Mechanism-based models in reproductive and developmental toxicology

Reproductive and Developmental Toxicology

Volumn , Issue , 2011, Pages 135-146

  Pamies, David ^a   Martínez, Carmen Estevan ^a   Sogorb, Miguel A ^a   Vilanova, Eugenio ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053475275     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-382032-7.10011-6     Document Type: Chapter

References (78)

1. S. Adler, J. Lindqvist, K. Uddenberg, J. Hyllner and R. Strehl (2008) Testing potential developmental toxicants with a cytotoxicity assay based on human embryonic stem cells. Altern Lab Anim 36 129-140
2. O.V. Anichtchik, J. Kaslin, N. Peitsaro, M. Scheinin and P. Panula (2004) Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurochem 88 443-453
3. R. Bacchetta, P. Mantecca, M. Andrioletti, C. Vismara and G. Vailati (2008) Axial-skeletal defects caused by Carbaryl in Xenopus laevis embryos. Sci Total Environ 392 110-118
4. J.A. Bantle, J.N. Dumont, R.A. Finch, G. Linder and D.J. Fort (1998) Atlas of Abnormalities: A Guide for the Performance of FETAX. 2nd ed. Oklahoma State University Press
5. J.A. Bantle, R.A. Finch, D.T. Burton, D.J. Fort, D.A. Dawson, G. Linder, J.R. Rayburn, M. Hull, M. Kumsher-King, A.M. Gaudet-Hull and S.D. Turley (1996) FETAX interlaboratory validation study: phase III – Part 1 testing. J Appl Toxicol 16 517-528
6. M. Barrier, S. Jeffay, H. Nichols and S. Hunter (2010) Evaluation of a mouse embryonic stem cell adherent cell differentiation and cytotoxicity (ACDC) assay. The Toxicologist 114 358-359
7. E. Benfenati, R. Benigni, D.M. Demarini, C. Helma, D. Kirkland, T.M. Martin, P. Mazzatorta, G. Ouédraogo-Arras, A.M. Richard, B. Schilter, W.G. Schoonen, R.D. Snyder and C. Yang (2009) Predictive models for carcinogenicity and mutagenicity: frameworks, state-of-the-art, and perspectives. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27 57-90
8. E. Borenfreund, H. Babich and N. Martin-Aguacil (1988) Comparisons of two in vitro cytotoxicity assays – the neutral red (NR) and tetrazolium MTT tests. Toxicol in Vitro 2 1-6
9. S. Bosisio, S. Fortaner, S. Bellinetto, M. Farina, R. Del Torchio, M. Prati, R. Gornati, G. Bernardini and E. Sabbioni (2009) Developmental toxicity, uptake and distribution of sodium chromate assayed by frog embryo teratogenesis assay-Xenopus (FETAX). Sci Total Environ 407 5039-5045
10. S. Bretaud, S. Lee and S. Guo (2004) Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol 26 857-864
11. R. Buesen, E. Genschow, B. Slawik, A. Visan, H. Spielmann, A. Luch and A. Seiler (2009) Embryonic stem cell test remastered: comparison between the validated EST and the new molecular FACS-EST for assessing developmental toxicity in vitro. Toxicol Sci 108 389-400
12. F. Busquet, R. Nagel, F. von Landenberg, S.O. Mueller, N. Huebler and T.H. Broschard (2008) Development of a new screening assay to identify proteratogenic substances using zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT). Toxicol Sci 104 177-188. Epub 2008 Mar 28
13. E.W. Carney, B. Tornesi, D.A. Markham, R.J. Rasoulpour and N. Moore (2008) Species-specificity of ethylene glycol-induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbit. Birth Defects Res B Dev Reprod Toxicol 83 573-581
14. L. Cicurel and B.P. Schmid (1988) Postimplantation embryo culture for the assessment of the teratogenic potential and potency of compounds. Experientia 44 833-840
15. M.T.D. Cronin and A.P. Worth (2008) (Q)SARs for predicting effects relating to reproductive toxicity. Qsar & Combinatorial Science 27 91-100
16. A. De Smedt, M. Steemans, M. De Boeck, A.K. Peters, B.J. van der Leede, F. Van Goethem, A. Lampo and P. Vanparys (2008) Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells. Toxicol in Vitro 22 1789-1796
17. ECVAM (European Centre for Validation of Alternative Methods) (2006a) Embryotoxicity Testing in Post-Implantation Embryo Culture – Method of Piersma. Available at: http://ecvam.jrc.ec.europa.eu/
