Il-12 family cytokines: General characteristics, pathogenic microorganisms, receptors, and signalling pathways

Acta Microbiologica et Immunologica Hungarica

Volumn 63, Issue 1, 2016, Pages 1-25

  Behzadi, Payam ^a   Behzadi, Elham ^a   Ranjbar, Reza ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

IL 12; IL 23; IL 27; IL 35

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 27; INTERLEUKIN 35; INTERLEUKIN 35 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN RECEPTOR; PROTEIN P40; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE;

ADAPTIVE IMMUNITY; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; HUMAN; INFECTION; INFLAMMATION; INNATE IMMUNITY; MICROORGANISM; NONHUMAN; PATHOGENICITY; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BACTERIAL INFECTION; GENETICS; METABOLISM; MULTIGENE FAMILY; MYCOSIS;

ANIMALS; BACTERIAL INFECTIONS; HUMANS; INTERLEUKIN-12; INTERLEUKINS; MULTIGENE FAMILY; MYCOSES; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION;

EID: 84962663297     PISSN: 12178950     EISSN: 15882640     Source Type: Journal    
DOI: 10.1556/030.63.2016.1.1     Document Type: Article

References (150)

1. Behzadi, P., Behzadi, E.: Word Mapping in Biology, Medicine & Microbiology, 1st Edition. Persian Science & Research Publisher, Tehran, 2012, pp. 38, 50.
2. Dinarello, C. A.: Proinflammatory cytokines. Chest Journal 118, 503-508 (2000).
3. Yuzhalin, A. E., Kutikhin, A. G.: Interleukin-12: clinical usage and molecular markers of cancer susceptibility. Growth Factors 30, 176-191 (2012). DOI: 10.3109/08977194.2012. 678843
4. Belladonna, M. L., Grohmann, U.: Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents. Biotechnol Genet Eng Rev 29, 149-174 (2013). DOI: 10.1080/02648725.2013.801228
5. Belladonna, M. L., Renauld, J. C., Bianchi, R., Vacca, C., Fallarino, F., Orabona, C., Fioretti, M. C., Grohmann, U., Puccetti, P.: IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol 168, 5448-5454 (2002).
6. Behzadi, P., Behzadi E.: Detection of apoptosis feature in ultraviolet light-exposed Trichophyton rubrum. Turkiye Klinikleri J Med Sci 26, 607-610 (2006).
7. Behzadi, P., Ranjbar, R.: Caspases and apoptosis. MEDT 1, 1-4 (2015).
8. Vignali, D. A., Kuchroo, V. K.: IL-12 family cytokines: immunological playmakers. Nat Immunol 13, 722-728 (2012). DOI: 10.1038/ni.2366
9. Banchereau, J., Pascual, V., O'Garra, A.: From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol 13, 925-931 (2012). DOI: 10.1038/ni.2406
10. Honda, K., Littman, D. R.: The microbiome in infectious disease and inflammation. Annu Rev Immunol 30, 759-795 (2012). DOI: 10.1146/annurev-immunol-020711-074937
11. Lee, Y. K., Mazmanian, S. K.: Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330, 1768-1773 (2010). DOI: 10.1126/science. 1195568
12. Hamza, T., Barnett, J. B., Li, B.: Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci 11, 789-806 (2010). DOI: 10.3390/ijms11030789
13. Sun, L., He, C., Nair, L., Yeung, J., Egwuagu, C. E.: Interleukin 12 (IL-12) family cytokines: role in immune pathogenesis and treatment of CNS autoimmune disease. Cytokine 75, 249-255 (2015). DOI: 10.1016/j.cyto.2015.01.030
14. Hao, S., Baltimore, D.: The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol 10, 281-288 (2009). DOI: 10.1038/ni.1699
15. Anderson, P.: Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol 10, 24-35 (2010). DOI: 10.1038/nri2685
16. Anderson, P.: Post-transcriptional control of cytokine production. Nat Immunol 9, 353-359 (2008). DOI: 10.1038/ni1584
17. Keene, J. D.: RNA regulons: coordination of post-transcriptional events. Nat Rev Genet 8, 533-543 (2007). DOI: 10.1038/nrg2111
18. Stoecklin, G., Anderson, P.: Posttranscriptional mechanisms regulating the inflammatory response. Adv Immunol 89, 1-37 (2006). DOI: 10.1016/S0065-2776(05)89001-7
19. Hamilton, T. A., Novotny, M., Datta, S., Mandal, P., Hartupee, J., Tebo, J., Li, X.: Chemokine and chemoattractant receptor expression: post-transcriptional regulation. J Leukoc Biol 82, 213-219 (2007). DOI: 10.1189/jlb.1206754
20. Hamilton, T. A., Ohmori, Y., Tebo, J.: Regulation of chemokine expression by antiinflammatory cytokines. Immunol Res 25, 229-245 (2002). DOI: 10.1385/IR:25:3:229
21. Behzadi, P., Ranjbar, R., Alavian, S. M.: Nucleic acid-based approaches for detection of viral hepatitis. Jundishapur J Microbiol 8, e17449 (2015). DOI: 10.5812/jjm.17449
22. Behzadi, P., Behzadi, E., Ranjbar, R.: Microarray probe set: biology, bioinformatics and biophysics. Alban Med J 2, 78-83 (2015).
