Assessment of the anti-obesity effects of the TNP-470 analog CKD-732

Journal of Molecular Endocrinology

Volumn 38, Issue 3-4, 2007, Pages 455-465

  Kim, Yoo Mee ^c   An, Juan Ji ^a   Jin, Yong Jun ^b   Rhee, Yumie ^a   Cha, Bong Soo ^a   Lee, Hyun Chul ^a   Lim, Sung Kil ^a  

^a Yonsei University College of Medicine   (South Korea)

^b YANBIAN UNIVERSITY   (China)

^c NHIC IIsan Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

6 O (4 DIMETHYLAMINOETHOXY)CINNAMOYLFUMAGILLOL HEMIOXALATE; ANTIOBESITY AGENT; CKD 732; FUMAGILLOL CHLOROACETYLCARBAMATE DERIVATIVE; MESSENGER RNA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARCUATE NUCLEUS; ARTICLE; BODY FAT; CELL SIZE; CONTROLLED STUDY; DRUG MECHANISM; EPIDIDYMIS; FOOD INTAKE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SINGLE DRUG DOSE; TASTE AVERSION; WEIGHT REDUCTION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; ARCUATE NUCLEUS; BODY WEIGHT; CELL SIZE; CINNAMATES; CYCLOHEXANES; EATING; EPOXY COMPOUNDS; HYPOTHALAMUS; LITHIUM CHLORIDE; MALE; MICE; MICE, OBESE; NEUROPEPTIDES; OBESITY; RATS; RATS, INBRED OLETF; SESQUITERPENES; TASTE;

EID: 34248143523     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.02165     Document Type: Article

References (31)

1. Abe J, Zhou W, Takuwa N, Taguchi J, Kurokawa K, Kumada M & Takuwa Y 1994 A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Research 54 3407-3412.
2. Benoit SC, Sheldon RJ, Air EL, Messerschmidt P, Wilmer KA, Hodge KMB, Jones MB, Eckstein DMM, McOsker CC, Woods SC et al. 2003 Assessment of the aversive consequences of acute and chronic administration of the melanocortin agonist, MTII. International Journal of Obesity 27 550-556.
3. Brakenhielm E, Cao R, Gao B, Angelin B, Cannon B, Parini P & Cao Y 2004a Angiogenesis inhibitor, TNP-470, prevents diet-induced and generic obesity in mice. Circulation Research 94 1579-1588.
4. Brakenhielm E, Veitonmaki N, Cao, R, Kihara, S, Matsuzawa Y, Zhivotovsky B, Funahashi T & Cao Y 2004b Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. PNAS 101 2476-2481.
5. Bray GA & Tartaglia IA 2000 Medicinal strategies in the treatment of obesity. Nature 404 672-677.
6. Broberger C, Johansen J, Johansson C, Schalling M & Hokfelt T 1998 The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. PNAS 95 15043-15048.
7. Chun E, Han CK, Yoon JH, Sim TB, Kim Y-K & Lee K-Y 2005 Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model. International Journal of Cancer 114 124-130.
8. Crandall DL, Hausman GJ & Kral JG 1997 A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4 211-232.
9. Dhanabal M, Ramchandran R, Waterman MJF, Lu H, Knebelmann B, Segal M & Sukhatme VP 1999 Endostatin induces endothelial cell apoptosis. Journal of Biological Chemistry 274 11721-11726.
10. Elmquist JK & Marcus JN 2003 Rethinking the central causes of diabetes. Nature Medicine 9 645-647.
11. Fan W, Boston B, Kesterson R, Hruby V & Cone R 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 165-168.
12. Griffith EC, Su Z, Turk BE, Chen S, Chang YH, Wu Z, Biemann K & Liu JO 1997 Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chemistry and Biology 4 461-471.
13. Huszar D, Lynch C, Fairchild-Huntress V, Dunmore J, Fang Q, Berkemeier L, Gu W, Kersterson R, Boston B, Cone R et al. 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 131-141.
14. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H & Folkman J 1990 Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555-557.
15. Kopelman PG 2000 Obesity as a medical problem. Nature 404 635-643.
16. Lucas R, Holmgren L, Garcia I, Jimenez B, Mandriota SJ, Borlat F, Sim BKL, Wu Z, Grau GE, Shing Y et al. 1998 Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood 92 4730-4741.
17. Minokoshi Y, Kim Y-B, Peroni OD, Fryer LGD, Muller C, Carling D & Kahn BB 2002 Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 339-343.
18. Mizuno T, Kleopoulos S, Bergen H, Roberts J, Priest C & Mobbs C 1998 Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47 294-297.
19. Peruzzo B, Pastor FE, Blazquez JL, Schobitz K, Pelaez B, Amat P & Rodriguez EM 2000 A second look at the barriers of the medial basal hypothalamus. Experimental Brain Research 132 10-26.
20. Rupnick MA, Panigrahy D, Zhang C-Y, Dallabrida SM, Lowell BB, Langer R & Folkman MJ 2002 Adipose tissue mass can be regulated through the vasculature. PNAS 99 10730-10735.
21. Schwartz MW, Seeley RJ, Weigle DS, Burn P, Campfield LA & Baskin DG 1997 Leptin increases hypothalamic proopiomelanocortin (POMC) mRNA expression in the rostral arcuate nucleus. Diabetes 46 294-297.
22. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ & Baskin DG 2000 Central nervous system control of food intake. Nature 404 661-671.
23. Seely R, Yagaloff K, Fisher S, Burn P, Thiele T, Van Dijk G, Baskin D & Schwartz M 1997 Melanocortin receptors in leptin effects. Nature 390 349.
24. Sharma HS & Dey PK 1988 EEG changes following increased blood-brain barrier permeability under long-term immobilization stress in young rats. Neuroscience Research 5 224-239.
25. Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG & Crews CM 1997 The anti-antiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase MetAP-2. PNAS 94 6099-6103.
26. Skultetyova I, Tokarev D & Jezova D 1998 Stress-induced increase in blood-brain barrier permeability in control and monosodium glutamate-treated rats. Brain Research Bulletin 45 175-178.
27. Spurlock ME, Hahn KJ & Miner JL 1996 Regulation of adipsin and body composition in the monosodium glutamate (MSG)-treated mouse. Physiology and Behavior 60 1217-1221.
28. Thiele T, Van Dijk G, Yagaloff K, Fisher S, Schwartz M, Burn P & Seeley R 1998 Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. American Journal of Physiology 274 R248-R254.
29. Thornton JE, Cheung CC, Clifton DK & Steiner RA 1997 Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138 5063-5067.
30. Weigle DS 2003 Pharmacological therapy of obesity: past, present, and future. Journal of Clinical Endocrinology and Metabolism 88 2462-2469.
31. Woods SC, Seeley RJ, Porte D & Schwartz MW 1998 Signals that regulate food intake and energy homeostasis. Science 280 1378-1383.