Molecular mechanisms of incretin hormone secretion

Current Opinion in Pharmacology

Volumn 13, Issue 6, 2013, Pages 922-927

  Ezcurra, Marina ^a   Reimann, Frank ^a   Gribble, Fiona M ^a   Emery, Edward ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CANNABINOID 1 RECEPTOR; CYCLIC AMP; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FASIGLIFAM; FATTY ACID TRANSPORTER 4; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 43; G PROTEIN COUPLED RECEPTOR T1R2; G PROTEIN COUPLED RECEPTOR T1R3; G PROTEIN COUPLED RECEPTOR TGR5; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; SODIUM GLUCOSE COTRANSPORTER 1; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CARBOHYDRATE SENSING; DRUG TARGETING; ENTEROENDOCRINE CELL; GLUCOSE METABOLISM; HORMONE RELEASE; HUMAN; INTRACELLULAR SIGNALING; KILLER CELL; L CELL; LIPID SENSING; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SATIETY; SODIUM TRANSPORT;

ANIMALS; ENTEROENDOCRINE CELLS; GASTROINTESTINAL HORMONES; HUMANS; INCRETINS; INTESTINAL MUCOSA;

EID: 84888204421     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.08.013     Document Type: Review

References (58)

1. K.L. Egerod, M.S. Engelstoft, K.V. Grunddal, M.K. Nohr, A. Secher, and I. Sakata A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin Endocrinology 153 2012 5782 5795
2. A.M. Habib, P. Richards, L.S. Cairns, G.J. Rogers, C.A.M. Bannon, and H.E. Parker Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry Endocrinology 153 2012 3054 3065
3. H.E. Parker, F. Reimann, and F.M. Gribble Molecular mechanisms underlying nutrient-stimulated incretin secretion Expert Rev Mol Med 12 2010 e1
4. F. Reimann, A.M. Habib, G. Tolhurst, H.E. Parker, G.J. Rogers, and F.M. Gribble Glucose sensing in L cells: a primary cell study Cell Metab 8 2008 532 539
5. H.E. Parker, A.M. Habib, G.J. Rogers, F.M. Gribble, and F. Reimann Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells Diabetologia 52 2009 289 298
6. F.M. Gribble, L. Williams, A.K. Simpson, and F. Reimann A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line Diabetes 52 2003 1147 1154 (Pubitemid 36523349)
7. H.E. Parker, A. Adriaenssens, G. Rogers, P. Richards, H. Koepsell, and F. Reimann Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion Diabetologia 55 2012 2445 2455
8. V. Gorboulev, A. Schurmann, V. Vallon, H. Kipp, A. Jaschke, and D. Klessen Na(+)-d-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion Diabetes 61 2012 187 196
9. D.R. Powell, M. Smith, J. Greer, A. Harris, S. Zhao, and C. DaCosta LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose J Pharmacol Exp Ther 345 2013 250 259
10. D.R. Powell, C.M. DaCosta, J. Gay, Z.M. Ding, M. Smith, and J. Greer Improved glycemic control in mice lacking Sglt1 and Sglt2 Am J Physiol Endocrinol Metab 304 2013 E117 E130
11. J.W. Stephens, T.B. Bodvarsdottir, K. Wareham, S.L. Prior, R.M. Bracken, and G.D. Lowe Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus Diabetes Res Clin Pract 94 2011 199 206
12. H.J. Jang, Z. Kokrashvili, M.J. Theodorakis, O.D. Carlson, B.J. Kim, and J. Zhou Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1 Proc Natl Acad Sci U S A 104 2007 15069 15074 (Pubitemid 47619594)
13. +-glucose cotransporter 1 Proc Natl Acad Sci U S A 104 2007 15075 15080 (Pubitemid 47619595)
14. R.L. Young, B. Chia, N.J. Isaacs, J. Ma, J. Khoo, and T. Wu Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes Diabetes 62 2013 3532 3541
15. Y. Fujita, R.D. Wideman, M. Speck, A. Asadi, D.S. King, and T.D. Webber Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo Am J Physiol Endocrinol Metab 296 2009 E473 E479
