메뉴 건너뛰기




Volumn 127, Issue 6, 1999, Pages 1295-1304

IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: Regulation of T helper 1/T helper 2 responses

Author keywords

Autoimmune disease; Catecholamine; Cytokines; Inflammation; Interferon ; Interleukin 10; Interleukin 2; Interleukin 4; Nitric oxide; Transcription factors

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE; CALCITONIN GENE RELATED PEPTIDE; CAPTOPRIL; CLOBETASOL; CYCLIC AMP; CYTOKINE ANTIBODY; DEXAMETHASONE; GLIBENCLAMIDE; GLUCOCORTICOID; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; LISINOPRIL; N(G) METHYLARGININE; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN P40; SALBUTAMOL;

EID: 0032773289     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702689     Document Type: Review
Times cited : (63)

References (129)
  • 2
    • 0028910222 scopus 로고
    • Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12
    • Bacon, C.M., McVicar, D.W., Ortaldo, J.R., Rees, R.C., O'Shea, J.J. & Johnston, J.A. (1995). Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med., 181, 399-404.
    • (1995) J. Exp. Med. , vol.181 , pp. 399-404
    • Bacon, C.M.1    McVicar, D.W.2    Ortaldo, J.R.3    Rees, R.C.4    O'Shea, J.J.5    Johnston, J.A.6
  • 4
    • 0028815553 scopus 로고
    • Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
    • Berg, D.J., Kühn, R., Rajewsky, K., Müller, W., Menon, S., Davidson, N., Grünig, G. & Rennick, D. (1995). Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest., 96, 2339-2347.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2339-2347
    • Berg, D.J.1    Kühn, R.2    Rajewsky, K.3    Müller, W.4    Menon, S.5    Davidson, N.6    Grünig, G.7    Rennick, D.8
  • 5
    • 0031019163 scopus 로고    scopus 로고
    • Activation and function of natural killer cell responses during viral infections
    • Biron, C.A. (1997). Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol., 9, 24-34.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 24-34
    • Biron, C.A.1
  • 7
    • 0033081332 scopus 로고    scopus 로고
    • Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression
    • Braun, M.C., He, J., Wu, C.Y. & Kelsall, B.L. (1999). Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J. Exp. Med., 189, 541-552.
    • (1999) J. Exp. Med. , vol.189 , pp. 541-552
    • Braun, M.C.1    He, J.2    Wu, C.Y.3    Kelsall, B.L.4
  • 8
    • 0032534750 scopus 로고    scopus 로고
    • Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline
    • Bright, J.J., Du, C., Coon, M., Sriram, S. & Klaus, S.J. (1998). Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: an effect of the novel anti-inflammatory drug lisofylline. J. Immunol., 161, 7015-7022.
    • (1998) J. Immunol. , vol.161 , pp. 7015-7022
    • Bright, J.J.1    Du, C.2    Coon, M.3    Sriram, S.4    Klaus, S.J.5
  • 9
    • 0032936918 scopus 로고    scopus 로고
    • Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change
    • Bussolati, B., Mariano, F., Biancone, L., Foa, R., David, S., Cambi, V. & Camussi, G. (1999). Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. Am. J. Pathol., 154, 623-632.
    • (1999) Am. J. Pathol. , vol.154 , pp. 623-632
    • Bussolati, B.1    Mariano, F.2    Biancone, L.3    Foa, R.4    David, S.5    Cambi, V.6    Camussi, G.7
  • 11
    • 0031752298 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 restores sensitivity to cyclophosphamide-induced apoptosis in non-obese diabetic (NOD) mice and protects against diabetes
    • Casteels, K., Waer, M., Bouillon, R., Depovere, J., Valckx, D., Laureys, J. & Mathieu, C. (1998). 1,25-Dihydroxyvitamin D3 restores sensitivity to cyclophosphamide-induced apoptosis in non-obese diabetic (NOD) mice and protects against diabetes, Clin. Exp. Immunol., 112, 181-187.
    • (1998) Clin. Exp. Immunol. , vol.112 , pp. 181-187
    • Casteels, K.1    Waer, M.2    Bouillon, R.3    Depovere, J.4    Valckx, D.5    Laureys, J.6    Mathieu, C.7
  • 13
    • 0031807166 scopus 로고    scopus 로고
    • Captopril and lisinopril suppress production of interleukin-12 by human peripheral blood mononuclear cells
    • Constantinescu, C.S., Goodman, D.B. & Ventura, E.S. (1998), Captopril and lisinopril suppress production of interleukin-12 by human peripheral blood mononuclear cells. Immun, Lett., 62, 25-31.
