-
1
-
-
0000021897
-
Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes
-
Draize, J. H., Woodard, G., and Calvery, H. O. (1944) Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes J. Pharmacol. Exp. Ther. 82, 377-390
-
(1944)
J. Pharmacol. Exp. Ther.
, vol.82
, pp. 377-390
-
-
Draize, J.H.1
Woodard, G.2
Calvery, H.O.3
-
2
-
-
0035348060
-
The Draize eye test
-
Wilhelmus, K. R. (2001) The Draize eye test Surv. Ophthalmol. 45, 493-515
-
(2001)
Surv. Ophthalmol.
, vol.45
, pp. 493-515
-
-
Wilhelmus, K.R.1
-
3
-
-
84871226460
-
-
United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS) () United Nations Publications, New York & Geneva
-
United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS) (2007) United Nations Publications, New York & Geneva.
-
(2007)
-
-
-
4
-
-
84871194085
-
-
EPA () (Office of Prevention, P. & S. O. Ed.) U.S. Environmental Protection Agency, Washington, DC
-
EPA (2012) Label Review Manual: EPA735-B-03-001 (Office of Prevention, P. &. S. O., Ed.) U.S. Environmental Protection Agency, Washington, DC.
-
(2012)
Label Review Manual: EPA735-B-03-001
-
-
-
8
-
-
0032461890
-
Draize eye scores and eye irritation thresholds in man can be combined into one QSAR
-
Abraham, M. H., Kumarsingh, R., Cometto-Muniz, J. E., and Cain, W. S. (1998) Draize eye scores and eye irritation thresholds in man can be combined into one QSAR Ann. N.Y. Acad. Sci. 855, 652-656 (Pubitemid 29110053)
-
(1998)
Annals of the New York Academy of Sciences
, vol.855
, pp. 652-656
-
-
Abraham, M.H.1
Kumarsingh, R.2
Cometto-Muniz, J.E.3
Cain, W.S.4
-
9
-
-
0031822868
-
A quantitative structure-activity relationship (QSAR) for a Draize eye irritation database
-
DOI 10.1016/S0887-2333(97)00117-3, PII S0887233397001173
-
Abraham, M. H., Kumarsingh, R., Cometto-Muniz, J. E., and Cain, W. S. (1998) A quantitative structure-activity relationship (QSAR) for a draize eye irritation database Toxicol. In Vitro 12, 201-207 (Pubitemid 28331383)
-
(1998)
Toxicology in Vitro
, vol.12
, Issue.3
, pp. 201-207
-
-
Abraham, M.H.1
Kumarsingh, R.2
Cometto-Muniz, J.E.3
Cain, W.S.4
-
10
-
-
0035124369
-
Prediction of eye irritation from organic chemicals using membrane-interaction QSAR analysis
-
DOI 10.1093/toxsci/59.2.335
-
Kulkarni, A., Hopfinger, A. J., Osborne, R., Bruner, L. H., and Thompson, E. D. (2001) Prediction of eye irritation from organic chemicals using membrane-interaction QSAR analysis Toxicol. Sci. 59, 335-345 (Pubitemid 32149565)
-
(2001)
Toxicological Sciences
, vol.59
, Issue.2
, pp. 335-345
-
-
Kulkarni, A.1
Hopfinger, A.J.2
Osborne, R.3
Bruner, L.H.4
Thompson, E.D.5
-
11
-
-
0032837628
-
Membrane-interaction QSAR analysis: Application to the estimation of eye irritation by organic compounds
-
DOI 10.1023/A:1014853731428
-
Kulkarni, A. S. and Hopfinger, A. J. (1999) Membrane-interaction QSAR analysis: application to the estimation of eye irritation by organic compounds Pharm. Res. 16, 1245-1253 (Pubitemid 29393614)
-
(1999)
Pharmaceutical Research
, vol.16
, Issue.8
, pp. 1245-1253
-
-
Kulkarni, A.S.1
Hopfinger, A.J.2
-
12
-
-
27944436628
-
A study of the relationship between cornea permeability and eye irritation using membrane-interaction QSAR analysis
-
DOI 10.1093/toxsci/kfi319
-
Li, Y., Liu, J., Pan, D., and Hopfinger, A. J. (2005) A study of the relationship between cornea permeability and eye irritation using membrane-interaction QSAR analysis Toxicol. Sci. 88, 434-446 (Pubitemid 41672151)
-
(2005)
Toxicological Sciences
, vol.88
, Issue.2
, pp. 434-446
-
-
Li, Y.1
Liu, J.2
Pan, D.3
Hopfinger, A.J.4
-
13
-
-
0032702655
-
Quantitative component analysis of mixtures for risk assessment: Application to eye irritation
-
Patel, H. C., Duca, J. S., Hopfinger, A. J., Glendening, C. D., and Thompson, E. D. (1999) Quantitative component analysis of mixtures for risk assessment: application to eye irritation Chem. Res. Toxicol. 12, 1050-1056
-
(1999)
Chem. Res. Toxicol.
