메뉴 건너뛰기




Volumn 33, Issue 2, 2016, Pages 167-182

Supporting read-across using biological data

Author keywords

Big data; Biological similarity; Read across; Safety assessment

Indexed keywords

CHEMICAL COMPOUND; DANGEROUS GOODS;

EID: 84962920734     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.1601252     Document Type: Article
Times cited : (83)

References (110)
  • 1
    • 60849101543 scopus 로고    scopus 로고
    • Similarity-based virtual screening with a Bayesian inference network
    • Abdo, A. and Salim, N. (2009). Similarity-based virtual screening with a Bayesian inference network. Chem Med Chem 4, 210-218. http://dx.doi.org/10.1002/cmdc.200800290.
    • (2009) Chem Med Chem , vol.4 , pp. 210-218
    • Abdo, A.1    Salim, N.2
  • 2
    • 84962790191 scopus 로고    scopus 로고
    • Flusilazole
    • Part II - Toxicological . Geneva: World Health Organization
    • Adcock, C. and Tasheva, M. (2009). Flusilazole. In Pesticide Residues in Food - 2007 Evaluations. Part II - Toxicological (317-347). Geneva: World Health Organization.
    • (2009) Pesticide Residues in Food - 2007 Evaluations , pp. 317-347
    • Adcock, C.1    Tasheva, M.2
  • 3
    • 79956348442 scopus 로고    scopus 로고
    • Alternative (non-animal) methods for cosmetics testing: Current status and future prospects - 2010
    • Adler, S., Basketter, D., Creton, S. et al. (2011). Alternative (non-animal) methods for cosmetics testing: Current status and future prospects - 2010. Arch Toxicol 85, 367-485. http://dx.doi.org/10.1007/s00204-011-0693-2.
    • (2011) Arch Toxicol , vol.85 , pp. 367-485
    • Adler, S.1    Basketter, D.2    Creton, S.3
  • 4
    • 77951118386 scopus 로고    scopus 로고
    • Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
    • Ankley, G. T., Bennett, R. S., Erickson, R. J. et al. (2010). Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem 29, 730-741. http://dx.doi.org/10.1002/etc.34.
    • (2010) Environ Toxicol Chem , vol.29 , pp. 730-741
    • Ankley, G.T.1    Bennett, R.S.2    Erickson, R.J.3
  • 5
    • 8444225024 scopus 로고    scopus 로고
    • NIH molecular libraries initiative
    • Austin, C. P., Brady, L. S., Insel, T. R. and Collins, F. S. (2004). NIH molecular libraries initiative. Science 306, 1138-1139. http://dx.doi.org/10.1126/science.1105511.
    • (2004) Science , vol.306 , pp. 1138-1139
    • Austin, C.P.1    Brady, L.S.2    Insel, T.R.3    Collins, F.S.4
  • 6
    • 84962861082 scopus 로고    scopus 로고
    • Toward good read-across practice (GRAP) guidance
    • Ball, N., Cronin, M. T. D., She, J. et al. (2016). Toward good read-across practice (GRAP) guidance. ALTEX 33, 149-166 http://dx.doi.org/10.14573/altex.1601251.
    • (2016) ALTEX , vol.33 , pp. 149-166
    • Ball, N.1    Cronin, M.T.D.2    She, J.3
  • 7
    • 84879577115 scopus 로고    scopus 로고
    • Tox21 to date: Steps toward modernizing human hazard characterization
    • Betts, K. S. (2013). Tox21 to date: Steps toward modernizing human hazard characterization. Environ Health Perspect 121, a228. http://dx.doi.org/10.1289/ehp.121-a228.
    • (2013) Environ Health Perspect , vol.121 , pp. a228
    • Betts, K.S.1
  • 8
    • 84871013688 scopus 로고    scopus 로고
    • The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
    • Blaauboer, B. J., Boekelheide, K., Clewell, H. J. et al. (2012). The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX 29, 411-425. http://dx.doi.org/10.14573/altex.2012.4.411.
    • (2012) ALTEX , vol.29 , pp. 411-425
    • Blaauboer, B.J.1    Boekelheide, K.2    Clewell, H.J.3
  • 9
    • 84937959352 scopus 로고    scopus 로고
    • Interpreting in vitro developmental toxicity test battery results: The considerations of toxicokinetics
    • Bosgra, S. and Westerhout, J. (2015). Interpreting in vitro developmental toxicity test battery results: The considerations of toxicokinetics. Reprod Toxicol 55, 73-80. http://dx.doi.org/10.1016/j.reprotox.2014.11.001.
    • (2015) Reprod Toxicol , vol.55 , pp. 73-80
    • Bosgra, S.1    Westerhout, J.2
  • 10
    • 84885964577 scopus 로고    scopus 로고
    • Review: Toxicometabolomics
    • Bouhifd, M., Hartung, T., Hogberg, H. T. et al. (2013). Review: Toxicometabolomics. J Appl Toxicol 33, 1365-1383. http://dx.doi.org/10.1002/jat.2874.
    • (2013) J Appl Toxicol , vol.33 , pp. 1365-1383
    • Bouhifd, M.1    Hartung, T.2    Hogberg, H.T.3
  • 11
    • 84946731469 scopus 로고    scopus 로고
    • Quality assurance of metabolomics
    • Bouhifd, M., Beger, R., Flynn, T. et al. (2015). Quality assurance of metabolomics. ALTEX 32, 319-326. http://dx.doi.org/10.14573/altex.1509161.
    • (2015) ALTEX , vol.32 , pp. 319-326
    • Bouhifd, M.1    Beger, R.2    Flynn, T.3
  • 12
    • 78650213212 scopus 로고    scopus 로고
    • A different approach to validating screening assays for developmental toxicity
    • Daston, G. P., Chapin, R. E., Scialli, A. R. et al. (2010). A different approach to validating screening assays for developmental toxicity. Birth Defects Res 89, 526-530. http://dx.doi.org/10.1002/bdrb.20276.
    • (2010) Birth Defects Res , vol.89 , pp. 526-530
    • Daston, G.P.1    Chapin, R.E.2    Scialli, A.R.3
  • 13
    • 84941026118 scopus 로고    scopus 로고
    • The comparative toxicogenomics database's 10th year anniversary: Update 2015
    • Davis, A. P., Grondin, C. J., Lennon-Hopkins, K., et al. (2014). The Comparative Toxicogenomics Database's 10th year anniversary: update 2015. Nucleic Acids Res 43, D914-20. http://dx.doi.org/10.1093/nar/gku935.
    • (2014) Nucleic Acids Res , vol.43 , pp. D914-D920
    • Davis, A.P.1    Grondin, C.J.2    Lennon-Hopkins, K.3
  • 14
    • 84962821080 scopus 로고
    • Hexaconazole
    • World Health Organization, WHO/PCS/91.47, 1991, nos 802-816 on INCHEM. (accessed November 13, 2015)
    • den Tonkelaar, E. M. and van Koten-Vermeulen, J. E. M. (1991). Hexaconazole. In Pesticide residues in food - 1990 evaluations. Toxicology. World Health Organization, WHO/PCS/91.47, 1991, nos 802-816 on INCHEM. http://www.inchem.org/documents/jmpr/jmpmono/v90pr09.htm (accessed November 13, 2015).
