메뉴 건너뛰기




Volumn 14, Issue 5, 2013, Pages 450-457

Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4

Author keywords

amino acid transporter; autophagy; mTORC1; Rab12; recycling endosome

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 4; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN DERIVATIVE; PROTEIN RAB12; UNCLASSIFIED DRUG;

EID: 84877582117     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.32     Document Type: Article
Times cited : (78)

References (39)
  • 1
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147: 728-741
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 2
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • DOI 10.1101/gad.1599207
    • Mizushima N (2007) Autophagy: process and function. Genes Dev 21: 2861-2873 (Pubitemid 350133435)
    • (2007) Genes and Development , vol.21 , Issue.22 , pp. 2861-2873
    • Mizushima, N.1
  • 3
    • 68049105101 scopus 로고    scopus 로고
    • Rab GTPases as coordinators of vesicle traffic
    • Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10: 513-525
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 513-525
    • Stenmark, H.1
  • 4
    • 38149044992 scopus 로고    scopus 로고
    • Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells
    • Fader CM, Sa'nchez D, Furla'n M, Colombo MI (2008) Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic 9: 230-250
    • (2008) Traffic , vol.9 , pp. 230-250
    • Fader, C.M.1    Sa'Nchez, D.2    Furla'N, M.3    Colombo, M.I.4
  • 5
    • 84862611041 scopus 로고    scopus 로고
    • TBC1D14 regulates autophagosome formation via Rab11- and ULK1- positive recycling endosomes
    • Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA (2012) TBC1D14 regulates autophagosome formation via Rab11- and ULK1- positive recycling endosomes. J Cell Biol 197: 659-675
    • (2012) J Cell Biol , vol.197 , pp. 659-675
    • Longatti, A.1    Lamb, C.A.2    Razi, M.3    Yoshimura, S.4    Barr, F.A.5    Tooze, S.A.6
  • 6
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140: 313-326
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 8
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • DOI 10.1083/jcb.200507002
    • Bjrky G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171: 603-614 (Pubitemid 41668720)
    • (2005) Journal of Cell Biology , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 9
    • 84862295360 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy
    • Klionsky DJ et al (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544
    • (2012) Autophagy , vol.8 , pp. 445-544
    • Klionsky, D.J.1
  • 10
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    • Hosokawa N et al (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 20: 1981-1991
    • (2009) Mol Biol Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1
  • 12
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR -mediated autophagy regulation
    • Chang YY, Neufeld TP (2009) An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 20: 2004-2014
    • (2009) Mol Biol Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 13
    • 66449083078 scopus 로고    scopus 로고
    • ULK1 -ATG13 - FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X (2009) ULK1 - ATG13 - FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284: 12297-12305
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam Du, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 14
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC et al (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023-8032
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1
  • 15
    • 78650510609 scopus 로고    scopus 로고
    • Mtor: From growth signal integration to cancer diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing.Nat RevMol Cell Biol 12: 21-35
    • (2011) Nat RevMol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 19
    • 84859778293 scopus 로고    scopus 로고
    • Mtor signaling in growth control and disease
    • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 13: 274-293
    • (2012) Cell , vol.13 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 22
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141: 290-303
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 23
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki K, Li Y, Xu T, Guan KL (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17: 1829-1834 (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 24
