-
1
-
-
84866163081
-
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
-
Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012; 489:318-21.
-
(2012)
Nature
, vol.489
, pp. 318-321
-
-
Mattison, J.A.1
Roth, G.S.2
Beasley, T.M.3
Tilmont, E.M.4
Handy, A.M.5
Herbert, R.L.6
Longo, D.L.7
Allison, D.B.8
Young, J.E.9
Bryant, M.10
Barnard, D.11
Ward, W.F.12
Qi, W.13
Ingram, D.K.14
de Cabo, R.15
-
2
-
-
67650439330
-
Caloric restriction delays disease onset and mortality in rhesus monkeys
-
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009; 325:201-4.
-
(2009)
Science
, vol.325
, pp. 201-204
-
-
Colman, R.J.1
Anderson, R.M.2
Johnson, S.C.3
Kastman, E.K.4
Kosmatka, K.J.5
Beasley, T.M.6
Allison, D.B.7
Cruzen, C.8
Simmons, H.A.9
Kemnitz, J.W.10
Weindruch, R.11
-
3
-
-
77951176737
-
Extending healthy life span: from yeast to humans
-
Fontana L, Partridge L, Longo VD. Extending healthy life span: from yeast to humans. Science 2010; 328:321-6.
-
(2010)
Science
, vol.328
, pp. 321-326
-
-
Fontana, L.1
Partridge, L.2
Longo, V.D.3
-
4
-
-
35948936851
-
Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
-
Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, He Q, Curb JD, Suzuki M. Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. Ann N Y Acad Sci 2007; 1114:434-55.
-
(2007)
Ann N Y Acad Sci
, vol.1114
, pp. 434-455
-
-
Willcox, B.J.1
Willcox, D.C.2
Todoriki, H.3
Fujiyoshi, A.4
Yano, K.5
He, Q.6
Curb, J.D.7
Suzuki, M.8
-
5
-
-
84883636484
-
Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys
-
Yamada Y, Colman RJ, Kemnitz JW, Baum ST, Anderson RM, Weindruch R, Schoeller DA. Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys. Exp Gerontol 2013; 48:1226-35.
-
(2013)
Exp Gerontol
, vol.48
, pp. 1226-1235
-
-
Yamada, Y.1
Colman, R.J.2
Kemnitz, J.W.3
Baum, S.T.4
Anderson, R.M.5
Weindruch, R.6
Schoeller, D.A.7
-
6
-
-
67149130284
-
Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension
-
Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet 20095:e1000467.
-
(2009)
PLoS Genet
, vol.5
, pp. e1000467
-
-
Wei, M.1
Fabrizio, P.2
Madia, F.3
Hu, J.4
Ge, H.5
Li, L.M.6
Longo, V.D.7
-
7
-
-
0035853552
-
Regulation of longevity and stress resistance by Sch9 in yeast
-
Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. Regulation of longevity and stress resistance by Sch9 in yeast. Science 2001; 292:288-90.
-
(2001)
Science
, vol.292
, pp. 288-290
-
-
Fabrizio, P.1
Pozza, F.2
Pletcher, S.D.3
Gendron, C.M.4
Longo, V.D.5
-
8
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6.
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
9
-
-
72949117234
-
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
-
Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 2009; 462:1061-4.
-
(2009)
Nature
, vol.462
, pp. 1061-1064
-
-
Grandison, R.C.1
Piper, M.D.2
Partridge, L.3
-
11
-
-
33847764645
-
Aging, adiposity, and calorie restriction
-
Fontana L, Klein S. Aging, adiposity, and calorie restriction. JAMA 2007; 297:986-94.
-
(2007)
JAMA
, vol.297
, pp. 986-994
-
-
Fontana, L.1
Klein, S.2
-
12
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996; 273:59-63.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
13
-
-
11144321344
-
Lessons learned from gene expression pro file studies of aging and caloric restriction
-
Park SK, Prolla TA. Lessons learned from gene expression pro file studies of aging and caloric restriction. Ageing Res Rev 20054:55-65.
-
(2005)
Ageing Res Rev
, vol.4
, pp. 55-65
-
-
Park, S.K.1
Prolla, T.A.2
-
14
-
-
84867880208
-
SIRT1 in metabolic syndrome: where to target matters
-
Wang Y, Xu C, Liang Y, Vanhoutte PM. SIRT1 in metabolic syndrome: where to target matters. Pharmacol Ther 2012; 136:305-18.
-
(2012)
Pharmacol Ther
, vol.136
, pp. 305-318
-
-
Wang, Y.1
Xu, C.2
Liang, Y.3
Vanhoutte, P.M.4
-
15
-
-
0028841317
-
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
-
Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 1995; 9:2888-902.
