Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: Involvement of PRDM16

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43112-43122

  Hondares, Elayne ^a   Rosell, Meritxell ^a   Díaz Delfín, Julieta ^a   Olmos, Yolanda ^b,c   Monsalve, Maria ^b   Iglesias, Roser ^a   Villarroya, Francesc ^a   Giralt, Marta ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTES; ADIPOSE TISSUE; BASAL CONDITIONS; COACTIVATORS; GENE PROMOTER; GENE TRANSCRIPTIONS; IN-VIVO; KEY COMPONENT; LIPID OXIDATION; MRNA EXPRESSION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PROTEIN KINASE A; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL CONTROL; UNCOUPLING PROTEIN-1;

CYTOLOGY; TISSUE; TRANSCRIPTION;

GENE EXPRESSION REGULATION;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; REGULATOR PROTEIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPOLYSIS; METABOLIC REGULATION; MOLECULAR BIOLOGY; MOUSE; NEWBORN; NONHUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; THERMOGENESIS; THERMOREGULATION; TRANSCRIPTION REGULATION; WHITE ADIPOSE TISSUE;

ADIPOCYTES, BROWN; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; MALE; MICE; PPAR ALPHA; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; THERMOGENESIS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 83355163350     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.252775     Document Type: Article

References (52)

1. Cannon, B., and Nedergaard, J. (2004) Physiol. Rev. 84, 277-359
2. Enerbäck, S. (2010) Cell Metab. 11, 248-252
3. Farmer, S. R. (2006) Cell Metab. 4, 263-273
4. Sears, I. B., MacGinnitie, M. A., Kovacs, L. G., and Graves, R. A. (1996) Mol. Cell. Biol. 16, 3410-3419
5. Yubero, P., Manchado, C., Cassard-Doulcier, A. M., Mampel, T., Viñas, O., Iglesias, R., Giralt, M., and Villarroya, F. (1994) Biochem. Biophys. Res. Commun. 198, 653-659
6. Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., and Spiegelman, B. M. (2007) Cell Metab. 6, 38-54
7. Carmona, M. C., Iglesias, R., Obregón, M. J., Darlington, G. J., Villarroya, F., and Giralt, M. (2002) J. Biol. Chem. 277, 21489-21498
8. Kajimura, S., Seale, P., and Spiegelman, B. M. (2010) Cell Metab. 11, 257-262
9. Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., and Spiegelman, B. M. (1998) Cell 92, 829-839
10. Uldry, M., Yang, W., St-Pierre, J., Lin, J., Seale, P., and Spiegelman, B. M. (2006) Cell Metab. 3, 333-341
11. Tiraby, C., Tavernier, G., Lefort, C., Larrouy, D., Bouillaud, F., Ricquier, D., and Langin, D. (2003) J. Biol. Chem. 278, 33370-33376
12. Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., and Collins, S. (2004) Mol. Cell. Biol. 24, 3057-3067
13. Hondares, E., Mora, O., Yubero, P., Rodriguez de la Concepción, M., Iglesias, R., Giralt, M., and Villarroya, F. (2006) Endocrinology 147, 2829-2838
14. Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., Tempst, P., Rudnicki, M. A., Beier, D. R., and Spiegelman, B. M. (2008) Nature 454, 961-967
15. Seale, P., Conroe, H. M., Estall, J., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., and Spiegelman, B. M. (2011) J. Clin. Invest. 121, 96-105
16. Mandard, S., Müller, M., and Kersten, S. (2004) Cell. Mol. Life Sci. 61, 393-416
17. Valmaseda, A., Carmona, M. C., Barberá, M. J., Viñas, O., Mampel, T., Iglesias, R., Villarroya, F., and Giralt, M. (1999) Mol. Cell. Endocrinol. 154, 101-109
18. Villarroya, F., Iglesias, R., and Giralt, M. (2007) PPAR Res. 2007, 74364
19. Barbera, M. J., Schluter, A., Pedraza, N., Iglesias, R., Villarroya, F., and Giralt, M. (2001) J. Biol. Chem. 276, 1486-1493
20. Carmona, M. C., Hondares, E., Rodríguez de la Concepción, M. L., Rodríguez- Sureda, V., Peinado-Onsurbe, J., Poli, V., Iglesias, R., Villarroya, F., and Giralt, M. (2005) Biochem. J. 389, 47-56
21. Olmos, Y., Valle, I., Borniquel, S., Tierrez, A., Soria, E., Lamas, S., and Monsalve, M. (2009) J. Biol. Chem. 284, 14476-14484