    • (1998) Immun, Lett. , vol.62 , pp. 25-31
    • Constantinescu, C.S.1    Goodman, D.B.2    Ventura, E.S.3
  • 14
    • 0031017252 scopus 로고    scopus 로고
    • Interferon-α/β inhibition of interleukine 12 and interferon-γ production in vitro and endogenously during viral infection
    • Cousens, L.P., Orange, J.S., Su, H.C. & Biron, C.A. (1997). Interferon-α/β inhibition of interleukine 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. U.S.A., 94, 634-639.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 634-639
    • Cousens, L.P.1    Orange, J.S.2    Su, H.C.3    Biron, C.A.4
  • 16
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea, A., Aste-Amezaga, M., Valiante, N.M., Ma, X., Kubin, M. & Trinchieri, G. (1993). Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells, J. Exp. Med., 178, 1041-1048.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 17
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of interleukin (IL)-4 and Il-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor α production
    • D'Andrea, A., Ma, X., Aste-Amexaga, M., Paganin, C. & Trinchieri, G. (1995). Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor α production. J. Exp. Med., 181, 537-546.
    • (1995) J. Exp. Med. , vol.181 , pp. 537-546
    • D'Andrea, A.1    Ma, X.2    Aste-Amexaga, M.3    Paganin, C.4    Trinchieri, G.5
  • 20
    • 0031911965 scopus 로고    scopus 로고
    • The concept of type-1 and type-2 helper T cells and their cytokines in humans
    • Del Prete, G. (1998). The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int. Rev. Immunol., 16, 427-455.
    • (1998) Int. Rev. Immunol. , vol.16 , pp. 427-455
    • Del Prete, G.1
  • 21
    • 0031892714 scopus 로고    scopus 로고
    • The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes
    • Dewit, D., Gourlet, P., Amraoui, Z., Vertongen, P., Willems, F., Robberecht, P. & Goldman, M. (1998). The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes. Immunol. Lett., 60, 57-60.
    • (1998) Immunol. Lett. , vol.60 , pp. 57-60
    • Dewit, D.1    Gourlet, P.2    Amraoui, Z.3    Vertongen, P.4    Willems, F.5    Robberecht, P.6    Goldman, M.7
  • 23
    • 0030227883 scopus 로고    scopus 로고
    • Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications
    • Elenkov, I.J., Papanicolau, D.A., Wilder, R.L. & Chrousos, G.P. (1996). Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc. Assoc. Am. Physicians, 108, 1-8.
    • (1996) Proc. Assoc. Am. Physicians , vol.108 , pp. 1-8
    • Elenkov, I.J.1    Papanicolau, D.A.2    Wilder, R.L.3    Chrousos, G.P.4
  • 25
    • 0028943066 scopus 로고
    • Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon 7 and tumor necrosis factor α
    • Flesch, I.E.A., Hess, J.H., Huang, S., Aguet, M., Rothe, J., Bluethmann, H. & Kaufmann, S.H.E. (1995). Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon 7 and tumor necrosis factor α. J. Exp. Med., 181, 1615-1621.
    • (1995) J. Exp. Med. , vol.181 , pp. 1615-1621
    • Flesch, I.E.A.1    Hess, J.H.2    Huang, S.3    Aguet, M.4    Rothe, J.5    Bluethmann, H.6    Kaufmann, S.H.E.7
  • 26
    • 0031015965 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: Effects on B7, interleukin 10, and interleukin 12
    • Fox, F.E., Kubin, M., Cassin, M., Niu, Z., Hosoi, J., Torii, H., Granstein, R.D., Trinchieri, G. & Rook, A.H. (1997). Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: effects on B7, interleukin 10, and interleukin 12. J. Invest. Dermatol., 108, 43-48.
    • (1997) J. Invest. Dermatol. , vol.108 , pp. 43-48
    • Fox, F.E.1    Kubin, M.2    Cassin, M.3    Niu, Z.4    Hosoi, J.5    Torii, H.6    Granstein, R.D.7    Trinchieri, G.8    Rook, A.H.9
  • 27
    • 0030997247 scopus 로고    scopus 로고
    • In vitro differentiation of human monocytes to macrophages: Change of PDE profile and its relationship to suppression of tumor necrosis factor-α release by PDE inhibitors
    • Gantner, F., Kupferschmidt, R., Schudt, C., Wendel, A. & Hatzelmann, A. (1997). In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumor necrosis factor-α release by PDE inhibitors. Br. J. Pharmacol., 121, 221-231.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 221-231
    • Gantner, F.1    Kupferschmidt, R.2    Schudt, C.3    Wendel, A.4    Hatzelmann, A.5
  • 28
    • 0030624139 scopus 로고    scopus 로고
    • Interleukin-12: Potential clinical applications in the treatment of chronic viral hepatitis
    • Gately, M.K. (1997). Interleukin-12: potential clinical applications in the treatment of chronic viral hepatitis. J. Viral. Hepat., Suppl. 1, 33-39.
    • (1997) J. Viral. Hepat., Suppl. , vol.1 , pp. 33-39
    • Gately, M.K.1
  • 30
    • 0028821825 scopus 로고
    • Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
    • Gavett, S.H., O'Hearn, D.J., Li, X., Huang, S.K., Finkelman, F.D. & Wills-Karp, M. (1995). Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med., 182, 1527-1536.
