Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily

Immunologic Research

Volumn 51, Issue 1, 2011, Pages 5-14

  Jones, Lindsay L ^a   Vignali, Dario A A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cytokine receptor; Cytokines; gp130; IL 12; IL 12R 1; IL 12R 2; IL 23; IL 23R; IL 27; IL 35; Structure; WSX 1

Indexed keywords

AMINO TERMINAL IMMUNOGLOBULIN; FIBRONECTIN; FIBRONECTIN TYPE III; GLYCOPROTEIN GP 130; IMMUNOGLOBULIN; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; PROTEIN P28; PROTEIN P35; PROTEIN P40; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; BINDING SITE; CRYSTALLIZATION; CYTOKINE RESPONSE; DISULFIDE BOND; HUMAN; HUMAN CELL; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN POLYMERIZATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANIMALS; HUMANS; MUTAGENESIS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-12; RECEPTORS, INTERLEUKIN-6; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 80053573336     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-011-8209-y     Document Type: Article

References (58)

1. K Gee C Guzzo NF Che Mat W Ma A Kumar 2009 The IL-12 family of cytokines in infection, inflammation and autoimmune disorders Inflamm Allergy Drug Targets 8 40 52 19275692 10.2174/187152809787582507 1:CAS:528:DC%2BD1MXkvVymtL8%3D
2. MK Gately LM Renzetti J Magram AS Stern L Adorini U Gubler DH Presky 1998 The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses Annu Rev Immunol 16 495 521 9597139 10.1146/annurev.immunol.16.1.495 1:CAS:528:DyaK1cXisl2gsbs%3D (Pubitemid 28183374)
3. B Oppmann R Lesley B Blom JC Timans Y Xu B Hunte F Vega N Yu J Wang K Singh F Zonin E Vaisberg T Churakova M Liu D Gorman J Wagner S Zurawski Y Liu JS Abrams KW Moore D Rennick R de Waal-Malefyt C Hannum JF Bazan RA Kastelein 2000 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 715 725 11114383 10.1016/S1074-7613(00)00070-4 1:CAS:528:DC%2BD3cXovV2ht7c%3D
4. S Aggarwal N Ghilardi MH Xie FJ de Sauvage AL Gurney 2003 Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J Biol Chem 278 1910 1914 12417590 10.1074/jbc.M207577200 1:CAS:528:DC%2BD3sXisFyksA%3D%3D (Pubitemid 36801431)
5. S Pflanz JC Timans J Cheung R Rosales H Kanzler J Gilbert L Hibbert T Churakova M Travis E Vaisberg WM Blumenschein JD Mattson JL Wagner W To S Zurawski TK McClanahan DM Gorman JF Bazan R de Waal Malefyt D Rennick RA Kastelein 2002 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells Immunity 16 779 790 12121660 10.1016/S1074-7613(02)00324-2 1:CAS:528:DC%2BD38XltF2gtbs%3D (Pubitemid 34786477)
6. S Lucas N Ghilardi J Li FJ de Sauvage 2003 IL-27 regulates IL-12 responsiveness of naive CD4 + T cells through Stat1-dependent and -independent mechanisms Proc Natl Acad Sci USA 100 15047 15052 14657353 10.1073/pnas. 2536517100 1:CAS:528:DC%2BD3sXpvFaqtb8%3D (Pubitemid 37518014)
7. AV Villarino JS Stumhofer CJ Saris RA Kastelein FJ de Sauvage CA Hunter 2006 IL-27 limits IL-2 production during Th1 differentiation J Immunol 176 237 247 16365415 1:CAS:528:DC%2BD2MXhtlagt7fE (Pubitemid 43023268)