    • (1991) Pesticide Residues in Food - 1990 Evaluations. Toxicology
    • Den Tonkelaar, E.M.1    Van Koten-Vermeulen, J.E.M.2
  • 15
    • 84962790164 scopus 로고    scopus 로고
    • Propiconazole
    • Part II - Toxicological . Geneva: World Health Organization
    • Dewhurst, I. and Dellarco, V. (2006). Propiconazole. In Pesticide residues in food - 2004 evaluations. Part II - Toxicological (281-323). Geneva: World Health Organization.
    • (2006) Pesticide Residues in Food - 2004 Evaluations , pp. 281-323
    • Dewhurst, I.1    Dellarco, V.2
  • 16
    • 33845620001 scopus 로고    scopus 로고
    • The toxcast program for prioritizing toxicity testing of environmental chemicals
    • Dix, D. J., Houck, K. A., Martin, M. T. et al. (2007). The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol Sci 95, 5-12. http://dx.doi.org/10.1093/toxsci/kfl103.
    • (2007) Toxicol Sci , vol.95 , pp. 5-12
    • Dix, D.J.1    Houck, K.A.2    Martin, M.T.3
  • 17
    • 84962887089 scopus 로고    scopus 로고
    • Workshop on the application of 'omics technologies in toxicology and ecotoxicology: Case studies and risk assessment
    • Brussels
    • ECETOC (2008). Workshop on the application of 'omics technologies in toxicology and ecotoxicology: Case studies and risk assessment. Workshop Report No. 11. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels.
    • (2008) Workshop Report No. 11. European Centre for Ecotoxicology and Toxicology of Chemicals
    • ECETOC1
  • 20
    • 0034096691 scopus 로고    scopus 로고
    • Toxnet: A computerized collection of toxicological and environmental health information
    • Fonger, G. C., Stroup, D., Thomas, P. L. and Wexler, P. (2000). TOXNET: A computerized collection of toxicological and environmental health information. Toxicol Ind Health 16, 4-6. http://dx.doi.org/10.1177/074823370001600101.
    • (2000) Toxicol Ind Health , vol.16 , pp. 4-6
    • Fonger, G.C.1    Stroup, D.2    Thomas, P.L.3    Wexler, P.4
  • 21
    • 20944433525 scopus 로고    scopus 로고
    • Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
    • Ganter, B., Tugendreich, S., Pearson, C. I. et al. (2005). Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. J Biotechnol 119, 219-244. http://dx.doi.org/10.1016/j.jbiotec.2005.03.022.
    • (2005) J Biotechnol , vol.119 , pp. 219-244
    • Ganter, B.1    Tugendreich, S.2    Pearson, C.I.3
  • 22
    • 84862192766 scopus 로고    scopus 로고
    • CHEMBL: A large-scale bioactivity database for drug discovery
    • Gaulton, A., Bellis, L. J., Bento, A. P. et al. (2012). CHEMBL: A large-scale bioactivity database for drug discovery. Nucleic Acids Res 40, D1100-D1107. http://dx.doi.org/10.1093/nar/gkr777.
    • (2012) Nucleic Acids Res , vol.40 , pp. D1100-D1107
    • Gaulton, A.1    Bellis, L.J.2    Bento, A.P.3
  • 23
    • 34250628103 scopus 로고    scopus 로고
    • Principles of QSAR models validation: Internal and external
    • Gramatica, P. (2007). Principles of QSAR models validation: Internal and external. QSAR Comb Sci 26, 694-701. http://dx.doi.org/10.1002/qsar.200610151.
    • (2007) QSAR Comb Sci , vol.26 , pp. 694-701
    • Gramatica, P.1
  • 24
    • 19944430250 scopus 로고    scopus 로고
    • Modular approach to the ECVAM principles on test validity
    • Hartung, T., Bremer, S., Casati, S. et al. (2004). Modular approach to the ECVAM principles on test validity. Altern Lab Anim 32, 467-472.
    • (2004) Altern Lab Anim , vol.32 , pp. 467-472
    • Hartung, T.1    Bremer, S.2    Casati, S.3
  • 25
    • 34249915306 scopus 로고    scopus 로고
    • Food for thought ... on validation
    • Hartung, T. (2007). Food for thought ... on validation. ALTEX 24, 67-72. http://www.altex.ch/en/All-issues/Issue.50.html?iid=86&aid=3.
    • (2007) ALTEX , vol.24 , pp. 67-72
    • Hartung, T.1
  • 26
    • 73949095137 scopus 로고    scopus 로고
    • Food for thought ... on in silico methods in toxicology
    • Hartung, T. and Hoffmann, S. (2009). Food for thought ... on in silico methods in toxicology. ALTEX 26, 155-166. http://www.altex.ch/resources/altex-2009-3-155-166-FFT-Hartung.pdf.
    • (2009) ALTEX , vol.26 , pp. 155-166
    • Hartung, T.1    Hoffmann, S.2
  • 27
    • 77954744712 scopus 로고    scopus 로고
    • Food for thought ... on alternative methods for chemical safety testing
    • Hartung, T. (2010). Food for thought ... on alternative methods for chemical safety testing. ALTEX 27, 3-14. http://www.altex.ch/resources/altex-2010-1-3-14-FFT-Hartung.pdf.
    • (2010) ALTEX , vol.27 , pp. 3-14
    • Hartung, T.1
  • 28
    • 84876323285 scopus 로고    scopus 로고
    • Integrated testing strategies for safety assessments
    • Hartung, T., Luechtefeld, T., Maertens, A. and Kleensang, A. (2013). Integrated testing strategies for safety assessments. ALTEX 30, 3-18. http://dx.doi.org/10.14573/altex.2013.1.003.
    • (2013) ALTEX , vol.30 , pp. 3-18
    • Hartung, T.1    Luechtefeld, T.2    Maertens, A.3    Kleensang, A.4
  • 29
    • 79951772038 scopus 로고    scopus 로고
    • The OECD validation program of the h295r steroidogenesis assay: Phase 3 final inter-laboratory validation study
    • Hecker, M., Hollert, H., Cooper, R. et al. (2011). The OECD validation program of the H295R steroidogenesis assay: Phase 3 final inter-laboratory validation study. Environ Sci Pollut Res Int 18, 503-515. http://dx.doi.org/10.1007/s11356-010-0396-x.
    • (2011) Environ Sci Pollut Res Int , vol.18 , pp. 503-515
    • Hecker, M.1    Hollert, H.2    Cooper, R.3
  • 30
    • 33244470902 scopus 로고    scopus 로고
    • The REACH concept and its impact on toxicological sciences
    • Hengstler, J. G., Foth, H., Kahl, R. et al. (2006). The REACH concept and its impact on toxicological sciences. Toxicol 220, 232-239. http://dx.doi.org/10.1016/j.tox.2005.12.005.
