Evaluation of an alternative in vitro test battery for detecting reproductive toxicants

Reproductive Toxicology

Volumn 38, Issue , 2013, Pages 53-64

  Piersma, A H ^a,b   Bosgra, S ^f   van Duursen, M B M ^b   Hermsen, S A B ^a,b,c   Jonker, L R A ^e   Kroese, E D ^f   van der Linden, S C ^e   Man, H ^e   Roelofs, M J E ^b   Schulpen, S H W ^a   Schwarz, M ^d   Uibel, F ^d   van Vugt Lussenburg, B M A ^e   Westerhout, J ^f   Wolterbeek, A P M ^f   van der Burg, B ^e  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e BIODETECTION SYSTEMS B V   (Netherlands)

^f TNO   (Netherlands)

Author keywords

Alternative assay; Aromatase; CALUX; Embryonic stem cell test; ReProGlo; Test battery; Toxicokinetics; Zebrafish embryotoxicity assay

Indexed keywords

AROMATASE; CYCLOSPORIN A; CYTOCHROME P450 17; DICHLORODIOCTYLSTANNANE; DIETHYLSTILBESTROL; ENDOSULFAN; FLUSILAZOLE; MANNITOL; METHOXYACETIC ACID; METHYLMERCURIC CHLORIDE; MONOETHYLHEXYLPHTHALATE; PHOSPHINOTHRICIN; RETINOIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID;

ACCURACY; ANIMAL CELL; AROMATASE ACTIVITY ASSAY; ARTICLE; BIOASSAY; CALUX BATTERY; CONCENTRATION (PARAMETERS); CYTOCHROME P450 17 ACTIVITY ASSAY; EMBRYONIC STEM CELL TEST; FALSE NEGATIVE RESULT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PREDICTION; REPRODUCTIVE TOXICITY; REPROGLO ASSAY; TOXICOKINETICS; TOXIN ANALYSIS; ZEBRAFISH EMBRYOTOXICITY TEST;

ANIMAL TESTING ALTERNATIVES; ANIMALS; AROMATASE; BIOLOGICAL ASSAY; CELL LINE; CELLS, CULTURED; EMBRYO, NONMAMMALIAN; EMBRYONIC STEM CELLS; HUMANS; MICE; RATS; RECEPTORS, STEROID; REPRODUCIBILITY OF RESULTS; REPRODUCTION; STEROID 17-ALPHA-HYDROXYLASE; TERATOGENS; TOXICITY TESTS; ZEBRAFISH;

DANIO RERIO;

EID: 84876341495     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2013.03.002     Document Type: Article

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