-
(1995)
Genes Dev
, vol.9
, pp. 2888-2902
-
-
Brachmann, C.B.1
Sherman, J.M.2
Devine, S.E.3
Cameron, E.E.4
Pillus, L.5
Boeke, J.D.6
-
16
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 2000; 97:5807-11.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
Sutton, A.2
Tafrov, S.T.3
Heller, R.C.4
Stebbins, J.5
Pillus, L.6
Sternglanz, R.7
-
17
-
-
0034687694
-
Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
-
Tanner KG, Landry J, Sternglanz R, Denu JM. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A 2000; 97:14178-82.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 14178-14182
-
-
Tanner, K.G.1
Landry, J.2
Sternglanz, R.3
Denu, J.M.4
-
18
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010; 5:253-95.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
19
-
-
84864708402
-
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis
-
Bai B, Liang Y, Xu C, Lee MY, Xu A, Wu D, Vanhoutte PM, Wang Y. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 2012; 126:729-40.
-
(2012)
Circulation
, vol.126
, pp. 729-740
-
-
Bai, B.1
Liang, Y.2
Xu, C.3
Lee, M.Y.4
Xu, A.5
Wu, D.6
Vanhoutte, P.M.7
Wang, Y.8
-
20
-
-
84864667383
-
Regulation of sirtuin function by posttranslational modifications
-
Flick F, Luscher B. Regulation of sirtuin function by posttranslational modifications. Front Pharmacol 2012; 3:29.
-
(2012)
Front Pharmacol
, vol.3
, pp. 29
-
-
Flick, F.1
Luscher, B.2
-
21
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999; 13:2570-80.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
22
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000; 289:2126-8.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
23
-
-
29244489494
-
Increased life span due to calorie restriction in respiratory-deficient yeast
-
Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 20051:e69.
-
(2005)
PLoS Genet
, vol.1
, pp. e69
-
-
Kaeberlein, M.1
Hu, D.2
Kerr, E.O.3
Tsuchiya, M.4
Westman, E.A.5
Dang, N.6
Fields, S.7
Kennedy, B.K.8
-
24
-
-
27744596999
-
Sir2 blocks extreme life-span extension
-
Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. Sir2 blocks extreme life-span extension. Cell 2005; 123:655-67.
-
(2005)
Cell
, vol.123
, pp. 655-667
-
-
Fabrizio, P.1
Gattazzo, C.2
Battistella, L.3
Wei, M.4
Cheng, C.5
McGrew, K.6
Longo, V.D.7
-
25
-
-
34548615053
-
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
-
Smith DL Jr, McClure JM, Matecic M, Smith JS. Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 2007; 6:649-62.
-
(2007)
Aging Cell
, vol.6
, pp. 649-662
-
-
Smith Jr., D.L.1
McClure, J.M.2
Matecic, M.3
Smith, J.S.4
-
26
-
-
84872596274
-
Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1
-
Salvi JS, Chan JN, Pettigrew C, Liu TT, Wu JD, Mekhail K. Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1. Aging Cell 2013; 12:67-75.
-
(2013)
Aging Cell
, vol.12
, pp. 67-75
-
-
Salvi, J.S.1
Chan, J.N.2
Pettigrew, C.3
Liu, T.T.4
Wu, J.D.5
Mekhail, K.6
-
28
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 2004; 101:15998-6003.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
29
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
Wang Y, Tissenbaum HA. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev 2006; 127:48-56.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
30
-
-
84865246956
-
Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans
-
Raynes R, Leckey BD Jr, Nguyen K, Westerheide SD. Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans. J Biol Chem 2012; 287:29045-53.
-
(2012)
J Biol Chem
, vol.287
, pp. 29045-29053
-
-
Raynes, R.1
Leckey Jr., B.D.2
Nguyen, K.3
Westerheide, S.D.4
-
31
-
-
80053168829
-
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
-
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011477:482-5.
-
(2011)
Nature
, vol.477
, pp. 482-485
-
-
Burnett, C.1
Valentini, S.2
Cabreiro, F.3
Goss, M.4
Somogyvari, M.5
Piper, M.D.6
Hoddinott, M.7
Sutphin, G.L.8
Leko, V.9
McElwee, J.J.10
Vazquez-Manrique, R.P.11
Orfila, A.M.12
Ackerman, D.13
Au, C.14
Vinti, G.15
Riesen, M.16
Howard, K.17
Neri, C.18
Bedalov, A.19
Kaeberlein, M.20
Soti, C.21
Partridge, L.22
Gems, D.23
more..
-
32
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004; 305:390-2.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
de Cabo, R.9
Sinclair, D.A.10
-
33
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
-
Herranz D, Munoz-Martin M, Canamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 2010; 1:3.
-
(2010)
Nat Commun
, vol.1
, pp. 3
-
-
Herranz, D.1
Munoz-Martin, M.2
Canamero, M.3
Mulero, F.4
Martinez-Pastor, B.5
Fernandez-Capetillo, O.6
Serrano, M.7
-
34
-
-
28844469898
-
Increase in activity during calorie restriction requires Sirt1
-
Chen D, Steele AD, Lindquist S, Guarente L. Increase in activity during calorie restriction requires Sirt1. Science 2005;310:1641.