, vol.12
, pp. 1050-1056
-
-
Patel, H.C.1
Duca, J.S.2
Hopfinger, A.J.3
Glendening, C.D.4
Thompson, E.D.5
-
14
-
-
70350508790
-
A current practice for predicting ocular toxicity of systemically delivered drugs
-
Somps, C. J., Greene, N., Render, J. A., Aleo, M. D., Fortner, J. H., Dykens, J. A., and Phillips, G. (2009) A current practice for predicting ocular toxicity of systemically delivered drugs Cutaneous Ocul. Toxicol. 28, 1-18
-
(2009)
Cutaneous Ocul. Toxicol.
, vol.28
, pp. 1-18
-
-
Somps, C.J.1
Greene, N.2
Render, J.A.3
Aleo, M.D.4
Fortner, J.H.5
Dykens, J.A.6
Phillips, G.7
-
15
-
-
0142057082
-
Quantitative structure-activity relationships for predicting skin and eye irritation
-
DOI 10.1897/01-439
-
Patlewicz, G., Rodford, R., and Walker, J. D. (2003) Quantitative structure-activity relationships for predicting skin and eye irritation Environ. Toxicol. Chem. 22, 1862-1869 (Pubitemid 37345110)
-
(2003)
Environmental Toxicology and Chemistry
, vol.22
, Issue.8
, pp. 1862-1869
-
-
Patlewicz, G.1
Rodford, R.2
Walker, J.D.3
-
16
-
-
44449173096
-
Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis
-
DOI 10.1021/ci700443v
-
Zhu, H., Tropsha, A., Fourches, D., Varnek, A., Papa, E., Gramatica, P., Oberg, T., Dao, P., Cherkasov, A., and Tetko, I. V. (2008) Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis J. Chem. Inf. Model. 48, 766-784 (Pubitemid 351757744)
-
(2008)
Journal of Chemical Information and Modeling
, vol.48
, Issue.4
, pp. 766-784
-
-
Zhu, H.1
Tropsha, A.2
Fourches, D.3
Varnek, A.4
Papa, E.5
Gramatical, P.6
Oberg, T.7
Dao, P.8
Cherkasov, A.9
Tetko, I.V.10
-
17
-
-
73849128409
-
Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure
-
Zhu, H., Martin, T. M., Ye, L., Sedykh, A., Young, D. M., and Tropsha, A. (2009) Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure Chem. Res. Toxicol. 22, 1913-1921
-
(2009)
Chem. Res. Toxicol.
, vol.22
, pp. 1913-1921
-
-
Zhu, H.1
Martin, T.M.2
Ye, L.3
Sedykh, A.4
Young, D.M.5
Tropsha, A.6
-
18
-
-
46749152924
-
QSAR modeling of the blood-brain barrier permeability for diverse organic compounds
-
Zhang, L., Zhu, H., Oprea, T. I., Golbraikh, A., and Tropsha, A. (2008) QSAR modeling of the blood-brain barrier permeability for diverse organic compounds Pharm. Res. 25, 1902-1914
-
(2008)
Pharm. Res.