    • (2006) Toxicol , vol.220 , pp. 232-239
    • Hengstler, J.G.1    Foth, H.2    Kahl, R.3
  • 31
    • 79952040775 scopus 로고    scopus 로고
    • Relative embryo-toxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies
    • Hermsen, S. A., van den Brandhof, E. J., van der Ven, L. T. and Piersma, A. H. (2011). Relative embryo-toxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies. Toxicol In Vitro 25, 745-753. http://dx.doi.org/10.1016/j.tiv.2011.01.005.
    • (2011) Toxicol in Vitro , vol.25 , pp. 745-753
    • Hermsen, S.A.1    Van Den Brandhof, E.J.2    Van Der Ven, L.T.3    Piersma, A.H.4
  • 32
    • 33746789921 scopus 로고    scopus 로고
    • Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
    • Inglese, J., Auld, D. S., Jadhav, A. et al. (2006). Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A 103, 11473-11478. http://dx.doi.org/10.1073/pnas.0604348103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11473-11478
    • Inglese, J.1    Auld, D.S.2    Jadhav, A.3
  • 33
    • 55649116409 scopus 로고    scopus 로고
    • ACTOR - Aggregated computational toxicology resource
    • Judson, R. S., Richard, A., Dix, D. et al. (2008). ACToR - Aggregated computational toxicology resource. Toxicol Appl Pharmacol 233, 7-13. http://dx.doi.org/10.1016/j.taap.2007.12.037.
    • (2008) Toxicol Appl Pharmacol , vol.233 , pp. 7-13
    • Judson, R.S.1    Richard, A.2    Dix, D.3
  • 34
    • 77951675220 scopus 로고    scopus 로고
    • In vitro screening of environmental chemicals for targeted testing prioritization: The toxcast project
    • Judson, R. S., Houck, K. A., Kavlock, R. J. et al. (2010). In vitro screening of environmental chemicals for targeted testing prioritization: The ToxCast project. Environ Health Perspect 118, 485-492. http://dx.doi.org/10.1289/ehp.0901392.
    • (2010) Environ Health Perspect , vol.118 , pp. 485-492
    • Judson, R.S.1    Houck, K.A.2    Kavlock, R.J.3
  • 35
    • 84863298868 scopus 로고    scopus 로고
    • Aggregating data for computational toxicology applications: The U.S. Environmental protection agency (EPA) aggregated computational toxicology resource (ACTOR) system
    • Judson, R. S., Martin, M. T., Egeghy, P. et al. (2012). Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) aggregated computational toxicology resource (ACToR) system. Int J Mol Sci 13, 1805-1831. http://dx.doi.org/10.3390/ijms13021805.
    • (2012) Int J Mol Sci , vol.13 , pp. 1805-1831
    • Judson, R.S.1    Martin, M.T.2    Egeghy, P.3
  • 36
    • 84867384668 scopus 로고    scopus 로고
    • Reproducibility and robustness of metabolome analysis in rat plasma of 28- day repeated dose toxicity studies
    • Kamp, H., Strauss, V., Wiemer, J. et al. (2012). Reproducibility and robustness of metabolome analysis in rat plasma of 28- day repeated dose toxicity studies. Toxicol Letters 215, 143- 149. http://dx.doi.org/10.1016/j.toxlet.2012.09.015.
    • (2012) Toxicol Letters , vol.215 , pp. 143-149
    • Kamp, H.1    Strauss, V.2    Wiemer, J.3
  • 37
    • 84897106909 scopus 로고    scopus 로고
    • Critical evaluation of human oral bioavailability for pharmaceutical drugs by using various cheminformatics approaches
    • Kim, M. T., Sedykh, A., Chakravarti, S. K. et al. (2014). Critical evaluation of human oral bioavailability for pharmaceutical drugs by using various cheminformatics approaches. Pharmaceut Res 31, 1002-1014. http://dx.doi.org/10.1007/s11095-013-1222-1.
    • (2014) Pharmaceut Res , vol.31 , pp. 1002-1014
    • Kim, M.T.1    Sedykh, A.2    Chakravarti, S.K.3
  • 38
    • 84964810430 scopus 로고    scopus 로고
    • Mechanism profiling of hepatotoxicity caused by oxidative stress using the antioxidant response element reporter gene assay models and big data
    • in press
    • Kim, M. T., Huang, R., Sedykh, A. et al. (2016). Mechanism profiling of hepatotoxicity caused by oxidative stress using the antioxidant response element reporter gene assay models and big data. Environ Health Perspect, in press.
    • (2016) Environ Health Perspect
    • Kim, M.T.1    Huang, R.2    Sedykh, A.3
  • 39
    • 84893141038 scopus 로고    scopus 로고
    • Pathways of toxicity
    • Kleensang, A., Maertens, A., Rosenberg, M. et al. (2014). Pathways of toxicity. ALTEX 31, 53-61. http://dx.doi.org/10.14573/altex.1309261.
    • (2014) ALTEX , vol.31 , pp. 53-61
    • Kleensang, A.1    Maertens, A.2    Rosenberg, M.3
  • 40
    • 80053009778 scopus 로고    scopus 로고
    • Environmental impact on vascular development predicted by high throughput screening (HTS)
    • Kleinstreuer, N., Judson, R., Reif, D. et al. (2011). Environmental impact on vascular development predicted by high throughput screening (HTS). Environ Health Perspect 119, 1596-1603. http://dx.doi.org/10.1289/ehp.1103412.
    • (2011) Environ Health Perspect , vol.119 , pp. 1596-1603
    • Kleinstreuer, N.1    Judson, R.2    Reif, D.3
  • 41
    • 84902166194 scopus 로고    scopus 로고
    • Bioactivity profiling of a diverse 800 chemical library in human primary cell systems
    • Kleinstreuer, N., Houck, K., Yang, J. et al. (2014). Bioactivity profiling of a diverse 800 chemical library in human primary cell systems. Nat Biotechnol 32, 583-591. http://dx.doi.org/10.1038/nbt.2914.
    • (2014) Nat Biotechnol , vol.32 , pp. 583-591
    • Kleinstreuer, N.1    Houck, K.2    Yang, J.3
  • 42
    • 84964891591 scopus 로고    scopus 로고
    • A curated database of rodent uterotrophic bioactivity
    • Epub ahead of print
    • Kleinstreuer, N. C., Ceger, P., Allen, D. et al. (2015). A curated database of rodent uterotrophic bioactivity. Environ Health Perspect, Epub ahead of print. http://dx.doi.org/10.1289/ehp.1510183.
