메뉴 건너뛰기




Volumn 24, Issue 4, 2003, Pages 207-212

Novel IL-12 family members shed light on the orchestration of Th1 responses

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 27; INTERLEUKIN DERIVATIVE; PROTEIN P19; PROTEIN P35; PROTEIN P40; UNCLASSIFIED DRUG;

EID: 0037385216     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(03)00067-X     Document Type: Review
Times cited : (233)

References (66)
  • 1
    • 0031943618 scopus 로고    scopus 로고
    • The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
    • Gately M.K., et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 495-521
    • Gately, M.K.1
  • 2
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: A cytokine at the interface of inflammation and immunity
    • Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70:1998;83-243.
    • (1998) Adv. Immunol. , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 3
    • 16044363695 scopus 로고    scopus 로고
    • IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses
    • Magram J., et al. IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses. Immunity. 4:1996;471-481.
    • (1996) Immunity , vol.4 , pp. 471-481
    • Magram, J.1
  • 4
    • 0030002111 scopus 로고    scopus 로고
    • Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2-cell response
    • Mattner F., et al. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2-cell response. Eur. J. Immunol. 26:1996;1553-1559.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1553-1559
    • Mattner, F.1
  • 5
    • 0034661678 scopus 로고    scopus 로고
    • IL-12 is required to maintain a Th1 response during Leishmania major infection
    • Park A.Y., et al. IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 165:2000;896-902.
    • (2000) J. Immunol. , vol.165 , pp. 896-902
    • Park, A.Y.1
  • 6
    • 0034662258 scopus 로고    scopus 로고
    • Cutting edge: IL-12 is required for the maintenance of IFNγ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii
    • Yap G., et al. Cutting edge: IL-12 is required for the maintenance of IFNγ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J. Immunol. 165:2000;628-631.
    • (2000) J. Immunol. , vol.165 , pp. 628-631
    • Yap, G.1
  • 7
    • 0026567028 scopus 로고
    • Sequence similarity between NKSF and the IL-6/G-CSF family
    • Merberg D.M., et al. Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol. Today. 13:1992;77-78.
    • (1992) Immunol. Today , vol.13 , pp. 77-78
    • Merberg, D.M.1
  • 8
    • 0025783528 scopus 로고
    • Homology of the p40 subunit of natural-killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor
    • Gearing D.P., Cosman D. Homology of the p40 subunit of natural-killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell. 66:1991;9-10.
    • (1991) Cell , vol.66 , pp. 9-10
    • Gearing, D.P.1    Cosman, D.2
  • 9
    • 0025808629 scopus 로고
    • Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
    • Gubler U., et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. U. S. A. 88:1991;4143-4147.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 4143-4147
    • Gubler, U.1
  • 10
    • 0026701132 scopus 로고
    • Production of natural-killer cell stimulatory factor (interleukin 12) by peripheral-blood mononuclear cells
    • D'Andrea A., et al. Production of natural-killer cell stimulatory factor (interleukin 12) by peripheral-blood mononuclear cells. J. Exp. Med. 176:1992;1387-1398.
    • (1992) J. Exp. Med. , vol.176 , pp. 1387-1398
    • D'Andrea, A.1
  • 11
    • 0030445948 scopus 로고    scopus 로고
    • A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
    • Presky D.H., et al. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U. S. A. 93:1996;14002-14007.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14002-14007
    • Presky, D.H.1
  • 12
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan M.H., et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 382:1996;174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1
  • 13
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated responses of natural-killer and T cells
    • Thierfelder W.E., et al. Requirement for Stat4 in interleukin-12-mediated responses of natural-killer and T cells. Nature. 382:1996;171-174.
    • (1996) Nature , vol.382 , pp. 171-174
    • Thierfelder, W.E.1
  • 14
    • 0031571205 scopus 로고    scopus 로고
    • Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor
    • Wu C., et al. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J. Immunol. 159:1997;1658-1665.
    • (1997) J. Immunol. , vol.159 , pp. 1658-1665
    • Wu, C.1
  • 15
    • 0034541139 scopus 로고    scopus 로고
    • IL-12 receptor β2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
    • Wu C., et al. IL-12 receptor β2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J. Immunol. 165:2000;6221-6228.
    • (2000) J. Immunol. , vol.165 , pp. 6221-6228
    • Wu, C.1
  • 16
    • 0027200981 scopus 로고
    • The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
    • Mattner F., et al. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:1993;2202-2208.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2202-2208
    • Mattner, F.1
  • 17
    • 0031132212 scopus 로고    scopus 로고
    • In vivo production and function of IL-12 p40 homodimers
    • Heinzel F.P., et al. In vivo production and function of IL-12 p40 homodimers. J. Immunol. 158:1997;4381-4388.