    • (1995) J. Exp. Med. , vol.182 , pp. 1527-1536
    • Gavett, S.H.1    Hearn, D.J.2    Li, X.3    Huang, S.K.4    Finkelman, F.D.5    Wills-Karp, M.6
  • 31
    • 0027264849 scopus 로고
    • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts
    • Gazzinelli, R.T., Hieny, S., Wynn, T.A., Wolf, S. & Sher, A. (1993). Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. U.S.A., 90, 6115-6119.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6115-6119
    • Gazzinelli, R.T.1    Hieny, S.2    Wynn, T.A.3    Wolf, S.4    Sher, A.5
  • 34
    • 0027427501 scopus 로고
    • Differential effects of tyrosine kinase inhibition in CD69 antigen expression and lytic activity induced by rIL-2, rIL-12, and rIFN-α in human NK cells
    • Gerosa, F., Tommasi, M., Benati, C., Gandini, G., Libonati, M., Tridente, G., Carra, G. & Trinchieri, G. (1993). Differential effects of tyrosine kinase inhibition in CD69 antigen expression and lytic activity induced by rIL-2, rIL-12, and rIFN-α in human NK cells. Cell. Immunol., 150, 382-390.
    • (1993) Cell. Immunol. , vol.150 , pp. 382-390
    • Gerosa, F.1    Tommasi, M.2    Benati, C.3    Gandini, G.4    Libonati, M.5    Tridente, G.6    Carra, G.7    Trinchieri, G.8
  • 36
    • 0031054302 scopus 로고    scopus 로고
    • Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
    • Gollob, J.A., Kawasaki, H. & Ritz, J. (1997). Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol., 27, 647-652.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 647-652
    • Gollob, J.A.1    Kawasaki, H.2    Ritz, J.3
  • 37
    • 0030612880 scopus 로고    scopus 로고
    • Interleukin-1β secretion is impaired by inhibitors of the Atp binding cassette transporter, ABCL
    • Hamon, Y., Luciant, M.-F., Becq, F., Verrier, B., Rubartelli, A. & Chimini, G. (1997). Interleukin-1β secretion is impaired by inhibitors of the Atp binding cassette transporter, ABCL Blood, 90, 2911-2915.
    • (1997) Blood , vol.90 , pp. 2911-2915
    • Hamon, Y.1    Luciant, M.-F.2    Becq, F.3    Verrier, B.4    Rubartelli, A.5    Chimini, G.6
  • 38
    • 0032500375 scopus 로고    scopus 로고
    • 3 adenosine receptors decreases IL-12, IFN-γ, and nitric oxide production and prevents lethality in endotoxemic mice
    • 3 adenosine receptors decreases IL-12, IFN-γ, and nitric oxide production and prevents lethality in endotoxemic mice. Eur. J. Pharmacol., 358, 261-268.
    • (1998) Eur. J. Pharmacol. , vol.358 , pp. 261-268
    • Haskó, G.1    Németh, Z.H.2    Vizi, E.S.3    Salman, A.L.4    Szabo, C.5
  • 39
    • 0031772806 scopus 로고    scopus 로고
    • Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1α via a β adrenoceptor mediated mechanism
    • Haskó, G., Shanley, T.P., Egnaczyk, G., Nemeth, Z.H., Salzman, A.L., Vizi, E.S. & Szabó, C. (1998b). Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1α via a β adrenoceptor mediated mechanism. Br. J Pharmacol., 125, 1297-1304.
    • (1998) Br. J Pharmacol. , vol.125 , pp. 1297-1304
    • Haskó, G.1    Shanley, T.P.2    Egnaczyk, G.3    Nemeth, Z.H.4    Salzman, A.L.5    Vizi, E.S.6    Szabó, C.7
  • 40
    • 0031741566 scopus 로고    scopus 로고
    • Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system
    • Haskó, G. & Szabó, C. (1998). Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system, Biochem. Pharmacol., 56, 1079-1087.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 1079-1087
    • Haskó, G.1    Szabó, C.2
  • 41
    • 0031853543 scopus 로고    scopus 로고
    • Modulation by dantrolene of endotoxin-induccd interleukin-10, tumor necrosis factor-α, and nitric oxide production in vivo and in vitro
    • Haskó, G., Szabó, C., Németh, Z.H., Lendval, B. & Vizi, E.S. (1998c). Modulation by dantrolene of endotoxin-induccd interleukin-10, tumor necrosis factor-α, and nitric oxide production in vivo and in vitro. Br. J. Pharmacol., 124, 1099-1106.
