379
-
-
Li, J.1
Kim, S.G.2
Blenis, J.3
-
46
-
-
84932137364
-
The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons
-
W.Y. Lin, C. Williams, C. Yan, T. Koledachkina, K. Luedke, J. Dalton, S. Bloomsburg, N. Morrison, K.E. Duncan, C.C. Kim, and J.Z. Parrish The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons Genes Dev. 29 2015 1120 1135
-
(2015)
Genes Dev.
, vol.29
, pp. 1120-1135
-
-
Lin, W.Y.1
Williams, C.2
Yan, C.3
Koledachkina, T.4
Luedke, K.5
Dalton, J.6
Bloomsburg, S.7
Morrison, N.8
Duncan, K.E.9
Kim, C.C.10
Parrish, J.Z.11
-
47
-
-
84948180491
-
Proline biosynthesis augments tumor cell growth and aerobic glycolysis: Involvement of pyridine nucleotides
-
W. Liu, C.N. Hancock, J.W. Fischer, M. Harman, and J.M. Phang Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides Sci. Rep. 5 2015 17206 17219
-
(2015)
Sci. Rep.
, vol.5
, pp. 17206-17219
-
-
Liu, W.1
Hancock, C.N.2
Fischer, J.W.3
Harman, M.4
Phang, J.M.5
-
48
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
O.D. Maddocks, C.R. Berkers, S.M. Mason, L. Zheng, K. Blyth, E. Gottlieb, and K.H. Vousden Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells Nature 493 2013 542 546
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
50
-
-
84877582117
-
Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4
-
T. Matsui, and M. Fukuda Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 EMBO Rep. 14 2013 450 457
-
(2013)
EMBO Rep.
, vol.14
, pp. 450-457
-
-
Matsui, T.1
Fukuda, M.2
-
51
-
-
84894114029
-
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
-
S. Menon, C.C. Dibble, G. Talbott, G. Hoxhaj, A.J. Valvezan, H. Takahashi, L.C. Cantley, and B.D. Manning Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome Cell 156 2014 771 785
-
(2014)
Cell
, vol.156
, pp. 771-785
-
-
Menon, S.1
Dibble, C.C.2
Talbott, G.3
Hoxhaj, G.4
Valvezan, A.J.5
Takahashi, H.6
Cantley, L.C.7
Manning, B.D.8
-
52
-
-
84929997950
-
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation
-
R. Milkereit, A. Persaud, L. Vanoaica, A. Guetg, F. Verrey, and D. Rotin LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation Nat. Commun. 6 2015 7250 7259
-
(2015)
Nat. Commun.
, vol.6
, pp. 7250-7259
-
-
Milkereit, R.1
Persaud, A.2
Vanoaica, L.3
Guetg, A.4
Verrey, F.5
Rotin, D.6
-
53
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
P. Nicklin, P. Bergman, B. Zhang, E. Triantafellow, H. Wang, B. Nyfeler, H. Yang, M. Hild, C. Kung, C. Wilson, and et al. Bidirectional transport of amino acids regulates mTOR and autophagy Cell 136 2009 521 534
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
Bergman, P.2
Zhang, B.3
Triantafellow, E.4
Wang, H.5
Nyfeler, B.6
Yang, H.7
Hild, M.8
Kung, C.9
Wilson, C.10
-
54
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
T. Nobukuni, M. Joaquin, M. Roccio, S.G. Dann, S.Y. Kim, P. Gulati, M.P. Byfield, J.M. Backer, F. Natt, J.L. Bos, and et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase Proc. Natl. Acad. Sci. USA 102 2005 14238 14243
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
-
55
-
-
84871260456
-
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
-
M.H. Ögmundsdóttir, S. Heublein, S. Kazi, B. Reynolds, S.M. Visvalingam, M.K. Shaw, and D.C. Goberdhan Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes PLoS ONE 7 2012 e36616
-
(2012)
PLoS ONE
, vol.7
, pp. e36616
-
-
Ögmundsdóttir, M.H.1
Heublein, S.2
Kazi, S.3
Reynolds, B.4
Visvalingam, S.M.5
Shaw, M.K.6
Goberdhan, D.C.7
-
56
-
-
84956702125
-
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
-
J. Okosun, R.L. Wolfson, J. Wang, S. Araf, L. Wilkins, B.M. Castellano, L. Escudero-Ibarz, A.F. Al Seraihi, J. Richter, S.H. Bernhart, and et al. Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma Nat. Genet. 48 2016 183 188
-
(2016)
Nat. Genet.
