Regulation of chemokine expression by antiinflammatory cytokines

Immunologic Research

Volumn 25, Issue 3, 2002, Pages 229-245

  Hamilton, Thomas A ^a   Ohmori, Yoshihiro ^a   Tebo, Julie ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Chemokines; IL 10; IL 4; Macrophages; MRNA stability; Transcription

Indexed keywords

CHEMOKINE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MESSENGER RNA; STAT1 PROTEIN; STAT6 PROTEIN;

3' UNTRANSLATED REGION; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; MACROPHAGE; MOLECULAR MECHANICS; MONONUCLEAR PHAGOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; INTERLEUKIN-10; INTERLEUKIN-4; MACROPHAGES; MICE; RNA STABILITY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0036241419     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:25:3:229     Document Type: Review

References (129)

1. Macrophages as destructive cells in host defense
2. Dendritic cell maturation and generation of immune responses
3. Dendritic cells
4. The role of chemokines in the regulation of dendritic cell trafficking
5. On the edge: The physiological and pathophysiological role of chemokines during inflammatory and immunological responses
6. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
7. Chemokines
8. Review articles: Mechanisms of disease: Chemokines - Chemotactic cytokines that mediate inflammation
9. Chemokines and leukocyte traffic
10. Chemokine receptors and their role in leukocyte activation
11. Chemokines and chemokine receptors: Biology and clinical relevance in inflammation and AIDS
12. The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells
13. Recent advances in chemokines and chemokine receptors
14. Macrophage inflammatory protein1α (MIP-1α) is required for the efferent phase of pulmonary cell-mediated immunity to a Cryptococcus neoformans infection
15. MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation
16. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice
17. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
18. Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattractant cytokines in vivo
19. Tissue-specific expression of murine IP-10 mRNA following systemic treatment with interferon gamma
20. Expression of IFN-inducible protein-10 in chronic hepatitis
21. T cell-dependent acceleration of chemoattractant cytokine gene expression during secondary rejection of allogeneic skin grafts
22. Gro-α-mediated recruitment of neutrophils is required for elicitation of contact hypersensitivity
23. Intraallograft chemokine RNA and protein during rejection of MHC-matched/multiple minor histocompatibility-disparate skin grafts
24. Regulation of macrophage gene expression by T cell derived lymphokines
25. Intracellular signaling pathways regulating inflammatory gene expression in mononuclear phagocytes
26. Endotoxin signal transduction in macrophages
27. Molecular basis of macrophage activation: From gene expression to phenotypic diversity
28. Old and new chemokines. Pharmacological regulation of chemokine production and receptor expression: Mini-review
29. Initiation of acute phase response and synthesis of cytokines
30. Inflammatory cytokines and cell response in surgery
31. The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia
32. The biology of Toll-like receptors
33. The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for pro-inflammatory interleukins and microbial products
34. Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity
35. Toll-like receptors
36. Innate immunity: The virtues of a nonclonal system of recognition
37. Tumor necrosis factor receptor and Fas signaling mechanisms
38. Tumor necrosis factor receptor family members in the immune system
39. STATs and gene regulation
40. How cells respond to interferons
41. Signaling by the cytokine receptor superfamily
42. Other functions, other genes: Alternative activation of antigen-presenting cells
43. Therapeutic implications of interleukin-10 in surgical disease
44. Alternative versus classical activation of macrophages
45. Antiinflammatory cytokines
46. Tumor-induced immune dysfunction: The macrophage connection
47. Interleukin-4: A prototypic immunoregulatory lymphokine
48. The IL-4 receptor: Signaling mechanisms and biologic functions
49. An update on interleukin-4 and its receptor
50. Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines
51. Interleukin-4 and interleukin-13: Their similarities and discrepancies
52. Role of lipopolysaccharide and IL-4 in control of transcription of the class II Aa gene
53. Modulation of macrophage function by transforming growth factor β, interleukin-4, and interleukin-10
54. IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes
55. Differential responses of human monocytes and macrophages to IL-4 and IL-13
56. Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation
57. IL-4/IL-13 signaling beyond JAK/STAT
58. IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4
59. IL-4 attenuates the transcriptional activation of both IFN-α and IFN-α-induced cellular gene expression in monocytes and monocytic cell lines
60. Mechanisms of IL-4-mediated suppression of IP-10 gene expression in murine macrophages
61. Interleukin-4 and interleukin-13 inhibit tumor necrosis factor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages
62. IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages
63. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
64. Components of a Stat recognition code: Evidence for two layers of molecular selectivity
65. STAT6 is required for the antiinflammatory activity of interleukin-4 in mouse peritoneal macrophages
66. Interleukin-4/STAT6 represses STAT1 and NF-kappa B-dependent transcription through distinct mechanisms
67. The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
68. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection
69. The CXC chemokines IP-10 and mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
70. Gamma interferon transcriptionally regulates an early response gene containing homology to platelet proteins
71. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines
72. Requirement for STAT1 in LPS-induced gene expression in macrophages
73. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
74. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
75. Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1
76. Tissue-specific regulation of IL-6 production by IL-4: Differential effects of IL-4 on nuclear factor-kappaB activity in monocytes and fibroblasts
77. Interleukin-4 suppression of tumor necrosis factor α-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB
78. Interleukin-10
79. Interleukin-10 and its receptor
80. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
81. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses
82. -/- mice: An overview
83. Interleukin-10 as a regulatory cytokine induced by cellular stress: Molecular aspects
84. Interleukin-10: Biology, role in inflammation and autoimmunity
85. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
86. Cutting edge: Clustered AU-rich elements are the target of IL-10- mediated mRNA destabilization in mouse macrophages
87. IL-10-mediated suppression of TNF-α production is independent of its ability to inhibit NF kappa B activity
88. IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes
89. IL-10 suppresses LPS-induced KC mRNA expression via a translation-dependent decrease in mRNA stability
90. Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-α induced activation and maturation of human peripheral blood monocyte-derived dendritic cells
91. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK 1/2-dependent pathway. A target of interleukin (IL)-4 and IL-10 antiinflammatory action
92. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
93. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
94. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
95. The role of tyrosine kinases and map kinases in LPS-induced signaling
96. Lipopolysaccharide-induced tumor necrosis factor-α promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent
97. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: Glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK
98. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
99. Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade
100. Stat-3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
101. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1α and STAT3 complexes in human T cells and monocytes
102. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for antiinflammatory action
103. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways
104. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-β and interleukin-10
105. Interleukin-10 suppresses IP-10 gene transcription by inhibiting the production of class I interferon
106. Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling
107. In vivo suppression of NF-kappa B and preservation of I kappa B α by interleukin-10 and interleukin-13
108. Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding
109. The platelet derived growth factor-inducible KC gene encodes a secretory protein related to platelet a granules
110. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues
111. mRNA stability in mammalian cells
112. mRNA stability in eukaryotes
113. The nonamer UUAUU-UAUU is the key AU-rich sequence motif that mediates mRNA degradation
114. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: The functional sequence within AU-rich elements may be UUAUUUA (U/A)(U/A)
115. Generation and initial characterizartion of mice lacking TNF AU rich control elements
116. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
117. Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-alpha)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13
118. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
119. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
120. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
121. Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin
122. Poly(A) shortening and degradation of the 3′ AU rich sequences of human c-myc mRNA in a cell-free system
123. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay
124. Interaction between a poly(A)-specific ribonuclease and the 5′ cap influences mRNA deadenylation rates in vitro
125. Poly(A) tail shortening by a mammalian poly(A)-specific 3′-exoribonuclease
126. The identification of an endonuclease that cleaves within an HuR binding site in mRNA
127. Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage
128. Possible involvement of proteasomes (prosomes) in AUUUA-mediated mRNA decay