16. J. Ma, M. Bellon, J.M. Wishart, R. Young, L.A. Blackshaw, and K.L. Jones Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects Am J Physiol Gastrointest Liver Physiol 296 2009 G735 G739
17. A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, and M. Yamada Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat Med 11 2005 90 94 (Pubitemid 40215843)
18. L.M. Lauffer, R. Iakoubov, and P.L. Brubaker GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell Diabetes 58 2009 1058 1066
19. Z.L. Chu, C. Carroll, J. Alfonso, V. Gutierrez, H. He, and A. Lucman A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release Endocrinology 149 2008 2038 2047 (Pubitemid 351574507)
20. S. Edfalk, P. Steneberg, and H. Edlund Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion Diabetes 57 2008 2280 2287
21. T. Hara, A. Hirasawa, A. Ichimura, I. Kimura, and G. Tsujimoto Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders J Pharm Sci 100 2011 3594 3601
22. K.B. Hansen, M.M. Rosenkilde, F.K. Knop, N. Wellner, T.A. Diep, and J.F. Rehfeld 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans J Clin Endocrinol Metab 96 2011 E1409 E1417
23. H.M. Cox, I.R. Tough, A.M. Woolston, L. Zhang, A.D. Nguyen, and A. Sainsbury Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses Cell Metab 11 2010 532 542
24. M.A. Poreba, C.X. Dong, S.K. Li, A. Stahl, J.H. Miner, and P.L. Brubaker Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells Am J Physiol Endocrinol Metab 303 2012 E899 E907
25. R. Iakoubov, A. Ahmed, L.M. Lauffer, R.P. Bazinet, and P.L. Brubaker Essential role for protein kinase Cζ in oleic acid-induced glucagon-like peptide-1 secretion in vivo in the rat Endocrinology 152 2011 1244 1252
26. K.R. Freeland, C. Wilson, and T.M. Wolever Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects Br J Nutr 103 2010 82 90
27. A. Everard, V. Lazarevic, M. Derrien, M. Girard, G.G. Muccioli, and G.M. Muccioli Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice Diabetes 60 2011 2775 2786
28. A.J. Brown, S.M. Goldsworthy, A.A. Barnes, M.M. Eilert, L. Tcheang, and D. Daniels The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids J Biol Chem 278 2003 11312 11319 (Pubitemid 36792688)
29. G. Tolhurst, H. Heffron, Y.S. Lam, H.E. Parker, A.M. Habib, and E. Diakogiannaki Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2 Diabetes 61 2012 364 371
30. F. Reimann, L. Williams, G. da Silva Xavier, G.A. Rutter, and F.M. Gribble Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells Diabetologia 47 2004 1592 1601 (Pubitemid 39371642)
31. 2+ and cAMP Endocrinology 152 2011 405 413
32. J.R. Greenfield, I.S. Farooqi, J.M. Keogh, E. Henning, A.M. Habib, and A. Blackwood Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects Am J Clin Nutr 89 2009 106 113
33. M. Oya, T. Kitaguchi, R. Pais, F. Reimann, F. Gribble, and T. Tsuboi The G protein-coupled receptor family C Group 6 Subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like Peptide-1 secretion from GLUTag cells J Biol Chem 288 2013 4513 4521
34. O.J. Mace, M. Schindler, and S. Patel The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine J Physiol 590 2012 2917 2936
35. R.A. Reimer, C. Darimont, S. Gremlich, V. Nicolas-Metral, U.T. Ruegg, and K. Mace A human cellular model for studying the regulation of glucagon-like peptide-1 secretion Endocrinology 142 2001 4522 4528 (Pubitemid 32907084)
36. M. Cordier-Bussat, C. Bernard, F. Levenez, N. Klages, B. Laser-Ritz, and J. Philippe Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene Diabetes 47 1998 1038 1045 (Pubitemid 28294545)
37. G.B. Flock, X. Cao, M. Maziarz, and D.J. Drucker Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice Diabetes 62 2013 283 290
