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Volumn 33, Issue 2, 2012, Pages 91-97

New directions in the basic and translational biology of interleukin-27

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 27; INTERLEUKIN 27P28; INTERLEUKIN 6; STAT1 PROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 84856554638     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2011.11.003     Document Type: Review
Times cited : (96)

References (108)
  • 1
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    • Pflanz S., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002, 16:779-790.
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1
  • 2
    • 10744222574 scopus 로고    scopus 로고
    • WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    • Pflanz S., et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J. Immunol. 2004, 172:2225-2231.
    • (2004) J. Immunol. , vol.172 , pp. 2225-2231
    • Pflanz, S.1
  • 3
    • 20444375878 scopus 로고    scopus 로고
    • Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    • Villarino A.V., et al. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. J. Immunol. 2005, 174:7684-7691.
    • (2005) J. Immunol. , vol.174 , pp. 7684-7691
    • Villarino, A.V.1
  • 4
    • 10644250867 scopus 로고    scopus 로고
    • No inhibition of IL-27 signaling by soluble gp130
    • Scheller J., et al. No inhibition of IL-27 signaling by soluble gp130. Biochem. Biophys. Res. Commun. 2005, 326:724-728.
    • (2005) Biochem. Biophys. Res. Commun. , vol.326 , pp. 724-728
    • Scheller, J.1
  • 5
    • 41449113342 scopus 로고    scopus 로고
    • Advances in understanding the anti-inflammatory properties of IL-27
    • Stumhofer J.S., Hunter C.A. Advances in understanding the anti-inflammatory properties of IL-27. Immunol. Lett. 2008, 117:123-130.
    • (2008) Immunol. Lett. , vol.117 , pp. 123-130
    • Stumhofer, J.S.1    Hunter, C.A.2
  • 6
    • 0345570521 scopus 로고    scopus 로고
    • The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    • Villarino A., et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 2003, 19:645-655.
    • (2003) Immunity , vol.19 , pp. 645-655
    • Villarino, A.1
  • 7
    • 10744221849 scopus 로고    scopus 로고
    • WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production
    • Hamano S., et al. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 2003, 19:657-667.
    • (2003) Immunity , vol.19 , pp. 657-667
    • Hamano, S.1
  • 8
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi A., et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 2007, 8:1380-1389.
    • (2007) Nat. Immunol. , vol.8 , pp. 1380-1389
    • Awasthi, A.1
  • 9
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald D.C., et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 2007, 8:1372-1379.
    • (2007) Nat. Immunol. , vol.8 , pp. 1372-1379
    • Fitzgerald, D.C.1
  • 10
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer J.S., et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 2007, 8:1363-1371.
    • (2007) Nat. Immunol. , vol.8 , pp. 1363-1371
    • Stumhofer, J.S.1
  • 11
    • 0037385216 scopus 로고    scopus 로고
    • Novel IL-12 family members shed light on the orchestration of Th1 responses
    • Brombacher F., et al. Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol. 2003, 24:207-212.
    • (2003) Trends Immunol. , vol.24 , pp. 207-212
    • Brombacher, F.1
  • 12
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
    • Trinchieri G., et al. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003, 19:641-644.
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1
  • 13
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    • Hunter C.A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 2005, 5:521-531.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 521-531
    • Hunter, C.A.1
  • 14
    • 34447345406 scopus 로고    scopus 로고
    • The biology and therapeutic potential of interleukin 27
    • Batten M., Ghilardi N. The biology and therapeutic potential of interleukin 27. J. Mol. Med. 2007, 85:661-672.
    • (2007) J. Mol. Med. , vol.85 , pp. 661-672
    • Batten, M.1    Ghilardi, N.2
  • 15
    • 0035062021 scopus 로고    scopus 로고
    • Interleukin-10 and the interleukin-10 receptor
    • Moore K.W., et al. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001, 19:683-765.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 683-765
    • Moore, K.W.1
  • 16
    • 33746338535 scopus 로고    scopus 로고
    • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    • Roncarolo M.G., et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 2006, 212:28-50.
    • (2006) Immunol. Rev. , vol.212 , pp. 28-50
    • Roncarolo, M.G.1
  • 17
    • 70149105112 scopus 로고    scopus 로고
    • IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
    • Murugaiyan G., et al. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 2009, 183:2435-2443.