, vol.48
, pp. 183-188
-
-
Okosun, J.1
Wolfson, R.L.2
Wang, J.3
Araf, S.4
Wilkins, L.5
Castellano, B.M.6
Escudero-Ibarz, L.7
Al Seraihi, A.F.8
Richter, J.9
Bernhart, S.H.10
-
57
-
-
84937253537
-
The utilization of extracellular proteins as nutrients is suppressed by mTORC1
-
W. Palm, Y. Park, K. Wright, N.N. Pavlova, D.A. Tuveson, and C.B. Thompson The utilization of extracellular proteins as nutrients is suppressed by mTORC1 Cell 162 2015 259 270
-
(2015)
Cell
, vol.162
, pp. 259-270
-
-
Palm, W.1
Park, Y.2
Wright, K.3
Pavlova, N.N.4
Tuveson, D.A.5
Thompson, C.B.6
-
58
-
-
84955326448
-
The emerging hallmarks of cancer metabolism
-
N.N. Pavlova, and C.B. Thompson The emerging hallmarks of cancer metabolism Cell Metab. 23 2016 27 47
-
(2016)
Cell Metab.
, vol.23
, pp. 27-47
-
-
Pavlova, N.N.1
Thompson, C.B.2
-
59
-
-
79961165137
-
MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
T.R. Peterson, S.S. Sengupta, T.E. Harris, A.E. Carmack, S.A. Kang, E. Balderas, D.A. Guertin, K.L. Madden, A.E. Carpenter, B.N. Finck, and D.M. Sabatini mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway Cell 146 2011 408 420
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
Sabatini, D.M.11
-
60
-
-
78951482110
-
SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes
-
S.M. Pillai, and D. Meredith SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes J. Biol. Chem. 286 2011 2455 2460
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 2455-2460
-
-
Pillai, S.M.1
Meredith, D.2
-
61
-
-
80053614972
-
SNAT2 transceptor signalling via mTOR: A role in cell growth and proliferation?
-
J. Pinilla, J.C. Aledo, E. Cwiklinski, R. Hyde, P.M. Taylor, and H.S. Hundal SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation? Front. Biosci. (Elite Ed.) 3 2011 1289 1299
-
(2011)
Front. Biosci. (Elite Ed.)
, vol.3
, pp. 1289-1299
-
-
Pinilla, J.1
Aledo, J.C.2
Cwiklinski, E.3
Hyde, R.4
Taylor, P.M.5
Hundal, H.S.6
-
62
-
-
84925777835
-
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
-
M. Rebsamen, L. Pochini, T. Stasyk, M.E. de Araújo, M. Galluccio, R.K. Kandasamy, B. Snijder, A. Fauster, E.L. Rudashevskaya, M. Bruckner, and et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 Nature 519 2015 477 481
-
(2015)
Nature
, vol.519
, pp. 477-481
-
-
Rebsamen, M.1
Pochini, L.2
Stasyk, T.3
De Araújo, M.E.4
Galluccio, M.5
Kandasamy, R.K.6
Snijder, B.7
Fauster, A.8
Rudashevskaya, E.L.9
Bruckner, M.10
-
63
-
-
84874961313
-
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
-
A.M. Robitaille, S. Christen, M. Shimobayashi, M. Cornu, L.L. Fava, S. Moes, C. Prescianotto-Baschong, U. Sauer, P. Jenoe, and M.N. Hall Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis Science 339 2013 1320 1323
-
(2013)
Science
, vol.339
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
Prescianotto-Baschong, C.7
Sauer, U.8
Jenoe, P.9
Hall, M.N.10
-
64
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
D.M. Sabatini, H. Erdjument-Bromage, M. Lui, P. Tempst, and S.H. Snyder RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs Cell 78 1994 35 43
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
65
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Y. Sancak, T.R. Peterson, Y.D. Shaul, R.A. Lindquist, C.C. Thoreen, L. Bar-Peled, and D.M. Sabatini The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 Science 320 2008 1496 1501
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
66
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Y. Sancak, L. Bar-Peled, R. Zoncu, A.L. Markhard, S. Nada, and D.M. Sabatini Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Cell 141 2010 290 303
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
67
-
-
84953319082
-
The Rag-Ragulator complex regulates lysosome function and phagocytic flux in microglia
-
K. Shen, H. Sidik, and W.S. Talbot The Rag-Ragulator complex regulates lysosome function and phagocytic flux in microglia Cell Rep. 14 2016 547 559
-
(2016)
Cell Rep.