    • (1997) J. Immunol. , vol.158 , pp. 4381-4388
    • Heinzel, F.P.1
  • 18
    • 0028967287 scopus 로고
    • Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
    • Gillessen S., et al. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25:1995;200-206.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 200-206
    • Gillessen, S.1
  • 19
    • 0028819316 scopus 로고
    • Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
    • Ling P., et al. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 154:1995;116-127.
    • (1995) J. Immunol. , vol.154 , pp. 116-127
    • Ling, P.1
  • 20
    • 0030817861 scopus 로고    scopus 로고
    • Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor α-dependent shock
    • Mattner F., et al. Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor α-dependent shock. Infect. Immun. 65:1997;4734-4737.
    • (1997) Infect. Immun. , vol.65 , pp. 4734-4737
    • Mattner, F.1
  • 21
    • 0031964713 scopus 로고    scopus 로고
    • Reduced T helper 1 responses in IL-12 p40 transgenic mice
    • Yoshimoto T., et al. Reduced T helper 1 responses in IL-12 p40 transgenic mice. J. Immunol. 160:1998;588-594.
    • (1998) J. Immunol. , vol.160 , pp. 588-594
    • Yoshimoto, T.1
  • 22
    • 0029049359 scopus 로고
    • The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer
    • Germann T., et al. The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer. Immunol. Today. 16:1995;500-501.
    • (1995) Immunol. Today , vol.16 , pp. 500-501
    • Germann, T.1
  • 23
    • 0036218351 scopus 로고    scopus 로고
    • Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T-lymphocyte responses for DNA immunization
    • Ha S.J., et al. Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T-lymphocyte responses for DNA immunization. Nat. Biotechnol. 20:2002;381-386.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 381-386
    • Ha, S.J.1
  • 24
    • 0031567892 scopus 로고    scopus 로고
    • + IFNγ-producing cells
    • + IFNγ-producing cells. J. Immunol. 158:1997;643-648.
    • (1997) J. Immunol. , vol.158 , pp. 643-648
    • Piccotti, J.R.1
  • 25
    • 0031940203 scopus 로고    scopus 로고
    • Alloantigen-reactive Th1 development in IL-12-deficient mice
    • Piccotti J.R., et al. Alloantigen-reactive Th1 development in IL-12-deficient mice. J. Immunol. 160:1998;1132-1138.
    • (1998) J. Immunol. , vol.160 , pp. 1132-1138
    • Piccotti, J.R.1
  • 26
    • 0035892749 scopus 로고    scopus 로고
    • A protective and agonistic funciton of IL-12p40 in mycobacterial infection
    • Hölscher C., et al. A protective and agonistic funciton of IL-12p40 in mycobacterial infection. J. Immunol. 167:2001;6957-6966.
    • (2001) J. Immunol. , vol.167 , pp. 6957-6966
    • Hölscher, C.1
  • 27
    • 0036467445 scopus 로고    scopus 로고
    • Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
    • Cooper A.M., et al. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J. Immunol. 168:2002;1322-1327.
    • (2002) J. Immunol. , vol.168 , pp. 1322-1327
    • Cooper, A.M.1
  • 28
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:2000;715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 29
    • 0035808784 scopus 로고    scopus 로고
    • Interleukin 12 p40 production by barrier epithelial cells during airway inflammation
    • Walter M.J., et al. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation. J. Exp. Med. 193:2001;339-351.
    • (2001) J. Exp. Med. , vol.193 , pp. 339-351
    • Walter, M.J.1
  • 30
    • 0000155803 scopus 로고    scopus 로고
    • A novel function of IL-12p40 as a chemotactic molecule for macrophages
    • Ha S.J., et al. A novel function of IL-12p40 as a chemotactic molecule for macrophages. J. Immunol. 163:1999;2902-2908.
    • (1999) J. Immunol. , vol.163 , pp. 2902-2908
    • Ha, S.J.1
  • 31
    • 0036721628 scopus 로고    scopus 로고
    • A profibrotic function of IL-12p40 in experimental pulmonary fibrosis
    • Huaux F., et al. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J. Immunol. 169:2002;2653-2661.
    • (2002) J. Immunol. , vol.169 , pp. 2653-2661
    • Huaux, F.1
  • 32
    • 0035896521 scopus 로고    scopus 로고
    • Induction of nitric-oxide synthase and activation of NFκB by interleukin-12 p40 in microglial cells
    • Pahan K., et al. Induction of nitric-oxide synthase and activation of NFκB by interleukin-12 p40 in microglial cells. J. Biol. Chem. 276:2001;7899-7905.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7899-7905
    • Pahan, K.1
  • 33
    • 0030448764 scopus 로고    scopus 로고
    • Evidence for multiple sites of interaction between IL-12 and its receptor
    • Presky D.H., et al. Evidence for multiple sites of interaction between IL-12 and its receptor. Ann. New York Acad. Sci. 795:1996;390-393.
