Regulation of the IL-12/IL-12R axis: A critical step in T-helper cell differentiation and effector function

Immunological Reviews

Volumn 170, Issue , 1999, Pages 65-72

  Sinigaglia, Francesco ^a   D'Ambrosio, Daniele ^a   Panina Bordignon, Paola ^a   Rogge, Lars ^a  

^a ROCHE MILANO RICERCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; RECEPTOR SUBUNIT; STAT4 PROTEIN;

ALLERGIC ASTHMA; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPER CELL; HUMAN; HUMAN CELL; LEUKOCYTE MOTILITY; LUNG SARCOIDOSIS; PHAGOCYTE; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL DIFFERENTIATION; CELL MOVEMENT; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; INTERFERON TYPE II; INTERFERONS; INTERLEUKIN-12; INTERLEUKIN-18; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 0032882699     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1999.tb01329.x     Document Type: Review

References (80)

1. 1. Mosmann TR, Coffman RL. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
2. 2. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994;12:227-257.
3. 3. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
4. + T cells from T cell receptor transgenic mice. J Exp Med 1992;176:1091-1098.
5. 5. Hsieh CS, Heimberger AB, Gold JS, O'Garra A, Murphy KM. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T cell-receptor transgenic system. Proc Natl Acad Sci USA 1992;89:6065-6069.
6. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-549.
7. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 1993;90:10188-10192.
8. 8. Manetti R, et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper 1 type (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993;177:1199-1204.
9. 9. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-276.
10. 10. Gately MK, et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998;16:495-521.
11. 11. Gazzinelli RT, Hieny S. Wynn TA, Wolf S, Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon of γ by an intracellular parasite and reduces resistance in T-cell deficient hosts. Proc Natl Acad Sci USA 1993;90:6115-6119.
12. 12. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-252.
13. + T cells. J Immunol 1995;154:5071-5079.
14. 14. Cella M, Scheidegger D, Palmerlehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996;184:747-752.
15. 15. Koch F, et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 1996;184:741-746.
16. 16. Grewal IS, Flavel R. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998;16:111-135.
17. 17. Rissoan MC, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999;283:1183-1186.
18. 18. Meyer DJ, Muimo R, Thomas M, Coates D, Isaac RE. Purification and characterization of prostaglandin-H E-isomerase, a sigma-class glutathione S-transferase, from Ascaridia galli. Biochem J 1996;313:223-227.
19. + T-cell subsets. Proc Natl Acad Sci USA 1994;91:18-22.
20. 20. Chougnet C, et al. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J Inf Dis 1996;174:46-53.
21. 21. Chehimi J, et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994;179:1361-1366.
22. 22. Karp CL, et al. Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996;273:228-231.
23. 23. Sutterwala F, Noel GJ, Clynes R, Mosser DM. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J Exp Med 1997;185:1977-1985.
24. 24. Marth T, Kelsall B. Regulation of interleukin-12 by complement receptor 3 signaling. J Exp Med 1997;185:1987-1995.
25. 25. Van der Pouw Kraan TCTM, Boeije LCM, Smeenk RJT, Wijdenes J, Aarden LA. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995;181:775-779.
26. 2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest 1997;100:1513-1519.
27. 27. D'Ambrosio D, et al. Inhibition of IL-12 production by 1,25-dihydroxivitamin D3: involvement of NF-κB downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998;101:252-262.
28. 28. Van der Pouw Kraan TCTM, et al. Histamine inhibits the production of interleukin-12 through interaction with H-2 receptors. J Clin Invest 1998;102:1866-1873.
29. 29. Mazzeo D, Panina-Bordignon P, Recalde H, Sinigaglia F, D'Ambrosio D. Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-κB. Eur J Immunol 1998;28:3205-3213.
30. + lymphocytes by inhibiting IL-12 production. J Immunol 1998;160:2231-2237.
31. 31. Huang FP, et al. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur J Immunol 1998;28:4062-4070.
32. 32. Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck and FynT-dependent T cell activation. J Biol Chem 1996;271:695.
33. 33. Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4-deficient mice. Nature 1996;382:174-177.
34. 34. Thierfelder WE, et al. Requirement for STAT4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996;382:171-174.
35. 35. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. STAT6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 1996;4:313-319.
36. 36. Shimoda K, et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted STAT6 gene. Nature 1996;380:630-633.
37. 37. Takeda K, et al. Essential role of STAT6 in IL-4 signalling. Nature 1996;380:627-630.
38. 38. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 1995;2:665-675.
39. 39. Rogge L, Barberis-Maino L, Passini N, Presky DH, Gubler U, Sinigaglia F. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 1997;185:825-832.
