Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance

Toxicology Letters

Volumn 225, Issue 2, 2014, Pages 240-251

  Montoya, G A ^a   Strauss, V ^a   Fabian, E ^a   Kamp, H ^a   Mellert, W ^a   Walk, T ^b   Looser, R ^b   Herold, M ^b   Krennrich, G ^a   Peter, E ^b   Van Ravenzwaay, B ^a  

^a BASF SE   (Germany)

^b Metanomics GmbH   (Germany)

Author keywords

Biomarker; Metabolomics; Mode of action; Pattern; Thyroid; Toxicity

Indexed keywords

2 IMIDAZOLIDINETHIONE; ALPHA TOCOPHEROL; ARGININE; AROCLOR 1254; BOSCALID; CAMPESTEROL; CHOLESTEROL; CITRIC ACID; DIHOMO GAMMA LINOLENIC ACID; FATTY ACID; FIPRONIL; GLUTAMIC ACID; LIGNOCERIC ACID; LINOLENIC ACID; LIVER ENZYME; METAZACHLOR; PENDIMETHALIN; PHYTOSPHINGOSINE; PROLINE DERIVATIVE; PROPYLTHIOURACIL; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOSINE DERIVATIVE; THIAMAZOLE; THYROID HORMONE; THYROXINE; TOXIC SUBSTANCE; TRIACYLGLYCEROL; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLEARANCE; CONTROLLED STUDY; DATA BASE; FATTY ACID METABOLISM; FEMALE; FOOD INTAKE; HYPOTHYROIDISM; MALE; METABOLIC REGULATION; METABOLITE; METABOLOME; METABOLOMICS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SEX DIFFERENCE; STEROID EXCRETION; THYROTOXICOSIS; TOXICOKINETICS; UREA CYCLE; WEIGHT CHANGE;

BIOMARKER; METABOLOMICS; MODE OF ACTION; PATTERN; THYROID; TOXICITY;

ANIMALS; ANTITHYROID AGENTS; BIPHENYL COMPOUNDS; CHLORODIPHENYL (54% CHLORINE); ETHYLENETHIOUREA; FEMALE; LIVER; MALE; METABOLOME; METABOLOMICS; METHIMAZOLE; NIACINAMIDE; RATS; RATS, WISTAR; THYROID GLAND; THYROID HORMONES;

EID: 84892466895     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.12.010     Document Type: Article

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