    • (1998) Br. J. Pharmacol. , vol.124 , pp. 1099-1106
    • Haskó, G.1    Szabó, C.2    Németh, Z.H.3    Lendval, B.4    Vizi, E.S.5
  • 42
    • 0032146334 scopus 로고    scopus 로고
    • Stimulation of β-adrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice
    • Haskó, G., Szabó, C., Nemeth, Z.H., Salzman, A.I., & Vizi, E.S. (1998d). Stimulation of β-adrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice. J. Neuroimmunol., 88, 57-61.
    • (1998) J. Neuroimmunol. , vol.88 , pp. 57-61
    • Haskó, G.1    Szabó, C.2    Nemeth, Z.H.3    Salzman, A.I.4    Vizi, E.S.5
  • 43
    • 0031914563 scopus 로고    scopus 로고
    • Suppression of interleukin-12 production by phosphodiesterase inhibition in murine endotoxemia is interleukin-10 independent
    • Haskó, G., Szabó, C., Nemeth, Z.H., Salzman, A.L. & Vizi, E.S. (1998e). Suppression of interleukin-12 production by phosphodiesterase inhibition in murine endotoxemia is interleukin-10 independent. Eur. J. Immunol. 28, 468-472.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 468-472
    • Haskó, G.1    Szabó, C.2    Nemeth, Z.H.3    Salzman, A.L.4    Vizi, E.S.5
  • 44
    • 85044699180 scopus 로고    scopus 로고
    • The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylococcal enterotoxin B
    • Haskó, G , Viråg, L., Egnaczyk, G., Salman, A.L. & Szahó, C. (1998f). The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylococcal enterotoxin B. Eur. J. Immunol., 28, 1417-1425.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1417-1425
    • Haskó, G.1    Viråg, L.2    Egnaczyk, G.3    Salman, A.L.4    Szahó, C.5
  • 45
    • 0027069591 scopus 로고
    • Membrane potential modulates release of tumor necrosis factor in lipopolysaccharide-stimulated mouse macrophages
    • Haslberger, A., Romanin, C. & Koerber, R. (1992). Membrane potential modulates release of tumor necrosis factor in lipopolysaccharide-stimulated mouse macrophages. Mol. Biol. Cell., 3, 451-460.
    • (1992) Mol. Biol. Cell. , vol.3 , pp. 451-460
    • Haslberger, A.1    Romanin, C.2    Koerber, R.3
  • 46
    • 0029040855 scopus 로고
    • Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes
    • Hayes, M.P., Wang, J. & Norcross, M.A. (1995). Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood, 86, 646-650.
    • (1995) Blood , vol.86 , pp. 646-650
    • Hayes, M.P.1    Wang, J.2    Norcross, M.A.3
  • 47
    • 0031132212 scopus 로고    scopus 로고
    • In vivo production and function of IL-12 p40 homodimers
    • Heinzel, F.P., Hujer, A.M., Ahmed, F.N. & Rerko, R.M. (1997). In vivo production and function of IL-12 p40 homodimers. J. Immunol., 158, 4381-4388.
    • (1997) J. Immunol. , vol.158 , pp. 4381-4388
    • Heinzel, F.P.1    Hujer, A.M.2    Ahmed, F.N.3    Rerko, R.M.4
  • 52
    • 0032103937 scopus 로고    scopus 로고
    • Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses
    • Homey, B., Assmann, T., Vohr, H.W., Ulrich, P., Lauerma, A.L., Ruzicka, T., Lehmann, P. & Schuppe, H.C. (1998). Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. J. Immunol., 160, 5331-5340.
    • (1998) J. Immunol. , vol.160 , pp. 5331-5340
    • Homey, B.1    Assmann, T.2    Vohr, H.W.3    Ulrich, P.4    Lauerma, A.L.5    Ruzicka, T.6    Lehmann, P.7    Schuppe, H.C.8
  • 54
    • 0031795118 scopus 로고    scopus 로고
    • Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages
    • Huang, F.P., Niedbala, W., Wei, X.Q., Xu, D., Feng, G.J., Robinson, J.H., Lam, C. & Liew, F.Y. (1998). Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur. J. Immunol., 28, 4062-4070.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 4062-4070
    • Huang, F.P.1    Niedbala, W.2    Wei, X.Q.3    Xu, D.4    Feng, G.J.5    Robinson, J.H.6    Lam, C.7    Liew, F.Y.8
  • 55
    • 0029414719 scopus 로고
    • ILI2, a direct stimulator and indirect inhibitor of haematopoiesis
    • Jacobsen, S.E. (1995). ILI2, a direct stimulator and indirect inhibitor of haematopoiesis. Res. Immunol., 146, 506-514.
    • (1995) Res. Immunol. , vol.146 , pp. 506-514
    • Jacobsen, S.E.1
  • 56
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, JR. J.E. & Murphy, K.M. (1995). Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med., 181, 1755-1762.