40. 40. Hilkens CMU, et al. Lack of IL-12 signaling in human allergen-specific Th2 cells. J Immunol 1996;157:4316-4321.
41. 41. Taki S, et al. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 1997;6:673-679.
42. 42. Lohoff M, et al. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 1997;6:681-689.
43. 43. Coccia EM, Passini N, Battistini A, Pini C, Sinigaglia F, Rogge L. Interleukin-12 induces expression of Interferon regulatory factor-1 via signal transducer and activator of transcription 4 in human T helper type I cells. J Biol Chem 1999;274:6698-6703.
44. 44. Chua AO, et al. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 1994;153:128-136.
45. 45. Presky DH, et al. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc Natl Acad Sci USA 1996;93:14002-14007.
46. 46. Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R β 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997;185:817-824.
47. 47. Braun MC, He J, Wu CY, Kelsall B. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor β1 and β2 chain expression. J Exp Med 1999;189:541-552.
48. 48. Parronchi P, et al. Effects of interferon-α on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells. Eur J Immunol 1996;26:697-703.
49. + T cells. J Exp Med 1993;178:1655-1663.
50. 50. Rogge L, et al. The role of STAT4 in species-specific regulation of Th cell development by type I IFNs. J Immunol 1998;161:6567-6574.
51. 51. Sareneva T, Matikainen S, Kurimoto M, Julkunen I. Influenza A virus-induced IFN α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells. J Immunol 1998;160:6032-6038.
52. 52. Dayal A, Jensen MA, Lledo A, Arnason RGW. Interferon-γ-secreting cells in multiple sclerosis patients treated with Interferon β-1b. Neurology 1995;45:2173-2177.
53. + T cells from human immunodeficiency virus-infected individuals. Blood 1997;89:3672-3681.
54. 54. Cho SS, et al. Activation of STAT4 by IL-12 and IFN-α. Evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol 1996;157:4781-4789.
55. 55. Wenner CA, et al. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J Immunol 1996;156:1442-1447.
56. 56. Okamura H, et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 1995;378:88-91.
57. 57. Robinson D, et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF κ B. Immunity 1997;7:571-581.
58. 58. Xu D, et al. Selective expression and functions of interluekin 18 receptor on T helper (Th) type I but not Th2 cells. J Exp Med 1998;188:1485-1492.
59. 59. Locksley RM, Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion, and effector function. Immunol Today 1991;12:58-61.
60. 60. Guler ML, Jacobson NG, Gubler U, Murphy KM. T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development. J Immunol 1997;159:1767-1774.
61. 61. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996;85:299-302.
62. 62. Chang JT, Shevach EM, Segal BM. Regulation of interleukin (IL)-12 receptor β2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 1999;189:969-978.
63. 63. de Jong R, et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 1998;280:1435-1438.
64. 64. Altare F, et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998;280:1432-1435.
65. 65. Rogge L, et al. Antibodies to the interleukin 12 receptor β2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J Immunol 1999;162:3926-3932.
66. 66. Zhang M, Gong J, Presky D, Xue W, Barnes PF. Expression of the II-12 receptor β1 and β2 subunits in human tuberculosis. J Immunol 1999;161:2441-2447.
67. 67. Del Prete GF, et al. Purified protein derivative of Mycobacteriurn tuberculosis and excretory/secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991;88:346-350.
68. 68. Moller DR, et al. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol 1996;156:4952-4960.
69. + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158:3539-3544.
70. 70. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-314.
71. 71. Austrup F, et al. P-and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 1997;385:81-83.
72. 72. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 1997;389:978-981.
73. 73. Leung DY, Gately M, Trumble A, Ferguson-Darnell B, Schlievert PM, Picker LJ. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 1995;181:747-753.
74. 74. Wagers AJ, Waters CM, Stoolman LM, Kansas GS. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on α1,3-fucosyltransferase VII gene expression. J Exp Med 1998;188:2225-2231.
75. 75. Lim YC, Henault L, Wagers L, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol 1999;162:3193-3201.
76. 76. Bonecchi R, et al. Differential expression of chemokine receptors and chemotactic responsiveness of Th1 and Th2 cells. J Exp Med 1998;187:129-134.
77. 77. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998;187:875-883.
78. 78. Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B. CCR5 is characteristic of Th1 lymphocytes. Nature 1998;391:344-345.
79. 79. Rott O, Evelyne C, Fleischer B. Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1-but not type 2-associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats. Eur J Immunol 1993;23:1745-1749.
80. 80. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-1048.