23. Wang, R.-X., Yu, C.-R., Dambuza, I. M., Mahdi, R. M., Dolinska, M. B., Sergeev, Y. V., Wingfield, P. T., Kim, S.-H., Egwuagu, C. E.: Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med 20, 633-641 (2014). DOI: 10.1038/nm.3554
24. Shen, P., Roch, T., Lampropoulou, V., O'Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Jaimes, Y., Daridon, C., Li, R.: IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 507, 366-370 (2014). DOI: 10.1038/nature12979
25. Steinman, R. M.: Linking innate to adaptive immunity through dendritic cells. Novartis 790, 101-109 (2006).
26. Beadling, C., Slifka, M. K.: Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27. Arch Immunol Ther Exp 54, 15-24 (2006). DOI: 10.1007/s00005-006-0002-6
27. Collison, L. W., Workman, C. J., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R. S., Vignali, D. A.: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450, 566-569 (2007). DOI: 10.1038/nature06306
28. Olson, B. M., Sullivan, J. A., Burlingham, W. J.: Interleukin 35: a key mediator of suppression and the propagation of infectious tolerance. Front Immunol 4, (2013). DOI: 10.3389/fimmu.2013.00315
29. Chang, A. Y., Bhattacharya, N.: Learning to live together: harnessing regulatory T cells to induce organ transplant tolerance. Yale J Biol Med 84, 345 (2011).
30. Collison, L. W., Chaturvedi, V., Henderson, A. L., Giacomin, P. R., Guy, C., Bankoti, J., Finkelstein, D., Forbes, K., Workman, C. J., Brown, S. A.: IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 11, 1093-1101 (2010). DOI: 10.1038/ni.1952
31. Jones, L. L., Vignali, D. A.: Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily. Immunol Res 51, 5-14 (2011). DOI: 10.1007/s12026-011-8209-y
32. Shimizu, J., Kaneko, F., Suzuki, N.: Skewed helper T-cell responses to IL-12 family cytokines produced by antigen-presenting cells and the genetic background in Behcet's disease. Genet Res Int 2013, 11 (2013). DOI: http://dx.doi.org/10.1155/2013/363859
33. Gee, K., Guzzo, C., Mat, C., Nor, F., Ma, W., Kumar, A.: The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets 8, 40-52 (2009). DOI: http://dx.doi.org/10.2174/187152809787582507
34. Bettelli, E., Korn, T., Kuchroo, V. K.: Th17: the third member of the effector T cell trilogy. Curr Opin Immunol 19, 652-657 (2007). DOI: 10.1016/j.coi.2007.07.020
35. Gaffen, S. L., Jain, R., Garg, A. V., Cua, D. J.: The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 14, 585-600 (2014). DOI: 10.1038/nri3707
36. Collison, L. W., Vignali, D. A.: Interleukin-35: odd one out or part of the family? Immunol Rev 226, 248-262 (2008). DOI: 10.1111/j.1600-065X.2008.00704.x
37. Lasek, W., Zagozdzon, R., Jakobisiak, M.: Interleukin 12: still a promising candidate for tumor immunotherapy? Cancer Immunol Immunother 63, 419-435 (2014). DOI: 10.1007/s00262-014-1523-1
38. Kastelein, R. A., Hunter, C. A., Cua, D. J.: Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25, 221-242 (2007). DOI: 10.1146/annurev.immunol.22.012703.104758
39. Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K.: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 (2000). DOI: 10.1016/S1074-7613(00)00070-4