    • (1995) J. Exp. Med. , vol.181 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell J.E., Jr.6    Murphy, K.M.7
  • 58
    • 0031943533 scopus 로고    scopus 로고
    • Characterization of phosphodiesterase 4 in guinea-pig macrophages: Multiple activities, association states and sensitivity to selective inhibitors
    • Kelly, J.J., Barnes, P.J. & Giembycz., M.A. (1998). Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors. Br. J. Pharmacol., 124, 129-140.
    • (1998) Br. J. Pharmacol. , vol.124 , pp. 129-140
    • Kelly, J.J.1    Barnes, P.J.2    Giembycz, M.A.3
  • 59
    • 0032895967 scopus 로고    scopus 로고
    • IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis
    • Kitching, A.R., Tipping, P.G. & Holdsworth, S.R. (1999). IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. Eur. J. Immunol., 29, 1-10.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1-10
    • Kitching, A.R.1    Tipping, P.G.2    Holdsworth, S.R.3
  • 60
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
    • Klinman, D.M., YI, A.K., Beaucage, S.L., Conover, J. & Krieg, A.M. (1996). CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc. Natl. Acad. Sci. U.S.A., 93, 2879-2883.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 61
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • Kobayashi, M., Fitz, L., Ryan, M., Hewick, R.M., Clark, S.C., Chan, S., Loudon, R., Sherman, F., Perussia, B. & Trinchieri, G. (1989). Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med., 170, 827-845.
    • (1989) J. Exp. Med. , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3    Hewick, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchieri, G.10
  • 62
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard, J.P., Waldburger, K.E & Goldman, S.J. (1995). Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med., 181, 381-386.
    • (1995) J. Exp. Med. , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 64
    • 0031921308 scopus 로고    scopus 로고
    • The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice
    • Liang, L., Beshay, F. & Prud'Homme, G.J. (1998). The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice. Diabetes, 47, 570-575.
    • (1998) Diabetes , vol.47 , pp. 570-575
    • Liang, L.1    Beshay, F.2    Prud'Homme, G.J.3
  • 67
    • 0030064148 scopus 로고    scopus 로고
    • The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
    • Ma, X., Chow, J.M., Gri, G., Carra, G., Gerosa, F., Wolf, S.F., Dzialo, R. & Trinchieri, G. (1996). The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med., 183, 147-157.
    • (1996) J. Exp. Med. , vol.183 , pp. 147-157
    • Ma, X.1    Chow, J.M.2    Gri, G.3    Carra, G.4    Gerosa, F.5    Wolf, S.F.6    Dzialo, R.7    Trinchieri, G.8
  • 69
    • 0031925465 scopus 로고    scopus 로고
    • Mice lacking inducible nitric oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses
    • MacLean, A., Wei, X.Q., Huang, F.P., Al-Alem, U.A., Chan, W.L. & Liew, F.Y. (1998). Mice lacking inducible nitric oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses. J. Gen. Virol., 79, 825-830.
    • (1998) J. Gen. Virol. , vol.79 , pp. 825-830
    • Maclean, A.1    Wei, X.Q.2    Huang, F.P.3    Al-Alem, U.A.4    Chan, W.L.5    Liew, F.Y.6
  • 70
    • 0030817861 scopus 로고    scopus 로고
    • Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor α-dependent shock
    • Mattner, F., Ozmen, L., Podlaski, F.J., Wilkinson, V.L., Presky, D.H., Gately, M.K. & Alber, G. (1997). Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor α-dependent shock. Infect. Immun., 65, 4734-4737.
    • (1997) Infect. Immun. , vol.65 , pp. 4734-4737
    • Mattner, F.1    Ozmen, L.2    Podlaski, F.J.3    Wilkinson, V.L.4    Presky, D.H.5    Gately, M.K.6    Alber, G.7
  • 71
    • 0031714451 scopus 로고    scopus 로고
    • Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-κB
    • Mazzeo, D., Panina-Bordignon, P., Recalde, H., Siniga-Glia, F. & D'Ambrosio, D. (1998). Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-κB. Eur. J. Immunol., 28, 3205-3213.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3205-3213
    • Mazzeo, D.1    Panina-Bordignon, P.2    Recalde, H.3    Siniga-Glia, F.4    D'Ambrosio, D.5
  • 77
  • 78
    • 0040958788 scopus 로고    scopus 로고
    • Retinoids inhibit interleukin-12 production in macrophages through physical association of retinoid X receptor and NFκB
    • Na, S.-Y., Kang, B.Y., Chung, S.W., Han, S.-J., Ma, X., Trinchieri, G., Im, S.-Y., Lee, J.W. & Kim, T.S. (1999). Retinoids inhibit interleukin-12 production in macrophages through physical association of retinoid X receptor and NFκB. J. Biol, Chem., 274, 7674-7680.