38. T. Inagaki, M. Choi, A. Moschetta, L. Peng, C.L. Cummins, and J.G. McDonald Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis Cell Metab 2 2005 217 225
39. H.E. Parker, K. Wallis, C.W. le Roux, K.Y. Wong, F. Reimann, and F.M. Gribble Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion Br J Pharmacol 165 2012 414 423
40. C. Thomas, A. Gioiello, L. Noriega, A. Strehle, J. Oury, and G. Rizzo TGR5-mediated bile acid sensing controls glucose homeostasis Cell Metab 10 2009 167 177
41. T. Wu, M.J. Bound, S.D. Standfield, K.L. Jones, M. Horowitz, and C.K. Rayner Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans J Clin Endocrinol Metab 98 2013 E718 E722
42. T.E. Adrian, S. Gariballa, K.A. Parekh, S.A. Thomas, H. Saadi, and J. Al Kaabi Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers Diabetologia 55 2012 2343 2347
43. M.E. Patti, S.M. Houten, A.C. Bianco, R. Bernier, P.R. Larsen, and J.J. Holst Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism Obesity (Silver Spring) 17 2009 1671 1677
44. C.E. Moss, W.J. Marsh, H.E. Parker, E. Ogunnowo-Bada, C.H. Riches, and A.M. Habib Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents Diabetologia 55 2012 3094 3103
45. C. Chisholm, and G.R. Greenberg Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures Am J Physiol Endocrinol Metab 283 2002 E311 E317
46. F. Reimann, G. Tolhurst, and F.M. Gribble G-protein-coupled receptors in intestinal chemosensation Cell Metab 15 2012 421 431
47. J.B. Buse, M. Nauck, T. Forst, W.H. Sheu, S.K. Shenouda, and C.R. Heilmann Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study Lancet 381 2013 117 124
48. M. Gejl, H.M. Sondergaard, C. Stecher, B.M. Bibby, N. Moller, and H.E. Botker Exenatide alters myocardial glucose transport and uptake depending on insulin resistance and increases myocardial blood flow in patients with type 2 diabetes J Clin Endocrinol Metab 97 2012 E1165 E1169
49. T. Araki, M. Hirayama, S. Hiroi, and K. Kaku GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes Diabetes Obesity Metab 14 2012 271 278
50. A.M. Habib, P. Richards, G.J. Rogers, F. Reimann, and F.M. Gribble Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells Diabetologia 56 2013 1413 1416
51. L.B. Katz, J.J. Gambale, P.L. Rothenberg, S.R. Vanapalli, N. Vaccaro, and L. Xi Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes Diabetes, Obesity Metab 14 2012 709 716
52. B. Zambrowicz, J. Freiman, P.M. Brown, K.S. Frazier, A. Turnage, and J. Bronner LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial Clin Pharmacol Ther 92 2012 158 169
53. C. Dirksen, D.L. Hansen, S. Madsbad, L.E. Hvolris, L.S. Naver, and J.J. Holst Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report Diabetes Care 33 2010 375 377
54. H. Buchwald, R. Estok, K. Fahrbach, D. Banel, M.D. Jensen, and W.J. Pories Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis Am J Med 122 2009 248 256 e5
55. Y. Falken, P.M. Hellstrom, J.J. Holst, and E. Naslund Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides J Clin Endocrinol Metab 96 2011 2227 2235
56. A. Jimenez, R. Casamitjana, L. Flores, J. Viaplana, R. Corcelles, and A. Lacy Long-term effects of sleeve gastrectomy and Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus in morbidly obese subjects Ann Surg 256 2012 1023 1029
57. M. Rizzello, F. Abbatini, G. Casella, G. Alessandri, A. Fantini, and F. Leonetti Early postoperative insulin-resistance changes after sleeve gastrectomy Obes Surg 20 2010 50 55
58. N.B. Jørgensen, C. Dirksen, K.N. Bojsen-Møller, S.H. Jacobsen, D. Worm, and D.L. Hansen The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes Diabetes 2013