, vol.25
, pp. 1902-1914
-
-
Zhang, L.1
Zhu, H.2
Oprea, T.I.3
Golbraikh, A.4
Tropsha, A.5
-
19
-
-
73849118979
-
Inter-laboratory study of short time exposure (STE) test for predicting eye irritation potential of chemicals and correspondence to globally harmonized system (GHS) classification
-
Takahashi, Y., Hayashi, T., Watanabe, S., Hayashi, K., Koike, M., Aisawa, N., Ebata, S., Sakaguchi, H., Nakamura, T., Kuwahara, H., and Nishiyama, N. (2009) Inter-laboratory study of short time exposure (STE) test for predicting eye irritation potential of chemicals and correspondence to globally harmonized system (GHS) classification J. Toxicol. Sci. 34, 611-626
-
(2009)
J. Toxicol. Sci.
, vol.34
, pp. 611-626
-
-
Takahashi, Y.1
Hayashi, T.2
Watanabe, S.3
Hayashi, K.4
Koike, M.5
Aisawa, N.6
Ebata, S.7
Sakaguchi, H.8
Nakamura, T.9
Kuwahara, H.10
Nishiyama, N.11
-
21
-
-
84871208294
-
-
Chemical Computing Group (), Chemical Computing Group, Montreal, Quebec, Canada
-
Chemical Computing Group (2011) MOE, Chemical Computing Group, Montreal, Quebec, Canada.
-
(2011)
MOE
-
-
-
22
-
-
0000378338
-
Novel variable selection quantitative structure-property relationship approach based on the k-nearest-neighbor principle
-
Zheng, W. and Tropsha, A. (2000) Novel variable selection quantitative structure-property relationship approach based on the k-nearest-neighbor principle J. Chem. Inf. Comput. Sci. 40, 185-194
-
(2000)
J. Chem. Inf. Comput. Sci.
, vol.40
, pp. 185-194
-
-
Zheng, W.1
Tropsha, A.2
-
23
-
-
36949022890
-
Predictive QSAR modeling workflow, model applicability domains, and virtual screening
-
DOI 10.2174/138161207782794257
-
Tropsha, A. and Golbraikh, A. (2007) Predictive QSAR modeling workflow, model applicability domains, and virtual screening Curr. Pharm. Des. 13, 3494-3504 (Pubitemid 350238939)
-
(2007)
Current Pharmaceutical Design
, vol.13
, Issue.34
, pp. 3494-3504
-
-
Tropsha, A.1
Golbraikh, A.2
-
24
-
-
0042355453
-
Rational selection of training and test sets for the development of validated QSAR models
-
DOI 10.1023/A:1025386326946
-
Golbraikh, A., Shen, M., Xiao, Z., Xiao, Y. D., Lee, K. H., and Tropsha, A. (2003) Rational selection of training and test sets for the development of validated QSAR models J. Comput.-Aided Mol. Des. 17, 241-253 (Pubitemid 37062785)
-
(2003)
Journal of Computer-Aided Molecular Design
, vol.17
, Issue.2-4
, pp. 241-253
-
-
Golbraikh, A.1
Shen, M.2
Xiao, Z.3
Xiao, Y.-D.4
Lee, K.-H.5
Tropsha, A.6
-
25
-
-
36949022890
-
Predictive QSAR modeling workflow, model applicability domains, and virtual screening
-
DOI 10.2174/138161207782794257
-
Tropsha, A. and Golbraikh, A. (2007) Predictive QSAR Modeling Workflow, Model Applicability Domains, and Virtual Screening Curr. Pharm. Des. 13, 3494-3504 (Pubitemid 350238939)
-
(2007)
Current Pharmaceutical Design
, vol.13
, Issue.34
, pp. 3494-3504
-
-
Tropsha, A.1
Golbraikh, A.2
-
26
-
-
0035478854
-
Random forests
-
DOI 10.1023/A:1010933404324
-
Breiman, L. (2001) Random forests Machine Learning 45, 5-32 (Pubitemid 32933532)
-
(2001)
Machine Learning
, vol.45
, Issue.1
, pp. 5-32
-
-
Breiman, L.1
-
28
-
-
44449173096
-
Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis
-
DOI 10.1021/ci700443v
-
Zhu, H., Tropsha, A., Fourches, D., Varnek, A., Papa, E., Gramatica, P., Oberg, T., Dao, P., Cherkasov, A., and Tetko, I. V. (2008) Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis J. Chem. Inf. Model. 48, 766-784 (Pubitemid 351757744)
-
(2008)
Journal of Chemical Information and Modeling
, vol.48
, Issue.4
, pp. 766-784
-
-
Zhu, H.1
Tropsha, A.2
Fourches, D.3
Varnek, A.4
Papa, E.5
Gramatical, P.6
Oberg, T.7
Dao, P.8
Cherkasov, A.9
Tetko, I.V.10
-
29
-
-
54249125512
-
Critical assessment of QSAR models of environmental toxicity against Tetrahymena pyriformis: Focusing on applicability domain and overfitting by variable selection
-
Tetko, I. V., Sushko, I., Pandey, A. K., Zhu, H., Tropsha, A., Papa, E., Oberg, T., Todeschini, R., Fourches, D., and Varnek, A. (2008) Critical assessment of QSAR models of environmental toxicity against Tetrahymena pyriformis: Focusing on applicability domain and overfitting by variable selection J. Chem. Inf. Model. 48, 1733-1746
-
(2008)