    • (1999) J. Biol, Chem. , vol.274 , pp. 7674-7680
    • Na, S.-Y.1    Kang, B.Y.2    Chung, S.W.3    Han, S.-J.4    Ma, X.5    Trinchieri, G.6    Im, S.-Y.7    Lee, J.W.8    Kim, T.S.9
  • 79
    • 13844322526 scopus 로고    scopus 로고
    • Calcium channel blockers and dantrolene differentially regulate the production of interleukin-12 and interferon-γ in endotoxemic mice
    • Németh, Z.H., Haskó, G., Szabó, C., Salzman, A.L. & Vizi, F.S. (1998b). Calcium channel blockers and dantrolene differentially regulate the production of interleukin-12 and interferon-γ in endotoxemic mice. Brain Res. Bull., 46, 257-261.
    • (1998) Brain Res. Bull. , vol.46 , pp. 257-261
    • Németh, Z.H.1    Haskó, G.2    Szabó, C.3    Salzman, A.L.4    Vizi, F.S.5
  • 80
    • 0032113523 scopus 로고    scopus 로고
    • Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-α, MIP-iα, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin
    • Németh, Z.H., Haskó, G. & Vizi, E.S. (1998a). Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-α, MIP-Iα, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin. Shock, 10, 49-53.
    • (1998) Shock , vol.10 , pp. 49-53
    • Németh, Z.H.1    Haskó, G.2    Vizi, E.S.3
  • 81
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath, M.F., Fuss, I., Kelsall, B.L., Stuber, E. & Strober, W. (1995). Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med., 182, 1281-1290.
    • (1995) J. Exp. Med. , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 82
    • 0027982098 scopus 로고
    • Interleukin 12, interferon gamma, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction
    • Ozmen, J., Pericin, M., Hakimi, J., Chizzonite, R.A., Wysocka, M., Trinchieri, G., Gately, M. & Garotta, G. (1994). Interleukin 12, interferon gamma, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med., 180, 907-915.
    • (1994) J. Exp. Med. , vol.180 , pp. 907-915
    • Ozmen, J.1    Pericin, M.2    Hakimi, J.3    Chizzonite, R.A.4    Wysocka, M.5    Trinchieri, G.6    Gately, M.7    Garotta, G.8
  • 84
    • 0030590104 scopus 로고    scopus 로고
    • Induction of IL-12 gene expression in the brain in septic shock
    • Park, J.H. & Shin, S.H. (1996). Induction of IL-12 gene expression in the brain in septic shock. Biochem. Biophys. Res. Commun., 224, 391-396.
    • (1996) Biochem. Biophys. Res. Commun. , vol.224 , pp. 391-396
    • Park, J.H.1    Shin, S.H.2
  • 85
    • 0029998380 scopus 로고    scopus 로고
    • The role of vasoactive drugs in the regulation of cytokine production in sepsis
    • Pastores, S.M., Haskó G., Vizi, E.S. & Kvetan, V. (1996). The role of vasoactive drugs in the regulation of cytokine production in sepsis. New Horiz., 4, 252-264.
    • (1996) New Horiz. , vol.4 , pp. 252-264
    • Pastores, S.M.1    Haskó, G.2    Vizi, E.S.3    Kvetan, V.4
  • 86
    • 0032055596 scopus 로고    scopus 로고
    • Diurnal rhythms of pro-inflammatory cytokines; regulation by plasma cortisol and therapeutic implications
    • Petrovsky, N., McNair, P. & Harrison, L.C. (1998). Diurnal rhythms of pro-inflammatory cytokines; regulation by plasma cortisol and therapeutic implications. Cytokine, 10, 307-312.
    • (1998) Cytokine , vol.10 , pp. 307-312
    • Petrovsky, N.1    McNair, P.2    Harrison, L.C.3
  • 87
    • 0030872393 scopus 로고    scopus 로고
    • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
    • Plevy, S.E., Gemberling, J.H., Hsu, S., Dorner, A.J. & Smale, S.T. (1997). Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol., 17, 4572-4588.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4572-4588
    • Plevy, S.E.1    Gemberling, J.H.2    Hsu, S.3    Dorner, A.J.4    Smale, S.T.5
  • 88
    • 0032571244 scopus 로고    scopus 로고
    • Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat
    • Poggi, A., Rubartelli, A. & Zocchi, M.R. (1998). Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat. J. Biol. Chem., 273, 7205-7209.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7205-7209
    • Poggi, A.1    Rubartelli, A.2    Zocchi, M.R.3
  • 90
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • Ralevic, V. & Burnstock, G. (1998). Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413-492.
    • (1998) Pharmacol. Rev. , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 91
    • 0031569105 scopus 로고    scopus 로고
    • In vitro prevention and reversal of lipopolysaccharide desensitization by INF-γ, IL-12, and granulocyte-macrophage colony-stimulating factor
    • Randow, F., Döcke, W.-D., Bundschuh, D.S., Hartung, T., Wendel, A. & Volk, H.-D. (1997). In vitro prevention and reversal of lipopolysaccharide desensitization by INF-γ, IL-12, and granulocyte-macrophage colony-stimulating factor. J. Immunol., 158, 2911-2918.
