메뉴 건너뛰기




Volumn 15, Issue 6, 2016, Pages 405-424

Convertible visceral fat as a therapeutic target to curb obesity

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; AMFEBUTAMONE PLUS NALTREXONE; AMFEPRAMONE; AMLEXANOX; BELORANIB; CANAGLIFLOZIN; DAPAGLIFLOZIN; DESVENLAFAXINE; EXENDIN 4; FENFLURAMINE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; JANUS KINASE INHIBITOR; LIRAGLUTIDE; LORCASERIN; METFORMIN; METRELEPTIN; MIRABEGRON; PHENTERMINE; PHENTERMINE PLUS TOPIRAMATE; PLACEBO; PRAMLINTIDE; RESVERATROL; RIMONABANT; SETMELANOTIDE; SIBUTRAMINE; TETRAHYDROLIPSTATIN; TOPIRAMATE; UNCOUPLING PROTEIN 1; UNINDEXED DRUG;

EID: 84960369640     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2016.31     Document Type: Review
Times cited : (191)

References (241)
  • 1
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics -2009 update: A report from the American Heart Association statistics committee and stroke statistics subcommittee
    • Lloyd-Jones, D., et al. Heart disease and stroke statistics -2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, e21-e181 (2009
    • (2009) Circulation , vol.119 , pp. e21-e181
    • Lloyd-Jones, D.1
  • 2
    • 80455128548 scopus 로고    scopus 로고
    • Insulin resistance, hyperglycemia, and atherosclerosis
    • Bornfeldt, K. E., & Tabas, I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 14, 575-585 (2011
    • (2011) Cell Metab , vol.14 , pp. 575-585
    • Bornfeldt, K.E.1    Tabas, I.2
  • 3
    • 84929461257 scopus 로고    scopus 로고
    • Metabolic syndrome and breast cancer: Is there a link?
    • Hauner, D., & Hauner, H. Metabolic syndrome and breast cancer: is there a link? Breast Care 9, 277-281 (2014
    • (2014) Breast Care , vol.9 , pp. 277-281
    • Hauner, D.1    Hauner, H.2
  • 4
    • 84862271958 scopus 로고    scopus 로고
    • Bariatric surgery for type 2 diabetes
    • Dixon, J. B., le Roux, C. W., Rubino, F., & Zimmet, P. Bariatric surgery for type 2 diabetes. Lancet 379, 2300-2311 (2012
    • (2012) Lancet , vol.379 , pp. 2300-2311
    • Dixon, J.B.1    Le Roux, C.W.2    Rubino, F.3    Zimmet, P.4
  • 5
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell, N. J., & Stock, M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35 (1979
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 6
    • 0037008157 scopus 로고    scopus 로고
    • ΒAR signaling required for diet-induced thermogenesis and obesity resistance
    • Bachman, E. S., et al. βAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297, 843-845 (2002
    • (2002) Science , vol.297 , pp. 843-845
    • Bachman, E.S.1
  • 7
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209 (2009
    • (2009) Cell Metab , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 8
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
    • Saito, M., et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531 (2009
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1
  • 9
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen, K. A., et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009
    • (2009) N. Engl. J. Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 10
    • 64349095231 scopus 로고    scopus 로고
    • Cold-activated brown adipose tissue in healthy men
    • van Marken Lichtenbelt, W. D., et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508 (2009
    • (2009) N. Engl. J. Med , vol.360 , pp. 1500-1508
    • Van Marken Lichtenbelt, W.D.1
  • 11
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess, A. M., et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517 (2009
    • (2009) N. Engl. J. Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1
  • 12
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti, M. C., et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120 (2009
    • (2009) FASEB J. , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1
  • 13
    • 79952089254 scopus 로고    scopus 로고
    • Brown adipose tissue in morbidly obese subjects
    • Vijgen, G. H., et al. Brown adipose tissue in morbidly obese subjects. PLoS ONE 6, e17247 (2011
    • (2011) Plos One , vol.6 , pp. e17247
    • Vijgen, G.H.1
  • 14
    • 0026075907 scopus 로고
    • Convertible adipose tissue in mice
    • Loncar, D. Convertible adipose tissue in mice. Cell Tissue Res. 266, 149-161 (1991
    • (1991) Cell Tissue Res , vol.266 , pp. 149-161
    • Loncar, D.1
  • 15
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu, H., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830 (2003
    • (2003) J. Clin. Invest , vol.112 , pp. 1821-1830
    • Xu, H.1
  • 16
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808 (2003
    • (2003) J. Clin. Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1
  • 17
    • 36849012057 scopus 로고    scopus 로고
    • Adipocyte death, adipose tissue remodeling and obesity complications
    • Strissel, K. J., et al. Adipocyte death, adipose tissue remodeling and obesity complications. Diabetes 56, 2910-2918 (2007
    • (2007) Diabetes , vol.56 , pp. 2910-2918
    • Strissel, K.J.1
  • 18
    • 50949108719 scopus 로고    scopus 로고
    • Dead adipocytes detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
    • Murano, I., et al. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J. Lipid Res. 49, 1562-1568 (2008
    • (2008) J. Lipid Res , vol.49 , pp. 1562-1568
    • Murano, I.1
  • 19
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Eckel, R. H., Grundy, S. M., & Zimmet, P. Z. The metabolic syndrome. Lancet 365, 1415-1428 (2005
    • (2005) Lancet , vol.365 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 22
    • 84900334867 scopus 로고    scopus 로고
    • Central neural regulation of brown adipose tissue thermogenesis and energy expenditure
    • Morrison, S. F., Madden, C. J., & Tupone, D. Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab. 19, 741-756 (2014
    • (2014) Cell Metab , vol.19 , pp. 741-756
    • Morrison, S.F.1    Madden, C.J.2    Tupone, D.3
  • 23
    • 0027934595 scopus 로고
    • Quantitative evaluations of gap junctions in old rat brown adipose tissue after cold acclimation: A freeze-fracture and ultra-structural study
    • Barbatelli, G., Heinzelmann, M., Ferrara, P., Morroni, M., & Cinti, S. Quantitative evaluations of gap junctions in old rat brown adipose tissue after cold acclimation: a freeze-fracture and ultra-structural study. Tissue Cell 26, 667-676 (1994
    • (1994) Tissue Cell , vol.26 , pp. 667-676
    • Barbatelli, G.1    Heinzelmann, M.2    Ferrara, P.3    Morroni, M.4    Cinti, S.5
  • 24
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B., & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004
    • (2004) Physiol. Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 25
    • 58149337340 scopus 로고    scopus 로고
    • Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ
    • Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J. Anat. 214, 171-178 (2009
    • (2009) J. Anat , vol.214 , pp. 171-178
    • Murano, I.1    Barbatelli, G.2    Giordano, A.3    Cinti, S.4
  • 26
    • 84859410604 scopus 로고    scopus 로고
    • The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
    • Vitali, A., et al. The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J. Lipid Res. 53, 619-629 (2012
    • (2012) J. Lipid Res , vol.53 , pp. 619-629
    • Vitali, A.1
  • 27
    • 77952623888 scopus 로고    scopus 로고
    • The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    • Barbatelli, G., et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 298, E1244-E1253 (2010
    • (2010) Am. J. Physiol. Endocrinol. Metab , vol.298 , pp. E1244-E1253
    • Barbatelli, G.1
  • 28
    • 84878525220 scopus 로고    scopus 로고
    • Bi directional interconversion of brite and white adipocytes
    • Rosenwald, M., Perdikari, A., Rulicke, T., & Wolfrum, C. Bi directional interconversion of brite and white adipocytes. Nat. Cell Biol. 15, 659-667 (2013
    • (2013) Nat. Cell Biol , vol.15 , pp. 659-667
    • Rosenwald, M.1    Perdikari, A.2    Rulicke, T.3    Wolfrum, C.4
  • 29
    • 84925787770 scopus 로고    scopus 로고
    • Cellular origins of cold-induced brown adipocytes in adult mice
    • Lee, Y. H., Petkova, A. P., Konkar, A. A., & Granneman, J. G. Cellular origins of cold-induced brown adipocytes in adult mice. FASEB J. 29, 286-299 (2015
    • (2015) FASEB J. , vol.29 , pp. 286-299
    • Lee, Y.H.1    Petkova, A.P.2    Konkar, A.A.3    Granneman, J.G.4
  • 30
    • 0026378292 scopus 로고
    • Rat interscapular brown adipose tissue at different ages: A morphometric study
    • Sbarbati, A., Morroni, M., Zancanaro, C., & Cinti, S. Rat interscapular brown adipose tissue at different ages: a morphometric study. Int. J. Obes. 15, 581-587 (1991
    • (1991) Int. J. Obes , vol.15 , pp. 581-587
    • Sbarbati, A.1    Morroni, M.2    Zancanaro, C.3    Cinti, S.4
  • 31
    • 0031053535 scopus 로고    scopus 로고
    • Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue
    • Cinti, S., et al. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 138, 797-804 (1997
    • (1997) Endocrinology , vol.138 , pp. 797-804
    • Cinti, S.1
  • 32
    • 0022389375 scopus 로고
    • Defective brown adipose tissue thermogenesis in obese mice
    • Himms-Hagen, J. Defective brown adipose tissue thermogenesis in obese mice. Int. J. Obes. 9 (Suppl. 2), 17-24 (1985
    • (1985) Int. J. Obes , vol.9 , Issue.SUPPL2 , pp. 17-24
    • Himms-Hagen, J.1
  • 33
    • 0021319695 scopus 로고
    • Brown adipose tissue in the parametrial fat pad of the mouse
    • Young, P., Arch, J. R., & Ashwell, M. Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett. 167, 10-14 (1984
    • (1984) FEBS Lett , vol.167 , pp. 10-14
    • Young, P.1    Arch, J.R.2    Ashwell, M.3
  • 34
    • 0027051199 scopus 로고
    • Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization
    • Cousin, B., et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J. Cell Sci. 103, 931-942 (1992
    • (1992) J. Cell Sci , vol.103 , pp. 931-942
    • Cousin, B.1
  • 35
    • 80052739107 scopus 로고    scopus 로고
    • White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis
    • Cao, L., et al. White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab. 14, 324-338 (2011
    • (2011) Cell Metab , vol.14 , pp. 324-338
    • Cao, L.1
  • 36
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1 α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom, P., et al. A PGC1 α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1
  • 37
    • 84878917267 scopus 로고    scopus 로고
    • Exercise as a new physiological stimulus for brown adipose tissue activity
    • De Matteis, R., et al. Exercise as a new physiological stimulus for brown adipose tissue activity. Nutr. Metab. Cardiovasc. Dis. 23, 582-590 (2013
    • (2013) Nutr. Metab. Cardiovasc. Dis , vol.23 , pp. 582-590
    • De Matteis, R.1
  • 38
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent ucp1 containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic, N., et al. Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1 containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164 (2009
    • (2009) J. Biol. Chem , vol.285 , pp. 7153-7164
    • Petrovic, N.1
  • 39
    • 84875367849 scopus 로고    scopus 로고
    • Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
    • Schulz, T. J., et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 495, 379-383 (2013
    • (2013) Nature , vol.495 , pp. 379-383
    • Schulz, T.J.1
  • 40
    • 78651094465 scopus 로고    scopus 로고
    • Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
    • Schulz, T. J., et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc. Natl Acad. Sci. USA 108, 143-148 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 143-148
    • Schulz, T.J.1
  • 41
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms, M., & Seale, P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252-1263 (2013
    • (2013) Nat. Med , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 42
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: Is beige the new brown?