    • (1996) Ann. New York Acad. Sci. , vol.795 , pp. 390-393
    • Presky, D.H.1
  • 34
    • 0032991684 scopus 로고    scopus 로고
    • Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits
    • Wang X., et al. Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits. Eur. J. Immunol. 29:1999;2007-2013.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2007-2013
    • Wang, X.1
  • 35
    • 0031041596 scopus 로고    scopus 로고
    • Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits β1 and β2 and JAK kinases
    • Zou J., et al. Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits β1 and β2 and JAK kinases. J. Biol. Chem. 272:1997;6073-6077.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6073-6077
    • Zou, J.1
  • 36
    • 0032565598 scopus 로고    scopus 로고
    • Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor β1 subunit
    • Kawashima T., et al. Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor β1 subunit. Cell. Immunol. 186:1998;39-44.
    • (1998) Cell. Immunol. , vol.186 , pp. 39-44
    • Kawashima, T.1
  • 37
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
    • Parham C., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:2002;5699-5708.
    • (2002) J. Immunol. , vol.168 , pp. 5699-5708
    • Parham, C.1
  • 38
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T-cell activation state characterized by the production of interleukin-17
    • Aggarwal S., et al. Interleukin-23 promotes a distinct CD4 T-cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278:2003;1910-1914.
    • (2003) J. Biol. Chem. , vol.278 , pp. 1910-1914
    • Aggarwal, S.1
  • 39
    • 0035877257 scopus 로고    scopus 로고
    • Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility and premature death
    • Wiekowski M.T., et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility and premature death. J. Immunol. 166:2001;7563-7570.
    • (2001) J. Immunol. , vol.166 , pp. 7563-7570
    • Wiekowski, M.T.1
  • 40
    • 0031707741 scopus 로고    scopus 로고
    • Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
    • Decken K., et al. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect. Immun. 66:1998;4994-5000.
    • (1998) Infect. Immun. , vol.66 , pp. 4994-5000
    • Decken, K.1
  • 41
    • 0035500298 scopus 로고    scopus 로고
    • IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella Enteritidis
    • Lehmann J., et al. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella Enteritidis. J. Immunol. 167:2001;5304-5315.
    • (2001) J. Immunol. , vol.167 , pp. 5304-5315
    • Lehmann, J.1
  • 42
    • 0034787546 scopus 로고    scopus 로고
    • Inflammatory skin disease in K14/p40 transgenic mice: Evidence for interleukin-12-like activities of p40
    • Kopp T., et al. Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40. J. Invest. Dermatol. 117:2001;618-626.
    • (2001) J. Invest. Dermatol. , vol.117 , pp. 618-626
    • Kopp, T.1
  • 43
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naïve CD4(+) T cells
    • Pflanz S., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naïve CD4(+) T cells. Immunity. 16:2002;779-790.
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1
  • 44
    • 0034687402 scopus 로고    scopus 로고
    • Development of Th1-type immune responses requires the type I cytokine receptor TCCR
    • Chen Q., et al. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature. 407:2000;916-920.
    • (2000) Nature , vol.407 , pp. 916-920
    • Chen, Q.1
  • 45
    • 17944377950 scopus 로고    scopus 로고
    • WSX1 is required for the initiation of Th1 responses and resistance to L. major infection
    • Yoshida H., et al. WSX1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity. 15:2001;569-578.
    • (2001) Immunity , vol.15 , pp. 569-578
    • Yoshida, H.1
  • 46
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo S.J., et al. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:1997;817-824.
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1
  • 47
    • 0030892136 scopus 로고    scopus 로고
    • Selective expression of an interleukin-12 receptor component by human T helper 1 cells
    • Rogge L., et al. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:1997;825-831.
    • (1997) J. Exp. Med. , vol.185 , pp. 825-831
    • Rogge, L.1
  • 48
    • 0030067819 scopus 로고    scopus 로고
    • A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    • Devergne O., et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J. Virol. 70:1996;1143-1153.
    • (1996) J. Virol. , vol.70 , pp. 1143-1153
    • Devergne, O.1
  • 49
    • 0035156672 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: Involvement of syncytiotrophoblasts and extravillous trophoblasts
    • Devergne O., et al. Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts. Am. J. Pathol. 159:2001;1763-1776.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1763-1776
    • Devergne, O.1
  • 50
    • 0030700003 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    • Devergne O., et al. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. U. S. A. 94:1997;12041-12046.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 12041-12046
    • Devergne, O.1
  • 51
    • 0037168543 scopus 로고    scopus 로고
    • Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
    • Nieuwenhuis E.E., et al. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 99:2002;16951-16956.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 16951-16956
    • Nieuwenhuis, E.E.1
  • 52
    • 0030033426 scopus 로고    scopus 로고
    • Effect of interleukin 12 neutralization on host resistance and γ interferon production in mouse typhoid
    • Mastroeni P., et al. Effect of interleukin 12 neutralization on host resistance and γ interferon production in mouse typhoid. Infect. Immun. 64:1996;189-196.