22. Wabitsch, M., Brenner, R. E., Melzner, I., Braun, M., Möller, P., Heinze, E., Debatin, K. M., and Hauner, H. (2001) Int. J. Obes. Relat. Metab. Disord. 25, 8-15
23. Handschin, C., Rhee, J., Lin, J., Tarr, P. T., and Spiegelman, B. M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 7111-7116
24. Fajas, L., Egler, V., Reiter, R., Hansen, J., Kristiansen, K., Debril, M. B., Miard, S., and Auwerx, J. (2002) Dev. Cell 3, 903-910
25. Issemann, I., and Green, S. (1990) Nature 347, 645-650
26. Hondares, E., Pineda-Torra, I., Iglesias, R., Staels, B., Villarroya, F., and Giralt, M. (2007) Biochem. Biophys. Res. Commun. 354, 1021-1027
27. Muramatsu, M., Kaibuchi, K., and Arai, K. (1989) Mol. Cell. Biol. 9, 831-836
28. Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., Kralli, A. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 1418-1423
29. Barbier, O., Villeneuve, L., Bocher, V., Fontaine, C., Torra, I. P., Duhem, C., Kosykh, V., Fruchart, J. C., Guillemette, C., and Staels, B. (2003) J. Biol. Chem. 278, 13975-13983
30. Petrovic, N., Shabalina, I. G., Timmons, J. A., Cannon, B., and Nedergaard, J. (2008) Am. J. Physiol. Endocrinol. Metab. 295, E287-96
31. Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., and Montminy, M. (2001) Nature 413, 179-183
32. Yubero, P., Barberá, M. J., Alvarez, R., Viñas, O., Mampel, T., Iglesias, R., Villarroya, F., and Giralt, M. (1998) Mol. Endocrinol. 12, 1023-1037
33. Petrovic, N., Walden, T. B, Shabalina, I. G., Timmons, J. A., Cannon, B., and Nedergaard, J. (2010) J. Biol. Chem. 285, 7153-7164
34. Rim, J. S., Xue, B., Gawronska-Kozak, B., and Kozak, L. P. (2004) J. Biol. Chem. 279, 25916-25926
35. Xue, B., Coulter, A., Rim, J. S., Koza, R. A., and Kozak, L. P. (2005) Mol. Cell. Biol. 25, 8311-8322
36. Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., and Wahli, W. (1999) J. Clin. Invest. 103, 1489-1498
37. Tong, Y., Hara, A., Komatsu, M., Tanaka, N., Kamijo, Y., Gonzalez, F. J., and Aoyama, T. (2005) Biochem. Biophys. Res. Commun. 336, 76-83
38. Komatsu, M., Tong, Y., Li, Y., Nakajima, T., Li, G., Hu, R., Sugiyama, E., Kamijo, Y., Tanaka, N., Hara, A., and Aoyama, T. (2010) Genes Cells 15, 91-100
39. van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., and Teule, G. J. (2009) N. Engl. J. Med. 360, 1500-1508
40. Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y. H., Doria, A., Kolodny, G. M., and Kahn, C. R. (2009) N. Engl. J. Med. 360, 1509-1517
41. Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerbäck, S., and Nuutila, P. (2009) N. Engl. J. Med. 360, 1518-1525
42. MacLaren, R., Cui, W., Simard, S., and Cianflone, K. (2008) J. Lipid Res. 49, 308-323
43. Bogacka, I., Ukropcova, B., McNeil, M., Gimble, J. M., and Smith, S. R. (2005) J. Clin. Endocrinol. Metab. 90, 6650-6656
44. Ribet, C., Montastier, E., Valle, C., Bezaire, V., Mazzucotelli, A., Mairal, A., Viguerie, N., and Langin, D. (2010) Endocrinology 151, 123-133
45. Young, P., Arch, J. R., and Ashwell, M. (1984) FEBS Lett. 167, 10-14
46. Guerra, C., Koza, R. A., Yamashita, H., Walsh, K, and Kozak, L. P. (1998) J. Clin. Invest. 102, 412-420
47. Granneman, J. G., Li, P., Zhu, Z., and Lu, Y. (2005) Am. J. Physiol. Endocrinol. Metab. 289, E608-16
48. Li, P., Zhu, Z., Lu, Y., and Granneman, J. G. (2005) Am. J. Physiol. Endocrinol. Metab. 289, E617-26
49. Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A, Himms-Hagen, J., Boyer, B. B., Kozak, L. P., and Flier, J. S. (1993) Nature 366, 740-742
50. Guerra, C., Navarro, P., Valverde, A. M., Arribas, M., Brüning, J., Kozak, L. P., Kahn, C. R., Benito, M. (2001) J. Clin. Invest. 108, 1205-1213
51. Arch, J. R. (2002) Eur. J. Pharmacol. 440, 99-107
52. Larsen, T. M., Toubro, S., van Baak, M. A., Gottesdiener, K. M., Larson, P., Saris, W. H., and Astrup, A. (2002) Am. J. Clin. Nutr. 76, 780-788