    • Wu, J., Cohen, P., & Spiegelman, B. M. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 27, 234-250 (2013
    • (2013) Genes Dev , vol.27 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 43
    • 50049122271 scopus 로고    scopus 로고
    • PRDM16 controls a brown fat/skeletal muscle switch
    • Seale, P., et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961-967 (2008
    • (2008) Nature , vol.454 , pp. 961-967
    • Seale, P.1
  • 44
    • 84900325394 scopus 로고    scopus 로고
    • A smooth muscle-like origin for beige adipocytes
    • Long, J. Z., et al. A smooth muscle-like origin for beige adipocytes. Cell Metab. 19, 810-820 (2014
    • (2014) Cell Metab , vol.19 , pp. 810-820
    • Long, J.Z.1
  • 45
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu, J., et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1
  • 46
    • 84975757439 scopus 로고    scopus 로고
    • A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
    • Kazak, L., et al. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell 163, 643-655 (2015
    • (2015) Cell , vol.163 , pp. 643-655
    • Kazak, L.1
  • 47
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC 1α and browning of white adipose tissues in adaptive thermogenesis
    • Fisher, F. M., et al. FGF21 regulates PGC 1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281 (2012
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1
  • 48
    • 84874450879 scopus 로고    scopus 로고
    • BMP4 mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
    • Qian, S. W., et al. BMP4 mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc. Natl Acad. Sci. USA 110, E798-E807 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E798-E807
    • Qian, S.W.1
  • 49
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • Sharp, L. Z., et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 7, e49452 (2012
    • (2012) Plos One , vol.7 , pp. e49452
    • Sharp, L.Z.1
  • 50
    • 84936771989 scopus 로고    scopus 로고
    • Genetic and functional characterization of clonally derived adult human brown adipocytes
    • Shinoda, K., et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat. Med. 21, 389-394 (2015
    • (2015) Nat. Med , vol.21 , pp. 389-394
    • Shinoda, K.1
  • 51
    • 84883665111 scopus 로고    scopus 로고
    • Adult epicardial fat exhibits beige features
    • Sacks, H. S., et al. Adult epicardial fat exhibits beige features. J. Clin. Endocrinol. Metab. 98, E1448-E1455 (2013
    • (2013) J. Clin. Endocrinol. Metab , vol.98 , pp. E1448-E1455
    • Sacks, H.S.1
  • 52
    • 34248372084 scopus 로고    scopus 로고
    • Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    • Timmons, J. A., et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl Acad. Sci. USA 104, 4401-4406 (2007
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 4401-4406
    • Timmons, J.A.1
  • 53
    • 84865792944 scopus 로고    scopus 로고
    • PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors
    • Sanchez-Gurmaches, J., et al. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 16, 348-362 (2012
    • (2012) Cell Metab , vol.16 , pp. 348-362
    • Sanchez-Gurmaches, J.1
  • 54
    • 84904636950 scopus 로고    scopus 로고
    • The origin and definition of brite versus white and classical brown adipocytes
    • Rosenwald, M., & Wolfrum, C. The origin and definition of brite versus white and classical brown adipocytes. Adipocyte 3, 4-9 (2014
    • (2014) Adipocyte , vol.3 , pp. 4-9
    • Rosenwald, M.1    Wolfrum, C.2
  • 55
    • 78650945931 scopus 로고    scopus 로고
    • Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    • Seale, P., et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J. Clin. Invest. 121, 96-105 (2011
    • (2011) J. Clin. Invest , vol.121 , pp. 96-105
    • Seale, P.1
  • 56
    • 20444399143 scopus 로고    scopus 로고
    • Morphology of ferret subcutaneous adipose tissue after 6 month daily supplementation with oral β-carotene
    • Murano, I., et al. Morphology of ferret subcutaneous adipose tissue after 6 month daily supplementation with oral β-carotene. Biochim. Biophys. Acta 1740, 305-312 (2005
    • (2005) Biochim. Biophys. Acta , vol.1740 , pp. 305-312
    • Murano, I.1
  • 57
    • 0033825933 scopus 로고    scopus 로고
    • Multilocular fat cells in WAT of CL 316243 treated rats derive directly from white adipocytes
    • Himms-Hagen, J., et al. Multilocular fat cells in WAT of CL 316243 treated rats derive directly from white adipocytes. Am. J. Physiol. Cell Physiol. 279, C670-C681 (2000
    • (2000) Am. J. Physiol. Cell Physiol , vol.279 , pp. C670-C681
    • Himms-Hagen, J.1
  • 58
    • 25144489034 scopus 로고    scopus 로고
    • Metabolic and cellular plasticity in white adipose tissue I: Effects of β3 adrenergic receptor activation
    • Granneman, J. G., Li, P., Zhu, Z., & Lu, Y. Metabolic and cellular plasticity in white adipose tissue I: effects of β3 adrenergic receptor activation. Am. J. Physiol. Endocrinol. Metab. 289, E608-E616 (2005
    • (2005) Am. J. Physiol. Endocrinol. Metab , vol.289 , pp. E608-E616
    • Granneman, J.G.1    Li, P.2    Zhu, Z.3    Lu, Y.4
  • 60
    • 84887502374 scopus 로고    scopus 로고
    • Tracking adipogenesis during white adipose tissue development, expansion and regeneration
    • Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19, 1338-1344 (2013
    • (2013) Nat. Med , vol.19 , pp. 1338-1344
    • Wang, Q.A.1    Tao, C.2    Gupta, R.K.3    Scherer, P.E.4
  • 61
    • 84893712287 scopus 로고    scopus 로고
    • Adipose tissue plasticity from WAT to BAT and in between
    • Lee, Y. H., Mottillo, E. P., & Granneman, J. G. Adipose tissue plasticity from WAT to BAT and in between. Biochim. Biophys. Acta 1842, 358-369 (2014
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 358-369
    • Lee, Y.H.1    Mottillo, E.P.2    Granneman, J.G.3
  • 62
    • 64749111074 scopus 로고    scopus 로고
    • Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
    • Tateishi, K., Okada, Y., Kallin, E. M., & Zhang, Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 458, 757-761 (2009
    • (2009) Nature , vol.458 , pp. 757-761
    • Tateishi, K.1    Okada, Y.2    Kallin, E.M.3    Zhang, Y.4
  • 63
    • 77957220857 scopus 로고    scopus 로고
    • Comparative epigenomic analysis of murine and human adipogenesis
    • Mikkelsen, T. S., et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell 143, 156-169 (2010
    • (2010) Cell , vol.143 , pp. 156-169
    • Mikkelsen, T.S.1
  • 64
    • 0018662833 scopus 로고
    • Electron microscopical studies on the genesis of white adipocytes: Differentiation of immature pericytes into adipocytes in transplanted preadipose tissue virchows archiv
    • Iyama, K., Ohzono, K., & Usuku, G. Electron microscopical studies on the genesis of white adipocytes: differentiation of immature pericytes into adipocytes in transplanted preadipose tissue. Virchows Archiv. B Cell Pathol. Incl. Mol. Pathol. 31, 143-155 (1979
    • (1979) B Cell Pathol. Incl. Mol. Pathol , vol.31 , pp. 143-155
    • Iyama, K.1    Ohzono, K.2    Usuku, G.3
  • 66
    • 53549130485 scopus 로고    scopus 로고
    • White fat progenitor cells reside in the adipose vasculature
    • Tang, W., et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583-586 (2008
    • (2008) Science , vol.322 , pp. 583-586
    • Tang, W.1
  • 67
    • 84856970831 scopus 로고    scopus 로고
    • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells
    • Gupta, R. K., et al. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 15, 230-239 (2012
    • (2012) Cell Metab , vol.15 , pp. 230-239
    • Gupta, R.K.1
  • 68
    • 84856954303 scopus 로고    scopus 로고
    • The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells
    • Tran, K. V., et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 15, 222-229 (2012
    • (2012) Cell Metab , vol.15 , pp. 222-229
    • Tran, K.V.1
  • 69
    • 84920945954 scopus 로고    scopus 로고
    • Myocardin-related transcription factor a regulates conversion of progenitors to beige adipocytes
    • McDonald, M. E., et al. Myocardin-related transcription factor a regulates conversion of progenitors to beige adipocytes. Cell 160, 105-188 (2015
    • (2015) Cell , vol.160 , pp. 105-188
    • McDonald, M.E.1
  • 70
    • 84897583271 scopus 로고    scopus 로고
    • Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source
    • Chau, Y. Y., et al. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nat. Cell Biol. 16, 367-375 (2014
    • (2014) Nat. Cell Biol , vol.16 , pp. 367-375
    • Chau, Y.Y.1
  • 71
    • 34347353314 scopus 로고    scopus 로고
    • The generation of adipocytes by the neural crest
    • Billon, N., et al. The generation of adipocytes by the neural crest. Development 134, 2283-2292 (2007
    • (2007) Development , vol.134 , pp. 2283-2292
    • Billon, N.1
  • 72
    • 33845299821 scopus 로고    scopus 로고
    • Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells
    • Crossno, J. T., et al. Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J. Clin. Invest. 116, 3220-3228 (2006
    • (2006) J. Clin. Invest , vol.116 , pp. 3220-3228
    • Crossno, J.T.1
  • 73
    • 40949132523 scopus 로고    scopus 로고
    • Characterization of transplanted green fluorescent protein+ bone marrow cells into adipose tissue
    • Tomiyama, K., et al. Characterization of transplanted green fluorescent protein+ bone marrow cells into adipose tissue. Stem Cells 26, 330-338 (2008
    • (2008) Stem Cells , vol.26 , pp. 330-338
    • Tomiyama, K.1
  • 74