18. ECVAM (European Centre for Validation of Alternative Methods) (2006b) The Micromass Test – Method of Brown. Available at: http://ecvam.jrc.ec.europa.eu/
19. ECVAM (European Centre for Validation of Alternative Methods) (2006c) Embryonic Stem Cell Test (EST). Available at: http://ecvam.jrc.ec.europa.eu/
20. ESAC (European Centre for Validation of Alternative Methods (ECVAM) Scientific Advisory Committee) (2002) The Use of Scientifically-Validated in Vitro Tests for Embryotoxicity. Available at: http://ecvam.jrc.ec.europa.eu/
21. A.G. Fantel (1982) Culture of whole rodent embryos in teratogen screening. Teratog Carcinog Mutagen 2 231-242
22. M. Festag, B. Viertel, P. Steinberg and C. Sehner (2007) An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds. Toxicol in Vitro 21 1631-1640
23. M. Fleischer (2004) Testing costs and testing capacity according to the REACH requirements – results of a survey of independent and corporate GLP laboratories in the EU and Switzerland. J Bus Chem 4 96-114
24. O.P. Flint and T.C. Orton (1984) An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells. Toxicol Appl Pharmacol 76 383-395
25. D.J. Fort, E.L. Stover, J.A. Bantle, J.R. Rayburn, M.A. Hull, R.A. Finch, D.T. Burton, S.D. Turley, D.A. Dawson, G. Linder, D. Buchwalter, J.N. Dumont, M. Kumsher-King and A.M. Gaudet-Hull (1998) Phase III interlaboratory study of FETAX, Part 2: interlaboratory validation of an exogenous metabolic activation system for frog embryo teratogenesis assay-Xenopus (FETAX). Drug Chem Toxicol 21 1-14
26. D.J. Fort, E.L. Stover, D.R. Farmer and J.K. Lemen (2000) Assessing the predictive validity of frog embryo teratogenesis assay-Xenopus (FETAX). Teratog Carcinog Mutagen 20 87-98
27. D.J. Fort, R.L. Rogers, J.H. Thomas, B.O. Buzzard, A.M. Noll and C.D. Spaulding (2004) Comparative sensitivity of Xenopus tropicalis and Xenopus laevis as test species for the FETAX model. J Appl Toxicol 24 443-457
28. M. Froehlicher, A. Liedtke, K.J. Groh, S.C. Neuhauss, H. Segner and R.I. Eggen (2009) Zebrafish (Danio rerio) neuromast: promising biological endpoint linking developmental and toxicological studies. Aquat Toxicol 95 307-319
29. E. Genschow, G. Scholz, N. Brown, A. Piersma, M. Brady, N. Clemann, H. Huuskonen, F. Paillard, S. Bremer, K. Becker and H. Spielmann (2000) Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study. In Vitro Mol Toxicol 13 51-66
30. E. Genschow, H. Spielmann, G. Scholz, I. Pohl, A. Seiler, N. Clemann, S. Bremer and K. Becker (2004) Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern Lab Anim 32 209-244
31. E. Genschow, H. Spielmann, G. Scholz, A. Seiler, N. Brown, A. Piersma, M. Brady, N. Clemann, H. Huuskonen, F. Paillard, S. Bremer and K. Becker (2002) The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Altern Lab Anim 30 151-176
32. L. Gunnarsson, A. Jauhiainen, E. Kristiansson, O. Nerman and D.G. Larsson (2008) Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 42 5807-5813
33. M. Hewitt, C.M. Ellison, S.J. Enoch, J.C. Madden and M.T. Cronin (2009) Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity. Reprod Toxicol 30 147-160
34. A.J. Hill, H. Teraoka, W. Heideman and R.E. Peterson (2005) Zebrafish as a model vertebrate for investigating chemical toxicity. Toxicol Sci 86 6-19
35. T. Höfer, I. Gerner, U. Gundert-Remy, M. Liebsch, A. Schulte, H. Spielmann, R. Vogel and K. Wettig (2004) Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation. Arch Toxicol 78 549-564
36. E.S. Hunter 3rd, M.R. Blanton, E.H. Rogers, M. Leonard Mole, J. Andrews and N. Chernoff (2006) Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro. Reprod Toxicol 22 443-448
37. S. Jeffay, H. Nichols, M. Barrier and S. Hunter (2010) Effects of haloacetic acids and their major metabolites in a mouse embryonic stem cell adherent cell differentiation and cytotoxicity (ACDC) assay. The Toxicologist 114 359
