Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action

Journal of Biotechnology

Volumn 119, Issue 3, 2005, Pages 219-244

  Ganter, Brigitte ^a   Tugendreich, Stuart ^a   Pearson, Cecelia I ^a   Ayanoglu, Eser ^a   Baumhueter, Susanne ^a,f   Bostian, Keith A ^a   Brady, Lindsay ^a   Browne, Leslie J ^a,g   Calvin, John T ^a   Day, Gwo Jen ^a   Breckenridge, Naiomi ^a   Dunlea, Shane ^a   Eynon, Barrett P ^a   Furness, L Mike ^a,e   Ferng, Joe ^a   Fielden, Mark R ^a   Fujimoto, Susan Y ^a   Gong, Li ^a   Hu, Christopher ^a   Idury, Radha ^a   Judo, Michael S B ^a   Kolaja, Kyle L ^a   Lee, May D ^a   McSorley, Christopher ^a   Minor, James M ^a,b   Nair, Ramesh V ^a   Natsoulis, Georges ^a   Nguyen, Peter ^a   Nicholson, Simone M ^a   Pham, Hang ^a   Roter, Alan H ^a   Sun, Dongxu ^a,c   Tan, Siqi ^a,f   Thode, Silke ^a,d   Tolley, Alexander M ^a   Vladimirova, Antoaneta ^a   Yang, Jian ^a   Zhou, Zhiming ^a   Jarnagin, Kurt ^a   more..

^a Entelos Inc   (United States)

^b AGILENT TECHNOLOGIES   (United States)

^c Mpex BioScience Inc   (United States)

^d Integrium   (United States)

^e Nuomics Consult Ltd   (United Kingdom)

^f Pharmacopeia Drug Discovery Inc ^*  (United States)

^g PHARMACOPEIA INC   (United States)

Author keywords

Bile duct hyperplasia; Carmustine; Chemogenomics; Contextual database; Drug discovery; Gene expression; Lead optimization; Microarray; Toxicogenomics

Indexed keywords

DATABASE SYSTEMS; DRUG PRODUCTS; GENETIC ENGINEERING; PATHOLOGY; TISSUE; TOXIC MATERIALS; TOXICITY;

BILE DUCT HYPERPLASIA; CARMUSTINE; CHEMOGENOMICS; CONTEXTUAL DATABASE; DRUG DISCOVERY; GENE EXPRESSION; LEAD OPTIMIZATION; MICROARRAYS; TOXICOGENOMICS;

GENES;

ANTINEOPLASTIC AGENT; CARMUSTINE; METHOTREXATE; TIOGUANINE;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; BONE MARROW; BONE MARROW TOXICITY; CHOLESTASIS; CONTROLLED STUDY; DATA BASE; DRUG ACTIVITY; DRUG APPROVAL; DRUG RESEARCH; DRUG SELECTIVITY; DRUG WITHDRAWAL; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; GENOMICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC TISSUE; HEPATOMEGALY; HUMAN; HYPERPLASIA; LIVER; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUALITY CONTROL; RAT;

5-AMINOLEVULINATE SYNTHETASE; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOMATION; BILE DUCTS; BIOTECHNOLOGY; CARMUSTINE; COMPUTATIONAL BIOLOGY; DATABASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG DESIGN; DRUG INDUSTRY; GENE EXPRESSION; HUMANS; HYPERPLASIA; LIVER; MALE; METHOTREXATE; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SIZE; PHARMACOLOGY; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES; RNA; RNA, COMPLEMENTARY; THIOGUANINE; TIME FACTORS; TISSUE DISTRIBUTION; TOXICOLOGY;

ANIMALIA;

EID: 20944433525     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2005.03.022     Document Type: Article

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