Adipocyte size threshold matters: Link with risk of type 2 diabetes and improved insulin resistance after gastric bypass

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 8, 2014, Pages

  Cotillard, Aurelie ^a,b   Poitou, Christine ^a,b   Torcivia, Adriana ^b   Bouillot, Jean Luc ^c   Dietrich, Arne ^d   Klöting, Nora ^d   Grégoire, Cécile ^b   Lolmede, Karine ^e   Blüher, Matthias ^d   Clément, Karine ^a,b  

^a Institute OfCardiometabolism and Nutrition   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c HÔPITAL AMBROISE PARÉ   (France)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e AdipoPhyt   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTES; ADULT; CELL SIZE; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FRANCE; GASTRIC BYPASS; GERMANY; HUMANS; INSULIN RESISTANCE; MIDDLE AGED; OBESITY, MORBID; POSTOPERATIVE PERIOD; RISK FACTORS;

EID: 84905820816     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1074     Document Type: Article

References (20)

1. Björntorp P, Sjöström L. Number and size of adipose tissue fat cells in relation to metabolism in human obesity. Metab Clin Exp. 1971; 20:703-713.
2. Salans LB, Knittle JL, Hirsch J. The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity. J Clin Invest. 1968;47:153-165.
3. Stern JS, Batchelor BR, Hollander N, Cohn CK, Hirsch J. Adiposecell size and immunoreactive insulin levels in obese and normalweight adults. Lancet. 1972;2:948-951.
4. Chandalia M, Lin P, Seenivasan T, et al. Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLoS ONE. 2007;2:e812.
5. Hoffstedt J, Arner E, Wahrenberg H, et al. Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. Diabetologia. 2010;53:2496-2503.
6. Klöting N, Fasshauer M, Dietrich A, et al. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab. 2010;299:E506-515.
7. Skurk T, Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab. 2007;92:1023-1033.
8. Sabanayagam C, Liew G, Tai ES, et al. Relationship between glycated haemoglobin and microvascular complications: is there a natural cut-off point for the diagnosis of diabetes? Diabetologia. 2009; 52:1279-1289.
9. Cancello R, Henegar C, Viguerie N, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005;54:2277-2286.
10. Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg. 1995;222:339-350; discussion 350-352.
11. Balkau B, CharlesMA.Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet. Med. 1999;16:442-443.
12. R Development Core Team 2011 R: A Language and Environment for Statistical Computing Internet. Vienna, Austria: R Foundation for Statistical Computing; Available from: http://www.R-project.org.
13. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc Series B Stat Methodol. 1995;57:289-300.
14. Thomas Lumley using Fortran code by Alan Miller 2009 leaps: regression subset selection Internet. Available from: http://CRAN.Rproject.org/package- leaps.
15. Ahn SM, Pomp A, Rubino F. Metabolic surgery for type 2 diabetes. Ann N Y Acad Sci. 2010;1212:E37-45.
16. Adams ST, Salhab M, Hussain ZI, Miller GV, Leveson SH. Preoperatively determinable factors predictive of diabetes mellitus remission following Roux-en-Y gastric bypass: a review of the literature. Acta Diabetol. 2013;50:475-478.
17. Laurencikiene J, Skurk T, Kulyté A, et al. Regulation of lipolysis in small and large fat cells of the same subject. J Clin Endocrinol Metab. 2011;96:E2045-2049.
18. Jo J, Shreif Z, Periwal V. Quantitative dynamics of adipose cells. Adipocyte. 2012;1:80-88.
19. Girousse A, Tavernier G, Valle C, et al. Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol. 2013;11:e1001485.
20. Dutia R, Brakoniecki K, Bunker P, et al. Limited recovery of β-cell function after gastric bypass despite clinical diabetes remission. Diabetes. 2014;63(4):1214-23.