Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

FASEB Journal

Volumn 28, Issue 8, 2014, Pages 3745-3757

  Armani, Andrea ^a   Cinti, Francesca ^a,b   Marzolla, Vincenzo ^a   Morgan, James ^c   Cranston, Greg A ^c   Antelmi, Antonella ^a   Carpinelli, Giulia ^d   Canese, Rossella ^d   Pagotto, Uberto ^e   Quarta, Carmelo ^e   Malorni, Walter ^d,f   Matarrese, Paola ^d,g   Marconi, Matteo ^d   Fabbri, Andrea ^h   Rosano, Giuseppe ^a   Cinti, Saverio ^b   Young, Morag J ⁱ   Caprio, Massimiliano ^a  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f San Raffaele Institute Sulmona   (Italy)

^g Center of Integrated Metabolomics   (Italy)

^h UNIVERSITY OF ROME TOR VERGATA   (Italy)

ⁱ MONASH UNIVERSITY   (Australia)

Author keywords

Adipogenesis; Aldosterone; Metabolic syndrome; Obesity; UCP1; Uncoupling protein 1

Indexed keywords

ADENYLATE CYCLASE; ADIPONECTIN; BAFILOMYCIN A1; BETA 3 ADRENERGIC RECEPTOR; DROSPIRENONE; FATTY ACID BINDING PROTEIN 4; GLUCOSE; LEPTIN; MINERALOCORTICOID RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SPIRONOLACTONE; TATA BINDING PROTEIN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BODY COMPOSITION; BODY WEIGHT; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HISTOLOGY; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INTRAABDOMINAL FAT; LIPID DIET; LIPID STORAGE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

ADIPOGENESIS; ALDOSTERONE; METABOLIC SYNDROME; OBESITY; UCP1; UNCOUPLING PROTEIN 1;

ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ALDOSTERONE; ANDROSTENES; ANIMALS; AUTOPHAGY; BODY COMPOSITION; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; DIET, HIGH-FAT; FEMALE; GENE EXPRESSION PROFILING; GLUCOSE INTOLERANCE; INGUINAL CANAL; INTRA-ABDOMINAL FAT; ION CHANNELS; MACROLIDES; MICE; MICE, INBRED C57BL; MINERALOCORTICOID RECEPTOR ANTAGONISTS; MITOCHONDRIAL PROTEINS; OBESITY; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE; UP-REGULATION; WEIGHT GAIN;

EID: 84905274646     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-245415     Document Type: Article

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