40. Jalah, R., Rosati, M., Ganneru, B., Pilkington, G. R., Valentin, A., Kulkarni, V., Bergamaschi, C., Chowdhury, B., Zhang, G.-M., Beach, R. K.: The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit implications for improved IL-12 cytokine production. J Biol Chem 288, 6763-6776 (2013). DOI: 10.1074/jbc.M112.436675
41. Watford, W. T., Moriguchi, M., Morinobu, A., O'Shea, J. J.: The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev 14, 361-368 (2003). DOI: 10.1016/S1359-6101(03)00043-1
42. Goriely, S., Neurath, M. F., Goldman, M.: How microorganisms tip the balance between interleukin-12 family members. Nat Rev Immunol 8, 81-86 (2008). DOI: 10.1038/nri2225
43. Takaoka, A., Yanai, H., Kondo, S., Duncan, G., Negishi, H., Mizutani, T., Kano, S. I., Honda, K., Ohba, Y., Mak, T. W.: Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434, 243-249 (2005). DOI: 10.1038/nature03308
44. Ouyang, X., Negishi, H., Takeda, R., Fujita, Y., Taniguchi, T., Honda, K.: Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation. Biochem Biophys Res Commun 354, 1045-1051 (2007). DOI: 10.1016/j.bbrc.2007.01.090
45. Weinmann, A. S., Mitchell, D. M., Sanjabi, S., Bradley, M. N., Hoffmann, A., Liou, H. C., Smale, S. T.: Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat Immunol 2, 51-57 (2001). DOI: 10.1038/83168
46. Murphy, T. L., Cleveland, M. G., Kulesza, P., Magram, J., Murphy, K. M.: Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol 15, 5258-5267 (1995). DOI: 10.1128/MCB.15.10.5258
47. Lyakh, L., Trinchieri, G., Provezza, L., Carra, G., Gerosa, F.: Regulation of interleukin- 12/interleukin-23 production and the T-helper 17 response in humans. Immunol Rev 226, 112-131 (2008). DOI: 10.1111/j.1600-065X.2008.00700.x
48. Carra, G., Gerosa, F., Trinchieri, G.: Biosynthesis and posttranslational regulation of human IL-12. The Journal of Immunology 164, 4752-4761 (2000). DOI: 10.4049/jimmunol.164.9.4752
49. Murphy, F. J., Hayes, M. P., Burd, P. R.: Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptide. J Immunol 164, 839-847 (2000). DOI: 10.4049/jimmunol.164.2.839
50. Gerosa, F., Baldani-Guerra, B., Lyakh, L. A., Batoni, G., Esin, S., Winkler-Pickett, R. T., Consolaro, M. R., De Marchi, M., Giachino, D., Robbiano, A.: Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. JEM 205, 1447-1461 (2008). DOI: 10.1084/jem.20071450
51. Cleveland, M. G., Gorham, J. D., Murphy, T. L., Tuomanen, E., Murphy, K. M.: Lipoteichoic acid preparations of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun 64, 1906-1912 (1996).
52. Gautier, G., Humbert, M., Deauvieau, F., Scuiller, M., Hiscott, J., Bates, E. E., Trinieri, G., Caux, C., Garrone, P.: A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. JEM 201, 1435-1446 (2005). DOI: 10.1084/jem.20041964
53. Croxford, A. L., Kulig, P., Becher, B.: IL-12-and IL-23 in health and disease. Cytokine Growth Factor Rev 25, 415-421 (2014). DOI: 10.1016/j.cytogfr.2014.07.017
54. Grohmann, U., Belladonna, M. L., Bianchi, R., Orabona, C., Ayroldi, E., Fioretti, M. C., Puccetti, P.: IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production. Immunity 9, 315-323 (1998). DOI: 10.1016/S1074- 7613(00)80614-7
55. Aste-Amezaga, M., Ma, X., Sartori, A., Trinchieri, G.: Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol 160, 5936-5944 (1998).