    • (2015) Environ Health Perspect
    • Kleinstreuer, N.C.1    Ceger, P.2    Allen, D.3
  • 43
    • 0032718443 scopus 로고    scopus 로고
    • Multiple computer-automated structure evaluation program study of aquatic toxicity 1: Guppy
    • Klopman, G., Saiakhov, R., Rosenkranz, H. S. and Hermens, J. L. M. (1999). Multiple computer-automated structure evaluation program study of aquatic toxicity 1: Guppy. Environ Toxicol Chem 18, 2497-2505. http://dx.doi.org/10.1002/etc.5620181116.
    • (1999) Environ Toxicol Chem , vol.18 , pp. 2497-2505
    • Klopman, G.1    Saiakhov, R.2    Rosenkranz, H.S.3    Hermens, J.L.M.4
  • 44
    • 3242727566 scopus 로고    scopus 로고
    • Searching for an enhanced predictive tool for mutagenicity
    • Klopman, G., Zhu, H., Fuller, M. A. and Saiakhov, R. D. (2004). Searching for an enhanced predictive tool for mutagenicity. SAR QSAR Environ Res 15, 251-263. http://dx.doi.org/10.1080/10629360410001724897.
    • (2004) SAR QSAR Environ Res , vol.15 , pp. 251-263
    • Klopman, G.1    Zhu, H.2    Fuller, M.A.3    Saiakhov, R.D.4
  • 45
    • 84856241088 scopus 로고    scopus 로고
    • Disruption of embryonic vascular development in predictive toxicology
    • Knudsen, T. B. and Kleinstreuer, N. C. (2012). Disruption of embryonic vascular development in predictive toxicology. Birth Defects Res C Embryo Today 93, 312-323. http://dx.doi.org/10.1002/bdrc.20223.
    • (2012) Birth Defects Res C Embryo Today , vol.93 , pp. 312-323
    • Knudsen, T.B.1    Kleinstreuer, N.C.2
  • 46
    • 84873038959 scopus 로고    scopus 로고
    • The toxbank data warehouse: Supporting the replacement of in vivo repeated dose systemic toxicity testing
    • Kohonen, P., Benfenati, E., Bower, D. et al. (2013). The ToxBank data warehouse: Supporting the replacement of in vivo repeated dose systemic toxicity testing. Molec Informat 32, 47-63. http://dx.doi.org/10.1002/minf.201200114.
    • (2013) Molec Informat , vol.32 , pp. 47-63
    • Kohonen, P.1    Benfenati, E.2    Bower, D.3
  • 47
    • 84937916430 scopus 로고    scopus 로고
    • Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
    • Kroese, E. D., Bosgra, S., Buist, H. E. et al. (2015). Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context. Reprod Toxicol 55, 11- 19. http://dx.doi.org/10.1016/j.reprotox.2014.10.003.
    • (2015) Reprod Toxicol , vol.55 , pp. 11-19
    • Kroese, E.D.1    Bosgra, S.2    Buist, H.E.3
  • 48
    • 33749335282 scopus 로고    scopus 로고
    • The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb, J., Crawford, E. D., Peck, D. et al. (2006). The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935. http://dx.doi.org/10.1126/science.1132939.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3
  • 49
    • 84904901979 scopus 로고    scopus 로고
    • Consensus report on the future of animal-free systemic toxicity testing
    • Leist, M., Hasiwa, N., Rovida, C. et al. (2014). Consensus report on the future of animal-free systemic toxicity testing. ALTEX 31, 341-356. http://dx.doi.org/10.14573/altex.1406091.
    • (2014) ALTEX , vol.31 , pp. 341-356
    • Leist, M.1    Hasiwa, N.2    Rovida, C.3
  • 50
    • 84921341268 scopus 로고    scopus 로고
    • From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods
    • Linkov, I., Massey, O., Keisler, J. et al. (2015). From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods. ALTEX 32, 3-8. http://dx.doi.org/10.14573/altex.1412231.
    • (2015) ALTEX , vol.32 , pp. 3-8
    • Linkov, I.1    Massey, O.2    Keisler, J.3
  • 52
    • 84882644463 scopus 로고    scopus 로고
    • Integrative chemical-biological read-across approach for chemical hazard classification
    • Low, Y., Sedykh, A., Fourches, D. et al. (2013). Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol 26, 1199-1208. http://dx.doi.org/10.1021/tx400110f.
    • (2013) Chem Res Toxicol , vol.26 , pp. 1199-1208
    • Low, Y.1    Sedykh, A.2    Fourches, D.3
  • 53
    • 84962788737 scopus 로고    scopus 로고
    • Global analysis of publicly available safety data for 9, 801 substances registered under reach from 2008-2014
    • Luechtefeld, T., Maertens, A., Russo, D. P. et al. (2016a). Global analysis of publicly available safety data for 9, 801 substances registered under REACH from 2008-2014. ALTEX 33, 95- 109. http://dx.doi.org/10.14573/altex.1510052.
    • (2016) ALTEX , vol.33 , pp. 95-109
    • Luechtefeld, T.1    Maertens, A.2    Russo, D.P.3
  • 54
    • 84962786551 scopus 로고    scopus 로고
    • Analysis of public oral toxicity data from reach registrations 2008-2014
    • Luechtefeld, T., Maertens, A., Russo, D. P. et al. (2016b). Analysis of public oral toxicity data from REACH registrations 2008-2014. ALTEX 33, 111-122. http://dx.doi.org/10.14573/altex.1510054.
    • (2016) ALTEX , vol.33 , pp. 111-122
    • Luechtefeld, T.1    Maertens, A.2    Russo, D.P.3
  • 55
    • 84962900969 scopus 로고    scopus 로고
    • Analysis of draize eye irritation testing and its prediction by mining publicly available 2008-2014 reach data
    • Luechtefeld, T., Maertens, A., Russo, D. P. et al. (2016c). Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data. ALTEX 33, 123- 134. http://dx.doi.org/10.14573/altex.1510053.
    • (2016) ALTEX , vol.33 , pp. 123-134
    • Luechtefeld, T.1    Maertens, A.2    Russo, D.P.3
  • 56
    • 84962821185 scopus 로고    scopus 로고
    • Analysis of publically available skin sensitization data from reach registrations 2008-2014
    • Luechtefeld, T., Maertens, A., Russo, D. P. et al. (2016d). Analysis of publically available skin sensitization data from REACH registrations 2008-2014. ALTEX 33, 135-148. http://dx.doi.org/10.14573/altex.1510055.
    • (2016) ALTEX , vol.33 , pp. 135-148
    • Luechtefeld, T.1    Maertens, A.2    Russo, D.P.3
  • 57
    • 33746931581 scopus 로고    scopus 로고
    • On outliers and activity cliffs - why QSAR often disappoints
    • Maggiora, G. M. (2006). On outliers and activity cliffs - why QSAR often disappoints. J Chem Inf Model 46, 1535. http://dx.doi.org/10.1021/ci060117s.