8. C Diveu MJ McGeachy K Boniface JS Stumhofer M Sathe B Joyce-Shaikh Y Chen CM Tato TK McClanahan R de Waal Malefyt CA Hunter DJ Cua RA Kastelein 2009 IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells J Immunol 182 5748 5756 19380822 10.4049/jimmunol.0801162 1:CAS:528: DC%2BD1MXkslKhsLg%3D
9. DC Fitzgerald B Ciric T Touil H Harle J Grammatikopolou J Das Sarma B Gran GX Zhang A Rostami 2007 Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis J Immunol 179 3268 3275 17709543 1:CAS:528:DC%2BD2sXpt1Smt7k%3D
10. C Neufert C Becker S Wirtz MC Fantini B Weigmann PR Galle MF Neurath 2007 IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1 Eur J Immunol 37 1809 1816 17549733 10.1002/eji.200636896 1:CAS:528:DC%2BD2sXnslyit7Y%3D (Pubitemid 47065120)
11. JS Stumhofer JS Silver A Laurence PM Porrett TH Harris LA Turka M Ernst CJ Saris JJ O'Shea CA Hunter 2007 Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 Nat Immunol 8 1363 1371 17994025 10.1038/ni1537 1:CAS:528:DC%2BD2sXhtlajtr7F (Pubitemid 350131173)
12. JS Stumhofer CA Hunter 2008 Advances in understanding the anti-inflammatory properties of IL-27 Immunol Lett 117 123 130 18378322 10.1016/j.imlet.2008.01.011 1:CAS:528:DC%2BD1cXktlWqsLw%3D
13. LW Collison DA Vignali 2008 Interleukin-35: odd one out or part of the family? Immunol Rev 226 248 262 19161429 10.1111/j.1600-065X.2008.00704.x 1:CAS:528:DC%2BD1MXhsFGls7%2FK
14. LW Collison CJ Workman TT Kuo K Boyd Y Wang KM Vignali R Cross D Sehy RS Blumberg DA Vignali 2007 The inhibitory cytokine IL-35 contributes to regulatory T-cell function Nature 450 566 569 18033300 10.1038/nature06306 1:CAS:528:DC%2BD2sXhtlCrtbzI (Pubitemid 350190247)
15. LW Collison V Chaturvedi AL Henderson PR Giacomin C Guy J Bankoti D Finkelstein K Forbes CJ Workman SA Brown JE Rehg ML Jones HT Ni D Artis MJ Turk DA Vignali 2010 IL-35-mediated induction of a potent regulatory T cell population Nat Immunol 11 1093 1101 20953201 10.1038/ni.1952 1:CAS:528:DC%2BC3cXhtlSgur7N
16. S Gillessen D Carvajal P Ling FJ Podlaski DL Stremlo PC Familletti U Gubler DH Presky AS Stern MK Gately 1995 Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist Eur J Immunol 25 200 206 7843232 10.1002/eji.1830250133 1:CAS:528:DyaK2MXjtlSjurw%3D
17. JS Stumhofer ED Tait WJ Quinn III N Hosken B Spudy R Goenka CA Fielding AC O'Hara Y Chen ML Jones CJ Saris S Rose-John DJ Cua SA Jones MM Elloso J Grotzinger MP Cancro SD Levin CA Hunter 2010 A role for IL-27p28 as an antagonist of gp130-mediated signaling Nat Immunol 11 1119 1126 21057510 10.1038/ni.1957 1:CAS:528:DC%2BC3cXhtl2jsbvN
18. S Crabe A Guay-Giroux AJ Tormo D Duluc R Lissilaa F Guilhot U Mavoungou-Bigouagou F Lefouili I Cognet W Ferlin G Elson P Jeannin JF Gauchat 2009 The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling J Immunol 183 7692 7702 19933857 10.4049/jimmunol.0901464 1:CAS:528:DC%2BD1MXhsFCkt7rP
19. DH Presky H Yang LJ Minetti AO Chua N Nabavi CY Wu MK Gately U Gubler 1996 A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits Proc Natl Acad Sci USA 93 14002 14007 8943050 10.1073/pnas.93.24.14002 1:CAS:528:DyaK28Xnt1Gksr8%3D (Pubitemid 26424235)