56. Segal, B. M., Dwyer, B. K., Shevach, E. M.: An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. JEM 187, 537-546 (1998). DOI: 10.1084/jem.187.4.537
57. Medzhitov, R.: Toll-like receptors and innate immunity. Nat Rev Immunol 1, 135-145 (2001). DOI: 10.1038/35100529
58. Novelli, F., Casanova, J.-L.: The role of IL-12, IL-23 and IFN-γ in immunity to viruses. Cytokine Growth Factor Rev 15, 367-377 (2004). DOI: 10.1016/j.cytogfr.2004.03.009
59. Fieschi, C., Casanova, J. L.: Mini-review. The role of interleukin-12 in human infectious diseases: only a faint signature. Eur J Immunol 33, 1461-1464 (2003). DOI: 10.1002/eji.200324038
60. Haskó, G., Szabó, C.: IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses. Br J Pharmacol 127, 1295-1304 (1999). DOI: 10.1038/sj.bjp.0702689
61. Ashman, R. B., Vijayan, D., Wells, C. A.: IL-12 and related cytokines: function and regulatory implications in Candida albicans infection. Clin Dev Immunol 2011, (2010). DOI: 10.1155/2011/686597
62. O'Garra, A., Murphy, K. M.: From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development. Nat Immunol 10, 929-932 (2009). DOI: 10.1038/ni0909-929
63. Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S.: Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. JEM 202, 761-769 (2005). DOI: 10.1084/jem.20050193
64. MacLennan, C., Fieschi, C., Lammas, D. A., Picard, C., Dorman, S. E., Sanal, O., MacLennan, J. M., Holland, S. M., Ottenhoff, T. H., Casanova, J.-L.: Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans. J Infect Dis 190, 1755-1757 (2004). DOI: 10.1086/425021
65. Goriely, S., Goldman, M.: Interleukin-12 family members and the balance between rejection and tolerance. Curr Opin Organ Transplant 13, 4-9 (2008). DOI: 10.1097/MOT.0b013e3282f406c4
66. Janßen, M.: Influence of IL-12 cytokine family members on T cell differentiation in experimental cerebral malaria. Hamburg, Universität Hamburg, Diss., 2012.
67. Dufour, J.-F., Clavien, P.-A., Graf, R., Trautwein, C.: Signaling pathways in liver diseases, 2nd Edition DOI: 10.1007/978-3-642-00150-5, Springer, 2010, pp.
68. Re, F., Strominger, J. L.: Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 276, 37692-37699 (2001). DOI: 10.1074/jbc. M105927200
69. Behzadi P., Ranjbar, R.: Enzymatic pathways of intracellular survival, replication and phagosomal escape of Francisella spp.: a review. MEDT 1, 1-5 (2015).
70. Gately, M. K., Renzetti, L. M., Magram, J., Stern, A. S., Adorini, L., Gubler, U., Presky, D. H.: The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 16, 495-521 (1998). DOI: 10.1146/annurev. immunol.16.1.495
71. Sinigaglia, F., D'Ambrosio, D., Panina-Bordignon, P., Rogge, L.: Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function. Immunol Rev 170, 65-72 (1999). DOI: 10.1111/j.1600-065X.1999.tb01329.x
72. Jacobson, N. G., Szabo, S. J., Weber-Nordt, R. M., Zhong, Z., Schreiber, R. D., Darnell, J., Murphy, K. M.: Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat) 3 and Stat4. JEM 181, 1755-1762 (1995). DOI: 10.1084/jem.181.5.1755
73. Bacon, C. M., McVicar, D. W., Ortaldo, J. R., Rees, R. C., O'Shea, J., Johnston, J. A.: Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. JEM 181, 399-404 (1995). DOI: 10.1084/jem.181.1.399
74. Bacon, C. M., Petricoin, E. F., Ortaldo, J. R., Rees, R. C., Larner, A. C., Johnston, J. A., O'Shea, J. J.: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci 92, 7307-7311 (1995).
75. Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C.-Y., Gately, M. K., Gubler, U.: A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc Natl Acad Sci 93, 14002-14007 (1996).
76. del Vecchio, M., Bajetta, E., Canova, S., Lotze, M. T., Wesa, A., Parmiani, G., Anichini, A.: Interleukin-12: biological properties and clinical application. Clin Cancer Res 13, 4677-4685 (2007). DOI: 10.1158/1078-0432.CCR-07-0776
77. Delgoffe, G. M., Vignali, D. A.: STAT heterodimers in immunity: a mixed message or a unique signal? JAKSTAT 2(1):e23060. DOI: 10.4161/jkst.23060
78. Villarino, A. V., Kanno, Y., Ferdinand, J. R., O'Shea, J. J.: Mechanisms of Jak/STAT signaling in immunity and disease. J Immunol 194, 21-27 (2015). DOI: 10.4049/jimmunol.1401867
79. Trinchieri, G., Pflanz, S., Kastelein, R. A.: The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19, 641-644 (2003). DOI: 10.1016/S1074-7613(03)00296-6
80. Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V., Gadina, M., Sher, A., Paul, W. E.: T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc Natl Acad Sci 98, 15137-15142 (2001). DOI: 10.1073/pnas.261570598
81. Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L., Cereb, N., Yao, T.-P., Yang, S. Y.: Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292, 1907-1910 (2001). DOI: 10.1126/science.1059835
82. Trinchieri, G.: Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3, 133-146 (2003). DOI: 10.1038/nri1001
83. Gaffen, S. L.: Recent advances in the IL-17 cytokine family. Curr Opin Immunol 23, 613-619 (2011). DOI: 10.1016/j.coi.2011.07.006
84. Steinman, L.: A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage. Nat Med 13, 139-145 (2007). DOI: 10.1038/nm1551
85. McWilliams, I. L., Rajbhandari, R., Nozell, S., Benveniste, E., Harrington, L. E.: STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. J Neuroinflammation 12, 128 (2015). DOI: 10.1186/s12974-015-0351-3
86. Good, S. R., Thieu, V. T., Mathur, A. N., Yu, Q., Stritesky, G. L., Yeh, N., O'Malley, J. T., Perumal, N. B., Kaplan, M. H.: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. J Immunol 183, 3839-3847 (2009). DOI: 10.4049/jimmunol.0901411
87. Alber, G., Al-Robaiy, S., Kleinschek, M., Knauer, J., Krumbholz, P., Richter, J., Schoeneberger, S., Schuetze, N., Schulz, S., Toepfer, K.: Induction of immunity and inflammation by interleukin-12 family members. In (eds): Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases, Edition. Springer, 2006, pp. 107-127.
88. Parham, C., Chirica, M., Timans, J., Vaisberg, E., Travis, M., Cheung, J., Pflanz, S., Zhang, R., Singh, K. P., Vega, F.: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168, 5699-5708 (2002). DOI: 10.4049/jimmunol.168.11.5699
89. Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T.: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003). DOI: 10.1038/nature01355
90. Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., Cua, D. J.: Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. JEM 198, 1951-1957 (2003). DOI: 10.1084/jem.20030896
91. Xu, M., Mizoguchi, I., Morishima, N., Chiba, Y., Mizuguchi, J., Yoshimoto, T.: Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clin Dev Immunol pii: 832454. (2010) DOI: 10.1155/2010/832454
92. McKenzie, B. S., Kastelein, R. A., Cua, D. J.: Understanding the IL-23-IL-17 immune pathway. Trends Immunol 27, 17-23 (2006). DOI: 10.1016/j.it.2005.10.003
93. Brombacher, F., Kastelein, R. A., Alber, G.: Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol 24, 207-212 (2003). DOI: 10.1016/S1471-4906(03)00067-X
94. Hunter, C. A.: New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 5, 521-531 (2005). DOI: 10.1038/nri1648
95. Damsker, J. M., Hansen, A. M., Caspi, R. R.: Th1 and Th17 cells. Ann N Y Acad Sci 1183, 211-221 (2010). DOI: 10.1111/j.1749-6632.2009.05133.x
96. Macatonia, S. E., Hosken, N. A., Litton, M., Vieira, P., Hsieh, C.-S., Culpepper, J. A., Wysocka, M., Trinchieri, G., Murphy, K. M., O'Garra, A.: Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154, 5071-5079 (1995).