    • 84940718419 scopus 로고    scopus 로고
    • Transplanted bone marrow-derived cells contribute to human adipogenesis
    • Ryden, M., et al. Transplanted bone marrow-derived cells contribute to human adipogenesis. Cell Metab. 22, 408-417 (2015
    • (2015) Cell Metab , vol.22 , pp. 408-417
    • Ryden, M.1
  • 75
    • 84874657953 scopus 로고    scopus 로고
    • Characterization of the adipocyte cellular lineage in vivo
    • Berry, R., & Rodeheffer, M. S. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Bio. 15, 302-308 (2013
    • (2013) Nat. Cell Bio , vol.15 , pp. 302-308
    • Berry, R.1    Rodeheffer, M.S.2
  • 76
    • 53549134683 scopus 로고    scopus 로고
    • Identification of white adipocyte progenitor cells in vivo
    • Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. Identification of white adipocyte progenitor cells in vivo. Cell 135, 240-249 (2008
    • (2008) Cell , vol.135 , pp. 240-249
    • Rodeheffer, M.S.1    Birsoy, K.2    Friedman, J.M.3
  • 77
    • 39149144034 scopus 로고    scopus 로고
    • Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life
    • Morrison, S. J., & Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 132, 598-611 (2008
    • (2008) Cell , vol.132 , pp. 598-611
    • Morrison, S.J.1    Spradling, A.C.2
  • 78
    • 84880794274 scopus 로고    scopus 로고
    • Unravelling stem cell dynamics by lineage tracing
    • Blanpain, C., & Simons, B. D. Unravelling stem cell dynamics by lineage tracing. Nat. Rev. Mol. Cell Biol. 14, 489-502 (2013
    • (2013) Nat. Rev. Mol. Cell Biol , vol.14 , pp. 489-502
    • Blanpain, C.1    Simons, B.D.2
  • 79
    • 77049292123 scopus 로고
    • The degree of masculine differentiation of obesities: A factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease
    • Vague, J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am. J. Clin. Nutr. 4, 20-34 (1956
    • (1956) Am. J. Clin. Nutr , vol.4 , pp. 20-34
    • Vague, J.1
  • 80
    • 0019943007 scopus 로고
    • Relation of body fat distribution to metabolic complications of obesity
    • Kissebah, A. H., et al. Relation of body fat distribution to metabolic complications of obesity. J. Clin. Endocrinol. Metab. 54, 254-260 (1982
    • (1982) J. Clin. Endocrinol. Metab , vol.54 , pp. 254-260
    • Kissebah, A.H.1
  • 81
    • 0021014504 scopus 로고
    • Impact of obesity on metabolism in men and women importance of regional adipose tissue distribution
    • Krotkiewski, M., Bjorntorp, P., Sjostrom, L., & Smith, U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J. Clin. Invest. 72, 1150-1162 (1983
    • (1983) J. Clin. Invest , vol.72 , pp. 1150-1162
    • Krotkiewski, M.1    Bjorntorp, P.2    Sjostrom, L.3    Smith, U.4
  • 82
    • 0021678265 scopus 로고
    • Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women in Gothenburg
    • Lapidus, L., et al. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. BMJ 289, 1257-1261 (1984
    • (1984) Sweden. BMJ , vol.289 , pp. 1257-1261
    • Lapidus, L.1
  • 83
    • 0022408652 scopus 로고
    • The influence of body fat distribution on the incidence of diabetes mellitus 13.5 years of follow up of the participants in the study of men born in 1913
    • Ohlson, L. O., et al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow up of the participants in the study of men born in 1913. Diabetes 34, 1055-1058 (1985
    • (1985) Diabetes , vol.34 , pp. 1055-1058
    • Ohlson, L.O.1
  • 84
    • 0023711594 scopus 로고
    • Relationship of anthropometric measurements of body fat distribution to metabolic profile in premenopausal women
    • Peiris, A. N., et al. Relationship of anthropometric measurements of body fat distribution to metabolic profile in premenopausal women. Acta Med. Scand. Suppl. 723, 179-188 (1988
    • (1988) Acta Med. Scand. Suppl , vol.723 , pp. 179-188
    • Peiris, A.N.1
  • 85
    • 0026214856 scopus 로고
    • Treatment of visceral fat obesity
    • Fujioka, S., et al. Treatment of visceral fat obesity. Int. J. Obes. 15 (Suppl. 2), 59-65 (1991
    • (1991) Int. J. Obes , vol.15 , Issue.SUPPL2 , pp. 59-65
    • Fujioka, S.1
  • 86
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Despres, J. P., & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature 444, 881-887 (2006
    • (2006) Nature , vol.444 , pp. 881-887
    • Despres, J.P.1    Lemieux, I.2
  • 87
    • 0036310157 scopus 로고    scopus 로고
    • Extreme insulin resistance of the central adipose depot in vivo
    • Mittelman, S. D., Van Citters, G. W., Kirkman, E. L., & Bergman, R. N. Extreme insulin resistance of the central adipose depot in vivo. Diabetes 51, 755-761 (2002
    • (2002) Diabetes , vol.51 , pp. 755-761
    • Mittelman, S.D.1    Van Citters, G.W.2    Kirkman, E.L.3    Bergman, R.N.4
  • 88
    • 0028919571 scopus 로고
    • Regional variation in adipose tissue metabolism of severely obese premenopausal women
    • Mauriege, P., et al. Regional variation in adipose tissue metabolism of severely obese premenopausal women. J. Lipid Res. 36, 672-684 (1995
    • (1995) J. Lipid Res , vol.36 , pp. 672-684
    • Mauriege, P.1
  • 89
    • 84893704706 scopus 로고    scopus 로고
    • Sex dimorphism and depot differences in adipose tissue function
    • White, U. A., & Tchoukalova, Y. D. Sex dimorphism and depot differences in adipose tissue function. Biochim. Biophys. Acta 1842, 377-392 (2014
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 377-392
    • White, U.A.1    Tchoukalova, Y.D.2
  • 90
    • 84929001601 scopus 로고    scopus 로고
    • Abdominal obesity: A marker of ectopic fat accumulation
    • Smith, U. Abdominal obesity: a marker of ectopic fat accumulation. J. Clin. Invest. 125, 1790-1792 (2015
    • (2015) J. Clin. Invest , vol.125 , pp. 1790-1792
    • Smith, U.1
  • 91
    • 15944425403 scopus 로고    scopus 로고
    • Adiponectinemia in visceral obesity: Impact on glucose tolerance and plasma lipoprotein and lipid levels in men
    • Cote, M., et al. Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. J. Clin. Endocrinol. Metab. 90, 1434-1439 (2005
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 1434-1439
    • Cote, M.1
  • 92
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti, S., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46, 2347-2355 (2005
    • (2005) J. Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1
  • 93
    • 84883157734 scopus 로고    scopus 로고
    • Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis
    • Giordano, A., et al. Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J. Lipid Res. 54, 2423-2436 (2013
    • (2013) J. Lipid Res , vol.54 , pp. 2423-2436
    • Giordano, A.1
  • 94
    • 84905820816 scopus 로고    scopus 로고
    • Adipocyte size threshold matters: Link with risk of type 2 diabetes and improved insulin resistance after gastric bypass
    • Cotillard, A., et al. Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulin resistance after gastric bypass. J. Clin. Endocrinol. Metab. 99, E1466-E1470 (2014
    • (2014) J. Clin. Endocrinol. Metab , vol.99 , pp. E1466-E1470
    • Cotillard, A.1
  • 95
    • 84872290190 scopus 로고    scopus 로고
    • Hypoxia and adipose tissue function and dysfunction in obesity
    • Trayhurn, P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol. Rev. 93, 1-21 (2013
    • (2013) Physiol. Rev , vol.93 , pp. 1-21
    • Trayhurn, P.1
  • 96
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367-377 (2008
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 97
    • 84880046877 scopus 로고    scopus 로고
    • Time course of histomorphological changes in adipose tissue upon acute lipoatrophy
    • Murano, I., et al. Time course of histomorphological changes in adipose tissue upon acute lipoatrophy. Nutr. Metab. Cardiovasc. Dis. 23, 723-731 (2013
    • (2013) Nutr. Metab. Cardiovasc. Dis , vol.23 , pp. 723-731
    • Murano, I.1
  • 98
    • 34347249246 scopus 로고    scopus 로고
    • Macrophage infiltration into omental versus subcutaneous fat across different populations: Effect of regional adiposity and the comorbidities of obesity
    • Harman-Boehm, I., et al. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J. Clin. Endocrinol. Metab. 92, 2240-2247 (2007
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 2240-2247
    • Harman-Boehm, I.1
  • 99
    • 0026811442 scopus 로고
    • Metabolic abnormalities in visceral obesity
    • Bjorntorp, P. Metabolic abnormalities in visceral obesity. Ann. Med. 24, 3-5 (1992
    • (1992) Ann. Med , vol.24 , pp. 3-5
    • Bjorntorp, P.1
  • 100
    • 84888859024 scopus 로고    scopus 로고
    • Mechanisms of perivascular adipose tissue dysfunction in obesity
    • Fernandez-Alfonso, M. S., et al. Mechanisms of perivascular adipose tissue dysfunction in obesity. Int. J. Endocrinol. 2013, 402053 (2013
    • (2013) Int. J. Endocrinol , vol.2013 , pp. 402053
    • Fernandez-Alfonso, M.S.1
  • 101
    • 84958763655 scopus 로고    scopus 로고
    • Perivascular adipose tissue, inflammation and insulin resistance: Link to vascular dysfunction and cardiovascular disease
    • Lastra, G., & Manrique, C. Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease. Horm. Mol. Biol. Clin. Investig. 22, 19-26 (2015
    • (2015) Horm. Mol. Biol. Clin. Investig , vol.22 , pp. 19-26
    • Lastra, G.1    Manrique, C.2
  • 102
    • 84928649039 scopus 로고    scopus 로고
    • The role of perivascular adipose tissue in vasoconstriction, arterial stiffness, and aneurysm
    • Villacorta, L., & Chang, L. The role of perivascular adipose tissue in vasoconstriction, arterial stiffness, and aneurysm. Horm. Mol. Biol. Clin. Investig. 21, 137-147 (2015