J. Chem. Inf. Model.
, vol.48
, pp. 1733-1746
-
-
Tetko, I.V.1
Sushko, I.2
Pandey, A.K.3
Zhu, H.4
Tropsha, A.5
Papa, E.6
Oberg, T.7
Todeschini, R.8
Fourches, D.9
Varnek, A.10
-
30
-
-
84871204230
-
-
OECD (Q)SAR Application Toolbox
-
OECD (Q)SAR Application Toolbox, http://www.oecd.org/chemicalsafety/ assessmentofchemicals/theoecdqsartoolbox.htm.
-
-
-
-
31
-
-
79951709784
-
Assessment of the dermal and ocular irritation potential of alcohol hand sanitizers containing aloe vera with in vitro and in vivo methods
-
Ahn, J. H., Eum, K. H., Kim, Y. K., Oh, S. W., Kim, Y. J., and Lee, M. (2010) Assessment of the dermal and ocular irritation potential of alcohol hand sanitizers containing aloe vera with in vitro and in vivo methods Mol. Cell. Toxicol. 6, 401-408
-
(2010)
Mol. Cell. Toxicol.
, vol.6
, pp. 401-408
-
-
Ahn, J.H.1
Eum, K.H.2
Kim, Y.K.3
Oh, S.W.4
Kim, Y.J.5
Lee, M.6
-
32
-
-
0035083022
-
Extent of initial corneal injury as a basis for alternative eye irritation tests
-
DOI 10.1016/S0887-2333(00)00065-5, PII S0887233300000655
-
aaJester, J. V., Li, L., Molai, A., and Maurer, J. K. (2001) Extent of initial corneal injury as a basis for alternative eye irritation tests Toxicol. In Vitro 15, 115-130 (Pubitemid 32245690)
-
(2001)
Toxicology in Vitro
, vol.15
, Issue.2
, pp. 115-130
-
-
Jester, J.V.1
Li, L.2
Molai, A.3
Maurer, J.K.4
-
33
-
-
84861630242
-
Toxic effect of using twenty percent alcohol on corneal epithelial tight junctions during LASEK
-
Zhang, P., Liu, M., and Liao, R. F. (2012) Toxic effect of using twenty percent alcohol on corneal epithelial tight junctions during LASEK Mol. Med. Rep. 6, 33-38
-
(2012)
Mol. Med. Rep.
, vol.6
, pp. 33-38
-
-
Zhang, P.1
Liu, M.2
Liao, R.F.3
-
34
-
-
0033039414
-
Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (3) Evaluation of the haemolysis test
-
DOI 10.1016/S0887-2333(98)00066-6, PII S0887233398000666
-
Okamoto, Y., Ohkoshi, K., Itagaki, H., Tsuda, T., Kakishima, H., Ogawa, T., Kasai, Y., Ohuchi, J., Kojima, H., Kurishita, A., Kaneko, T., Matsushima, Y., Iwabuchi, Y., and Ohno, Y. (1999) Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (3) evaluation of the haemolysis test Toxicol. In Vitro 13, 115-124 (Pubitemid 29143338)
-
(1999)
Toxicology in Vitro
, vol.13
, Issue.1
, pp. 115-124
-
-
Okamoto, Y.1
Ohkoshi, K.2
Itagaki, H.3
Tsuda, T.4
Kakishima, H.5
Ogawa, T.6
Kasai, Y.7
Ohuchi, J.8
Kojima, H.9
Kurishita, A.10
Kaneko, T.11
Matsushima, Y.12
Iwabuchi, Y.13
Ohno, Y.14
-
35
-
-
0032600640
-
A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
-
Ghose, A. K., Viswanadhan, V. N., and Wendoloski, J. J. (1999) A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases J. Comb. Chem. 1, 55-68
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 55-68
-
-
Ghose, A.K.1
Viswanadhan, V.N.2
Wendoloski, J.J.3
-
36
-
-
0027034521
-
Ocular side effects of selected systemic drugs
-
Jaanus, S. D. (1992) Ocular side effects of selected systemic drugs Optom. Clin. 2, 73-96
-
(1992)
Optom. Clin.