20. C Parham M Chirica J Timans E Vaisberg M Travis J Cheung S Pflanz R Zhang KP Singh F Vega W To J Wagner AM O'Farrell T McClanahan S Zurawski C Hannum D Gorman DM Rennick RA Kastelein R de Waal Malefyt KW Moore 2002 A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R J Immunol 168 5699 5708 12023369 1:CAS:528: DC%2BD38XktFCrtrw%3D (Pubitemid 34556153)
21. S Pflanz L Hibbert J Mattson R Rosales E Vaisberg JF Bazan JH Phillips TK McClanahan R de Waal Malefyt RA Kastelein 2004 WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 J Immunol 172 2225 2231 14764690 1:CAS:528:DC%2BD2cXpslWmtw%3D%3D (Pubitemid 38182370)
22. JF Bazan 1990 Structural design and molecular evolution of a cytokine receptor superfamily Proc Natl Acad Sci USA 87 6934 6938 2169613 10.1073/pnas.87.18.6934 1:CAS:528:DyaK3cXlvV2nurc%3D
23. J Bravo D Staunton JK Heath EY Jones 1998 Crystal structure of a cytokine-binding region of gp130 EMBO J 17 1665 1674 9501088 10.1093/emboj/17.6.1665 1:CAS:528:DyaK1cXit1Gitrc%3D (Pubitemid 28119120)
24. D Chow X He AL Snow S Rose-John KC Garcia 2001 Structure of an extracellular gp130 cytokine receptor signaling complex Science 291 2150 2155 11251120 10.1126/science.1058308 1:CAS:528:DC%2BD3MXitFClt7Y%3D (Pubitemid 32224446)
25. DC Chow L Brevnova XL He MM Martick A Bankovich KC Garcia 2002 A structural template for gp130-cytokine signaling assemblies Biochim Biophys Acta 1592 225 235 12421668 10.1016/S0167-4889(02)00317-8 1:CAS:528: DC%2BD38Xotl2gu7o%3D (Pubitemid 35291103)
26. MJ Boulanger DC Chow EE Brevnova KC Garcia 2003 Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex Science 300 2101 2104 12829785 10.1126/science.1083901 1:CAS:528:DC%2BD3sXkvVOrtrw%3D (Pubitemid 36760138)
27. MJ Boulanger AJ Bankovich T Kortemme D Baker KC Garcia 2003 Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130 Mol Cell 12 577 589 14527405 10.1016/S1097-2765(03)00365-4 1:CAS:528:DC%2BD3sXnvFGrtrw%3D (Pubitemid 37222481)
28. G Skiniotis MJ Boulanger KC Garcia T Walz 2005 Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor Nat Struct Mol Biol 12 545 551 15895091 10.1038/nsmb941 1:CAS:528: DC%2BD2MXks12rtrg%3D (Pubitemid 43085886)
29. I Kurth U Horsten S Pflanz A Timmermann A Kuster H Dahmen I Tacken PC Heinrich G Muller-Newen 2000 Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130 J Immunol 164 273 282 10605021 1:CAS:528:DC%2BD3cXisV2r (Pubitemid 30013000)
30. G Skiniotis PJ Lupardus M Martick T Walz KC Garcia 2008 Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex Mol Cell 31 737 748 18775332 10.1016/j.molcel.2008.08.011 1:CAS:528:DC%2BD1cXhtFant7jL
31. AO Chua VL Wilkinson DH Presky U Gubler 1995 Cloning and characterization of a mouse IL-12 receptor-beta component J Immunol 155 4286 4294 7594587 1:CAS:528:DyaK2MXovFWltbw%3D
32. CA Sprecher FJ Grant JW Baumgartner SR Presnell SK Schrader T Yamagiwa TE Whitmore PJ O'Hara DF Foster 1998 Cloning and characterization of a novel class I cytokine receptor Biochem Biophys Res Commun 246 82 90 9600072 10.1006/bbrc.1998.8576 1:CAS:528:DyaK1cXjtFWrtbw%3D (Pubitemid 28413931)
