Developing Enhanced Blood-Brain Barrier Permeability Models: Integrating External Bio-Assay Data in QSAR Modeling

Pharmaceutical Research

Volumn 32, Issue 9, 2015, Pages 3055-3065

  Wang, Wenyi ^a   Kim, Marlene T ^a,b   Sedykh, Alexander ^b,c   Zhu, Hao ^a,b  

^a USA   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c MULTICASE Inc   (United States)

Author keywords

biological descriptors; blood brain barrier; hybrid model; permeability

Indexed keywords

DRUG; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 5;

ARTICLE; BIOASSAY; BLOOD BRAIN BARRIER; BRAIN-TO-PLASMA RATIO; CONSENSUS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PENETRATION; HUMAN; K NEAREST NEIGHBOR; MACHINE LEARNING; MEMBRANE PERMEABILITY; PHARMACOPHORE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOM FOREST; STEREOISOMERISM; SUPPORT VECTOR MACHINE; WORKFLOW; FACTUAL DATABASE; METABOLISM; PERMEABILITY; PHYSIOLOGY; PROCEDURES; THEORETICAL MODEL; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; DATABASES, FACTUAL; HUMANS; MODELS, THEORETICAL; PERMEABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84938739311     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1687-1     Document Type: Article

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