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous Sclerosis Complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • DOI 10.1016/S0960-9822(03)00506-2
    • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J (2003) Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13: 1259-1268 (Pubitemid 36953298)
    • (2003) Current Biology , vol.13 , Issue.15 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 25
    • 80052626406 scopus 로고    scopus 로고
    • Small GTPase Rab12 regulates constitutive degradation of transferrin receptor
    • Matsui T, Itoh T, Fukuda M (2011) Small GTPase Rab12 regulates constitutive degradation of transferrin receptor. Traffic 12: 1432-1443
    • (2011) Traffic , vol.12 , pp. 1432-1443
    • Matsui, T.1    Itoh, T.2    Fukuda, M.3
  • 26
    • 59049087460 scopus 로고    scopus 로고
    • Bidirectional transport of amino acids regulates mTOR and autophagy
    • Nicklin P et al (2009) Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136: 521-534
    • (2009) Cell , vol.136 , pp. 521-534
    • Nicklin, P.1
  • 30
    • 77954757143 scopus 로고    scopus 로고
    • Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-aciddependent mTORC1 activation
    • Heublein S, Kazi S, Ogmundsdó ttir MH, Attwood EV, Kala S, Boyd CAR, Wilson C, Goberdhan DCI (2010) Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-aciddependent mTORC1 activation. Oncogene 29: 4068-4079
    • (2010) Oncogene , vol.29 , pp. 4068-4079
    • Heublein, S.1    Kazi, S.2    Ogmundsdóttir, M.H.3    Attwood, E.V.4    Kala, S.5    Car, B.6    Wilson, C.7    Dci, G.8
  • 31
    • 1242295153 scopus 로고    scopus 로고
    • The SLC36 family: Proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
    • DOI 10.1007/s00424-003-1073-4, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Boll M, Daniel H, Gasnier B (2004) The SLC36 family: protoncoupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis. Pflu?gers Arch Eur J Physiol 447: 776-779 (Pubitemid 38241466)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 776-779
    • Boll, M.1    Daniel, H.2    Gasnier, B.3
  • 32
    • 80555143078 scopus 로고    scopus 로고
    • MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase
    • Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase. Science 334: 678-683
    • (2011) Science , vol.334 , pp. 678-683
    • Zoncu, R.1    Bar-Peled, L.2    Efeyan, A.3    Wang, S.4    Sancak, Y.5    Sabatini, D.M.6
  • 33
    • 78951482110 scopus 로고    scopus 로고
    • SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes
    • Pillai SM, Meredith D (2011) SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. J Biol Chem 286: 2455-2460
    • (2011) J Biol Chem , vol.286 , pp. 2455-2460
    • Pillai, S.M.1    Meredith, D.2
  • 35
    • 37249042829 scopus 로고    scopus 로고
    • Dissecting eIF4E action in tumorigenesis
    • Wendel HG et al (2007) Dissecting eIF4E action in tumorigenesis. Genes Dev 21: 3232-3237
    • (2007) Genes Dev , vol.21 , pp. 3232-3237
    • Wendel, H.G.1
  • 36
    • 79955377420 scopus 로고    scopus 로고
    • Autophagy-deficient mice develop multiple liver tumors
    • Takamura A et al (2011) Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25: 795-800
    • (2011) Genes Dev , vol.25 , pp. 795-800
    • Takamura, A.1
  • 37
    • 50249098491 scopus 로고    scopus 로고
    • Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation
    • Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M (2008) Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell 19: 2916-2925
    • (2008) Mol Biol Cell , vol.19 , pp. 2916-2925
    • Itoh, T.1    Fujita, N.2    Kanno, E.3    Yamamoto, A.4    Yoshimori, T.5    Fukuda, M.6
  • 38
    • 79952422876 scopus 로고    scopus 로고
    • OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation
    • Itoh T, Kanno E, Uemura T, Waguri S, Fukuda M (2011) OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J Cell Biol 192: 839-853
    • (2011) J Cell Biol , vol.192 , pp. 839-853
    • Itoh, T.1    Kanno, E.2    Uemura, T.3    Waguri, S.4    Fukuda, M.5
  • 39
    • 33845307154 scopus 로고    scopus 로고
    • Identification of EPI64 as a GTPase-activating protein specific for Rab27A
    • DOI 10.1074/jbc.M603808200
    • Itoh T, Fukuda M (2006) Identification of EPI64 as a GTPase-activating protein specific for Rab27A. J Biol Chem 281: 31823-31831 (Pubitemid 46041447)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.42 , pp. 31823-31831
    • Itoh, T.1    Fukuda, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.