A nutrient sensor mechanism controls Drosophila growth

Cell

Volumn 114, Issue 6, 2003, Pages 739-749

  Colombani, Julien ^a   Raisin, Sophie ^a   Pantalacci, Sophie ^a   Radimerski, Thomas ^b   Montagne, Jacques ^b   Léopold, Pierre ^a  

^a CENTRE DE BIOCHIMIE   (France)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER;

AMINO ACID TRANSPORT; ARTICLE; BIOAVAILABILITY; BIOSENSOR; DOWN REGULATION; DROSOPHILA; GENETIC CODE; GENETIC SCREENING; GROWTH INHIBITION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; VERTEBRATE;

ANIMALIA; HEXAPODA; INSECTA; METAZOA; TOR; VERTEBRATA;

EID: 0141733277     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)00713-X     Document Type: Article

References (51)

1. Araki E., Lipes M.A., Patti M.E., Bruning J.C., Haag B. 3rd, Johnson R.S., Kahn C.R. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 372:1994;186-190.
2. Bohni R., Riesgo-Escovar J., Oldham S., Brogiolo W., Stocker H., Andruss B.F., Beckingham K., Hafen E. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell. 97:1999;865-875.
3. Boisclair Y.R., Rhoads R.P., Ueki I., Wang J., Ooi G.T. The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex. an important but forgotten component of the circulating IGF system J. Endocrinol. 170:2001;63-70.
4. Britton J.S., Edgar B.A. Environmental control of the cell cycle in Drosophila. nutrition activates mitotic and endoreplicative cells by distinct mechanisms Development. 125:1998;2149-2158.
5. Britton J.S., Lockwood W.K., Li L., Cohen S.M., Edgar B.A. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell. 2:2002;239-249.
6. Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11:2001;213-221.
7. Butler A.A., Le Roith D. Control of growth by the somatropic axis. growth hormone and the insulin-like growth factors have related and independent roles Annu. Rev. Physiol. 63:2001;141-164.
8. Campbell L.E., Wang X., Proud C.G. Nutrients differentially regulate multiple translation factors and their control by insulin. Biochem. J. 344:1999;433-441.
9. Conlon I., Raff M. Size control in animal development. Cell. 96:1999;235-244.
10. Crace C.J., Swenne I., Hill D.J., Milner R.D. Tissue and serum insulin-like growth factor I (IGF I) concentrations in rats subjected to temporary protein-energy malnutrition early in life. Ups. J. Med. Sci. 96:1991;17-22.
11. Davis K.T., Shearn A. In vitro growth of imaginal disks from Drosophila melanogaster. Science. 196:1977;438-440.
12. Dean R.L., Locke M., Collins J.V. Structure of the fat body. Biochemistry and Pharmacology G.A., Kerkut, Gilbert L.I. Comprehensive Insect Physiology. 1985;Pergamonn Press, New York. 155-210.pp.
13. Duan C. Specifying the cellular responses to IGF signals. roles of IGF-binding proteins J. Endocrinol. 175:2002;41-54.
14. Efstratiadis A. Genetics of mouse growth. Int. J. Dev. Biol. 42:1998;955-976.
15. Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R.S., Ru B., Pan D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell Biol. 4:2002;699-704.
16. Garami A., Zwartkruis F.J., Nobukuni T., Joaquin M., Roccio M., Stocker H., Kozma S.C., Hafen E., Bos J.L., Thomas G. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell. 11:2003;1457-1466.
17. Garofalo R.S. Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol. Metab. 13:2002;156-162.
18. Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826.
19. Hara K., Yonezawa K., Weng Q.P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273:1998;14484-14494.
20. Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 110:2002;177-189.
21. Hennig K.M., Neufeld T.P. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila. Genesis. 34:2002;107-110.
22. Huang H., Potter C.J., Tao W., Li D.M., Brogiolo W., Hafen E., Sun H., Xu T. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development. 126:1999;5365-5372.
23. Ikeya T., Galic M., Belawat P., Nairz K., Hafen E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12:2002;1293-1300.
24. Inoki K., Li Y., Zhu T., Wu J., Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:2002;648-657.