    • (2015) Horm. Mol. Biol. Clin. Investig , vol.21 , pp. 137-147
    • Villacorta, L.1    Chang, L.2
  • 103
    • 84862908572 scopus 로고    scopus 로고
    • The role of perivascular adipose tissue in vascular smooth muscle cell growth
    • Miao, C. Y., & Li, Z. Y. The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br. J. Pharmacol. 165, 643-658 (2012
    • (2012) Br. J. Pharmacol , vol.165 , pp. 643-658
    • Miao, C.Y.1    Li, Z.Y.2
  • 104
    • 84905666728 scopus 로고    scopus 로고
    • Obesity, inflammation and endothelial dysfunction
    • Iantorno, M., et al. Obesity, inflammation and endothelial dysfunction. J. Biol. Regul. Homeost. Agents 28, 169-176 (2014
    • (2014) J. Biol. Regul. Homeost. Agents , vol.28 , pp. 169-176
    • Iantorno, M.1
  • 105
    • 84920627180 scopus 로고    scopus 로고
    • Activation of human brown adipose tissue by a β3 adrenergic receptor agonist
    • Cypess, A. M., et al. Activation of human brown adipose tissue by a β3 adrenergic receptor agonist. Cell Metab. 21, 33-38 (2015
    • (2015) Cell Metab , vol.21 , pp. 33-38
    • Cypess, A.M.1
  • 106
    • 3042818968 scopus 로고    scopus 로고
    • Presence and distribution of cholinergic nerves in rat mediastinal brown adipose tissue
    • Giordano, A., Frontini, A., Castellucci, M., & Cinti, S. Presence and distribution of cholinergic nerves in rat mediastinal brown adipose tissue. J. Histochem. Cytochem. 52, 923-930 (2004
    • (2004) J. Histochem. Cytochem , vol.52 , pp. 923-930
    • Giordano, A.1    Frontini, A.2    Castellucci, M.3    Cinti, S.4
  • 107
    • 84928797463 scopus 로고    scopus 로고
    • A clinical approach to brown adipose tissue in the para-aortic area of the human thorax
    • Wei, H., et al. A clinical approach to brown adipose tissue in the para-aortic area of the human thorax. PLoS ONE 10, e0122594 (2015
    • (2015) Plos One , vol.10 , pp. e0122594
    • Wei, H.1
  • 108
    • 0002454649 scopus 로고
    • Thermogenesis of brown adipose tissue in cold-acclimated rats
    • Smith, R. E., & Roberts, J. C. Thermogenesis of brown adipose tissue in cold-acclimated rats. Am. J. Physiol. 206, 143-148 (1964
    • (1964) Am. J. Physiol , vol.206 , pp. 143-148
    • Smith, R.E.1    Roberts, J.C.2
  • 109
    • 44349084943 scopus 로고    scopus 로고
    • Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma
    • Kuji, I., Imabayashi, E., Minagawa, A., Matsuda, H., & Miyauchi, T. Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma. Ann. Nucl. Med. 22, 231-235 (2008
    • (2008) Ann. Nucl. Med , vol.22 , pp. 231-235
    • Kuji, I.1    Imabayashi, E.2    Minagawa, A.3    Matsuda, H.4    Miyauchi, T.5
  • 110
    • 84877331455 scopus 로고    scopus 로고
    • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    • Cypess, A. M., et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med. 19, 635-639 (2013
    • (2013) Nat. Med , vol.19 , pp. 635-639
    • Cypess, A.M.1
  • 111
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans, A. A., et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J. Clin. Invest. 123, 3395-3403 (2013
    • (2013) J. Clin. Invest , vol.123 , pp. 3395-3403
    • Van Der Lans, A.A.1
  • 112
    • 84860752148 scopus 로고    scopus 로고
    • Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: Results from the inspire me iaa study
    • Smith, J. D., et al. Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: results from the INSPIRE ME IAA study. J. Clin. Endocrinol. Metab. 97, 1517-1525 (2012
    • (2012) J. Clin. Endocrinol. Metab , vol.97 , pp. 1517-1525
    • Smith, J.D.1
  • 113
    • 84875858745 scopus 로고    scopus 로고
    • White to brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma
    • Frontini, A., et al. White to brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim. Biophys. Acta 1831, 950-959 (2013
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 950-959
    • Frontini, A.1
  • 114
    • 84859650824 scopus 로고    scopus 로고
    • Intense FDG activity in the brown adipose tissue in omental and mesenteric regions in a patient with malignant pheochromocytoma
    • Cheng, W., et al. Intense FDG activity in the brown adipose tissue in omental and mesenteric regions in a patient with malignant pheochromocytoma. Clin. Nucl. Med. 37, 514-515 (2012
    • (2012) Clin. Nucl. Med , vol.37 , pp. 514-515
    • Cheng, W.1
  • 115
    • 85028105813 scopus 로고    scopus 로고
    • Hypermetabolic mesenteric brown adipose tissue on dual-time point FDG PET/CT in a patient with benign retroperitoneal pheochromocytoma
    • Dong, A., Wang, Y., Lu, J., & Zuo, C. Hypermetabolic mesenteric brown adipose tissue on dual-time point FDG PET/CT in a patient with benign retroperitoneal pheochromocytoma. Clin. Nucl. Med. 39, e229-e232 (2014
    • (2014) Clin. Nucl. Med , vol.39 , pp. e229-e232
    • Dong, A.1    Wang, Y.2    Lu, J.3    Zuo, C.4
  • 116
    • 0030876952 scopus 로고    scopus 로고
    • Valvular heart disease associated with fenfluramine-phentermine
    • Connolly, H. M., et al. Valvular heart disease associated with fenfluramine-phentermine. N. Engl. J. Med. 337, 581-588 (1997
    • (1997) N. Engl. J. Med , vol.337 , pp. 581-588
    • Connolly, H.M.1
  • 117
    • 77956284607 scopus 로고    scopus 로고
    • Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects
    • James, W. P., et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N. Engl. J. Med. 363, 905-917 (2010
    • (2010) N. Engl. J. Med , vol.363 , pp. 905-917
    • James, W.P.1
  • 118
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Despres, J. P., Golay, A., & Sjostrom, L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N. Engl. J. Med. 353, 2121-2134 (2005
    • (2005) N. Engl. J. Med , vol.353 , pp. 2121-2134
    • Despres, J.P.1    Golay, A.2    Sjostrom, L.3
  • 119
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid 1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1 year experience from the RIO-Europe study
    • Van Gaal, L. F., et al. Effects of the cannabinoid 1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1 year experience from the RIO-Europe study. Lancet 365, 1389-1397 (2005
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1
  • 120
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid 1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: A randomized controlled trial
    • Pi Sunyer, F. X., et al. Effect of rimonabant, a cannabinoid 1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295, 761-775 (2006
    • (2006) JAMA , vol.295 , pp. 761-775
    • Pi Sunyer, F.X.1
  • 121
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomised controlled study
    • Scheen, A. J., et al. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 368, 1660-1672 (2006
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1
  • 123
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup, A., et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374, 1606-1616 (2009
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1
  • 124
    • 84907495079 scopus 로고    scopus 로고
    • GLP 1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
    • Beiroa, D., et al. GLP 1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes 63, 3346-3358 (2014
    • (2014) Diabetes , vol.63 , pp. 3346-3358
    • Beiroa, D.1
  • 125
    • 84925282923 scopus 로고    scopus 로고
    • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
    • Finan, B., et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat. Med. 21, 27-36 (2015
    • (2015) Nat. Med , vol.21 , pp. 27-36
    • Finan, B.1
  • 126
    • 0036678477 scopus 로고    scopus 로고
    • Adipose tissue mass can be regulated through the vasculature
    • Rupnick, M. A., et al. Adipose tissue mass can be regulated through the vasculature. Proc. Natl Acad. Sci. USA 99, 10730-10735 (2002
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 10730-10735
    • Rupnick, M.A.1
  • 127
    • 34248143523 scopus 로고    scopus 로고
    • Assessment of the anti-obesity effects of the TNP 470 analog CKD 732
    • Kim, Y. M., et al. Assessment of the anti-obesity effects of the TNP 470 analog, CKD 732. J. Mol. Endocrinol. 38, 455-465 (2007
    • (2007) J. Mol. Endocrinol , vol.38 , pp. 455-465
    • Kim, Y.M.1
  • 128
    • 3042786130 scopus 로고    scopus 로고
    • Angiogenesis inhibitor, TNP 470, prevents diet-induced and genetic obesity in mice
    • Brakenhielm, E., et al. Angiogenesis inhibitor, TNP 470, prevents diet-induced and genetic obesity in mice. Circul. Res. 94, 1579-1588 (2004
    • (2004) Circul. Res , vol.94 , pp. 1579-1588
    • Brakenhielm, E.1
  • 129
    • 84896045360 scopus 로고    scopus 로고
    • Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity
    • Joharapurkar, A. A., Dhanesha, N. A., & Jain, M. R. Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity. Diabetes Metab. Syndr. Obes. 7, 73-84 (2014
    • (2014) Diabetes Metab. Syndr. Obes , vol.7 , pp. 73-84
    • Joharapurkar, A.A.1    Dhanesha, N.A.2    Jain, M.R.3
  • 130
    • 84928424095 scopus 로고    scopus 로고
    • Efficacy and safety of beloranib for weight loss in obese adults: A randomized controlled trial
    • Kim, D. D., et al. Efficacy and safety of beloranib for weight loss in obese adults: a randomized controlled trial. Diabetes Obes. Metab. 17, 566-572 (2015
    • (2015) Diabetes Obes. Metab , vol.17 , pp. 566-572
    • Kim, D.D.1
  • 131
    • 77949817711 scopus 로고    scopus 로고
    • AMPK and SIRT1: A long-standing partnership?