    • (2006) J Chem Inf Model , vol.46 , pp. 1535
    • Maggiora, G.M.1
  • 59
    • 1342310907 scopus 로고    scopus 로고
    • Promoting comparative molecular studies in environmental health research: An overview of the comparative toxicogenomics database (CTD)
    • Mattingly, C. J., Colby, G. T., Rosenstein, M. C. et al. (2004). Promoting comparative molecular studies in environmental health research: An overview of the comparative toxicogenomics database (CTD). Pharmacogenomics J 4, 5-8. http://dx.doi.org/10.1038/sj.tpj.6500225.
    • (2004) Pharmacogenomics J , vol.4 , pp. 5-8
    • Mattingly, C.J.1    Colby, G.T.2    Rosenstein, M.C.3
  • 60
    • 33748502967 scopus 로고    scopus 로고
    • The comparative toxicogenomics database (CTD): A resource for comparative toxicological studies
    • Mattingly, C. J., Rosenstein, M. C., Colby, G. T. et al. (2006a). The comparative toxicogenomics database (CTD): A resource for comparative toxicological studies. J Exp Zool A Comp Exp Biol 305, 689-692. http://dx.doi.org/10.1002/jez.a.307.
    • (2006) J Exp Zool a Comp Exp Biol , vol.305 , pp. 689-692
    • Mattingly, C.J.1    Rosenstein, M.C.2    Colby, G.T.3
  • 61
    • 33745795732 scopus 로고    scopus 로고
    • The comparative toxicogenomics database: A cross-species resource for building chemical-gene interaction networks
    • Mattingly, C. J., Rosenstein, M. C., Davis, A. P. et al. (2006b). The comparative toxicogenomics database: A cross-species resource for building chemical-gene interaction networks. Toxicol Sci 92, 587-595. http://dx.doi.org/10.1093/toxsci/kfl008.
    • (2006) Toxicol Sci , vol.92 , pp. 587-595
    • Mattingly, C.J.1    Rosenstein, M.C.2    Davis, A.P.3
  • 62
    • 78650231595 scopus 로고    scopus 로고
    • Toxicogenomic profiling of chemically exposed humans in risk assessment
    • McHale, C. M., Zhang, L., Hubbard, A. E. and Smith, M. T. (2010). Toxicogenomic profiling of chemically exposed humans in risk assessment. Mutat Res 705, 172-183. http://dx.doi.org/10.1016/j.mrrev.2010.04.001.
    • (2010) Mutat Res , vol.705 , pp. 172-183
    • McHale, C.M.1    Zhang, L.2    Hubbard, A.E.3    Smith, M.T.4
  • 63
    • 80053437091 scopus 로고    scopus 로고
    • Nutritional impact on the plasma metabolome of rats
    • Mellert, W., Kapp, M., Strauss, V. et al. (2011). Nutritional impact on the plasma metabolome of rats. Toxicol Letters 207, 173-181. http://dx.doi.org/10.1016/j.toxlet.2011.08.013.
    • (2011) Toxicol Letters , vol.207 , pp. 173-181
    • Mellert, W.1    Kapp, M.2    Strauss, V.3
  • 64
    • 84892466895 scopus 로고    scopus 로고
    • Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance
    • Montoya, G. A., Strauss, V., Fabian, E. et al. (2014). Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance. Toxicol Lett 225, 240-251. http://dx.doi.org/10.1016/j.toxlet.2013.12.010.
    • (2014) Toxicol Lett , vol.225 , pp. 240-251
    • Montoya, G.A.1    Strauss, V.2    Fabian, E.3
  • 65
    • 0036096659 scopus 로고    scopus 로고
    • Quantitative structure-permeability relationships (QSPRS) for percutaneous absorption
    • Moss, G. P., Dearden, J. C., Patel, H. and Cronin, M. T. D. (2002). Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption. Toxicol In Vitro 16, 299-317. http://dx.doi.org/10.1016/S0887-2333(02)00003-6.
    • (2002) Toxicol in Vitro , vol.16 , pp. 299-317
    • Moss, G.P.1    Dearden, J.C.2    Patel, H.3    Cronin, M.T.D.4
  • 66
    • 84885857859 scopus 로고    scopus 로고
    • Establishment and assessment of a new human embryonic stem cell-based biomarker assay for developmental toxicity screening
    • Palmer, J. A., Smith, A. M., Egnash, L. A. et al. (2013). Establishment and assessment of a new human embryonic stem cell-based biomarker assay for developmental toxicity screening. Birth Defects Res B Dev Reprod Toxicol 98, 343- 363. http://dx.doi.org/10.1002/bdrb.21078.
    • (2013) Birth Defects Res B Dev Reprod Toxicol , vol.98 , pp. 343-363
    • Palmer, J.A.1    Smith, A.M.2    Egnash, L.A.3
  • 67
    • 80053475275 scopus 로고    scopus 로고
    • Mechanism-based models in reproductive and development toxicology
    • R. C. Gupta (ed.), San Diego, CA: Academic Press-Elsevier
    • Pamies, D., Martinéz, C. E., Sogorb, M. A. and Vilanova, E. (2011). Mechanism-based models in reproductive and development toxicology. In R. C. Gupta (ed.), Reproductive and Developmental Toxicology (135-146). San Diego, CA: Academic Press-Elsevier. http://dx.doi.org/10.1016/B978-0-12-382032-7.10011-6.
    • (2011) Reproductive and Developmental Toxicology , pp. 135-146
    • Pamies, D.1    Martinéz, C.E.2    Sogorb, M.A.3    Vilanova, E.4
  • 68
    • 84910681772 scopus 로고    scopus 로고
    • Read-across approaches - misconceptions, promises and challenges ahead
    • Patlewicz, G., Ball, N., Becker, R. A. et al. (2014). Read-across approaches - misconceptions, promises and challenges ahead. ALTEX 31, 387-396. http://dx.doi.org/10.14573/altex.1410071.
    • (2014) ALTEX , vol.31 , pp. 387-396
    • Patlewicz, G.1    Ball, N.2    Becker, R.A.3
  • 69
    • 84876341495 scopus 로고    scopus 로고
    • Evaluation of an alternative in vitro test battery for detecting reproductive toxicants
    • Piersma, A. H., Bosgra, S., van Duursen, M. B. M. et al. (2013). Evaluation of an alternative in vitro test battery for detecting reproductive toxicants. Reprod Toxicol 38, 53-64. http://dx.doi.org/10.1016/j.reprotox.2013.03.002.
    • (2013) Reprod Toxicol , vol.38 , pp. 53-64
    • Piersma, A.H.1    Bosgra, S.2    Van Duursen, M.B.M.3
  • 70
    • 84877593138 scopus 로고    scopus 로고
    • Metabolomics in toxicology and preclinical research
    • Ramirez, T., Daneshian, M., Kamp, H. et al. (2013). Metabolomics in toxicology and preclinical research. ALTEX 30, 209-225. http://dx.doi.org/10.14573/altex.2013.2.209.