33. AM de Vos M Ultsch AA Kossiakoff 1992 Human growth hormone and extracellular domain of its receptor: crystal structure of the complex Science 255 306 312 1549776 10.1126/science.1549776
34. Y Xu NJ Kershaw CS Luo P Soo MJ Pocock PE Czabotar DJ Hilton NA Nicola TP Garrett JG Zhang 2010 Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes J Biol Chem 285 21214 21218 20489211 10.1074/jbc.C110.129502 1:CAS:528: DC%2BC3cXos1WrsLw%3D
35. C Yoon SC Johnston J Tang M Stahl JF Tobin WS Somers 2000 Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12 EMBO J 19 3530 3541 10899108 10.1093/emboj/19.14.3530 1:CAS:528:DC%2BD3cXmtlegsr4%3D (Pubitemid 30462112)
36. PJ Lupardus KC Garcia 2008 The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12 J Mol Biol 382 931 941 18680750 10.1016/j.jmb.2008.07.051 1:CAS:528:DC%2BD1cXhtFWltL7M
37. BM Beyer R Ingram L Ramanathan P Reichert HV Le V Madison P Orth 2008 Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody J Mol Biol 382 942 955 18708069 10.1016/j.jmb.2008.08.001 1:CAS:528:DC%2BD1cXhtFWltL7N
38. J Luo SJ Wu ER Lacy Y Orlovsky A Baker A Teplyakov G Obmolova GA Heavner HT Richter J Benson 2010 Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab J Mol Biol 402 797 812 20691190 10.1016/j.jmb.2010.07.046 1:CAS:528:DC%2BC3cXht1Cgu7vF
39. D Perret C Guillet G Elson J Froger H Plun-Favreau F Rousseau M Chabbert JF Gauchat H Gascan 2004 Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines J Biol Chem 279 43961 43970 15272019 10.1074/jbc.M407686200 1:CAS:528:DC%2BD2cXot1ygtLc%3D (Pubitemid 39390704)
40. F Rousseau S Chevalier C Guillet E Ravon C Diveu J Froger F Barbier L Grimaud H Gascan 2008 Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain J Biol Chem 283 30341 30350 18728012 10.1074/jbc.M803239200 1:CAS:528:DC%2BD1cXht1yntL%2FE
41. F Rousseau L Basset J Froger N Dinguirard S Chevalier H Gascan 2010 IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants Proc Natl Acad Sci USA 107 19420 19425 20974977 10.1073/pnas.1005793107 1:CAS:528: DC%2BC3cXhsVGltrrO
42. I Tacken H Dahmen O Boisteau S Minvielle Y Jacques J Grotzinger A Kuster U Horsten C Blanc FA Montero-Julian PC Heinrich G Muller-Newen 1999 Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis Eur J Biochem 265 645 655 10504396 10.1046/j.1432-1327.1999.00755.x 1:CAS:528:DyaK1MXmslGltbw%3D (Pubitemid 29488997)
43. DJ Hilton SS Watowich L Katz HF Lodish 1996 Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor J Biol Chem 271 4699 4708 8617735 10.1074/jbc.271.23.13754 1:CAS:528:DyaK28XhtlOntrk%3D (Pubitemid 26187988)
44. DH Presky LJ Minetti S Gillessen VL Wilkinson CY Wu U Gubler R Chizzonite MK Gately 1998 Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex J Immunol 160 2174 2179 9498755 1:CAS:528:DyaK1cXhtlertbc%3D (Pubitemid 28119896)
45. X Wang VL Wilkinson FJ Podlaski C Wu AS Stern DH Presky J Magram 1999 Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits Eur J Immunol 29 2007 2013 10382764 10.1002/(SICI)1521-4141(199906)29:06<2007::AID-IMMU2007>3.0.CO;2-0 1:CAS:528:DyaK1MXjslKktbo%3D (Pubitemid 29265557)