, vol.14
, pp. 547-559
-
-
Shen, K.1
Sidik, H.2
Talbot, W.S.3
-
68
-
-
84953357060
-
Multiple amino acid sensing inputs to mTORC1
-
M. Shimobayashi, and M.N. Hall Multiple amino acid sensing inputs to mTORC1 Cell Res. 26 2016 7 20
-
(2016)
Cell Res.
, vol.26
, pp. 7-20
-
-
Shimobayashi, M.1
Hall, M.N.2
-
69
-
-
84906971940
-
Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins
-
D. Stracka, S. Jozefczuk, F. Rudroff, U. Sauer, and M.N. Hall Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins J. Biol. Chem. 289 2014 25010 25020
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 25010-25020
-
-
Stracka, D.1
Jozefczuk, S.2
Rudroff, F.3
Sauer, U.4
Hall, M.N.5
-
70
-
-
84912068759
-
Rab1A is an mTORC1 activator and a colorectal oncogene
-
J.D. Thomas, Y.J. Zhang, Y.H. Wei, J.H. Cho, L.E. Morris, H.Y. Wang, and X.F. Zheng Rab1A is an mTORC1 activator and a colorectal oncogene Cancer Cell 26 2014 754 769
-
(2014)
Cancer Cell
, vol.26
, pp. 754-769
-
-
Thomas, J.D.1
Zhang, Y.J.2
Wei, Y.H.3
Cho, J.H.4
Morris, L.E.5
Wang, H.Y.6
Zheng, X.F.7
-
71
-
-
84888200442
-
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
-
Z.Y. Tsun, L. Bar-Peled, L. Chantranupong, R. Zoncu, T. Wang, C. Kim, E. Spooner, and D.M. Sabatini The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 Mol. Cell 52 2013 495 505
-
(2013)
Mol. Cell
, vol.52
, pp. 495-505
-
-
Tsun, Z.Y.1
Bar-Peled, L.2
Chantranupong, L.3
Zoncu, R.4
Wang, T.5
Kim, C.6
Spooner, E.7
Sabatini, D.M.8
-
72
-
-
84885448500
-
Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth, and tumor development
-
Q. Wang, J. Tiffen, C.G. Bailey, M.L. Lehman, W. Ritchie, L. Fazli, C. Metierre, Y.J. Feng, E. Li, M. Gleave, and et al. Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development J. Natl. Cancer Inst. 105 2013 1463 1473
-
(2013)