    • (2009) J. Immunol. , vol.183 , pp. 2435-2443
    • Murugaiyan, G.1
  • 18
    • 14844340837 scopus 로고    scopus 로고
    • The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages
    • Cao S., et al. The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J. Immunol. 2005, 174:3484-3492.
    • (2005) J. Immunol. , vol.174 , pp. 3484-3492
    • Cao, S.1
  • 19
    • 73249149628 scopus 로고    scopus 로고
    • C-Maf regulates IL-10 expression during Th17 polarization
    • Xu J., et al. c-Maf regulates IL-10 expression during Th17 polarization. J. Immunol. 2009, 182:6226-6236.
    • (2009) J. Immunol. , vol.182 , pp. 6226-6236
    • Xu, J.1
  • 20
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva M., et al. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 2009, 31:209-219.
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1
  • 21
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T cells by gamma(c) family cytokines
    • Rochman Y., et al. New insights into the regulation of T cells by gamma(c) family cytokines. Nat. Rev. Immunol. 2009, 9:480-490.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 480-490
    • Rochman, Y.1
  • 22
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C., et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 2009, 183:797-801.
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1
  • 23
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L., et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 2010, 11:854-861.
    • (2010) Nat. Immunol. , vol.11 , pp. 854-861
    • Apetoh, L.1
  • 24
    • 79952317431 scopus 로고    scopus 로고
    • IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3
    • Wang H., et al. IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3. Immunol. Lett. 2011, 136:21-28.
    • (2011) Immunol. Lett. , vol.136 , pp. 21-28
    • Wang, H.1
  • 25
    • 69049116053 scopus 로고    scopus 로고
    • Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    • Ilarregui J.M., et al. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat. Immunol. 2009, 10:981-991.
    • (2009) Nat. Immunol. , vol.10 , pp. 981-991
    • Ilarregui, J.M.1
  • 26
    • 67649976583 scopus 로고    scopus 로고
    • IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance
    • Shiokawa A., et al. IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance. Immunol. Lett. 2009, 125:7-14.
    • (2009) Immunol. Lett. , vol.125 , pp. 7-14
    • Shiokawa, A.1
  • 27
    • 77954939162 scopus 로고    scopus 로고
    • Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation
    • Murugaiyan G., et al. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:11495-11500.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 11495-11500
    • Murugaiyan, G.1
  • 28
    • 79952527975 scopus 로고    scopus 로고
    • Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10
    • Lee Y.S., et al. Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology 2011, 132:492-502.
    • (2011) Immunology , vol.132 , pp. 492-502
    • Lee, Y.S.1
  • 29
    • 79952994082 scopus 로고    scopus 로고
    • CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    • Sun J., et al. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat. Immunol. 2011, 12:327-334.
    • (2011) Nat. Immunol. , vol.12 , pp. 327-334
    • Sun, J.1
  • 30
    • 78650647259 scopus 로고    scopus 로고
    • Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages
    • Iyer S.S., et al. Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. J. Immunol. 2010, 185:6599-6607.
    • (2010) J. Immunol. , vol.185 , pp. 6599-6607
    • Iyer, S.S.1
  • 31
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 2011, 29:621-663.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 32
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet A.T., et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 2009, 10:167-175.
    • (2009) Nat. Immunol. , vol.10 , pp. 167-175
    • Bauquet, A.T.1
  • 33
    • 79956081339 scopus 로고    scopus 로고
    • The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
    • Ise W., et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 2011, 12:536-543.
    • (2011) Nat. Immunol. , vol.12 , pp. 536-543
    • Ise, W.1
  • 34
    • 77950554986 scopus 로고    scopus 로고
    • C-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells
    • Hiramatsu Y., et al. c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. J. Leuk. Biol. 2010, 87:703-712.
    • (2010) J. Leuk. Biol. , vol.87 , pp. 703-712
    • Hiramatsu, Y.1
  • 35
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva R.I., et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008, 29:138-149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1
  • 36
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman M.A., et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 2010, 207:353-363.