    • (1997) J. Immunol. , vol.158 , pp. 2911-2918
    • Randow, F.1    Döcke, W.-D.2    Bundschuh, D.S.3    Hartung, T.4    Wendel, A.5    Volk, H.-D.6
  • 92
    • 0032532309 scopus 로고    scopus 로고
    • Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides
    • Redford, T.W., Yi, A.-K., Ward, C.T. & Krieg, A.M. (1998). Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides. J. Immunol., 161, 3930-3935.
    • (1998) J. Immunol. , vol.161 , pp. 3930-3935
    • Redford, T.W.1    Yi, A.-K.2    Ward, C.T.3    Krieg, A.M.4
  • 97
    • 0030570509 scopus 로고    scopus 로고
    • Interleukin-12 gene-expression of macrophages is regulated by nitric oxide
    • Rothe, H., Hartmann, B., Geerlings, P. & kolb, H. (1996). Interleukin-12 gene-expression of macrophages is regulated by nitric oxide. Biochem. Biophys. Res. Commun., 224, 159-163.
    • (1996) Biochem. Biophys. Res. Commun. , vol.224 , pp. 159-163
    • Rothe, H.1    Hartmann, B.2    Geerlings, P.3    Kolb, H.4
  • 101
    • 0028266692 scopus 로고
    • Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3
    • Smith, T.J., Ducharme, L.A. & Weis, J.H. (1994). Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3. Eur. J. Immunol., 24, 822-826.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 822-826
    • Smith, T.J.1    Ducharme, L.A.2    Weis, J.H.3
  • 102
    • 0030064036 scopus 로고    scopus 로고
    • Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
    • Snijders, A., Hilkens, C.M.U., Van Der Pouw Kraan, T.C.T.M., Engel, M., Aarden, L.A. & Kapsenberg, M.L. (1996). Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol., 156, 1207-1212.
    • (1996) J. Immunol. , vol.156 , pp. 1207-1212
    • Snijders, A.1    Hilkens, C.M.U.2    Van Der Pouw Kraan, T.C.T.M.3    Engel, M.4    Aarden, L.A.5    Kapsenberg, M.L.6
  • 104
    • 0029982516 scopus 로고    scopus 로고
    • Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF-α generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer
    • Souness, J.E., Griffin, M., Maslen, C., Ebsworth, K., Scott, L.C., Pollock, K., Palfreyman, M.N. & Karlsson, J.A. (1996). Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF-α generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer. Br. J. Pharmacol., 118, 649-658.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 649-658
    • Souness, J.E.1    Griffin, M.2    Maslen, C.3    Ebsworth, K.4    Scott, L.C.5    Pollock, K.6    Palfreyman, M.N.7    Karlsson, J.A.8
  • 105
    • 0000060327 scopus 로고    scopus 로고
    • In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
    • Sousa, C.R., Hieny, S., Scharton-Kersten, T., Jankovic, D., Charest, H., Germain, R.N. & Sher, A. (1997). In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med., 186, 1819-1829.
    • (1997) J. Exp. Med. , vol.186 , pp. 1819-1829
    • Sousa, C.R.1    Hieny, S.2    Scharton-Kersten, T.3    Jankovic, D.4    Charest, H.5    Germain, R.N.6    Sher, A.7
  • 106
  • 107
    • 0031112099 scopus 로고    scopus 로고
    • Calcium entry blockers increase interleukin-10 production in endotoxemia
    • Szabó, C., Haskó, G., Németh, Z.H. & Vizi, E.S. (1997a). Calcium entry blockers increase interleukin-10 production in endotoxemia. Shock, 7, 304-307.
    • (1997) Shock , vol.7 , pp. 304-307
    • Szabó, C.1    Haskó, G.2    Németh, Z.H.3    Vizi, E.S.4
  • 108
    • 0031691973 scopus 로고    scopus 로고
    • Suppression of macrophage inflammatory protein (MIP)-1 α production and collagen-induced arthritis by adenosine receptor agonists
    • Szabó, C., Scott, G.S., Viråg, L., Egnaczyk, G., Salzman, A.L., Shanley, T.P. & Haskó, G. (1998). Suppression of macrophage inflammatory protein (MIP)-1 α production and collagen-induced arthritis by adenosine receptor agonists. Br. J. Pharmacol., 125, 379-387.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 379-387
    • Szabó, C.1    Scott, G.S.2    Viråg, L.3    Egnaczyk, G.4    Salzman, A.L.5    Shanley, T.P.6    Haskó, G.7
  • 109
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. (1997b). Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med., 185, 817-824b.
    • (1997) J. Exp. Med. , vol.185
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 110
    • 0029925752 scopus 로고    scopus 로고
    • LPS induces NKL1 alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells
    • Takahashi, M., Ogasawara, K., Takeda, K., Hashimoto, W., Sakihara, H., Kumagai, K., Anzai, R., Satoh, M. & Seki, S. (1996). LPS induces NKL1 alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells. J. Immunol., 156, 2436-2442.