J. Natl. Cancer Inst.
, vol.105
, pp. 1463-1473
-
-
Wang, Q.1
Tiffen, J.2
Bailey, C.G.3
Lehman, M.L.4
Ritchie, W.5
Fazli, L.6
Metierre, C.7
Feng, Y.J.8
Li, E.9
Gleave, M.10
-
73
-
-
84922743269
-
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
-
S. Wang, Z.Y. Tsun, R.L. Wolfson, K. Shen, G.A. Wyant, M.E. Plovanich, E.D. Yuan, T.D. Jones, L. Chantranupong, W. Comb, and et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 Science 347 2015 188 194
-
(2015)
Science
, vol.347
, pp. 188-194
-
-
Wang, S.1
Tsun, Z.Y.2
Wolfson, R.L.3
Shen, K.4
Wyant, G.A.5
Plovanich, M.E.6
Yuan, E.D.7
Jones, T.D.8
Chantranupong, L.9
Comb, W.10
-
74
-
-
77953578193
-
Proximity ligation assays: A recent addition to the proteomics toolbox
-
I. Weibrecht, K.J. Leuchowius, C.M. Clausson, T. Conze, M. Jarvius, W.M. Howell, M. Kamali-Moghaddam, and O. Söderberg Proximity ligation assays: a recent addition to the proteomics toolbox Expert Rev. Proteomics 7 2010 401 409
-
(2010)
Expert Rev. Proteomics
, vol.7
, pp. 401-409
-
-
Weibrecht, I.1
Leuchowius, K.J.2
Clausson, C.M.3
Conze, T.4
Jarvius, M.5
Howell, W.M.6
Kamali-Moghaddam, M.7
Söderberg, O.8
-
75
-
-
84952915479
-
Sestrin2 is a leucine sensor for the mTORC1 pathway
-
R.L. Wolfson, L. Chantranupong, R.A. Saxton, K. Shen, S.M. Scaria, J.R. Cantor, and D.M. Sabatini Sestrin2 is a leucine sensor for the mTORC1 pathway Science 351 2016 43 48
-
(2016)
Science
, vol.351
, pp. 43-48
-
-
Wolfson, R.L.1
Chantranupong, L.2
Saxton, R.A.3
Shen, K.4
Scaria, S.M.5
Cantor, J.R.6
Sabatini, D.M.7
-
76
-
-
84940749205
-
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A
-
B.H. Xu, X.X. Li, Y. Yang, M.Y. Zhang, H.L. Rao, H.Y. Wang, and X.F. Zheng Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A Oncotarget 6 2015 20813 20828
-
(2015)
Oncotarget
, vol.6
, pp. 20813-20828
-
-
Xu, B.H.1
Li, X.X.2
Yang, Y.3
Zhang, M.Y.4
Rao, H.L.5
Wang, H.Y.6
Zheng, X.F.7
-
77
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
L. Yu, C.K. McPhee, L. Zheng, G.A. Mardones, Y. Rong, J. Peng, N. Mi, Y. Zhao, Z. Liu, F. Wan, and et al. Termination of autophagy and reformation of lysosomes regulated by mTOR Nature 465 2010 942 946
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.3
Mardones, G.A.4
Rong, Y.5
Peng, J.6
Mi, N.7
Zhao, Y.8
Liu, Z.9
Wan, F.10
-
78
-
-
84885105969
-
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS
-
J. Zhang, J. Kim, A. Alexander, S. Cai, D.N. Tripathi, R. Dere, A.R. Tee, J. Tait-Mulder, A. Di Nardo, J.M. Han, and et al. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS Nat. Cell Biol. 15 2013 1186 1196
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 1186-1196
-
-
Zhang, J.1
Kim, J.2
Alexander, A.3
Cai, S.4
Tripathi, D.N.5
Dere, R.6
Tee, A.R.7
Tait-Mulder, J.8
Di Nardo, A.9
Han, J.M.10
-
79
-
-
84980398096
-
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1
-
T. Zhang, Q. Zhou, M.H. Ögmundsdóttir, K. Möller, R. Siddaway, L. Larue, M. Hsing, S.W. Kong, C.R. Goding, A. Palsson, and et al. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1 J. Cell Sci. 128 2015 2938 2950
-
(2015)
J. Cell Sci.
, vol.128
, pp. 2938-2950
-
-
Zhang, T.1
Zhou, Q.2
Ögmundsdóttir, M.H.3
Möller, K.4
Siddaway, R.5
Larue, L.6
Hsing, M.7
Kong, S.W.8
Goding, C.R.9
Palsson, A.10
-
80
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
-
R. Zoncu, L. Bar-Peled, A. Efeyan, S. Wang, Y. Sancak, and D.M. Sabatini mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase Science 334 2011 678 683
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
|