    • (2010) J. Exp. Med. , vol.207 , pp. 353-363
    • Linterman, M.A.1
  • 37
    • 78650357814 scopus 로고    scopus 로고
    • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    • Batten M., et al. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J. Exp. Med. 2010, 207:2895-2906.
    • (2010) J. Exp. Med. , vol.207 , pp. 2895-2906
    • Batten, M.1
  • 38
    • 1842477302 scopus 로고    scopus 로고
    • Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    • Artis D., et al. Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J. Immunol. 2004, 172:4672-4675.
    • (2004) J. Immunol. , vol.172 , pp. 4672-4675
    • Artis, D.1
  • 39
    • 23444445743 scopus 로고    scopus 로고
    • Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice
    • Miyazaki Y., et al. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice. J. Immunol. 2005, 175:2401-2407.
    • (2005) J. Immunol. , vol.175 , pp. 2401-2407
    • Miyazaki, Y.1
  • 40
    • 28244474156 scopus 로고    scopus 로고
    • Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)
    • Shimizu S., et al. Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J. Immunol. 2005, 175:7185-7192.
    • (2005) J. Immunol. , vol.175 , pp. 7185-7192
    • Shimizu, S.1
  • 41
    • 4043122529 scopus 로고    scopus 로고
    • Induction of IgG2a class switching in B cells by IL-27
    • Yoshimoto T., et al. Induction of IgG2a class switching in B cells by IL-27. J. Immunol. 2004, 173:2479-2485.
    • (2004) J. Immunol. , vol.173 , pp. 2479-2485
    • Yoshimoto, T.1
  • 42
    • 34249996831 scopus 로고    scopus 로고
    • IL-27 induces the production of IgG1 by human B cells
    • Boumendjel A., et al. IL-27 induces the production of IgG1 by human B cells. Eur. Cytokine Netw. 2006, 17:281-289.
    • (2006) Eur. Cytokine Netw. , vol.17 , pp. 281-289
    • Boumendjel, A.1
  • 43
    • 33646467806 scopus 로고    scopus 로고
    • Differential effects of IL-27 on human B cell subsets
    • Larousserie F., et al. Differential effects of IL-27 on human B cell subsets. J. Immunol. 2006, 176:5890-5897.
    • (2006) J. Immunol. , vol.176 , pp. 5890-5897
    • Larousserie, F.1
  • 44
    • 83555165176 scopus 로고    scopus 로고
    • Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model
    • Canale S., et al. Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model. Leukemia 2011, 10.1038/leu.2011.158.
    • (2011) Leukemia
    • Canale, S.1
  • 45
    • 27144495833 scopus 로고    scopus 로고
    • How do CD4+CD25+ regulatory T cells control autoimmunity?
    • Bluestone J.A., Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity?. Curr. Opin. Immunol. 2005, 17:638-642.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 638-642
    • Bluestone, J.A.1    Tang, Q.2
  • 46
    • 77951483356 scopus 로고    scopus 로고
    • Plasticity of T reg at infected sites
    • Wohlfert E., Belkaid Y. Plasticity of T reg at infected sites. Mucosal Immunol. 2010, 3:213-215.
    • (2010) Mucosal Immunol. , vol.3 , pp. 213-215
    • Wohlfert, E.1    Belkaid, Y.2
  • 47
    • 51349095960 scopus 로고    scopus 로고
    • Tuning microenvironments: induction of regulatory T cells by dendritic cells
    • Belkaid Y., Oldenhove G. Tuning microenvironments: induction of regulatory T cells by dendritic cells. Immunity 2008, 29:362-371.
    • (2008) Immunity , vol.29 , pp. 362-371
    • Belkaid, Y.1    Oldenhove, G.2
  • 48
    • 33847415066 scopus 로고    scopus 로고
    • Natural regulatory T cells: mechanisms of suppression
    • Miyara M., Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol. Med. 2007, 13:108-116.
    • (2007) Trends Mol. Med. , vol.13 , pp. 108-116
    • Miyara, M.1    Sakaguchi, S.2
  • 49
    • 34447567140 scopus 로고    scopus 로고
    • IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    • Neufert C., et al. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur. J. Immunol. 2007, 37:1809-1816.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1809-1816
    • Neufert, C.1
  • 50
    • 39549114268 scopus 로고    scopus 로고
    • Negative regulation of Th17 responses
    • Stumhofer J.S., et al. Negative regulation of Th17 responses. Semin. Immunol. 2007, 19:394-399.
    • (2007) Semin. Immunol. , vol.19 , pp. 394-399
    • Stumhofer, J.S.1
  • 51
    • 39049152572 scopus 로고    scopus 로고
    • IL-27 inhibits the development of regulatory T cells via STAT3
    • Huber M., et al. IL-27 inhibits the development of regulatory T cells via STAT3. Int. Immunol. 2008, 20:223-234.
    • (2008) Int. Immunol. , vol.20 , pp. 223-234
    • Huber, M.1
  • 52
    • 33644536099 scopus 로고    scopus 로고
    • IL-27 suppresses CD28-medicated IL-2 production through suppressor of cytokine signaling 3
    • Owaki T., et al. IL-27 suppresses CD28-medicated IL-2 production through suppressor of cytokine signaling 3. J. Immunol. 2006, 176:2773-2780.
    • (2006) J. Immunol. , vol.176 , pp. 2773-2780
    • Owaki, T.1
  • 53
    • 29644443883 scopus 로고    scopus 로고
    • IL-27 limits IL-2 production during Th1 differentiation
    • Villarino A.V., et al. IL-27 limits IL-2 production during Th1 differentiation. J. Immunol. 2006, 176:237-247.
    • (2006) J. Immunol. , vol.176 , pp. 237-247
    • Villarino, A.V.1
  • 54
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • Malek T.R. The main function of IL-2 is to promote the development of T regulatory cells. J. Leuk. Biol. 2003, 74:961-965.
    • (2003) J. Leuk. Biol. , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 55
    • 64249118418 scopus 로고    scopus 로고
    • Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow
    • Salcedo R., et al. Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow. J. Immunol. 2009, 182:4328-4338.
    • (2009) J. Immunol. , vol.182 , pp. 4328-4338
    • Salcedo, R.1
  • 56
    • 78651492594 scopus 로고    scopus 로고
    • IL-27 promotes T cell-dependent colitis through multiple mechanisms
    • Cox J.H., et al. IL-27 promotes T cell-dependent colitis through multiple mechanisms. J. Exp. Med. 2011, 208:115-123.
    • (2011) J. Exp. Med. , vol.208 , pp. 115-123
    • Cox, J.H.1
  • 57
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang X.O., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008, 29:44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1
  • 58
    • 79960400849 scopus 로고    scopus 로고
    • A Role for IL-27 in limiting T regulatory cell populations
    • Tait Wojno E.D., et al. A Role for IL-27 in limiting T regulatory cell populations. J. Immunol. 2011, 187:266-273.
    • (2011) J. Immunol. , vol.187 , pp. 266-273
    • Tait Wojno, E.D.1
  • 59
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M., et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 2006, 7:929-936.
    • (2006) Nat. Immunol. , vol.7 , pp. 929-936
    • Batten, M.1
  • 60
    • 79953172216 scopus 로고    scopus 로고
    • Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression
    • Goodman W.A., et al. Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression. J. Immunol. 2011, 186:3336-3345.
    • (2011) J. Immunol. , vol.186 , pp. 3336-3345
    • Goodman, W.A.1
  • 61
    • 79551624297 scopus 로고    scopus 로고
    • The WSX-1 pathway restrains intestinal T-cell immunity
    • McAleer J.P., et al. The WSX-1 pathway restrains intestinal T-cell immunity. Int. Immunol. 2011, 23:129-137.
    • (2011) Int. Immunol. , vol.23 , pp. 129-137
    • McAleer, J.P.1
  • 62
    • 0042932806 scopus 로고    scopus 로고
    • Molecular phylogeny within type I cytokines and their cognate receptors
    • Boulay J.L., et al. Molecular phylogeny within type I cytokines and their cognate receptors. Immunity 2003, 19:159-163.
    • (2003) Immunity , vol.19 , pp. 159-163
    • Boulay, J.L.1
  • 63
    • 0032168152 scopus 로고    scopus 로고
    • Interlukin-6-type cytokine signaling through the gp130/Jak/STAT pathway
    • Heinrich P.C., et al. Interlukin-6-type cytokine signaling through the gp130/Jak/STAT pathway. Biochem. J. 1998, 334:297-314.
    • (1998) Biochem. J. , vol.334 , pp. 297-314
    • Heinrich, P.C.1
  • 64
    • 36248970671 scopus 로고    scopus 로고
    • IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    • Niedbala W., et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur. J. Immunol. 2007, 37:3021-3029.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3021-3029
    • Niedbala, W.1
  • 65
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison L.W., et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450:566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1
  • 66
    • 78449296907 scopus 로고    scopus 로고
    • IL-35-mediated induction of a potent regulatory T cell population
    • Collison L.W., et al. IL-35-mediated induction of a potent regulatory T cell population. Nat. Immunol. 2010, 11:1093-1101.
    • (2010) Nat. Immunol. , vol.11 , pp. 1093-1101
    • Collison, L.W.1
  • 67
    • 0030700003 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    • Devergne O., et al. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:12041-12046.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 12041-12046
    • Devergne, O.1
  • 68
    • 76249108969 scopus 로고    scopus 로고
    • The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
    • Crabe S., et al. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J. Immunol. 2009, 183:7692-7702.
    • (2009) J. Immunol. , vol.183 , pp. 7692-7702
    • Crabe, S.1
  • 69
    • 68249142908 scopus 로고    scopus 로고
    • The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses
    • Shimozato O., et al. The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses. Immunology 2009, 128:e816-e825.
    • (2009) Immunology , vol.128
    • Shimozato, O.1
  • 70
    • 78650602324 scopus 로고    scopus 로고
    • IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants
    • Rousseau F., et al. IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:19420-19425.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 19420-19425
    • Rousseau, F.1
  • 71
    • 78449300568 scopus 로고    scopus 로고
    • A role for IL-27p28 as an antagonist of gp130-mediated signaling
    • Stumhofer J.S., et al. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat. Immunol. 2010, 11:1119-1126.
    • (2010) Nat. Immunol. , vol.11 , pp. 1119-1126
    • Stumhofer, J.S.1
  • 72
    • 47249124078 scopus 로고    scopus 로고
    • Human regulatory T cells: role in autoimmune disease and therapeutic opportunities
    • Brusko T.M., et al. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol. Rev. 2008, 223:371-390.
    • (2008) Immunol. Rev. , vol.223 , pp. 371-390
    • Brusko, T.M.1
  • 73
    • 34547749066 scopus 로고    scopus 로고
    • Emerging challenges in regulatory T cell function and biology
    • Sakaguchi S., Powrie F. Emerging challenges in regulatory T cell function and biology. Science 2007, 317:627-629.
    • (2007) Science , vol.317 , pp. 627-629
    • Sakaguchi, S.1    Powrie, F.2
  • 74
    • 50949129546 scopus 로고    scopus 로고
    • Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis
    • Jaron B., et al. Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis. PLoS ONE 2008, 3:e2833.
    • (2008) PLoS ONE , vol.3
    • Jaron, B.1
  • 75
    • 63849333830 scopus 로고    scopus 로고
    • Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines
    • Ruter J., et al. Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines. Front. Biosci. 2009, 14:1761-1770.
    • (2009) Front. Biosci. , vol.14 , pp. 1761-1770
    • Ruter, J.1
  • 76
    • 0842347431 scopus 로고    scopus 로고
    • Potent antitumor activity of interleukin-27
    • Hisada M., et al. Potent antitumor activity of interleukin-27. Cancer Res. 2004, 64:1152-1156.
    • (2004) Cancer Res. , vol.64 , pp. 1152-1156
    • Hisada, M.1
  • 77
    • 10344228778 scopus 로고    scopus 로고
    • IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells
    • Salcedo R., et al. IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells. J. Immunol. 2004, 173:7170-7182.
    • (2004) J. Immunol. , vol.173 , pp. 7170-7182
    • Salcedo, R.1
  • 78
    • 40449100736 scopus 로고    scopus 로고
    • IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    • Cao Y., et al. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J. Immunol. 2008, 180:922-930.
    • (2008) J. Immunol. , vol.180 , pp. 922-930
    • Cao, Y.1
  • 79
    • 40449137091 scopus 로고    scopus 로고
    • Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection
    • Mayer K.D., et al. Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J. Immunol. 2008, 180:693-697.
    • (2008) J. Immunol. , vol.180 , pp. 693-697
    • Mayer, K.D.1
  • 80
    • 78650338317 scopus 로고    scopus 로고
    • IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells
    • Schneider R., et al. IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells. Eur. J. Immunol. 2011, 41:47-59.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 47-59
    • Schneider, R.1
  • 81
    • 45549106117 scopus 로고    scopus 로고
    • Antiproliferative activity of IL-27 on melanoma
    • Yoshimoto T., et al. Antiproliferative activity of IL-27 on melanoma. J. Immunol. 2008, 180:6527-6535.
    • (2008) J. Immunol. , vol.180 , pp. 6527-6535
    • Yoshimoto, T.1
  • 82
    • 77952483010 scopus 로고    scopus 로고
    • IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities
    • Ho M.Y., et al. IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities. J. Immunol. 2009, 183:6217-6226.
    • (2009) J. Immunol. , vol.183 , pp. 6217-6226
    • Ho, M.Y.1
  • 83
    • 77955720345 scopus 로고    scopus 로고
    • Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma
    • Cocco C., et al. Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma. Clin. Cancer Res. 2010, 16:4188-4197.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4188-4197
    • Cocco, C.1
  • 84
    • 79955064497 scopus 로고    scopus 로고
    • Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells
    • Sasaoka T., et al. Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells. Am. J. Physiol. Gastroenterol. Liver Physiol. 2011, 300:G568-G576.
    • (2011) Am. J. Physiol. Gastroenterol. Liver Physiol. , vol.300
    • Sasaoka, T.1
  • 85
    • 78951491805 scopus 로고    scopus 로고
    • Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis
    • Rajaiah R., et al. Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis. J. Biol. Chem. 2011, 286:2817-2825.
    • (2011) J. Biol. Chem. , vol.286 , pp. 2817-2825
    • Rajaiah, R.1
  • 86
    • 51049094818 scopus 로고    scopus 로고
    • Interleukin 27 attenuates collagen-induced arthritis
    • Niedbala W., et al. Interleukin 27 attenuates collagen-induced arthritis. Ann. Rheum. Dis. 2008, 67:1474-1479.
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1474-1479
    • Niedbala, W.1
  • 87
    • 35648988381 scopus 로고    scopus 로고
    • Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
    • Fitzgerald D.C., et al. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 2007, 179:3268-3275.
    • (2007) J. Immunol. , vol.179 , pp. 3268-3275
    • Fitzgerald, D.C.1
  • 88
    • 47249144061 scopus 로고    scopus 로고
    • Amelioration of delayed-type hypersensitivity responses by IL-27 administration
    • Miyazaki Y., et al. Amelioration of delayed-type hypersensitivity responses by IL-27 administration. Biochem. Biophys. Res. Commun. 2008, 373:397-402.
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 397-402
    • Miyazaki, Y.1
  • 89
    • 38149045608 scopus 로고    scopus 로고
    • IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation
    • Yoshimoto T., et al. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol. 2007, 179:4415-4423.
    • (2007) J. Immunol. , vol.179 , pp. 4415-4423
    • Yoshimoto, T.1
  • 90
    • 78649741783 scopus 로고    scopus 로고
    • Gp130 at the nexus of inflammation, autoimmunity, and cancer
    • Silver J.S., Hunter C.A. gp130 at the nexus of inflammation, autoimmunity, and cancer. J. Leuk. Biol. 2010, 88:1145-1156.
    • (2010) J. Leuk. Biol. , vol.88 , pp. 1145-1156
    • Silver, J.S.1    Hunter, C.A.2
  • 91
    • 33947626493 scopus 로고    scopus 로고
    • Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population
    • Chae S.C., et al. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. J. Hum. Genet. 2007, 52:355-361.
    • (2007) J. Hum. Genet. , vol.52 , pp. 355-361
    • Chae, S.C.1
  • 92
    • 70649113728 scopus 로고    scopus 로고
    • Common variants at five new loci associated with early-onset inflammatory bowel disease
    • Imielinski M., et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat. Genet. 2009, 41:1335-1340.
    • (2009) Nat. Genet. , vol.41 , pp. 1335-1340
    • Imielinski, M.1
  • 93
    • 70349659805 scopus 로고    scopus 로고
    • Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population
    • Li C.S., et al. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. J. Gastroenterol. Hepatol. 2009, 24:1692-1696.
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 1692-1696
    • Li, C.S.1
  • 94
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff A., et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 1999, 397:263-266.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1
  • 95
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski R., et al. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 2009, 182:2859-2867.
    • (2009) J. Immunol. , vol.182 , pp. 2859-2867
    • Spolski, R.1
  • 96
    • 77956207524 scopus 로고    scopus 로고
    • In vivo regulation of Bcl6 and T follicular helper cell development
    • Poholek A.C., et al. In vivo regulation of Bcl6 and T follicular helper cell development. J. Immunol. 2010, 185:313-326.
    • (2010) J. Immunol. , vol.185 , pp. 313-326
    • Poholek, A.C.1
  • 97
    • 79952637807 scopus 로고    scopus 로고
    • IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
    • Eto D., et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE 2011, 6:e17739.
    • (2011) PLoS ONE , vol.6
    • Eto, D.1
  • 98
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 99
    • 2942692037 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    • Herman A.E., et al. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 2004, 199:1479-1489.
    • (2004) J. Exp. Med. , vol.199 , pp. 1479-1489
    • Herman, A.E.1
  • 100
    • 43549110961 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by IL-17F
    • Yang X.O., et al. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 2008, 205:1063-1075.
    • (2008) J. Exp. Med. , vol.205 , pp. 1063-1075
    • Yang, X.O.1
  • 101
    • 70049118519 scopus 로고    scopus 로고
    • Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    • Collison L.W., et al. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J. Immunol. 2009, 182:6121-6128.
    • (2009) J. Immunol. , vol.182 , pp. 6121-6128
    • Collison, L.W.1
  • 102
    • 77953627758 scopus 로고    scopus 로고
    • IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10
    • Kochetkova I., et al. IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. J. Immunol. 2010, 184:7144-7153.
    • (2010) J. Immunol. , vol.184 , pp. 7144-7153
    • Kochetkova, I.1
  • 103
    • 79960434330 scopus 로고    scopus 로고
    • Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2 cell line can be effectively attenuated by IL-35
    • Huang C.H., et al. Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2 cell line can be effectively attenuated by IL-35. J. Immunol. 2011, 187:462-471.
    • (2011) J. Immunol. , vol.187 , pp. 462-471
    • Huang, C.H.1
  • 104
    • 79953030082 scopus 로고    scopus 로고
    • Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients
    • Liu F., et al. Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients. Clin. Immunol. 2011, 139:1-5.
    • (2011) Clin. Immunol. , vol.139 , pp. 1-5
    • Liu, F.1
  • 105
    • 79959572627 scopus 로고    scopus 로고
    • Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance
    • Chaturvedi V., et al. Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J. Immunol. 2011, 186:6661-6666.
    • (2011) J. Immunol. , vol.186 , pp. 6661-6666
    • Chaturvedi, V.1
  • 106
    • 58149188484 scopus 로고    scopus 로고
    • Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35
    • Bardel E., et al. Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35. J. Immunol. 2008, 181:6898-6905.
    • (2008) J. Immunol. , vol.181 , pp. 6898-6905
    • Bardel, E.1
  • 107
    • 77249097317 scopus 로고    scopus 로고
    • Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice
    • Tong H., et al. Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice. Immunol. Lett. 2010, 128:108-115.
    • (2010) Immunol. Lett. , vol.128 , pp. 108-115
    • Tong, H.1
  • 108
    • 79960110593 scopus 로고    scopus 로고
    • Interleukin-35 enhances lyme arthritis in borrelia-vaccinated and -infected mice
    • Kuo J., et al. Interleukin-35 enhances lyme arthritis in borrelia-vaccinated and -infected mice. Clin. Vaccine Immunol. 2011, 18:1125-1132.
    • (2011) Clin. Vaccine Immunol. , vol.18 , pp. 1125-1132
    • Kuo, J.1


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