    • Ruderman, N. B., et al. AMPK and SIRT1: a long-standing partnership? Am. J. Physiol. Endocrinol. Metab. 298, E751-E760 (2010
    • (2010) Am. J. Physiol. Endocrinol. Metab , vol.298 , pp. E751-E760
    • Ruderman, N.B.1
  • 132
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
    • Picard, F., et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 429, 771-776 (2004
    • (2004) Nature , vol.429 , pp. 771-776
    • Picard, F.1
  • 133
    • 84864615516 scopus 로고    scopus 로고
    • Brown remodeling of white adipose tissue by SIRT1 dependent deacetylation of PPARγ
    • Qiang, L., et al. Brown remodeling of white adipose tissue by SIRT1 dependent deacetylation of Pparγ. Cell 150, 620-632 (2012
    • (2012) Cell , vol.150 , pp. 620-632
    • Qiang, L.1
  • 134
    • 84925424159 scopus 로고    scopus 로고
    • Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?
    • De Ligt, M., Timmers, S., & Schrauwen, P. Resveratrol and obesity: can resveratrol relieve metabolic disturbances? Biochim. Biophys. Acta 1852, 1137-1144 (2015
    • (2015) Biochim. Biophys. Acta , vol.1852 , pp. 1137-1144
    • De Ligt, M.1    Timmers, S.2    Schrauwen, P.3
  • 135
    • 0031025546 scopus 로고    scopus 로고
    • Strain-specific response to β3 adrenergic receptor agonist treatment of diet-induced obesity in mice
    • Collins, S., Daniel, K. W., Petro, A. E., & Surwit, R. S. Strain-specific response to β3 adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138, 405-413 (1997
    • (1997) Endocrinology , vol.138 , pp. 405-413
    • Collins, S.1    Daniel, K.W.2    Petro, A.E.3    Surwit, R.S.4
  • 136
    • 0030745159 scopus 로고    scopus 로고
    • Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3 adrenoceptor agonist
    • Ghorbani, M., Claus, T. H., & Himms-Hagen, J. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3 adrenoceptor agonist. Biochem. Pharmacol. 54, 121-131 (1997
    • (1997) Biochem. Pharmacol , vol.54 , pp. 121-131
    • Ghorbani, M.1    Claus, T.H.2    Himms-Hagen, J.3
  • 137
    • 0031011161 scopus 로고    scopus 로고
    • Appearance of brown adipocytes in white adipose tissue during CL 316,243 induced reversal of obesity and diabetes in Zucker fa/fa rats
    • Ghorbani, M., & Himms-Hagen, J. Appearance of brown adipocytes in white adipose tissue during CL 316,243 induced reversal of obesity and diabetes in Zucker fa/fa rats. Int. J. Obes. Relat. Metab. Disord. 21, 465-475 (1997
    • (1997) Int. J. Obes. Relat. Metab. Disord , vol.21 , pp. 465-475
    • Ghorbani, M.1    Himms-Hagen, J.2
  • 138
    • 0028987429 scopus 로고
    • Distribution of β 3 adrenoceptor mRNA in human tissues
    • Berkowitz, D. E., et al. Distribution of β 3 adrenoceptor mRNA in human tissues. Eur. J. Pharmacol. 289, 223-228 (1995
    • (1995) Eur. J. Pharmacol , vol.289 , pp. 223-228
    • Berkowitz, D.E.1
  • 139
    • 0036224375 scopus 로고    scopus 로고
    • Acute effect of L-796568, a novel β 3 adrenergic receptor agonist, on energy expenditure in obese men
    • van Baak, M. A., et al. Acute effect of L-796568, a novel β 3 adrenergic receptor agonist, on energy expenditure in obese men. Clin. Pharmacol. Ther. 71, 272-279 (2002
    • (2002) Clin. Pharmacol. Ther , vol.71 , pp. 272-279
    • Van Baak, M.A.1
  • 140
    • 0036783754 scopus 로고    scopus 로고
    • Effect of a 28 d treatment with L-796568 a novel β 3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men
    • Larsen, T. M., et al. Effect of a 28 d treatment with L-796568, a novel β(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am. J. Clin. Nutr. 76, 780-788 (2002
    • (2002) Am. J. Clin. Nutr , vol.76 , pp. 780-788
    • Larsen, T.M.1
  • 141
    • 34247205378 scopus 로고    scopus 로고
    • Effect of (R)-2-(2 aminothiazol 4 yl)-4′ {2-[(2 hydroxy 2 phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3 adrenoceptor agonist, on bladder function
    • Takasu, T., et al. Effect of (R)-2-(2 aminothiazol 4 yl)-4′ {2-[(2 hydroxy 2 phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3 adrenoceptor agonist, on bladder function. J. Pharmacol. Exp. Ther. 321, 642-647 (2007
    • (2007) J. Pharmacol. Exp. Ther , vol.321 , pp. 642-647
    • Takasu, T.1
  • 142
    • 79960044076 scopus 로고    scopus 로고
    • Challenges in β 3)-adrenoceptor agonist drug development
    • Arch, J. R. Challenges in β(3)-adrenoceptor agonist drug development. Ther. Adv. Endocrinol. Metab. 2, 59-64 (2011
    • (2011) Ther. Adv. Endocrinol. Metab , vol.2 , pp. 59-64
    • Arch, J.R.1
  • 143
    • 34250722133 scopus 로고    scopus 로고
    • Nebivolol: More than a highly selective Beta blocker
    • Karter, Y. Nebivolol: more than a highly selective Beta blocker. Recent Pat. Cardiovasc. Drug Discov. 2, 152-155 (2007
    • (2007) Recent Pat. Cardiovasc. Drug Discov , vol.2 , pp. 152-155
    • Karter, Y.1
  • 144
    • 84893023959 scopus 로고    scopus 로고
    • Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes
    • Bordicchia, M., et al. Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes. J. Hypertension 32, 389-396 (2014
    • (2014) J. Hypertension , vol.32 , pp. 389-396
    • Bordicchia, M.1
  • 145
    • 0030752403 scopus 로고    scopus 로고
    • Long-term testosterone administration increases visceral fat in female to male transsexuals
    • Elbers, J. M., Asscheman, H., Seidell, J. C., Megens, J. A., & Gooren, L. J. Long-term testosterone administration increases visceral fat in female to male transsexuals. J. Clin. Endocrinol. Metab. 82, 2044-2047 (1997
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 2044-2047
    • Elbers, J.M.1    Asscheman, H.2    Seidell, J.C.3    Megens, J.A.4    Gooren, L.J.5
  • 146
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki, H., et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 294, 2166-2170 (2001
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1
  • 147
    • 0034997787 scopus 로고    scopus 로고
    • Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes
    • Viengchareun, S., Penfornis, P., Zennaro, M. C., & Lombes, M. Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes. Am. J. Physiol. Endocrinol. Metab. 280, E640-E649 (2001
    • (2001) Am. J. Physiol. Endocrinol. Metab , vol.280 , pp. E640-E649
    • Viengchareun, S.1    Penfornis, P.2    Zennaro, M.C.3    Lombes, M.4
  • 148
    • 0032520920 scopus 로고    scopus 로고
    • Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action
    • Zennaro, M. C., et al. Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action. J. Clin. Invest. 101, 1254-1260 (1998
    • (1998) J. Clin. Invest , vol.101 , pp. 1254-1260
    • Zennaro, M.C.1
  • 149
    • 34347406538 scopus 로고    scopus 로고
    • Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis
    • Caprio, M., et al. Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis. FASEB J. 21, 2185-2194 (2007
    • (2007) FASEB J. , vol.21 , pp. 2185-2194
    • Caprio, M.1
  • 150
    • 10744220710 scopus 로고    scopus 로고
    • Human adipocytes secrete mineralocorticoid-releasing factors
    • Ehrhart-Bornstein, M., et al. Human adipocytes secrete mineralocorticoid-releasing factors. Proc. Natl Acad. Sci. USA 100, 14211-14216 (2003
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 14211-14216
    • Ehrhart-Bornstein, M.1
  • 151
    • 32544448025 scopus 로고    scopus 로고
    • Prevalence and characteristics of the metabolic syndrome in primary aldosteronism
    • Fallo, F., et al. Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J. Clin. Endocrinol. Metab. 91, 454-459 (2006
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 454-459
    • Fallo, F.1
  • 152
    • 84892154015 scopus 로고    scopus 로고
    • Proinflammatory cytokine induction of 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) in human adipocytes is mediated by MEK C/EBPβ, and NF ?B/RelA
    • Esteves, C. L., et al. Proinflammatory cytokine induction of 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) in human adipocytes is mediated by MEK, C/EBPβ, and NF ?B/RelA. J. Clin. Endocrinol. Metab. 99, E160-E168 (2014
    • (2014) J. Clin. Endocrinol. Metab , vol.99 , pp. E160-E168
    • Esteves, C.L.1
  • 153
    • 84905274646 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice
    • Armani, A., et al. Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice. FASEB J. 28, 3745-3757 (2014
    • (2014) FASEB J. , vol.28 , pp. 3745-3757
    • Armani, A.1
  • 154
    • 84933678746 scopus 로고    scopus 로고
    • Emerging cardiovascular indications of mineralocorticoid receptor antagonists
    • Parviz, Y., et al. Emerging cardiovascular indications of mineralocorticoid receptor antagonists. Trends Endocrinol. Metab. 26, 201-211 (2015
    • (2015) Trends Endocrinol. Metab , vol.26 , pp. 201-211
    • Parviz, Y.1
  • 155
    • 0034085884 scopus 로고    scopus 로고