97. Schulz, O., Edwards, A. D., Schito, M., Aliberti, J., Manickasingham, S., Sher, A., e Sousa, C. R.: CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13, 453-462 (2000). DOI: 10.1016/S1074-7613(00)00045-5
98. Abdi, K., Singh, N., Matzinger, P.: T-cell control of IL-12p75 production. Scand J Immunol 64, 83-92 (2006). DOI: 10.1111/j.1365-3083.2006.01767.x
99. Wei, X.-Q., Rogers, H., Lewis, M. A., Williams, D. W.: The role of the IL-12 cytokine family in directing T-cell responses in oral candidosis. Clin Dev Immunol 2011 (2011): 697340. DOI: 10.1155/2011/697340
100. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K.: A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000). DOI: 10.1038/35047123
101. Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., Lanzavecchia, A.: Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6, 769-776 (2005). DOI: 10.1038/ni1223
102. Bek eredjian-Ding, I., Roth, S. I., Gilles, S., Giese, T., Ablasser, A., Hornung, V., Endres, S., Hartmann, G.: T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. J Immunol 176, 7438-7446 (2006). DOI: 10.4049/jimmunol.176.12.7438
103. Han, K. H., Choi, S. J., Lee, K. H.: Immunological features of macrophages induced by various morphological structures of Candida albicans. J Microbiol Biotechnol 23, 1031-1040 (2013). DOI: http://dx.doi.org/10.4014/jmb.1212.12030
104. Fedele, G., Stefanelli, P., Spensieri, F., Fazio, C., Mastrantonio, P., Ausiello, C. M.: Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression. Infect Immun 73, 1590-1597 (2005). DOI: 10.1128/IAI.73.3.1590-1597.2005
105. Behzadi, P., Behzadi, E., Ranjbar, R.: The incidence and prevalence of Crohn's disease in global scale. SOJ Immunol 3, 1-6 (2015). DOI: http://dx.doi.org/10.15226/soji/3/2/00125
106. Behzadi, P., Behzadi, E., Ranjbar, R.: Autoimmunity, Crohn's disease and anti-Saccharomyces cerevisiae autoantibodies. Farmacist.ro 156, 50-52 (2014).
107. Behzadi, P., Behzadi, E.: A study on apoptosis inducing effects of uvb irradiation in Pseudomonas aeruginosa. Roum Arch Microbiol Immunol 70, 30-33 (2011).
108. Behzadi, P., Behzadi, E.: Evaluation of uvb light efficacy for inducing apoptosis in Candida albicans cultures. Roum Arch Microbiol Immunol 71, 39-42 (2012).
109. Behzadi, P., Behzadi, E., Ranjbar, R.: Urinary tract infections and Candida albicans. CEJU 68, 96-101 (2015). DOI: 10.5173/ceju.2015.01.474
110. Jahandeh, N., Ranjbar, R., Behzadi, P., Behzadi, E.: Uropathogenic Escherichia coli virulence genes: invaluable approaches for DNA microarray probe designing. CEJU 68, 452-458 (2015). DOI: 10.5173/ceju.2015.625
111. Behzadi, P., Behzadi, E., Ranjbar, R.: Pediatric oral thrush. Pediatru.ro 34, 36-39 (2014).
112. Behzadi, P., Behzadi, E.: The microbial agents of urinary tract infections at central laboratory of Dr. Shariati Hospital, Tehran, Iran. Turkiye Klinikleri J Med Sci 28, 445-449 (2008).
113. Behzadi, E., Behzadi, P., Ranjbar, R.: In vitro apoptotic activity of UVB light in Klebsiella pneumoniae. Alban Med J 2, 18-22 (2014).