    • (1996) J. Immunol. , vol.156 , pp. 2436-2442
    • Takahashi, M.1    Ogasawara, K.2    Takeda, K.3    Hashimoto, W.4    Sakihara, H.5    Kumagai, K.6    Anzai, R.7    Satoh, M.8    Seki, S.9
  • 112
    • 0030894793 scopus 로고    scopus 로고
    • Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: An indirect interleukin-10-mediated effect
    • Taoufik, Y., Lantz, O., Wallon, C., Charles, A., Dussaix, E. & Delfraissy, J.F. (1997). Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89, 2842-2848.
    • (1997) Blood , vol.89 , pp. 2842-2848
    • Taoufik, Y.1    Lantz, O.2    Wallon, C.3    Charles, A.4    Dussaix, E.5    Delfraissy, J.F.6
  • 113
    • 0028926524 scopus 로고
    • Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
    • Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M.K. & Adorini, L. (1995). Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med., 181, 817-821.
    • (1995) J. Exp. Med. , vol.181 , pp. 817-821
    • Trembleau, S.1    Penna, G.2    Bosi, E.3    Mortara, A.4    Gately, M.K.5    Adorini, L.6
  • 114
    • 0030587817 scopus 로고    scopus 로고
    • Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production
    • Trepicchio, W.L., Bozza, M., Pedneault, G. & Dorner, A.J. (1996). Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J. Immunol., 157, 3627-3634.
    • (1996) J. Immunol. , vol.157 , pp. 3627-3634
    • Trepicchio, W.L.1    Bozza, M.2    Pedneault, G.3    Dorner, A.J.4
  • 115
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol., 13, 251-276.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 116
    • 0027530129 scopus 로고
    • Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist
    • Tripp, C.S., Wolf, S.F. & Unanue, E.R. (1993). Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. U.S.A., 90, 3725-3729.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 3725-3729
    • Tripp, C.S.1    Wolf, S.F.2    Unanue, E.R.3
  • 121
    • 0032533826 scopus 로고    scopus 로고
    • Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential
    • Vieira, P.L., Kalinski, P., Wierenga, E.A., Kapsenberg, M.L., & De Jong, E.C. (1998). Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential. J. Immunol., 161, 5245-5251.
    • (1998) J. Immunol. , vol.161 , pp. 5245-5251
    • Vieira, P.L.1    Kalinski, P.2    Wierenga, E.A.3    Kapsenberg, M.L.4    De Jong, E.C.5
  • 122
    • 0030802018 scopus 로고    scopus 로고
    • Glucocorticoids and immune function: Unknown dimensions and new frontiers
    • Wilckens, T. & De Rijk, R. (1997). Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol. Today, 18, 418-424.
    • (1997) Immunol. Today , vol.18 , pp. 418-424
    • Wilckens, T.1    De Rijk, R.2
  • 123
    • 0032529844 scopus 로고    scopus 로고
    • 2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness
    • 2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J. Immunol., 161, 2723-2730.
    • (1998) J. Immunol. , vol.161 , pp. 2723-2730
    • Wu, C.-Y.1    Wang, K.2    McDyer, J.F.3    Seder, R.A.4
  • 124
    • 0031030398 scopus 로고    scopus 로고
    • Regulation of interleukin-12 receptor β1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells
    • Wu, C., Warrier, R.R., Wang, X., Presky, D.H. & Gately, M.K. (1997). Regulation of interleukin-12 receptor β1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells. Eur. J. Immunol., 27, 147-154.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 147-154
    • Wu, C.1    Warrier, R.R.2    Wang, X.3    Presky, D.H.4    Gately, M.K.5
  • 125
    • 0028987562 scopus 로고
    • Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
    • Wysocka, M., Kubin, M., Vieira, L.Q., Ozmen, L., Garrotta, G., Scott, P. & Trinchieri, G. (1995). Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol., 25, 672-676.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 672-676
    • Wysocka, M.1    Kubin, M.2    Vieira, L.Q.3    Ozmen, L.4    Garrotta, G.5    Scott, P.6    Trinchieri, G.7
  • 126
    • 0032516760 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages
    • Xin, Z., & Sriram, S. (1998). Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages. J. Neuroimmunol., 89, 206-212.
    • (1998) J. Neuroimmunol. , vol.89 , pp. 206-212
    • Xin, Z.1    Sriram, S.2
  • 128
    • 0029100898 scopus 로고
    • Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line
    • Ye, J., Ortaldo, J.R., Conlon, K., Winkler-Pickett, R. & Young, H.A. (1995). Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line. J. Leuk. Biol., 58, 225-233.
    • (1995) J. Leuk. Biol. , vol.58 , pp. 225-233
    • Ye, J.1    Ortaldo, J.R.2    Conlon, K.3    Winkler-Pickett, R.4    Young, H.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.