, vol.2
, pp. 73-96
-
-
Jaanus, S.D.1
-
37
-
-
0033831195
-
Effect of anti-infective ophthalmic solutions on corneal cells in vitro
-
Matsumoto, S. and Stern, M. E. (2000) Effect of anti-infective ophthalmic solutions on corneal cells in vitro Adv. Ther. 17, 148-151 (Pubitemid 30660333)
-
(2000)
Advances in Therapy
, vol.17
, Issue.3
, pp. 148-151
-
-
Matsumoto, S.1
Stern, M.E.2
-
38
-
-
0027059028
-
The potential ocular phototoxicity of antidepressant drugs
-
Wang, R. H., Dillon, J., Reme, C., Whitt, R., and Roberts, J. E. (1992) The potential ocular phototoxicity of antidepressant drugs Lens Eye Toxic. Res. 9, 483-491 (Pubitemid 23111718)
-
(1992)
Lens and Eye Toxicity Research
, vol.9
, Issue.3-4
, pp. 483-491
-
-
Wang, R.H.1
Dillon, J.2
Reme, C.3
Whitt, R.4
Roberts, J.E.5
-
39
-
-
21844470270
-
Ocular complications of neurological therapy
-
DOI 10.1111/j.1468-1331.2005.01025.x
-
Hadjikoutis, S., Morgan, J. E., Wild, J. M., and Smith, P. E. (2005) Ocular complications of neurological therapy Eur. J. Neurol. 12, 499-507 (Pubitemid 40956805)
-
(2005)
European Journal of Neurology
, vol.12
, Issue.7
, pp. 499-507
-
-
Hadjikoutis, S.1
Morgan, J.E.2
Wild, J.M.3
Smith, P.E.M.4
-
40
-
-
41249086336
-
Toxicology of the retina: Advances in understanding the defence mechanisms and pathogenesis of drug- and light-induced retinopathy
-
DOI 10.1111/j.1442-9071.2008.01699.x
-
Siu, T. L., Morley, J. W., and Coroneo, M. T. (2008) Toxicology of the retina: Advances in understanding the defence mechanisms and pathogenesis of drug- and light-induced retinopathy Clin. Exp. Ophthalmol. 36, 176-185 (Pubitemid 351445154)
-
(2008)
Clinical and Experimental Ophthalmology
, vol.36
, Issue.2
, pp. 176-185
-
-
Siu, T.L.1
Morley, J.W.2
Coroneo, M.T.3
-
41
-
-
44749091428
-
Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: Evaluation of their utility in treating ocular HSV infections
-
Katragadda, S., Gunda, S., Hariharan, S., and Mitra, A. K. (2008) Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: evaluation of their utility in treating ocular HSV infections Int. J. Pharm. 359, 15-24
-
(2008)
Int. J. Pharm.
, vol.359
, pp. 15-24
-
-
Katragadda, S.1
Gunda, S.2
Hariharan, S.3
Mitra, A.K.4
-
42
-
-
84871211544
-
Acids, Carboxylic
-
In (Patnaik, P. Ed.) pp, Wiley, New York
-
Patnaik, P. (2007) Acids, Carboxylic. In A Comprehensive Guide to the Hazardous Properties of Chemical Substances (Patnaik, P., Ed.) pp 105-114, Wiley, New York.
-
(2007)
A Comprehensive Guide to the Hazardous Properties of Chemical Substances
, pp. 105-114
-
-
Patnaik, P.1
-
43
-
-
0032915504
-
Effects of experimental exposure to triethylamine on vision and the eye
-
Jarvinen, P., Engstrom, K., Riihimaki, V., Ruusuvaara, P., and Setala, K. (1999) Effects of experimental exposure to triethylamine on vision and the eye Occup. Environ. Med. 56, 1-5 (Pubitemid 29103640)
-
(1999)
Occupational and Environmental Medicine
, vol.56
, Issue.1
, pp. 1-5
-
-
Jarvinen, P.1
Engstrom, K.2
Riihimaki, V.3
Ruusuvaara, P.4
Setala, K.5
|