    • (1996) Infect. Immun. , vol.64 , pp. 189-196
    • Mastroeni, P.1
  • 53
    • 0030790652 scopus 로고    scopus 로고
    • Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
    • Cooper A.M., et al. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J. Exp. Med. 186:1997;39-45.
    • (1997) J. Exp. Med. , vol.186 , pp. 39-45
    • Cooper, A.M.1
  • 54
    • 0032522640 scopus 로고    scopus 로고
    • Mice lacking IL-12 develop polarized Th1 cells during viral infection
    • Schijns V.E., et al. Mice lacking IL-12 develop polarized Th1 cells during viral infection. J. Immunol. 160:1998;3958-3964.
    • (1998) J. Immunol. , vol.160 , pp. 3958-3964
    • Schijns, V.E.1
  • 55
    • 0032738008 scopus 로고    scopus 로고
    • The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL- 12 p40
    • Carr J.A., et al. The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL- 12 p40. J. Interferon Cytokine Res. 19:1999;1145-1152.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 1145-1152
    • Carr, J.A.1
  • 56
    • 0033556145 scopus 로고    scopus 로고
    • IL-12 is not required for induction of type 1 cytokine responses in viral infections
    • Oxenius A., et al. IL-12 is not required for induction of type 1 cytokine responses in viral infections. J. Immunol. 162:1999;965-973.
    • (1999) J. Immunol. , vol.162 , pp. 965-973
    • Oxenius, A.1
  • 57
    • 0033964865 scopus 로고    scopus 로고
    • IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFNγ and nitric oxide synthetase 2
    • van Den B.M., et al. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFNγ and nitric oxide synthetase 2. J. Immunol. 164:2000;371-378.
    • (2000) J. Immunol. , vol.164 , pp. 371-378
    • Van Den, B.M.1
  • 58
    • 0032213010 scopus 로고    scopus 로고
    • Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria
    • Ottenhoff T.H., et al. Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria. Immunol. Today. 19:1998;491-494.
    • (1998) Immunol. Today , vol.19 , pp. 491-494
    • Ottenhoff, T.H.1
  • 59
    • 0035712801 scopus 로고    scopus 로고
    • Conditioning of dendritic cells by pathogen-derived stimuli
    • Reis e Sousa C., et al. Conditioning of dendritic cells by pathogen-derived stimuli. Immunobiology. 204:2001;595-597.
    • (2001) Immunobiology , vol.204 , pp. 595-597
    • Reis E Sousa, C.1
  • 60
    • 0033697454 scopus 로고    scopus 로고
    • CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
    • Schulz O., et al. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity. 13:2000;453-462.
    • (2000) Immunity , vol.13 , pp. 453-462
    • Schulz, O.1
  • 61
    • 0036890125 scopus 로고    scopus 로고
    • Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells
    • van Seventer J.M., et al. Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J. Neuroimmunol. 133:2002;60-71.
    • (2002) J. Neuroimmunol. , vol.133 , pp. 60-71
    • Van Seventer, J.M.1
  • 63
    • 0035884846 scopus 로고    scopus 로고
    • IL-12-independent IFNγ production by T cells in experimental Chagas' disease is mediated by IL-18
    • Müller U., et al. IL-12-independent IFNγ production by T cells in experimental Chagas' disease is mediated by IL-18. J. Immunol. 167:2001;3346-3353.
    • (2001) J. Immunol. , vol.167 , pp. 3346-3353
    • Müller, U.1
  • 64
    • 0036127059 scopus 로고    scopus 로고
    • In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70
    • Elkins K.L., et al. In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect. Immun. 70:2002;1936-1948.
    • (2002) Infect. Immun. , vol.70 , pp. 1936-1948
    • Elkins, K.L.1
  • 65
    • 0344958627 scopus 로고    scopus 로고
    • IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes
    • Brombacher F., et al. IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes. Int. Immunol. 11:1999;325-332.
    • (1999) Int. Immunol. , vol.11 , pp. 325-332
    • Brombacher, F.1
  • 66
    • 18844481515 scopus 로고    scopus 로고
    • Defective NK-cell activity and Th1 response in IL-18-deficient mice
    • Takeda K., et al. Defective NK-cell activity and Th1 response in IL-18-deficient mice. Immunity. 8:1998;383-390.
    • (1998) Immunity , vol.8 , pp. 383-390
    • Takeda, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.