25. Inoki K., Li Y., Xu T., Guan K.L. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:2003;1829-1834.
26. Kawamura K., Shibata T., Saget O., Peel D., Bryant P.J. A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells. Development. 126:1999;211-219.
27. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 110:2002;163-175.
28. Kimball S.R., Jefferson L.S. Regulation of translation initation in mammalian cells by amino acids. Sonenberg N., Hershey J.W., Mathews M.B. Translational Control of Gene Expression. 2000;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 561-579.pp.
29. Kimball S.R., Shantz L.M., Horetsky R.L., Jefferson L.S. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J. Biol. Chem. 274:1999;11647-11652.
30. Leevers S.J., Weinkove D., MacDougall L.K., Hafen E., Waterfield M.D. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15:1996;6584-6594.
31. Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell. 10:2002;457-468.
32. Martin J.F., Hersperger E., Simcox A., Shearn A. minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation. Mech. Dev. 92:2000;155-167.
33. Montagne J., Stewart M.J., Stocker H., Hafen E., Kozma S.C., Thomas G. Drosophila S6 kinase. a regulator of cell size Science. 285:1999;2126-2129.
34. Oldham S., Montagne J., Radimerski T., Thomas G., Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14:2000;2689-2694.
35. Patti M.E., Brambilla E., Luzi L., Landaker E.J., Kahn C.R. Bidirectional modulation of insulin action by amino acids. J. Clin. Invest. 101:1998;1519-1529.
36. Radimerski T., Montagne J., Rintelen F., Stocker H., van Der Kaay J., Downes C.P., Hafen E., Thomas G. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat. Cell Biol. 4:2002;251-255.
37. Raisin S., Pantalacci S., Breittmayer J.-P., Léopold P. A new genetic locus controlling growth and proliferation in Drosophila melanogaster. Genetics. 164:2003;1015-1025.
38. Rulifson E.J., Kim S.K., Nusse R. Ablation of insulin-producing neurons in flies. growth and diabetic phenotypes Science. 296:2002;1118-1120.
39. Saucedo L.J., Gao X., Chiarelli D.A., Li L., Pan D., Edgar B.A. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5:2003;566-571.
40. Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262.
41. Shioi T., Kang P.M., Douglas P.S., Hampe J., Yballe C.M., Lawitts J., Cantley L.C., Izumo S. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19:2000;2537-2548.
42. Shioi T., McMullen J.R., Kang P.M., Douglas P.S., Obata T., Franke T.F., Cantley L.C., Izumo S. Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22:2002;2799-2809.
43. Stern D. Body-size evolution. how to evolve a mammoth moth Curr. Biol. 11:2001;R917-R919.
44. Stocker H., Hafen E. Genetic control of cell size. Curr. Opin. Genet. Dev. 10:2000;529-535.
45. Stocker H., Radimerski T., Schindelholz B., Wittwer F., Belawat P., Daram P., Breuer S., Thomas G., Hafen E. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5:2003;559-565.
46. Tamemoto H., Kadowaki T., Tobe K., Yagi T., Sakura H., Hayakawa T., Terauchi Y., Ueki K., Kaburagi Y., Satoh S.et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature. 372:1994;182-186.
47. Tapon N., Ito N., Dickson B.J., Treisman J.E., Hariharan I.K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell. 105:2001;345-355.
48. Zhang H., Stallock J.P., Ng J.C., Reinhard C., Neufeld T.P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14:2000;2712-2724.
49. Zhang Y., Gao X., Saucedo L.J., Ru B., Edgar B.A., Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5:2003;578-581.
50. Zinke I., Kirchner C., Chao L.C., Tetzlaff M.T., Pankratz M.J. Suppression of food intake and growth by amino acids in Drosophila. the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system Development. 126:1999;5275-5284.
51. Zinke I., Schutz C.S., Katzenberger J.D., Bauer M., Pankratz M.J. Nutrient control of gene expression in Drosophila. microarray analysis of starvation and sugar-dependent response EMBO J. 21:2002;6162-6173.