    • (2013) ALTEX , vol.30 , pp. 209-225
    • Ramirez, T.1    Daneshian, M.2    Kamp, H.3
  • 71
    • 78650284457 scopus 로고    scopus 로고
    • Endocrine profiling and prioritization of environmental chemicals using toxcast data
    • Reif, D. M., Martin, M. T., Tan, S. W. et al. (2010). Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environ Health Perspect 118, 1714-1720. http://dx.doi.org/10.1289/ehp.1002180.
    • (2010) Environ Health Perspect , vol.118 , pp. 1714-1720
    • Reif, D.M.1    Martin, M.T.2    Tan, S.W.3
  • 72
    • 84938603406 scopus 로고    scopus 로고
    • Integrated testing strategies (ITS) for safety assessment
    • Rovida, C., Alépée, N., Api, A. M. et al. (2015). Integrated Testing Strategies (ITS) for safety assessment. ALTEX 32, 171- 181. http://dx.doi.org/10.14573/altex.1506201.
    • (2015) ALTEX , vol.32 , pp. 171-181
    • Rovida, C.1    Alépée, N.2    Api, A.M.3
  • 73
    • 77954086651 scopus 로고    scopus 로고
    • The reprotect feasibility study, a novel comprehensive in vitro approach to detect reproductive toxicants
    • Schenk, B., Weimer, M., Bremer, S. et al. (2010). The ReProTect feasibility study, a novel comprehensive in vitro approach to detect reproductive toxicants. Reprod Toxicol 30, 200-218. http://dx.doi.org/10.1016/j.reprotox.2010.05.012.
    • (2010) Reprod Toxicol , vol.30 , pp. 200-218
    • Schenk, B.1    Weimer, M.2    Bremer, S.3
  • 74
    • 0032745067 scopus 로고    scopus 로고
    • Embryotoxicity screening using embryonic stem cells in vitro: Correlation to in vivo teratogenicity
    • Scholz, G., Pohl, I., Genschow, E. et al. (1999). Embryotoxicity screening using embryonic stem cells in vitro: Correlation to in vivo teratogenicity. Cells Tissues Organs 165, 203-211. http://dx.doi.org/10.1159/000016700.
    • (1999) Cells Tissues Organs , vol.165 , pp. 203-211
    • Scholz, G.1    Pohl, I.2    Genschow, E.3
  • 75
    • 0037424630 scopus 로고    scopus 로고
    • The present status of QSAR in toxicology
    • Schultz, T. W., Cronin, M. T. D. and Netzeva, T. I. (2003). The present status of QSAR in toxicology. J Molec Struct - Theo Chem 622, 23-38. http://dx.doi.org/10.1016/S0166-1280(02)00615-2.
    • (2003) J Molec Struct - Theo Chem , vol.622 , pp. 23-38
    • Schultz, T.W.1    Cronin, M.T.D.2    Netzeva, T.I.3
  • 76
    • 84879179678 scopus 로고    scopus 로고
    • Profiling 976 toxcast chemicals across 331 enzymatic and receptor signaling assays
    • Sipes, N. S., Martin, M. T., Kothiya, P. et al. (2013). Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol 26, 878-895. http://dx.doi.org/10.1021/tx400021f.
    • (2013) Chem Res Toxicol , vol.26 , pp. 878-895
    • Sipes, N.S.1    Martin, M.T.2    Kothiya, P.3
  • 77
    • 84871210792 scopus 로고    scopus 로고
    • Predicting chemical ocular toxicity using a combinatorial QSAR approach
    • Solimeo, R., Zhang, J., Kim, M. et al. (2012). Predicting chemical ocular toxicity using a combinatorial QSAR approach. Chem Res Toxicol 25, 2763-2769. http://dx.doi.org/10.1021/tx300393v.
    • (2012) Chem Res Toxicol , vol.25 , pp. 2763-2769
    • Solimeo, R.1    Zhang, J.2    Kim, M.3
  • 78
    • 12344265705 scopus 로고    scopus 로고
    • Development of androgen- And estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid responsive bioassays
    • Sonneveld, E., Jansen, H. J., Riteco, J. A. C. et al. (2005). Development of androgen- And estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid responsive bioassays. Toxicol Sci 83, 136-148. http://dx.doi.org/10.1093/toxsci/kfi005.
    • (2005) Toxicol Sci , vol.83 , pp. 136-148
    • Sonneveld, E.1    Jansen, H.J.2    Riteco, J.A.C.3
  • 79
    • 70449133447 scopus 로고    scopus 로고
    • Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies
    • Strauss, V., Wiemer, J., Leibold, E. et al. (2009). Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies. Toxicol Lett 191, 88-95. http://dx.doi.org/10.1016/j.toxlet.2009.08.004.
    • (2009) Toxicol Lett , vol.191 , pp. 88-95
    • Strauss, V.1    Wiemer, J.2    Leibold, E.3
  • 80
    • 79953727844 scopus 로고    scopus 로고
    • Eu framework 6 project: Predictive toxicology (predtox) - overview and outcome
    • Suter, L., Schroeder, S., Meyer, K. et al. (2011). EU Framework 6 project: Predictive toxicology (PredTox) - overview and outcome. Toxicol Appl Pharmacol 252, 73-84. http://dx.doi.org/10.1016/j.taap.2010.10.008.
    • (2011) Toxicol Appl Pharmacol , vol.252 , pp. 73-84
    • Suter, L.1    Schroeder, S.2    Meyer, K.3
  • 81
    • 74249111318 scopus 로고    scopus 로고
    • The pilot phase of the NIH chemical genomics center
    • Thomas, C. J., Auld, D. S., Huang, R. et al. (2009). The pilot phase of the NIH Chemical Genomics Center. Curr Top Med Chem 9, 1181-1193. http://dx.doi.org/10.2174/156802609789753644.
    • (2009) Curr Top Med Chem , vol.9 , pp. 1181-1193
    • Thomas, C.J.1    Auld, D.S.2    Huang, R.3
  • 82
    • 79952098323 scopus 로고    scopus 로고
    • Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment
    • Thomas, R. S., Clewell III, H. J., Allen, B. C. et al. (2011). Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment. Toxicol Sci 120, 194-205. http://dx.doi.org/10.1093/toxsci/kfq355.
    • (2011) Toxicol Sci , vol.120 , pp. 194-205
    • Thomas, R.S.1    Clewell, H.J.2    Allen, B.C.3
  • 83
    • 84862802259 scopus 로고    scopus 로고
    • Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study
    • Thomas, R. S., Clewell III, H. J., Allen, B. C. et al. (2012). Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study. Mutat Res 746, 135-143. http://dx.doi.org/10.1016/j.mrgentox.2012.01.007.
    • (2012) Mutat Res , vol.746 , pp. 135-143
    • Thomas, R.S.1    Clewell, H.J.2    Allen, B.C.3
  • 84
    • 76749102991 scopus 로고    scopus 로고
    • The Japanese toxicogenomics project: Application of toxicogenomics
    • Uehara, T., Ono, A., Maruyama, T. et al. (2010). The Japanese toxicogenomics project: Application of toxicogenomics. Molecul Nutrition Food Res 54, 218-227. http://dx.doi.org/10.1002/mnfr.200900169.
