1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

Journal of Medicinal Chemistry

Volumn 59, Issue 4, 2016, Pages 1471-1491

  Valente, Sergio ^a   Mellini, Paolo ^a   Spallotta, Francesco ^b   Carafa, Vincenzo ^c   Nebbioso, Angela ^c   Polletta, Lucia ^a   Carnevale, Ilaria ^a   Saladini, Serena ^a   Trisciuoglio, Daniela ^d   Gabellini, Chiara ^d   Tardugno, Maria ^a   Zwergel, Clemens ^a   Cencioni, Chiara ^b   Atlante, Sandra ^b   Moniot, Sébastien ^e   Steegborn, Clemens ^e   Budriesi, Roberta ^f   Tafani, Marco ^a   Del Bufalo, Donatella ^d   Altucci, Lucia ^c,g   Gaetano, Carlo ^b   Mai, Antonello ^a   more..

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b GOETHE UNIVERSITY   (Germany)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^e UNIVERSITY OF BAYREUTH   (Germany)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 2,6 DIMETHYL 4 PHENYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXAMIDE; 1 BENZYL 2,6 DIMETHYL 4 PHENYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 (FURAN 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 (NAPHTHALEN 1 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 (NAPHTHALEN 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXAMIDE; 1 BENZYL 4 (THIAZOL 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 (THIAZOL 5 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 (THIOPHEN 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 (THIOPHEN 3 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID; 1 BENZYL 4 PHENYL 1,4 DIHYDROPYRIDINE 3,5 DICARBONITRILE; 1 BENZYL 5 (ETHOXYCARBONYL) 4 PHENYL 1,4 DIHYDROPYRIDINE 3 CARBOXYLIC ACID; 1 BENZYL 5 CARBAMOYL 4 PHENYL 1,4 DIHYDROPYRIDINE 3 CARBOXYLIC ACID; 1,4 DIHYDROPYRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DIETHYL 1 BENZOYL 4 (3 METHOXYPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (FURAN 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (NAPHTHALEN 1 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (NAPHTHALEN 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (QUINOLIN 3 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (THIAZOL 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (THIAZOL 5 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 (THIOPHEN 2 YL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 1 BENZYL 4 [4 [(4 METHYLPIPERAZIN 1 YL)METHYL]PHENYL]1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE DIHYDROCHLORIDE; DIETHYL 4 (BENZO[B]THIOPHEN 2 YL) 1 BENZYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 O TOLYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4-[[1,1 BIPHENYL] 4 YL]1 BENZYL 1,4 DIHYDROPYRIDINE 3,5DICARBOXYLATE; ETHYL 1 BENZYL 5 CARBAMOYL 4 PHENYL 1,4 DIHYDROPYRIDINE 3 CARBOXYLATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SIRTUIN 1; UNCLASSIFIED DRUG; 1,4-DIHYDROPYRIDINE; DIHYDROPYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; AORTA STRIP; ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEACETYLATION; DRUG SYNTHESIS; HEATING; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; MALE; MASS SPECTROMETRY; MITOCHONDRION; MOUSE; MYOBLAST; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; WESTERN BLOTTING; WOUND HEALING; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; NEOPLASMS; PATHOLOGY; SIGNAL TRANSDUCTION; SKIN; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DIHYDROPYRIDINES; ENZYME ACTIVATION; HUMANS; MALE; MICE; MITOCHONDRIA; NEOPLASMS; SIGNAL TRANSDUCTION; SIRTUIN 1; SKIN; WOUND HEALING;

EID: 84959335947     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01117     Document Type: Article

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