Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Nature Cell Biology

Volumn 16, Issue 4, 2014, Pages 367-375

  Chau, You Ying ^a   Bandiera, Roberto ^b   Serrels, Alan ^a   Martínez Estrada, Ofelia M ^c   Qing, Wei ^a   Lee, Martin ^a   Slight, Joan ^a   Thornburn, Anna ^a   Berry, Rachel ^a   Mchaffie, Sophie ^a   Stimson, Roland H ^d   Walker, Brian R ^d   Chapuli, Ramon Muñoz ^e   Schedl, Andreas ^b   Hastie, Nick ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b CENTRE DE BIOCHIMIE   (France)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

WT1 PROTEIN;

ADIPOCYTE; ADULT; ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CELL LINEAGE; CELL POPULATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INTRAABDOMINAL FAT; MALE; MESOTHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBCUTANEOUS FAT; TISSUE DIFFERENTIATION; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINEAGE; GENE KNOCK-IN TECHNIQUES; GREEN FLUORESCENT PROTEINS; MESODERM; MICE; TAMOXIFEN; WT1 PROTEINS;

EID: 84897583271     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2922     Document Type: Article

References (29)

1. Rodeheffer, M. S., Birsoy, K. & Friedman, J. M. Identification of white adipocyte progenitor cells in vivo. Cell 135, 240-249 (2008).
2. Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583-586 (2008).
3. Tran, K. V. et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 15, 222-229 (2012).
4. Berry, R. & Rodeheffer, M. S. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 15, 302-308 (2013).
5. Berry, R. et al. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla. Hum. Mol. Genet. 20, 917-926 (2011).
6. Billon, N. & Dani, C. Developmental origins of the adipocyte lineage: New insights from genetics and genomics studies. Stem. Cell Rev. 8, 55-66 (2012).
7. Macotela, Y. et al. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes 61, 1691-1699 (2012).
8. Tchkonia, T. et al. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am. J. Physiol. Endocrinol. Metab. 292, E298-E307 (2007).
9. Yamamoto, Y. et al. Adipose depots possess unique developmental gene signatures. Obesity 18, 872-878 (2010).
10. Martinez-Estrada, O. M. et al. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat. Genet. 42, 89-93 (2010).
11. Essafi, A. et al. A wt1-controlled chromatin switching mechanism underpins tissuespecific wnt4 activation and repression. Dev. Cell 21, 559-574 (2011).
12. Chau, Y. Y. et al. Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1. PLoS Genet. 7, e1002404 (2011).
13. Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global doublefluorescent Cre reporter mouse. Genesis 45, 593-605 (2007).
14. Chau, Y. Y. & Hastie, N. D. The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis. Trends Genet. 28, 515-524 (2012).
15. Wilm, B., Ipenberg, A., Hastie, N. D., Burch, J. B. & Bader, D. M. The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. Dev. 132, 5317-5328 (2005).
16. Rosito, G. A. et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study. Circulation 117, 605-613 (2008).
17. Ding, J. et al. The association of pericardial fat with incident coronary heart disease: The multi-ethnic study of atherosclerosis (MESA). Am. J. Clin. Nutr. 90, 499-504 (2009).
18. Asahina, K., Zhou, B., Pu, W. T. & Tsukamoto, H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53, 983-995 (2011).
19. Ijpenberg, A. et al. Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. Dev. Biol. 312, 157-170 (2007).
20. Rinkevich, Y. et al. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat. Cell Biol. 14, 1251-1260 (2012).
21. Que, J. et al. Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc. Natl Acad. Sci. USA 105, 16626-16630 (2008).
22. Carmona, R., Cano, E., Mattiotti, A., Gaztambide, J. & Munoz-Chapuli, R. Cells derived from the coelomic epithelium contribute to multiple gastrointestinal tissues in mouse embryos. PLoS One 8, e55890 (2013).
23. Cano, E., Carmona, R. & Munoz-Chapuli, R. Wt1-expressing progenitors contribute to multiple tissues in the developing lung. Am. J. Physiol. Lung Cell Mol. Physiol. 305, L322-L332 (2013).
24. Han, J. et al. The spatiotemporal development of adipose tissue. Development 138, 5027-5037 (2011).
25. Kanamori-Katayama, M. et al. LRRN4 and UPK3B are markers of primary mesothelial cells. PLoS One 6, e25391 (2011).
26. Sanchez-Gurmaches, J. et al. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 348-362 (2012).
27. Hosen, N. et al. The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis. Leukemia 21, 1783-1791 (2007).
28. del Monte, G. et al. Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ. Res. 108, 824-836 (2011).
29. Wessels, A. et al. Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev. Biol. 366, 111-124 (2012).