-
(2005)
Science
, vol.310
, pp. 1641
-
-
Chen, D.1
Steele, A.D.2
Lindquist, S.3
Guarente, L.4
-
35
-
-
45549098657
-
SirT1 regulates energy metabolism and response to caloric restriction in mice
-
Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J, Evans M, Harper M-E, McBurney MW. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One 2008:3:e1759.
-
(2008)
PLoS One
, vol.3
, pp. e1759
-
-
Boily, G.1
Seifert, E.L.2
Bevilacqua, L.3
He, X.H.4
Sabourin, G.5
Estey, C.6
Moffat, C.7
Crawford, S.8
Saliba, S.9
Jardine, K.10
Xuan, J.11
Evans, M.12
Harper, M.-E.13
McBurney, M.W.14
-
36
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007; 6:759-67.
-
(2007)
Aging Cell
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
Motta, M.C.4
van Veen, E.5
Czopik, A.6
Steele, A.D.7
Crowe, H.8
Marmor, S.9
Luo, J.10
Gu, W.11
Guarente, L.12
-
37
-
-
84892500218
-
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice
-
Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell 2014; 13:193-6.
-
(2014)
Aging Cell
, vol.13
, pp. 193-196
-
-
Mercken, E.M.1
Hu, J.2
Krzysik-Walker, S.3
Wei, M.4
Li, Y.5
McBurney, M.W.6
de Cabo, R.7
Longo, V.D.8
-
38
-
-
63549094179
-
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
-
Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol 2009; 3:31.
-
(2009)
BMC Syst Biol
, vol.3
, pp. 31
-
-
Smith, J.J.1
Kenney, R.D.2
Gagne, D.J.3
Frushour, B.P.4
Ladd, W.5
Galonek, H.L.6
Israelian, K.7
Song, J.8
Razvadauskaite, G.9
Lynch, A.V.10
Carney, D.P.11
Johnson, R.J.12
Lavu, S.13
Iffland, A.14
Elliott, P.J.15
Lambert, P.D.16
Elliston, K.O.17
Jirousek, M.R.18
Milne, J.C.19
Boss, O.20
more..
-
39
-
-
84878326433
-
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice
-
Xu C, Bai B, Fan P, Cai Y, Huang B, Law IK, Liu L, Xu A, Tung C, Li X, Siu M, Che CM, Vanhoutte PM, Wang Y. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. Am J Transl Res 2013; 5:412-26.
-
(2013)
Am J Transl Res
, vol.5
, pp. 412-426
-
-
Xu, C.1
Bai, B.2
Fan, P.3
Cai, Y.4
Huang, B.5
Law, I.K.6
Liu, L.7
Xu, A.8
Tung, C.9
Li, X.10
Siu, M.11
Che, C.M.12
Vanhoutte, P.M.13
Wang, Y.14
-
40
-
-
33845868198
-
Sirtuins as potential targets for metabolic syndrome
-
Guarente L. Sirtuins as potential targets for metabolic syndrome Nature 2006;444:868-74.
-
(2006)
Nature
, vol.444
, pp. 868-874
-
-
Guarente, L.1
-
41
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschop MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A 2008; 105:9793-8.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
42
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 2008; 22:1753-7.
-
(2008)
Genes Dev
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.J.4
Cheng, H.L.5
Alt, F.W.6
Guarente, L.7
-
43
-
-
0034193776
-
Sir2 links chromatin silencing, metabolism, and aging
-
Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 2000; 14:1021-6.
-
(2000)
Genes Dev
, vol.14
, pp. 1021-1026
-
-
Guarente, L.1
-
44
-
-
0035170286
-
Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae
-
Bakker BM, Overkamp KM, van Maris AJ, Kotter P, Luttik MA, van Dijken JP, Pronk JT. Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae. FEMS Microbiol Rev 2001; 25:15-37.
-
(2001)
FEMS Microbiol Rev
, vol.25
, pp. 15-37
-
-
Bakker, B.M.1
Overkamp, K.M.2
van Maris, A.J.3
Kotter, P.4
Luttik, M.A.5
van Dijken, J.P.6
Pronk, J.T.7
-
45
-
-
0347128279
-
Calorie restriction extends yeast life span by lowering the level of NADH
-
Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 2004; 18:12-6.
-
(2004)
Genes Dev
, vol.18
, pp. 12-16
-
-
Lin, S.J.1
Ford, E.2
Haigis, M.3
Liszt, G.4
Guarente, L.5
-
46
-
-
0345731468
-
Yeast life-span extension by calorie restriction is independent of NAD fluctuation
-
Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 2003; 302:2124-6.
-
(2003)
Science
, vol.302
, pp. 2124-2126
-
-
Anderson, R.M.1
Latorre-Esteves, M.2
Neves, A.R.3
Lavu, S.4
Medvedik, O.5
Taylor, C.6
Howitz, K.T.7
Santos, H.8
Sinclair, D.A.9
-
47
-
-
41649119244
-
The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast
-
Easlon E, Tsang F, Skinner C, Wang C, