Regulation of interleukin-12 production in antigen-presenting cells

Advances in Immunology

Volumn 79, Issue , 2001, Pages 55-92

  Ma, X ^a   Trinchieri, G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ENDOTOXIN; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR;

ANTIGEN PRESENTING CELL; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034763143     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(01)79002-5     Document Type: Review

References (183)

1. Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells
2. Differential ability of human blood monocyte subsets to release various cytokines
3. CCR5 provides a signal for microbial induced production of IL-12 by CD8a+dendritic cells
4. CD47 ligation selectively downregulates human interleukin 12 production
5. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
6. Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-α and IL-12 production by monocytes and dendritic cells
7. CD47 Ligation selectively inhibits the development of human native T cells into Th1 effectors
8. Expression of murine IL-12 is regulated by translational control of the p35 subunit
9. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12
10. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes
11. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia
12. Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
13. IL-12 expression in AIDS-related lymphoma B cell lines
14. Immune complexes are potent inhibitors of interleukin-12 secretion by human monocytes
15. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ
16. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
17. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection
18. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor β1 and β2 chain expression
19. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
20. Type I interferons and IL-12: Convergence and cross-regulation among mediators of cellular immunity
21. Suppression of macrophage IL-12 transcription following Fcg receptor ligation
22. Biosynthesis and posttranslational regulation of human IL-12
23. Interleukin-12 production by human polymorphonuclear leukocytes
24. The transcription factor PU.1 is involved in macrophage proliferation
25. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
26. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
27. Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130
28. Cloning and characterization of a mouse IL-12 receptor-β component
29. Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway
30. Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling
31. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection
32. Two roads diverged: Interferon α/β- and interleukin-12-mediated pathways in promoting T cell interferon gamma responses during viral infection
33. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NFκB downregulation in transcriptional repression of the p40 gene
34. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
35. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production
36. Regulation of B lymphocyte and macrophage development by graded expression of PU.1
37. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor κB and ets activation
38. IL-12 receptor. II. Distribution and regulation of receptor expression
39. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
40. Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-β in ANA-1 cells
41. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
42. PU.1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91 (phox) expression
43. Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors
44. Listeriosis in p47(phox-/-) and TRp55-/- mice: Protection despite absence of ROI and susceptibility despite presence of RNI
45. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
46. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
47. Role of PU.1 in hematopoiesis
48. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α
49. Thrombospondin modulates α v β 3 function through integrin-associated protein
50. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
51. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor
52. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
53. Suppression of IL-12 transcription in macrophages following Fc gamma receptor ligation
54. Synergistic regulation of the human interleukin-12 p40 promoter by NFκB and ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages
55. IL-12 acts directly on DC to promote nuclear localization of NFκB and primes DC for IL-12 production
56. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
57. Cell-type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
58. Stimulation of betaadrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice
59. Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes
60. Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells
61. Generation of a cloned NK cell line derived from the "null cell" fraction of human peripheral blood
62. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
63. PU.1/Pip and basic helix loop helix zipper transcription factors interact with binding sites in the CD20 promoter to help confer lineage- and stage-specific expression of CD20 in B lymphocytes
64. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
65. Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages
66. Inhibition of interferon gamma induced interleukin 12 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factor
67. IL-10 and the dangers of immune polarization: Excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
68. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
69. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
70. IL-4 is a mediator of IL-12 p70 induction by human Th2 cells: Reversal of polarized Th2 phenotype by dendritic cells
71. Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens
72. IL-12 synthesis by human Langerhans cells
73. Mechanism of suppression of cell-mediated immunity by measles virus
74. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance
75. Interferon β in multiple sclerosis: Is IL-12 suppression the key?
76. Modulation of natural killer activity in mice following infection with Listeria monocytogenes
77. CD40/CD40 ligand interactions are required for T celldependent production of interleukin-12 by mouse macrophages
78. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
79. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
80. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
81. Causing a commotion in the blood: Immunotherapy progresses from bacteria to bacterial DNA
82. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells
83. Effects of a corticosteroid, budesonide, on production of bioactive IL-12 by human monocytes
84. Subtherapeutic doses of interleukin-15 augment the antitumor effect of interleukin-12 in a B16F10 melanoma model in mice
85. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-γ production
86. Molecular cloning of integrinassociated protein: An immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding
87. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
88. Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes
89. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
90. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
91. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
92. Inhibition of IL-12 production in human monocyte-derived macrophages by TNF
93. Dendritic cells produce IL-12 and direct the development of Th 1 cells from naive CD4+ T cells
94. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
95. Polyinosinic acid: Polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-α and interleukin-12
96. Characterization of tumor necrosis factor-deficient mice
97. Priming with IL-4 and IL-13 during HIV-1 infection restores in vitro IL-12 production by mononuclear cells of HIV-infected patients
98. Regulation of interleukin-12 by complement receptor 3 signaling
99. Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-κB
100. Sequence similarity between NKSF and the IL-6/G-CSF family
101. Inhibition of IL-12 production by thalidomide
102. Inhibition of human interleukin-12 production by pentoxifylline
103. Disparate intracellular processing of human IL-12 preprotein subunits: Atypical processing of the P35 signal peptide
104. Regulation of interleukin 12 p40 expression through an NF-κB half site
105. IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells
106. Endotoxin-induced serum factor that stimulates gamma interferon production
107. The interleukin-12 β subunit (p40) maps to mouse chromosome 11
108. Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
109. Novel p19 protein engages IL-12 p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
110. Mutation analysis of the Pip interaction domain reveals critical residues for protein-protein interactions
111. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
112. β2-agonists prevent Th1 development by selective inhibition of interleukin 12
113. CD11b/CD18 acts in concert with CD14 and toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression
114. A leukocyte subset bearing HLA-DR antigens is responsible for in vitro alpha interferon production in response to viruses
115. Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells
116. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
117. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
118. PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3′ enhancer activity
119. Effect of PU.1 phospholylation on interaction with NF-EM5 and transcriptional activation
120. Rare polymorphisms in the promoter regions of the human interleukin-12 p35 and interleukin-12 p40 subunit genes: Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene
121. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
122. Differential inhibitory mechanism of cyclic AMP on TNF-alpha and IL-12 synthesis by macrophages exposed to microbial stimuli
123. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
124. Gamma interferon induction in human thymocytes activated by lectins and B cell lines
125. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology
126. Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: Synergistic activation of interleukin 12 production
127. Reciprocal control of T helper cell and dendritic cell differentiation
128. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
129. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
130. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction
131. Cloning and expression of murine IL-12
132. The ets-related transcription factor PU.1 immortalizes erythroblasts
133. Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon gamma, and IL-10: Role of B cells in the maintenance of T cell responses
134. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
135. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
136. Assignment of genes encoding a unique cytokine (IL 12) composed of two unrelated subunits to chromoscomes 3 and 5
137. Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3
138. High-level IL-12 production by human dendritic cells requires two signals
139. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
140. Bacterial DNA causes septic shock
141. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
142. Scavenger receptor-mediated delivery of muramyl dipeptide activates antitumor efficacy of macrophages by enhanced secretion of tumor-suppressive cytokines
143. Macrophages ingest and are activated by bacterial DNA
144. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
145. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
146. Selective suppression of interleukin-12 induction after macrophage receptor ligation
147. Morphological transformation of microglia in vitro
148. The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model
149. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
150. Cytokine receptors and signal transduction
151. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4
152. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
153. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
154. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
155. Bacterial activation of human natural killer cells. Characteristics of the activation process and identification of the effector cell
156. Oligosaccharides of hyaluronan are potent activators of dendritic cells
157. Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors
158. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes
159. Interleukin-12 and its role in the generation of TH1 cells
160. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production
161. Histamine inhibits the production of interleukin-12 through interaction with H2 receptors
162. Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
163. Residual type 1 immunity in patients genetically deficient for interleukin-12 receptor β1 (IL-12Rβ1). Evidence for an il-12rβ1-independent pathway of IL-12 responsiveness in human T cells
164. Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro
165. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
166. Bacterial CpG DNA activates immune cells to signal infectious danger
167. An IFNγ-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages
168. Interferon-γ-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major
169. Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription
170. Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
171. Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide
172. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
173. CD18-deficient cells respond to lipopolysaccharide in vitro
174. Adhesion-promoting receptors on human macrophages recognize. Escherichia coli by binding to lipopolysaccharide
175. Biological function and distribution of human interleukin-12 receptor beta chain
176. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity
177. Identification of a cell membrane receptor for interferon induction by poly rI:rC
178. Molecular cloning and characterization of murine IL-12 genes
179. IL-12 directly up-regulates the expression of HLA class I, HLA class II and ICAM-1 on human melanoma cells: A mechanism for its antitumor activity?
180. Control of IL-12 and IFN-γ production in response to live or dead bacteria by TNF and other factors
181. Interferon γ-independent rejection of interleukin 12-transduced carcinoma cells requires CD4+ T cells and granulocyte/macrophage colony-stimulating factor
182. Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits β1 and β2 and JAK kinases