    • A new thiazolidinedione, NC 2100, which is a weak PPAR-γ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
    • Fukui, Y., Masui, S., Osada, S., Umesono, K., & Motojima, K. A new thiazolidinedione, NC 2100, which is a weak PPAR-γ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 49, 759-767 (2000
    • (2000) Diabetes , vol.49 , pp. 759-767
    • Fukui, Y.1    Masui, S.2    Osada, S.3    Umesono, K.4    Motojima, K.5
  • 156
    • 84920403959 scopus 로고    scopus 로고
    • Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers
    • Loft, A., et al. Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. Genes Dev. 29, 7-22 (2015
    • (2015) Genes Dev , vol.29 , pp. 7-22
    • Loft, A.1
  • 157
    • 39549101229 scopus 로고    scopus 로고
    • Hepatic NF B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
    • Wunderlich, F. T., et al. Hepatic NF B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proc. Natl Acad. Sci. USA 105, 1297-1302 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 1297-1302
    • Wunderlich, F.T.1
  • 158
    • 69449097633 scopus 로고    scopus 로고
    • The protein kinase IKKe regulates energy balance in obese mice
    • Chiang, S. H., et al. The protein kinase IKKe regulates energy balance in obese mice. Cell 138, 961-975 (2009
    • (2009) Cell , vol.138 , pp. 961-975
    • Chiang, S.H.1
  • 159
    • 84923110854 scopus 로고    scopus 로고
    • A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis
    • Reilly, S. M., et al. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat. Commun. 6, 6047 (2015
    • (2015) Nat. Commun , vol.6 , pp. 6047
    • Reilly, S.M.1
  • 160
    • 84875179301 scopus 로고    scopus 로고
    • An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice
    • Reilly, S. M., et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19, 313-321 (2013
    • (2013) Nat. Med , vol.19 , pp. 313-321
    • Reilly, S.M.1
  • 161
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff, J. R., & Artis, D. Immune regulation of metabolic homeostasis in health and disease. Cell 161, 146-160 (2015
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 162
    • 0036866711 scopus 로고    scopus 로고
    • Immunohistochemical identification of the β 3)-adrenoceptor in intact human adipocytes and ventricular myocardium: Effect of obesity and treatment with ephedrine and caffeine
    • De Matteis, R., et al. Immunohistochemical identification of the β(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine. Int. J. Obes. Relat. Metab. Disord. 26, 1442-1450 (2002
    • (2002) Int. J. Obes. Relat. Metab. Disord , vol.26 , pp. 1442-1450
    • De Matteis, R.1
  • 163
    • 64349121056 scopus 로고    scopus 로고
    • Transcriptional control of brown adipocyte development and physiological function -of mice and men
    • Seale, P., Kajimura, S., & Spiegelman, B. M. Transcriptional control of brown adipocyte development and physiological function -of mice and men. Genes Dev. 23, 788-797 (2009
    • (2009) Genes Dev , vol.23 , pp. 788-797
    • Seale, P.1    Kajimura, S.2    Spiegelman, B.M.3
  • 164
    • 84860009214 scopus 로고    scopus 로고
    • Essential role for miR 196a in brown adipogenesis of white fat progenitor cells
    • Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K., & Kaneda, Y. Essential role for miR 196a in brown adipogenesis of white fat progenitor cells. PLoS Biol. 10, e1001314 (2012
    • (2012) Plos Biol , vol.10 , pp. e1001314
    • Mori, M.1    Nakagami, H.2    Rodriguez-Araujo, G.3    Nimura, K.4    Kaneda, Y.5
  • 165
    • 84857800070 scopus 로고    scopus 로고
    • Instruction of mesenchymal cell fate by the transcription factor C/EBPβ
    • Smink, J. J., & Leutz, A. Instruction of mesenchymal cell fate by the transcription factor C/EBPβ. Gene 497, 10-17 (2012
    • (2012) Gene , vol.497 , pp. 10-17
    • Smink, J.J.1    Leutz, A.2
  • 166
    • 69349088117 scopus 로고    scopus 로고
    • Initiation of myoblast to brown fat switch by a PRDM16 C/EBP-β transcriptional complex
    • Kajimura, S., et al. Initiation of myoblast to brown fat switch by a PRDM16 C/EBP-β transcriptional complex. Nature 460, 1154-1158 (2009
    • (2009) Nature , vol.460 , pp. 1154-1158
    • Kajimura, S.1
  • 167
    • 84892702771 scopus 로고    scopus 로고
    • Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
    • Cohen, P., et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156, 304-316 (2014
    • (2014) Cell , vol.156 , pp. 304-316
    • Cohen, P.1
  • 168
    • 84897525104 scopus 로고    scopus 로고
    • Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
    • Harms, M. J., et al. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 19, 593-604 (2014
    • (2014) Cell Metab , vol.19 , pp. 593-604
    • Harms, M.J.1
  • 169
    • 84875900015 scopus 로고    scopus 로고
    • EBF2 determines and maintains brown adipocyte identity
    • Rajakumari, S., et al. EBF2 determines and maintains brown adipocyte identity. Cell Metab. 17, 562-574 (2013
    • (2013) Cell Metab , vol.17 , pp. 562-574
    • Rajakumari, S.1
  • 170
    • 84870595878 scopus 로고    scopus 로고
    • MyomiR 133 regulates brown fat differentiation through Prdm16
    • Trajkovski, M., Ahmed, K., Esau, C. C., & Stoffel, M. MyomiR 133 regulates brown fat differentiation through Prdm16. Nat. Cell Biol. 14, 1330-1335 (2012
    • (2012) Nat. Cell Biol , vol.14 , pp. 1330-1335
    • Trajkovski, M.1    Ahmed, K.2    Esau, C.C.3    Stoffel, M.4
  • 171
    • 84858039282 scopus 로고    scopus 로고
    • PPARγ agonists induce a white to brown fat conversion through stabilization of PRDM16 protein
    • Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. PPARγ agonists induce a white to brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15, 395-404 (2012
    • (2012) Cell Metab , vol.15 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 172
    • 27144476457 scopus 로고    scopus 로고
    • RIP140 targeted repression of gene expression in adipocytes
    • Christian, M., et al. RIP140 targeted repression of gene expression in adipocytes. Mol. Cell Biol. 25, 9383-9391 (2005
    • (2005) Mol. Cell Biol , vol.25 , pp. 9383-9391
    • Christian, M.1
  • 173
    • 0034770191 scopus 로고    scopus 로고
    • Adipose tissue reduction in mice lacking the translational inhibitor 4E BP1
    • Tsukiyama-Kohara, K., et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E BP1. Nat. Med. 7, 1128-1132 (2001
    • (2001) Nat. Med , vol.7 , pp. 1128-1132
    • Tsukiyama-Kohara, K.1
  • 174
    • 84951806052 scopus 로고    scopus 로고
    • Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure
    • Shinoda, K., et al. Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure. Cell Metab. 22, 997-1008 (2015
    • (2015) Cell Metab , vol.22 , pp. 997-1008
    • Shinoda, K.1
  • 175
    • 0037294115 scopus 로고    scopus 로고
    • HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis
    • Cantile, M., Procino, A., D'Armiento, M., Cindolo, L., & Cillo, C. HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis. J. Cell Physiol. 194, 225-236 (2003
    • (2003) J. Cell Physiol , vol.194 , pp. 225-236
    • Cantile, M.1    Procino, A.2    D'Armiento, M.3    Cindolo, L.4    Cillo, C.5
  • 176
    • 84883149316 scopus 로고    scopus 로고
    • MicroRNA networks regulate development of brown adipocytes
    • Trajkovski, M., & Lodish, H. MicroRNA networks regulate development of brown adipocytes. Trends Endocrinol. Metab. 24, 442-450 (2013
    • (2013) Trends Endocrinol. Metab , vol.24 , pp. 442-450
    • Trajkovski, M.1    Lodish, H.2
  • 177
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • Swinney, D. C., & Anthony, J. How were new medicines discovered? Nat. Rev. Drug Discov. 10, 507-519 (2011
    • (2011) Nat. Rev. Drug Discov , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 178
    • 69249136243 scopus 로고    scopus 로고
    • Target profiling of small molecules by chemical proteomics
    • Rix, U., & Superti-Furga, G. Target profiling of small molecules by chemical proteomics. Nat. Chem. Biol. 5, 616-624 (2009
    • (2009) Nat. Chem. Biol , vol.5 , pp. 616-624
    • Rix, U.1    Superti-Furga, G.2
  • 179
    • 84856402803 scopus 로고    scopus 로고
    • How chemoproteomics can enable drug discovery and development
    • Moellering, R. E., & Cravatt, B. F. How chemoproteomics can enable drug discovery and development. Chem. Biol. 19, 11-22 (2012
    • (2012) Chem. Biol , vol.19 , pp. 11-22
    • Moellering, R.E.1    Cravatt, B.F.2
  • 180
    • 84925857018 scopus 로고    scopus 로고
    • White to brown metabolic conversion of human adipocytes by JAK inhibition
    • Moisan, A., et al. White to brown metabolic conversion of human adipocytes by JAK inhibition. Nat. Cell Biol. 17, 57-67 (2015
    • (2015) Nat. Cell Biol , vol.17 , pp. 57-67
    • Moisan, A.1
