Biosynthesis and posttranslational regulation of human IL-12

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4752-4761

  Carra, Giuseppe ^a   Gerosa, Franca ^a   Trinchieri, Giorgio ^b,c  

^a UNIVERSITY OF VERONA   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

^c WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; SIALIC ACID;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; GLYCOSYLATION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN STRUCTURE;

EID: 0034194222     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4752     Document Type: Article

References (32)

1. Trinchieri, G. 1998. Interleukin-12: a cylokine at the interface of inflammation and immunity. Adv. Immunol. 70:83.
2. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin-12 p40 gene promoter is primed by interferon-γ in monocytic cells. J. Exp. Med. 183:147.
3. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
4. Podlaski, F. J., V. B. Nanduri, J. D. Hulmes, Y. E. Pan, W. Levin, W. Danho, R. Chizzonite, M. K. Gately, and A. S. Stern. 1992. Molecular characterization of interleukin 12. Arch. Biochem. Biophys. 294:230.
5. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. E. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Truitt, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad Sci. USA 87:6708.
6. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
7. Snijders, A., P. Kalinski, C. M. U. Hilkens, and M. K. Kapsember. 1998. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10:1593.
8. Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25: 200.
9. Gately, M. K., D. M. Carvajal, S. E. Connaughton, S. Gillessen, R. R. Warrier, K. D. Kolinsky, V. L. Wilkinson, C. M. Dwyer, G. F. Higgins, Jr., F. J. Podlaski, et al. 1996. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. NY Acad. Sci. 795:1.
10. Heinzel, F. P., A. M. Hujer, F. N. Ahmed, and R. M. Rerko. 1997. In vivo production and function of IL-12 p40 homodimers. J. Immunol. 158:4381.
11. Ling, P., M. K. Gately, U. Gubler, A. S. Stern, P. Lin, K. Hollfelder, C. Su, Y. C. Pan, and J. Hakimi. 1995. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 154:116.
12. Aste-Amezaga, M., X. Ma, A. Sartori, and G. Trinchieri. 1998. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J. Immunol. 160: 5936.
13. Drickamer, K., and M. E. Taylor. 1998. Evolving views of protein glycosylation. Trends Biol. Sci. 23:321.
14. Lis, H., and N. Sharon. 1993. Protein glycosylation: structural and functional aspects. Eur. J. Biochem. 218:1.
15. Hurtley, S. M., and A. Helenius. 1989. Protein oligomerization in the endoplasmic reticulum. Annu. Rev. Cell Biol. 5:277.
16. Schroeder, K., B. Martoglio, M. Hofmann, C. Holscher, E. Hartmann, S. Prehn, T. A. Rapoport, and B. Dobberstein. 1999. Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J. 18: 4804.
17. D'Andrea, A., X. Ma, M. Aste-Amezaga, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor a production. J. Exp. Med. 181:537.
18. Ploegh, H. L. 1995. Post-translational modification: glycosylation. In Current Protocols in Protein Science. J. E. Coligan, B. M. Dunn, H. L. Ploegh, D. W. Speicher, and P. T. Wingfield, eds. John Wiley & Sons, New York.
19. Harlow, E., and D. Lane. 1988. Immunoprecipitation. In Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, New York, p. 421.
20. Maizel, J. V. 1971. Polyacrylamide gel electrophoresis of viral proteins. In Methods in Virology, Vol. 5. K. Maramorosch and H. Koprowski, eds. Academic, New York, p. 179.
21. O'Farrel, P. Z., H. M. Goodman, and P. H. O'Farrel. 1977. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell 12:1133.
22. Mole, L. E. 1975. A genetic marker in the variable region of rabbit immunoglobulin heavy chain. Biochem. J. 151:351.
23. Elder, J. H., and S. Alexander. 1982. Endo-B-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins. Proc. Natl. Acad. Sci. USA 79:4540.
24. Neefjes, J. J., V. Stollrz, P. J. Peters, H. J. Geuze, and H. L. Ploegh. 1990. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell 61:171.
25. Tarentino, A. L., and T. H. Plummer. 1994. Enzymatic deglycosylation of asparagine-linked glycans: purification, properties and specificity of oligosaccharide-cleaving enzymes from Flavobacterium meningosepticum. Methods Enzymol. 230:44.
26. Huttner, W. B. 1988. Tyrosine sulfation and the secretory pathway. Annu. Rev. Physiol. 50:363.
27. Dwyer, D. S. 1996. Molecular model of interleukin 12 that highlights amino acid sequence homologies with adhesion domains and gastrointestinal peptides. J. Mol. Graphics 14:148.
28. Gearing, D. P., and D. Cosman. 1990. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66:9.
29. Ozmen, M. F., F. J. Podlaski, V. L. Wilkinson, D. H. Presky, M. K. Gately, and G. Alber. 1997. Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor α-dependent shock. Infect. Immun. 65:4734.
30. Snijders, A., C. M. U. Hilkens, T. C. T. M. van der Pouw Kraan, M. Engel, L. A. Aarden, and M. L. Kapsenberg. 1996. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocyles is determined by the expression of the p35 subunit. J. Immunol. 156:1207.
31. Haynes, M. P., F. J. Murphy, and P. R. Burd. 1998. Interferon-γ-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells. Blood 91:4645.
32. Babik, J. M., E. Adams, Y. Tone, P. J. Fairchild, M. Tone, and H. Waldmann. 1999. Expression of murine IL-12 is regulated by translational control of the p35 subunit. J. Immunol. 162:4069.