    • (2010) Molecul Nutrition Food Res , vol.54 , pp. 218-227
    • Uehara, T.1    Ono, A.2    Maruyama, T.3
  • 85
    • 84939416316 scopus 로고    scopus 로고
    • Prediction of embryotoxic potential using the reproglo stem cell-based wnt reporter assay
    • Uibel, F. and Schwarz, M. (2015). Prediction of embryotoxic potential using the ReProGlo stem cell-based WNT reporter assay. Reprod Toxicol 55, 30-49. http://dx.doi.org/10.1016/j.reprotox.2014.09.009.
    • (2015) Reprod Toxicol , vol.55 , pp. 30-49
    • Uibel, F.1    Schwarz, M.2
  • 86
    • 75349083872 scopus 로고    scopus 로고
    • Chemo-preventive actions by enterolactone and 13 VIOXX-related lactone derivatives in H295R human adrenocortical carcinoma cells
    • van Duursen, M. B., Nijmeijer, S. M., Ruchirawat, S. and van den Berg, M. (2010). Chemo-preventive actions by enterolactone and 13 VIOXX-related lactone derivatives in H295R human adrenocortical carcinoma cells. Toxicol Lett 192, 271- 277. http://dx.doi.org/10.1016/j.toxlet.2009.11.001.
    • (2010) Toxicol Lett , vol.192 , pp. 271-277
    • Van Duursen, M.B.1    Nijmeijer, S.M.2    Ruchirawat, S.3    Van Den Berg, M.4
  • 87
    • 80052876477 scopus 로고    scopus 로고
    • Towards a pragmatic alternative testing strategy for the detection of reproductive toxicants
    • van der Burg, B., Kroese, E. D. and Piersma, A. H. (2011). Towards a pragmatic alternative testing strategy for the detection of reproductive toxicants. Reprod Toxicol 31, 558-561. http://dx.doi.org/10.1016/j.reprotox.2011.02.012.
    • (2011) Reprod Toxicol , vol.31 , pp. 558-561
    • Van Der Burg, B.1    Kroese, E.D.2    Piersma, A.H.3
  • 88
    • 84876322827 scopus 로고    scopus 로고
    • A panel of quantitative calux® reporter gene assays for reliable high throughput toxicity screening of chemicals and complex mixtures
    • P. Steinberg (ed.), . New York: John Wiley and Sons, Inc
    • van der Burg, B., van der Linden, S. C., Man, H. Y. et al. (2013). A panel of quantitative CALUX® reporter gene assays for reliable high throughput toxicity screening of chemicals and complex mixtures. In P. Steinberg (ed.), High Throughput Screening Methods in Toxicity Testing (519- 532). New York: John Wiley and Sons, Inc. http://dx.doi.org/10.1002/9781118538203.ch28.
    • (2013) High Throughput Screening Methods in Toxicity Testing , pp. 519-532
    • Van Der Burg, B.1    Van Der Linden, S.C.2    Man, H.Y.3
  • 89
    • 84900929576 scopus 로고    scopus 로고
    • The use of metabolomics in cancer research
    • W. C. S. Cho (ed.), . Berlin, Germany: Springer
    • van Ravenzwaay, B., Coelho-Palermo Cunha, G., Fabian, E. et al. (2010a). The use of metabolomics in cancer research. In W. C. S. Cho (ed.), An Omics Perspective of Cancer (141-166). Berlin, Germany: Springer. http://dx.doi.org/10.1007/978-90-481-2675-0-8.
    • (2010) An Omics Perspective of Cancer , pp. 141-166
    • Van Ravenzwaay, B.1    Coelho-Palermo Cunha, G.2    Fabian, E.3
  • 90
    • 77955927758 scopus 로고    scopus 로고
    • The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di(2-ethyl-hexyl)phthalate following a 28-day dietary exposure in rats
    • van Ravenzwaay, B., Coelho-Palermo Cunha, G., Strauss, V. et al. (2010b). The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di(2-ethylhexyl)phthalate following a 28-day dietary exposure in rats. Toxicol Lett 198, 159-170. http://dx.doi.org/10.1016/j.toxlet.2010.06.009.
    • (2010) Toxicol Lett , vol.198 , pp. 159-170
    • Van Ravenzwaay, B.1    Coelho-Palermo Cunha, G.2    Strauss, V.3
  • 91
    • 84861571209 scopus 로고    scopus 로고
    • Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from qsar to qbar
    • van Ravenzwaay, B., Herold, M., Kamp, H. et al. (2012). Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR. Mutat Res 746, 144-150. http://dx.doi.org/10.1016/j.mrgentox.2012.01.006.
    • (2012) Mutat Res , vol.746 , pp. 144-150
    • Van Ravenzwaay, B.1    Herold, M.2    Kamp, H.3
  • 92
    • 84896947291 scopus 로고    scopus 로고
    • The sensitivity of metabolomics versus classical regulatory toxicology from a noael perspective
    • van Ravenzwaay, B., Montoya, G. A., Fabian, E. et al. (2014). The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective. Toxicol Lett 227, 20- 28. http://dx.doi.org/10.1016/j.toxlet.2014.03.004.
    • (2014) Toxicol Lett , vol.227 , pp. 20-28
    • Van Ravenzwaay, B.1    Montoya, G.A.2    Fabian, E.3
  • 94
    • 79958288447 scopus 로고    scopus 로고
    • Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century
    • van Vliet, E. (2011). Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century. ALTEX 28, 17-44. http://dx.doi.org/10.14573/altex.2011.1.017.
    • (2011) ALTEX , vol.28 , pp. 17-44
    • Van Vliet, E.1
  • 95
    • 84858073341 scopus 로고    scopus 로고
    • Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients
    • Vinken, M., Pauwels, M., Ates, G. et al. (2012). Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients. Arch Toxicol 86, 405- 412. http://dx.doi.org/10.1007/s00204-011-0769-z.
    • (2012) Arch Toxicol , vol.86 , pp. 405-412
    • Vinken, M.1    Pauwels, M.2    Ates, G.3
  • 96
    • 84884178912 scopus 로고    scopus 로고
    • Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury
    • Vinken, M., Landesmann, B., Goumenou, M. et al. (2013a). Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury. Toxicol Sci 136, 97-106. http://dx.doi.org/10.1093/toxsci/kft177.
    • (2013) Toxicol Sci , vol.136 , pp. 97-106
    • Vinken, M.1    Landesmann, B.2    Goumenou, M.3
  • 97
    • 84884179017 scopus 로고    scopus 로고
    • The adverse outcome pathway concept: A pragmatic tool in toxicology
    • Vinken, M. (2013b). The adverse outcome pathway concept: A pragmatic tool in toxicology. Toxicol 312, 158-165. http://dx.doi.org/10.1016/j.tox.2013.08.011.