  • 181
    • 84870484174 scopus 로고    scopus 로고
    • Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity
    • Derecka, M., et al. Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab. 16, 814-824 (2012
    • (2012) Cell Metab , vol.16 , pp. 814-824
    • Derecka, M.1
  • 182
    • 84921538870 scopus 로고    scopus 로고
    • Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat
    • Dempersmier, J., et al. Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Mol. Cell. 57, 235-246 (2015
    • (2015) Mol. Cell , vol.57 , pp. 235-246
    • Dempersmier, J.1
  • 183
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang, T. J., et al. Metabolite profiles and the risk of developing diabetes. Nat. Med. 17, 448-453 (2011
    • (2011) Nat. Med , vol.17 , pp. 448-453
    • Wang, T.J.1
  • 184
    • 84891840977 scopus 로고    scopus 로고
    • Β-aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors
    • Roberts, L. D., et al. β-aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 19, 96-108 (2014
    • (2014) Cell Metab , vol.19 , pp. 96-108
    • Roberts, L.D.1
  • 185
    • 10044251948 scopus 로고    scopus 로고
    • Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
    • Morroni, M., et al. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc. Natl Acad. Sci. USA 101, 16801-16806 (2004
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 16801-16806
    • Morroni, M.1
  • 186
    • 84908116572 scopus 로고    scopus 로고
    • Molecular aspects of adipoepithelial transdifferentiation in mouse mammary gland
    • Prokesch, A., et al. Molecular aspects of adipoepithelial transdifferentiation in mouse mammary gland. Stem Cells 32, 2756-2766 (2014
    • (2014) Stem Cells , vol.32 , pp. 2756-2766
    • Prokesch, A.1
  • 187
    • 72849145483 scopus 로고    scopus 로고
    • In vivo physiological transdifferentiation of adult adipose cells
    • De Matteis, R., et al. In vivo physiological transdifferentiation of adult adipose cells. Stem Cells 27, 2761-2768 (2009
    • (2009) Stem Cells , vol.27 , pp. 2761-2768
    • De Matteis, R.1
  • 188
    • 84899759104 scopus 로고    scopus 로고
    • White brown and pink adipocytes: The extraordinary plasticity of the adipose organ
    • Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ. Eur. J. Endocrinol. 170, R159-R171 (2014
    • (2014) Eur. J. Endocrinol , vol.170 , pp. R159-R171
    • Giordano, A.1    Smorlesi, A.2    Frontini, A.3    Barbatelli, G.4    Cinti, S.5
  • 189
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184 (2007
    • (2007) J. Clin. Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 190
    • 84893116082 scopus 로고    scopus 로고
    • Obesity alters adipose tissue macrophage iron content and tissue iron distribution
    • Orr, J. S., et al. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes 63, 421-432 (2014
    • (2014) Diabetes , vol.63 , pp. 421-432
    • Orr, J.S.1
  • 192
    • 82555186955 scopus 로고    scopus 로고
    • Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    • Nguyen, K. D., et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480, 104-108 (2011
    • (2011) Nature , vol.480 , pp. 104-108
    • Nguyen, K.D.1
  • 193
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu, Y., et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308 (2014
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1
  • 194
    • 84920940721 scopus 로고    scopus 로고
    • Activated type 2 innate lymphoid cells regulate beige fat biogenesis
    • Lee, M. W., et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015
    • (2015) Cell , vol.160 , pp. 74-87
    • Lee, M.W.1
  • 195
    • 84924969384 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    • Brestoff, J. R., et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015
    • (2015) Nature , vol.519 , pp. 242-246
    • Brestoff, J.R.1
  • 196
    • 84922570654 scopus 로고    scopus 로고
    • Pharmacological management of obesity: An endocrine society clinical practice guideline
    • Apovian, C. M., et al. Pharmacological management of obesity: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 100, 342-362 (2015
    • (2015) J. Clin. Endocrinol. Metab , vol.100 , pp. 342-362
    • Apovian, C.M.1
  • 197
    • 84910003856 scopus 로고    scopus 로고
    • Medical treatment of obesity: The past, the present and the future
    • Bray, G. A. Medical treatment of obesity: the past, the present and the future. Best Pract. Res. Clin. Gastroenterol. 28, 665-684 (2014
    • (2014) Best Pract. Res. Clin. Gastroenterol , vol.28 , pp. 665-684
    • Bray, G.A.1
  • 198
  • 199
    • 84925841979 scopus 로고    scopus 로고
    • Neural control of energy balance: Translating circuits to therapies
    • Gautron, L., Elmquist, J. K., & Williams, K. W. Neural control of energy balance: translating circuits to therapies. Cell 161, 133-145 (2015
    • (2015) Cell , vol.161 , pp. 133-145
    • Gautron, L.1    Elmquist, J.K.2    Williams, K.W.3
  • 200
    • 85027936258 scopus 로고    scopus 로고
    • Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin 4 or FGF2
    • Muller, T. D., et al. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin 4 or FGF2. J. Pept. Sci. 18, 383-393 (2012
    • (2012) J. Pept. Sci , vol.18 , pp. 383-393
    • Muller, T.D.1
  • 201
    • 84927618698 scopus 로고    scopus 로고
    • RM 493, a melanocortin 4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals
    • Chen, K.Y., et al. RM 493, a melanocortin 4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals. J. Clin. Endocrinol. Metab. 100, 1639-1645 (2015
    • (2015) J. Clin. Endocrinol. Metab , vol.100 , pp. 1639-1645
    • Chen, K.Y.1
  • 202
    • 70450245171 scopus 로고    scopus 로고
    • Potent and selective agonism of the melanocortin receptor 4 with MK 0493 does not induce weight loss in obese human subjects: Energy intake predicts lack of weight loss efficacy
    • Krishna, R., et al. Potent and selective agonism of the melanocortin receptor 4 with MK 0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin. Pharmacol. Ther. 86, 659-666 (2009
    • (2009) Clin. Pharmacol. Ther , vol.86 , pp. 659-666
    • Krishna, R.1
  • 204
    • 70349308687 scopus 로고    scopus 로고
    • A new glucagon and GLP 1 co agonist eliminates obesity in rodents
    • Day, J. W., et al. A new glucagon and GLP 1 co agonist eliminates obesity in rodents. Nat. Chem. Biol. 5, 749-757 (2009
    • (2009) Nat. Chem. Biol , vol.5 , pp. 749-757
    • Day, J.W.1
  • 205
    • 84956925002 scopus 로고    scopus 로고
    • Energy balance and metabolic changes with SGLT2 inhibition
    • Rajeev, S. P., Cuthbertson, D. J., & Wilding, J. P. Energy balance and metabolic changes with SGLT2 inhibition. Diabetes Obes. Metab. 18, 125-134 (2015
    • (2015) Diabetes Obes. Metab , vol.18 , pp. 125-134
    • Rajeev, S.P.1    Cuthbertson, D.J.2    Wilding, J.P.3
  • 206
    • 84973356291 scopus 로고    scopus 로고
    • Zafgen Zafgen [online
    • Zafgen. Zafgen announces beloranib program update. Zafgen [online], http://ir.zafgen.com/releasedetail. cfm'ReleaseID=937850 (2015
    • (2015) Zafgen Announces Beloranib Program Update
  • 207
    • 84973356303 scopus 로고    scopus 로고
    • US National Library of Medicine ClinicalTrials.gov [online
    • US National Library of Medicine. Resveratrol and the metabolic syndrome. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01714102'term= resveratrol+AND+obesity& rank=7 (2016
    • (2016) Resveratrol and the Metabolic Syndrome
  • 208
    • 84920052826 scopus 로고    scopus 로고
    • Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
    • Gnad, T., et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 516, 395-399 (2014
    • (2014) Nature , vol.516 , pp. 395-399
    • Gnad, T.1
  • 209
    • 0024470363 scopus 로고
    • Molecular characterization of the human β3 adrenergic receptor
    • Emorine, L. J., et al. Molecular characterization of the human β3 adrenergic receptor. Science 245, 1118-1121 (1989
    • (1989) Science , vol.245 , pp. 1118-1121
    • Emorine, L.J.1
  • 210
    • 50049127055 scopus 로고    scopus 로고
    • New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    • Tseng, Y. H., et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008
    • (2008) Nature , vol.454 , pp. 1000-1004
    • Tseng, Y.H.1
  • 211
    • 84860850964 scopus 로고    scopus 로고
    • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
    • Whittle, A. J., et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149, 871-885 (2012
    • (2012) Cell , vol.149 , pp. 871-885
    • Whittle, A.J.1
  • 212
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares, E., et al. Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11, 206-212 (2010
    • (2010) Cell Metab , vol.11 , pp. 206-212
    • Hondares, E.1
  • 213
    • 84863229962 scopus 로고    scopus 로고
    • Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    • Bordicchia, M., et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J. Clin. Invest. 122, 1022-1036 (2012
    • (2012) J. Clin. Invest , vol.122 , pp. 1022-1036
    • Bordicchia, M.1
  • 214
    • 77956431307 scopus 로고    scopus 로고
    • Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    • Lopez, M., et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 16, 1001-1008 (2010
    • (2010) Nat. Med , vol.16 , pp. 1001-1008
    • Lopez, M.1
  • 215
    • 4944224365 scopus 로고    scopus 로고
    • Control of 4E BP1 expression in mouse brown adipose tissue by the β3 adrenoceptor
    • Lehr, L., et al. Control of 4E BP1 expression in mouse brown adipose tissue by the β3 adrenoceptor. FEBS Lett. 576, 179-182 (2004
    • (2004) FEBS Lett , vol.576 , pp. 179-182
    • Lehr, L.1
  • 216
    • 80455143723 scopus 로고    scopus 로고
    • The arrestin domain-containing 3 protein regulates body mass and energy expenditure
    • Patwari, P., et al. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 14, 671-683 (2011
    • (2011) Cell Metab , vol.14 , pp. 671-683
    • Patwari, P.1
  • 217
    • 79960955885 scopus 로고    scopus 로고
    • Cardiotrophin 1 is a key regulator of glucose and lipid metabolism
    • Moreno-Aliaga, M. J., et al. Cardiotrophin 1 is a key regulator of glucose and lipid metabolism. Cell Metab. 14, 242-253 (2011
    • (2011) Cell Metab , vol.14 , pp. 242-253
    • Moreno-Aliaga, M.J.1
  • 218
    • 77952970098 scopus 로고    scopus 로고
    • Cyclooxygenase 2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
    • Vegiopoulos, A., et al. Cyclooxygenase 2 controls energy homeostasis in mice by De novo recruitment of brown adipocytes. Science 328, 1158-1161 (2010
    • (2010) Science , vol.328 , pp. 1158-1161
    • Vegiopoulos, A.1
  • 219
    • 77955333533 scopus 로고    scopus 로고
    • UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity
    • Madsen, L., et al. UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity. PLoS ONE 5, e11391 (2010
    • (2010) Plos One , vol.5 , pp. e11391
    • Madsen, L.1
  • 220
    • 84889604511 scopus 로고    scopus 로고
    • EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
    • Ohno, H., Shinoda, K., Ohyama, K., Sharp, L. Z., & Kajimura, S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 504, 163-167 (2013
    • (2013) Nature , vol.504 , pp. 163-167
    • Ohno, H.1    Shinoda, K.2    Ohyama, K.3    Sharp, L.Z.4    Kajimura, S.5
  • 221
    • 17944377509 scopus 로고    scopus 로고
    • FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    • Cederberg, A., et al. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106, 563-573 (2001
    • (2001) Cell , vol.106 , pp. 563-573
    • Cederberg, A.1
  • 222
    • 24144490445 scopus 로고    scopus 로고
    • LXRs regulate the balance between fat storage and oxidation
    • Kalaany, N. Y., et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 1, 231-244 (2005
    • (2005) Cell Metab , vol.1 , pp. 231-244
    • Kalaany, N.Y.1
  • 223
    • 84902097377 scopus 로고    scopus 로고
    • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
    • Rao, R. R., et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157, 1279-1291 (2014
    • (2014) Cell , vol.157 , pp. 1279-1291
    • Rao, R.R.1
  • 224
    • 84877747920 scopus 로고    scopus 로고
    • MiR 155 regulates differentiation of brown and beige adipocytes via a bistable circuit
    • Chen, Y., et al. miR 155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat. Commun. 4, 1769 (2013
    • (2013) Nat. Commun , vol.4 , pp. 1769
    • Chen, Y.1
  • 225
    • 79960984113 scopus 로고    scopus 로고
    • Mir193b 365 is essential for brown fat differentiation
    • Sun, L., et al. Mir193b 365 is essential for brown fat differentiation. Nat. Cell Biol. 13, 958-965 (2011
    • (2011) Nat. Cell Biol , vol.13 , pp. 958-965
    • Sun, L.1
  • 226
    • 0347579845 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
    • Nisoli, E., et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299, 896-899 (2003
    • (2003) Science , vol.299 , pp. 896-899
    • Nisoli, E.1
  • 227
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1
  • 228
    • 83355163350 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC 1α) gene expression and contributes to thermogenic activation of brown fat: Involvement of PRDM16
    • Hondares, E., et al. Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC 1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J. Biol. Chem. 286, 43112-43122 (2011
    • (2011) J. Biol. Chem , vol.286 , pp. 43112-43122
    • Hondares, E.1
  • 229
    • 33645064540 scopus 로고    scopus 로고
    • Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC 1α
    • Scime, A., et al. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC 1α. Cell Metab. 2, 283-295 (2005
    • (2005) Cell Metab , vol.2 , pp. 283-295
    • Scime, A.1
  • 230
    • 34347326271 scopus 로고    scopus 로고
    • Transcriptional control of brown fat determination by PRDM16
    • Seale, P., et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 6, 38-54 (2007
    • (2007) Cell Metab , vol.6 , pp. 38-54
    • Seale, P.1
  • 231
    • 84858037735 scopus 로고    scopus 로고
    • PTEN positively regulates brown adipose function, energy expenditure, and longevity
    • Ortega-Molina, A., et al. PTEN positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 15, 382-394 (2012
    • (2012) Cell Metab , vol.15 , pp. 382-394
    • Ortega-Molina, A.1
  • 232
    • 2942532305 scopus 로고    scopus 로고
    • Nuclear receptor corepressor RIP140 regulates fat accumulation
    • Leonardsson, G., et al. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl Acad. Sci. USA 101, 8437-8442 (2004
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8437-8442
    • Leonardsson, G.1
  • 233
    • 27844551588 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP regulates PGC 1α expression and energy production in brown adipocytes
    • Wang, L., et al. The orphan nuclear receptor SHP regulates PGC 1α expression and energy production in brown adipocytes. Cell Metab. 2, 227-238 (2005
    • (2005) Cell Metab , vol.2 , pp. 227-238
    • Wang, L.1
  • 234
    • 79959933148 scopus 로고    scopus 로고
    • Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
    • Yadav, H., et al. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 14, 67-79 (2011
    • (2011) Cell Metab , vol.14 , pp. 67-79
    • Yadav, H.1
  • 235
    • 84875358826 scopus 로고    scopus 로고
    • Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs
    • Villanueva, C. J., et al. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 17, 423-435 (2013
    • (2013) Cell Metab , vol.17 , pp. 423-435
    • Villanueva, C.J.1
  • 236
    • 33749266191 scopus 로고    scopus 로고
    • TLQP 21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity
    • Bartolomucci, A., et al. TLQP 21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc. Natl Acad. Sci. USA 103, 14584-14589 (2006
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 14584-14589
    • Bartolomucci, A.1
  • 237
    • 84958955461 scopus 로고    scopus 로고
    • The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway
    • Pisani, D. F., et al. The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway. FASEB J. http://dx.doi.org/10.1096/fj.15 277475 (2015
    • (2015) FASEB J.
    • Pisani, D.F.1
  • 238
    • 84860176201 scopus 로고    scopus 로고
    • Activation of the cold-sensing TRPM8 channel triggers UCP1 dependent thermogenesis and prevents obesity
    • Ma, S., et al. Activation of the cold-sensing TRPM8 channel triggers UCP1 dependent thermogenesis and prevents obesity. J. Mol. Cell Biol. 4, 88-96 (2012
    • (2012) J. Mol. Cell Biol , vol.4 , pp. 88-96
    • Ma, S.1
  • 239
    • 84869101137 scopus 로고    scopus 로고
    • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
    • Ye, L., et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151, 96-110 (2012
    • (2012) Cell , vol.151 , pp. 96-110
    • Ye, L.1
  • 240
    • 63049083171 scopus 로고    scopus 로고
    • Twist 1 is a PPARδ-inducible, negative-feedback regulator of PGC 1α in brown fat metabolism
    • Pan, D., Fujimoto, M., Lopes, A., & Wang, Y. X. Twist 1 is a PPARδ-inducible, negative-feedback regulator of PGC 1α in brown fat metabolism. Cell 137, 73-86 (2009
    • (2009) Cell , vol.137 , pp. 73-86
    • Pan, D.1    Fujimoto, M.2    Lopes, A.3    Wang, Y.X.4
  • 241
    • 84862000905 scopus 로고    scopus 로고
    • Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
    • Kiefer, F. W., et al. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat. Med. 18, 918-925 (2012
    • (2012) Nat. Med , vol.18 , pp. 918-925
    • Kiefer, F.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.