Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-From QSAR to QBAR

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 746, Issue 2, 2012, Pages 144-150

  Van Ravenzwaay, B ^a   Herold, M ^b   Kamp, H ^a   Kapp, M D ^a   Fabian, E ^a   Looser, R ^b   Krennrich, G ^a   Mellert, W ^a   Prokoudine, A ^b   Strauss, V ^a   Walk, T ^b   Wiemer, J ^b  

^a BASF SE   (Germany)

^b Metanomics GmbH   (Germany)

Author keywords

Chemical grouping, QBAR; Metabolite profiling; Metabolomics; Mode of action

Indexed keywords

2 (4 CHLORO 2 METHYLPHENOXY)ACETIC ACID; 2 IMIDAZOLIDINETHIONE; AROCLOR 1254; CAMPHECLOR; CYPROTERONE ACETATE; ETHYLBENZENE; FLUORENE DERIVATIVE; LIVER ENZYME; N (2 FLUORENYL)ACETAMIDE; N (4 FLUORENYL)ACETAMIDE; N,N DIMETHYLFORMAMIDE; PENTACHLOROBENZENE; PENTOBARBITAL; PROPYLTHIOURACIL; TETRAHYDROFURAN; THIAMAZOLE; THYROXINE; UNCLASSIFIED DRUG; VINCLOZOLIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; ENZYME INDUCTION; FEMALE; LIVER TOXICITY; MALE; METABOLOME; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE BIOLOGICAL ACTIVITY RELATIONSHIP; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STRUCTURE ACTIVITY RELATION; THYROID DISEASE; THYROID TOXICITY; TOXICITY;

ANIMALS; LIVER; MALE; METABOLOMICS; MODELS, THEORETICAL; NOXAE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; THYROID GLAND; TOXICOLOGY;

ANIMALIA; RATTUS;

EID: 84861571209     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.01.006     Document Type: Article

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