    • (2013) Toxicol , vol.312 , pp. 158-165
    • Vinken, M.1
  • 98
    • 84938739311 scopus 로고    scopus 로고
    • Developing enhanced blood-brain barrier permeability models: Integrating external bio-assay data in qsar modeling
    • Wang, W. Y., Kim, M. T., Sedykh, A and Zhu, H. (2015). Developing enhanced blood-brain barrier permeability models: Integrating external bio-assay data in QSAR modeling. Pharmaceut Res 32, 3055-3065. http://dx.doi.org/10.1007/s11095-015-1687-1.
    • (2015) Pharmaceut Res , vol.32 , pp. 3055-3065
    • Wang, W.Y.1    Kim, M.T.2    Sedykh, A.3    Zhu, H.4
  • 99
    • 67849104638 scopus 로고    scopus 로고
    • Pubchem: A public information system for analyzing bioactivities of small molecules
    • Wang, Y., Xiao, J., Suzek, T. O. et al. (2009). PubChem: A public information system for analyzing bioactivities of small molecules. Nucleic Acids Res 37, W623-W633. http://dx.doi.org/10.1093/nar/gkp456.
    • (2009) Nucleic Acids Res , vol.37 , pp. W623-W633
    • Wang, Y.1    Xiao, J.2    Suzek, T.O.3
  • 100
    • 75549087817 scopus 로고    scopus 로고
    • An overview of the pubchem bioassay resource
    • Wang, Y., Bolton, E., Dracheva, S. et al. (2010). An overview of the PubChem BioAssay resource. Nucleic Acids Res 38, D255-D266. http://dx.doi.org/10.1093/nar/gkp965.
    • (2010) Nucleic Acids Res , vol.38 , pp. D255-D266
    • Wang, Y.1    Bolton, E.2    Dracheva, S.3
  • 101
    • 38549162759 scopus 로고    scopus 로고
    • CEBS - chemical effects in biological systems: A public data repository integrating study design and toxicity data with microarray and proteomics data
    • Waters, M., Stasiewicz, S., Merrick, B. A. et al. (2008). CEBS - chemical effects in biological systems: A public data repository integrating study design and toxicity data with microarray and proteomics data. Nucleic Acids Res 36, D892-D900. http://dx.doi.org/10.1093/nar/gkm755.
    • (2008) Nucleic Acids Res , vol.36 , pp. D892-D900
    • Waters, M.1    Stasiewicz, S.2    Merrick, B.A.3
  • 102
    • 84890474514 scopus 로고    scopus 로고
    • Frame-work for identifying chemicals with structural features associated with the potential to act as developmental or reproductive toxicants
    • Wu, S., Fisher, J., Nacliff, J. et al. (2013). Frame-work for identifying chemicals with structural features associated with the potential to act as developmental or reproductive toxicants. Chem Res Toxicol 26, 1840-1861. http://dx.doi.org/10.1021/tx400226u.
    • (2013) Chem Res Toxicol , vol.26 , pp. 1840-1861
    • Wu, S.1    Fisher, J.2    Nacliff, J.3
  • 103
    • 85019507456 scopus 로고    scopus 로고
    • Development of new cosmos repeat dose and non-cancer threshold of toxicological concern (ttc) databases to support alternative testing methods for cosmetics related chemicals
    • Yang, C. H., Ambrosio, M., Arvidson, K. et al. (2013). Development of new COSMOS repeat dose and non-cancer threshold of toxicological concern (TTC) databases to support alternative testing methods for cosmetics related chemicals. Toxicol Lett 221, S80. http://dx.doi.org/10.1016/j.toxlet.2013.05.082.
    • (2013) Toxicol Lett , vol.221 , pp. S80
    • Yang, C.H.1    Ambrosio, M.2    Arvidson, K.3
  • 104
  • 105
    • 0031911722 scopus 로고    scopus 로고
    • Extraperoxisomal targets of peroxisome proliferators: Mitochondrial, microsomal, and cytosolic effects. Implications for health and disease
    • Youssef, J. and Badr, M. (1998). Extraperoxisomal targets of peroxisome proliferators: Mitochondrial, microsomal, and cytosolic effects. Implications for health and disease. Crit Rev Toxicol 28, 1-33. http://dx.doi.org/10.1080/10408449891344182.
    • (1998) Crit Rev Toxicol , vol.28 , pp. 1-33
    • Youssef, J.1    Badr, M.2
  • 106
    • 85049849306 scopus 로고    scopus 로고
    • Triadimenol and triadimefon
    • Part II - Toxicological . World Health Organization, WHO/PCS/06.1
    • Zarn, J., Davies, L. and Boobis, A. (2006). Triadimenol and Triadimefon. In Pesticide Residues in Food - 2004 Evaluations. Part II - Toxicological (325-386). World Health Organization, WHO/PCS/06.1.
    • (2006) Pesticide Residues in Food - 2004 Evaluations , pp. 325-386
    • Zarn, J.1    Davies, L.2    Boobis, A.3
  • 107
    • 84903291814 scopus 로고    scopus 로고
    • Profiling animal toxicants by automatically mining public bioassay data: A big data approach for computational toxicology
    • Zhang, J., Hsieh, J. H. and Zhu, H. (2014). Profiling animal toxicants by automatically mining public bioassay data: A big data approach for computational toxicology. Plos One 9, e99863. http://dx.doi.org/10.1371/journal.pone.0099863.
    • (2014) Plos One , vol.9 , pp. e99863
    • Zhang, J.1    Hsieh, J.H.2    Zhu, H.3
  • 108
    • 44449173096 scopus 로고    scopus 로고
    • Combinatorial QSAR modeling of chemical toxicants tested against tetrahymena pyriformis
    • Zhu, H., Tropsha, A., Fourches, D. et al. (2008). Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis. J Chem Inf Model 48, 766-784. http://dx.doi.org/10.1021/ci700443v.
    • (2008) J Chem Inf Model , vol.48 , pp. 766-784
    • Zhu, H.1    Tropsha, A.2    Fourches, D.3
  • 109
    • 73849128409 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure
    • Zhu, H., Martin, T. M., Ye, L. et al. (2009). Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure. Chem Res Toxicol 22, 1913-1921. http://dx.doi.org/10.1021/tx900189p.
    • (2009) Chem Res Toxicol , vol.22 , pp. 1913-1921
    • Zhu, H.1    Martin, T.M.2    Ye, L.3
  • 110
    • 84908137021 scopus 로고    scopus 로고
    • Big data in chemical toxicity research: The use of high-throughput screening assays to identify potential toxicants
    • Zhu, H., Zhang, J., Kim, M. T. et al. (2014). Big data in chemical toxicity research: The use of high-throughput screening assays to identify potential toxicants. Chem Res Toxicol 27, 1643-1651. http://dx.doi.org/10.1021/tx500145h.
    • (2014) Chem Res Toxicol , vol.27 , pp. 1643-1651
    • Zhu, H.1    Zhang, J.2    Kim, M.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.