Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

Nature Medicine

Volumn 18, Issue 1, 2012, Pages 159-165

  Jeong, Hyunkyung ^a   Cohen, Dena E ^b   Cui, Libin ^a   Supinski, Andrea ^b   Savas, Jeffrey N ^c   Mazzulli, Joseph R ^a   Yates, John R ^c   Bordone, Laura ^d   Guarente, Leonard ^b   Krainc, Dimitri ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMINE; HUNTINGTIN; HYDROLASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MUTANT PROTEIN; SIRTUIN 1; SIRTUIN 1 DEACETYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DISEASE EXACERBATION; EMBRYO; ENZYME ACTIVITY; EXPERIMENTAL MODEL; FEMALE; HUNTINGTON CHOREA; MALE; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SURVIVAL; TRANSCRIPTION INITIATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; HUNTINGTON DISEASE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; RATS; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

MAMMALIA; MUS;

EID: 84855563516     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2559     Document Type: Article

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