114. Jarchum, I., Pamer, E. G.: Regulation of innate and adaptive immunity by the commensal microbiota. Curr Opin Immunol 23, 353-360 (2011). DOI: 10.1016/j.coi.2011.03.001
115. Littm an, D. R., Pamer, E. G.: Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe 10, 311-323 (2011). DOI: 10.1016/j.chom.2011.10.004
116. Mal, X., Trinchieri, G.: Regulation of interleukin-12 production in antigen-presenting cells. Adv Immunol 79, 55-92 (2001). DOI: 10.1016/S0065-2776(01)79002-5
117. Kroenke, M. A., Carlson, T. J., Andjelkovic, A. V., Segal, B. M.: IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. JEM 205, 1535-1541 (2008). DOI: 10.1084/jem.20080159
118. Zhou, L., Ivanov, I. I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., Littman, D. R.: IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8, 967-974 (2007). DOI: 10.1038/ni1488
119. Croxford, A. L., Mair, F., Becher, B.: IL-23: One cytokine in control of autoimmunity. Eur J Immunol 42, 2263-2273 (2012). DOI: 10.1002/eji.201242598
120. O'Shea, J. J., Plenge, R.: JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 36, 542-550 (2012). DOI: 10.1016/j.immuni.2012.03.014
121. Devergne, O., Birkenbach, M., Kieff, E.: Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci 94, 12041-12046 (1997).
122. Pflanz, S., Timans, J. C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M., Vaisberg, E.: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 16, 779-790 (2002). DOI: 10.1016/S1074-7613(02)00324-2
123. Abdalla, A. E., Li, Q., Xie, L., Xie, J.: Biology of IL-27 and its role in the host immunity against Mycobacterium tuberculosis. Int J Biol Sci 11, 168 (2015). DOI: 10.7150/ijbs.10464
124. Hunter, C. A., Kastelein, R.: Interleukin-27: balancing protective and pathological immunity. Immunity 37, 960-969 (2012). DOI: 10.1016/j.immuni.2012.11.003
125. Pirhonen, J., Sirén, J., Julkunen, I., Matikainen, S.: IFN-α regulates Toll-like receptormediated IL-27 gene expression in human macrophages. J Leukoc Biol 82, 1185-1192 (2007). DOI: 10.1189/jlb.0307157
126. Liu, J., Guan, X., Ma, X.: Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-γ-mediated pathways. JEM 204, 141-152 (2007). DOI: 10.1084/jem.20061440
127. Zhang, J., Qian, X., Ning, H., Yang, J., Xiong, H., Liu, J.: Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. J Biol Chem 285, 21269-21281 (2010). DOI: 10.1074/jbc.M110.100818
128. Pot, C., Apetoh, L., Kuchroo, V. K.: Type 1 regulatory T cells (Tr1) in autoimmunity. In: editor. editors. Seminars in immunology. Semin Immunol 23(3): 202-208 (2011). DOI: 10.1016/j.smim.2011.07.005
129. Wojno, E. D. T., Hunter, C. A.: New directions in the basic and translational biology of interleukin-27. Trends Immunol 33, 91-97 (2012). DOI: 10.1016/j.it.2011.11.003
130. Owaki, T., Asakawa, M., Kamiya, S., Takeda, K., Fukai, F., Mizuguchi, J., Yoshimoto, T.: IL-27 suppresses CD28-medicated IL-2 production through suppressor of cytokine signaling 3. J Immunol 176, 2773-2780 (2006). DOI: 10.4049/jimmunol.176.5.2773
131. Rosas, L. E., Satoskar, A. A., Roth, K. M., Keiser, T. L., Barbi, J., Hunter, C., de Sauvage, F. J., Satoskar, A. R.: Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology. Am J Pathol 168, 158-169 (2006). DOI: 10.2353/ajpath.2006. 050013
132. Hölscher, C., Hölscher, A., Rückerl, D., Yoshimoto, T., Yoshida, H., Mak, T., Saris, C., Ehlers, S.: The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 174, 3534-3544 (2005). DOI: 10.4049/jimmunol.174.6.3534
133. Villarino, A. V., Huang, E., Hunter, C. A.: Understanding the pro- and anti-inflammatory properties of IL-27. J Immunol 173, 715-720 (2004). DOI: 10.4049/jimmunol.173.2.715
134. Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A. C., Nishina, H., Potter, J.: WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15, 569-578 (2001). DOI: 10.1016/S1074- 7613(01)00206-0
135. Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.-H., Gurney, A., Grewal, I. S., de Sauvage, F. J.: Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407, 916-920 (2000). DOI: 10.1038/35038103
136. Guzzo, C., Mat, N. F. C., Gee, K.: Interleukin-27 induces a STAT1/3- and NF-κBdependent proinflammatory cytokine profile in human monocytes. J Biol Chem 285, 24404-24411 (2010). DOI: 10.1074/jbc.M110.112599
137. Hibbert, L., Pflanz, S., de Waal Malefyt, R., Kastelein, R. A.: IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-Bet and IL-12R β 2 in naive T cells. J Interferon Cytokine Res 23, 513-522 (2003). DOI: 10.1089/10799900360708632
138. Kamiya, S., Owaki, T., Morishima, N., Fukai, F., Mizuguchi, J., Yoshimoto, T.: An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J Immunol 173, 3871-3877 (2004). DOI: 10.4049/jimmunol.173.6.387
139. Lucas, S., Ghilardi, N., Li, J., de Sauvage, F. J.: IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci 100, 15047-15052 (2003). DOI: 10.1073/pnas.2536517100
140. Collison, L. W., Delgoffe, G. M., Guy, C. S., Vignali, K. M., Chaturvedi, V., Fairweather, D., Satoskar, A. R., Garcia, K. C., Hunter, C. A., Drake, C. G.: The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol 13, 290-299 (2012). DOI: 10.1038/ni.2227
141. Garbers, C., Aparicio-S iegmund, S., Rose-John, S.: The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition. Curr Opin Immunol 34, 75-82 (2015). DOI: 10.1016/j.coi.2015.02.008
142. Dittrich, A., Hessenkemper, W., Schaper, F.: Systems biology of IL-6, IL-12 family cytokines. Cytokine Growth Factor Rev 26, 595-602 (2015). DOI: 10.1016/j.cytogfr.2015.07.002
143. Boulay, J.-L., O'Shea, J. J., Paul, W. E.: Molecular phylogeny within type I cytokines and their cognate receptors. Immunity 19, 159-163 (2003). DOI: 10.1016/S1074-7613(03)00211-5
144. Mihara, M., Hashizume, M., Yoshida, H., Suzuki, M., Shiina, M.: IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci 122, 143-159 (2012). DOI: 10.1042/CS20110340
145. Mihara, M., Nishimoto, N., Ohsugi, Y.: The therapy of autoimmune diseases by anti-interleukin- 6 receptor antibody. Expert Opin Biol Ther 5, 683-690 (2005). DOI: 10.1517/14712598.5.5.683
146. Wong, P. K., Campbell, I. K., Egan, P. J., Ernst, M., Wicks, I. P.: The role of the interleukin- 6 family of cytokines in inflammatory arthritis and bone turnover. Arthritis Rheum 48, 1177-1189 (2003). DOI: 10.1002/art.10943
147. Pflanz, S., Hibbert, L., Mattson, J., Rosales, R., Vaisberg, E., Bazan, J. F., Phillips, J. H., McClanahan, T. K., de Waal Malefyt, R., Kastelein, R. A.: WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 172, 2225-2231 (2004). DOI: 10.4049/jimmunol.172.4.2225
148. Boulanger, M. J., Chow, D.-C., Brevnova, E. E., Garcia, K. C.: Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex. Science 300, 2101-2104 (2003). DOI: 10.1126/science.1083901
149. Lee, S.-Y., Jung, Y. O., Kim, D.-J., Kang, C.-M., Moon, Y.-M., Heo, Y.-J., Oh, H.-J., Park, S.-J., Yang, S.-H., Kwok, S. K.: IL-12p40 Homodimer ameliorates experimental autoimmune arthritis. J Immunol 195, 3001-3010 (2015). DOI: 10.4049/jimmunol.1500400
150. Gillessen, S., Carvajal, D., Ling, P., Podlaski, F. J., Stremlo, D. L., Familletti, P. C., Gubler, U., Presky, D. H., Stern, A. S., Gately, M. K.: Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol 25, 200-206 (1995). DOI: 10.1002/eji.1830250133