46. I Kurth U Horsten S Pflanz H Dahmen A Kuster J Grotzinger PC Heinrich G Muller-Newen 1999 Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes J Immunol 162 1480 1487 9973404 1:CAS:528:DyaK1MXhtVSmt7o%3D (Pubitemid 29307020)
47. D Man W He KH Sze K Gong DK Smith G Zhu NY Ip 2003 Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex J Biol Chem 278 23285 23294 12707266 10.1074/jbc.M301976200 1:CAS:528: DC%2BD3sXkslygs74%3D (Pubitemid 36830142)
48. H Yawata K Yasukawa S Natsuka M Murakami K Yamasaki M Hibi T Taga T Kishimoto 1993 Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130 EMBO J 12 1705 1712 8467812 1:CAS:528: DyaK3sXisFejsLo%3D (Pubitemid 23112825)
49. AL Salvati A Lahm G Paonessa G Ciliberto C Toniatti 1995 Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface J Biol Chem 270 12242 12249 7744875 10.1074/jbc.270.20. 12242 1:CAS:528:DyaK2MXlvVWktbg%3D
50. P Auguste O Robledo C Olivier J Froger V Praloran A Pouplard-Barthelaix H Gascan 1996 Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a specific antagonist for the CNTF response J Biol Chem 271 26049 26056 8824245 10.1074/jbc.271.42.26049 1:CAS:528:DyaK28XmsVChtr0%3D (Pubitemid 26347444)
51. RL Moritz LD Ward GF Tu LJ Fabri H Ji K Yasukawa RJ Simpson 1999 The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex Growth Factors 16 265 278 10427501 10.3109/08977199909069145 1:STN:280:DyaK1Mzls1Gjug%3D%3D (Pubitemid 29366410)
52. T Huyton JG Zhang CS Luo MZ Lou DJ Hilton NA Nicola TP Garrett 2007 An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor Proc Natl Acad Sci USA 104 12737 12742 17652170 10.1073/pnas.0705577104 1:CAS:528: DC%2BD2sXptVejtrk%3D (Pubitemid 47255224)
53. JP Brakenhoff FD de Hon V Fontaine E ten Boekel H Schooltink S Rose-John PC Heinrich J Content LA Aarden 1994 Development of a human interleukin-6 receptor antagonist J Biol Chem 269 86 93 8276883 1:CAS:528:DyaK2cXnsFWhuw%3D%3D (Pubitemid 24026627)
54. M Inoue C Nakayama K Kikuchi T Kimura Y Ishige A Ito M Kanaoka H Noguchi 1995 D1 cap region involved in the receptor recognition and neural cell survival activity of human ciliary neurotrophic factor Proc Natl Acad Sci USA 92 8579 8583 7567978 10.1073/pnas.92.19.8579 1:CAS:528:DyaK2MXotVGrtbs%3D
55. G Paonessa R Graziani A De Serio R Savino L Ciapponi A Lahm AL Salvati C Toniatti G Ciliberto 1995 Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling EMBO J 14 1942 1951 7744001 1:CAS:528:DyaK2MXlvVCqsr4%3D
56. MC Deller KR Hudson S Ikemizu J Bravo EY Jones JK Heath 2000 Crystal structure and functional dissection of the cytostatic cytokine oncostatin M Structure 8 863 874 10997905 10.1016/S0969-2126(00)00176-3 1:CAS:528: DC%2BD3cXlsFCmtrk%3D
57. A Di Marco I Gloaguen R Graziani G Paonessa I Saggio KR Hudson R Laufer 1996 Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists Proc Natl Acad Sci USA 93 9247 9252 8799186 10.1073/pnas.93.17.9247 1:CAS:528:DyaK28Xlt1CntLs%3D (Pubitemid 26282049)
58. H Plun-Favreau D Perret C Diveu J Froger S Chevalier E Lelievre H Gascan M Chabbert 2003 Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor J Biol Chem 278 27169 27179 12707269 10.1074/jbc. M303168200 1:CAS:528:DC%2BD3sXltlKqu7o%3D (Pubitemid 36876873)