Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Nature

Volumn 493, Issue 7433, 2013, Pages 542-546

  Maddocks, Oliver D K ^a   Berkers, Celia R ^a   Mason, Susan M ^a   Zheng, Liang ^a   Blyth, Karen ^a   Gottlieb, Eyal ^a   Vousden, Karen H ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; GLUTATHIONE; PROTEIN P53; SERINE;

APOPTOSIS; CANCER; CYTOLOGY; METABOLISM; OXIC CONDITIONS; PROTEIN;

AMINO ACID SYNTHESIS; ANAEROBIC GLYCOLYSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

AEROBIOSIS; ANIMALS; ANTIOXIDANTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CITRIC ACID CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; FEMALE; G1 PHASE; GLUTATHIONE; GLYCOLYSIS; HCT116 CELLS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NUCLEOTIDES; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; SERINE; STARVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84872905650     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11743     Document Type: Article

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