38. M. Jergil, K. Kultima, A.L. Gustafson, L. Dencker and M. Stigson (2009) Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects. Toxicol Sci 108 132-148
39. C.B. Kimmel, W.W. Ballard, S.R. Kimmel, B. Ullmann and T.F. Schilling (1995) Stages of embryonic development of the zebrafish. Dev Dyn 203 253-310
40. J. Kirchmair, S. Ristic, K. Eder, P. Markt, G. Wolber, C. Laggner and T. Langer (2007) Fast and efficient in silico 3D screening: toward maximum computational efficiency of pharmacophore-based and shape-based approaches. J Chem Inf Model 47 2182-2196
41. T. Kosazuma, S. Hashimoto, H. Ohno, M.J. Chou and K. Shiota (2004) Organ culture of the fetal mouse palate for screening the developmental toxicity of chemicals: a validation study. Congenit Anom (Kyoto) 44 60-71
42. H.W. Laale (1977) Biology and use of zebrafish, brachydanio-rerio in fisheries research. J Fish Biol 10 121-173
43. U. Langheinrich (2003) Zebrafish: a new model on the pharmaceutical catwalk. Bioessays 25 904-912
44. H. Li, W. Kloosterman and D.M. Fekete (2010) MicroRNA-183 family members regulate sensorineural fates in the inner ear. J Neurosci 30 3254-3263
45. A. Liedtke, J. Muncke, K. Rüfenacht and R.I. Eggen (2008) Molecular multi-effect screening of environmental pollutants using the MolDarT. Environ Toxicol 23 59-67
46. E. Linney, L. Upchurch and S. Donerly (2004) Zebrafish as a neurotoxicological model. Neurotoxicol Teratol 26 709-718. Erratum in: Neurotoxicol Teratol 2005 27: 175
47. M. Longo, S. Zanoncelli, P. Della Torre, F. Rosa, A. Giusti, P. Colombo, M. Brughera, G. Mazué and P. Olliaro (2008) Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX). Reprod Toxicol 25 433-441
48. C.A. Marchant, K.A. Briggs and A. Long (2008) In silico tools for sharing data and knowledge on toxicity and metabolism: derek for windows, meteor, and vitic. Toxicol Mech Methods 18 177-187
49. P. Marx-Stoelting, E. Adriaens, H.J. Ahr, S. Bremer, B. Garthoff, H.P. Gelbke, A. Piersma, C. Pellizzer, U. Reuter, V. Rogiers, B. Schenk, S. Schwengberg, A. Seiler, H. Spielmann, M. Steemans, D.B. Stedman, P. Vanparys, J.A. Vericat, M. Verwei, F. van der Water, M. Weimer and M. Schwarz (2009) A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop. Altern Lab Anim 37 313-328
50. L. Maves and C.B. Kimmel (2005) Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Dev Biol 285 593-605
51. O. Mekenyan, S. Dimitrov, P. Schmieder and G. Veith (2003) In silico modelling of hazard endpoints: current problems and perspectives. SAR QSAR Environ Res 14 361-371
52. R.A. Miller, N. Christoforou, J. Pevsner, A.S. McCallion and J.D. Gearhart (2008) Efficient array-based identification of novel cardiac genes through differentiation of mouse ESCs. PLoS One 3 e2176
53. Y. Mino, H. Mizusawa and K. Shiota (1994) Effects of anticonvulsant drugs on fetal mouse palates cultured in vitro. Reprod Toxicol 8 225-230
54. Minutes of the Expert Panel Meeting on the Frog Embryo Teratogenesis Assay-Xenopus (FETAX): A Proposed Screening Method for Identifying the Developmental Toxicity Potential of Chemicals and Environmental Samples, May 16–18, 2000. Available at: http://iccvam.niehs.nih.gov/meetings/minutes/fetaxMin.pdf
55. J. Muncke and R.I. Eggen (2006) Vitellogenin 1 mRNA as an early molecular biomarker for endocrine disruption in developing zebrafish (Danio rerio). Environ Toxicol Chem 25 2734-2741
56. J. Muncke, M. Junghans and R.I. Eggen (2007) Testing estrogenicity of known and novel (xeno)estrogens in the MolDarT using developing zebrafish (Danio rerio). Environ Toxicol 22 185-193
57. R. Nagel, H. Bresch, N. Caspers, P.D. Hansen, M. Markert, R. Munk, N. Scholz and B.B. ter Höfte (1991) Effect of 3,4-dichloroaniline on the early life stages of the zebrafish (Brachydanio rerio): results of a comparative laboratory study. Ecotoxicol Environ Saf 21 157-164
