The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective

Toxicology Letters

Volumn 227, Issue 1, 2014, Pages 20-28

  van Ravenzwaay, B ^a   Montoya, G A ^a   Fabian, E ^a   Herold, M ^b   Krennrich, G ^a   Looser, R ^b   Mellert, W ^a   Peter, E ^b   Strauss, V ^a   Walk, T ^b   Kamp, H ^a  

^a BASF SE   (Germany)

^b Metanomics GmbH   (Germany)

Author keywords

Metabolomics; NOAEL, sensitivity; Toxicology rat

Indexed keywords

TOXIC SUBSTANCE;

ARTICLE; DRUG SURVEILLANCE PROGRAM; ENZYME INDUCTION; LIVER TOXICITY; METABOLITE; METABOLOME; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TOXICOLOGICAL PARAMETERS; TOXICOLOGY;

METABOLOMICS; NOAEL, SENSITIVITY; TOXICOLOGY, RAT;

AGROCHEMICALS; ANIMALS; DATABASES, CHEMICAL; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; FEMALE; GERMANY; GUIDELINES AS TOPIC; HUMANS; LEGISLATION, DRUG; MALE; METABOLOMICS; MODELS, BIOLOGICAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NONPRESCRIPTION DRUGS; PRESCRIPTION DRUGS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SEX CHARACTERISTICS; TOXICITY TESTS; TOXICOLOGY;

EID: 84896947291     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.03.004     Document Type: Article

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