58. NICEATM (National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods) (2000). Background Review Document Frog Embryo Teratogenesis Assay-Xenopus (FETAX) (2000) Available at: http//ecvam.niehs/nih/gov/methods/fetaxdoc/
59. M. Novic and M. Vracko (2010) QSAR models for reproductive toxicity and endocrine disruption activity. Molecules 15 1987-1999
60. M. Paparella, E. Kolossov, B.K. Fleischmann, J. Hescheler and S. Bremer (2002) The use of quantitative image analysis in the assessment of in vitro embryotoxicity endpoints based on a novel embryonic stem cell clone with endoderm-related GFP expression. Toxicol in Vitro 16 589-597
61. A.K. Peters, G.V. Wouwer, B. Weyn, G.R. Verheyen, P. Vanparys and J.V. Gompel (2008) Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity. Toxicol in Vitro 22 1948-1956
62. C. Rovida and T. Hartung (2009) Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals – a report by the transatlantic think tank for toxicology (t(4)). ALTEX 26 187-208
63. A. Seiler, A. Visan, R. Buesen, E. Genschow and H. Spielmann (2004) Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test. Reprod Toxicol 18 231-240
64. R. Serafimova, M. Todorov, D. Nedelcheva, T. Pavlov, Y. Akahori, M. Nakai and O. Mekenyan (2007) QSAR and mechanistic interpretation of estrogen receptor binding. SAR QSAR Environ Res 18 389-421
65. K. Shiota, T. Kosazuma, S. Klug and D. Neubert (1990) Development of the fetal mouse palate in suspension organ culture. Acta Anat (Basel) 137 59-64
66. H. Spielmann (2005) Predicting the risk of developmental toxicity from in vitro assays. Toxicol Appl Pharmacol 207(2 Suppl), 375-380
67. H. Spielmann, A. Seiler, S. Bremer, L. Hareng, T. Hartung, H. Ahr, E. Faustman, U. Haas, G.J. Moffat, H. Nau, P. Vanparys, A. Piersma, J.R. Sintes and J. Stuart (2006) The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57). Altern Lab Anim 34 527-538
68. T.C. Stummann, L. Hareng and S. Bremer (2009) Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells. Toxicology 257 117-126
69. B.S. Ticho, D.Y. Stainier, M.C. Fishman and R.E. Breitbart (1996) Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos. Mech Dev 59 205-218
70. D.A. van Dartel, J.L. Pennings, F.J. van Schooten and A.H. Piersma (2010) Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells. Toxicol Appl Pharmacol 243 420-428
71. D.A.M. van Dartel, J.L.A. Pennings, L.J.J. de la Fonteyne, M.H. van Herwijnen, J.H. van Delft, F.J. van Schooten and A.H. Piersma (2010) Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes. Tox Sci 16 130-139
72. D.A. van Dartel, N.J. Zeijen, L.J. de la Fonteyne, F.J. van Schooten and A.H. Piersma (2009) Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol. Reprod Toxicol 28 254-261
73. M. Verwei, J.A. van Burgsteden, C.A. Krul, J.J. van de Sandt and A.P. Freidig (2006) Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. Toxicol Lett 165 79-87
74. P.S. Walmod, U. Gravemann, H. Nau, V. Berezin and E. Bock (2004) Discriminative power of an assay for automated in vitro screening of teratogens. Toxicol in Vitro 18 511-525
75. W.S. Webster, P.D. Brown-Woodman and H.E. Ritchie (1997) A review of the contribution of whole embryo culture to the determination of hazard and risk in teratogenicity testing. Int J Dev Biol 41 329-335
76. S. Weigt, F. Busquet, F. Landenberg, T. Braunbeck, N. Huebler and T.H. Broschard (2008) Application of human and rat liver microsomes in teratogenicity testing using zebrafish Danio rerio embryos (mDarT). Toxicol Lett 180 S96-S97
77. A.C. White, R.A. Mueller, R.H. Gallavan, S. Aaron and A.G. Wilson (2003) A multiple in silico program approach for the prediction of mutagenicity from chemical structure. Mutat Res 539 77-89
78. L. Yang, N.Y. Ho, R. Alshut, J. Legradi, C. Weiss, M. Reischl, R. Mikut, U. Liebel, F. Müller and U. Strähle (2009) Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reprod Toxicol 28 245-253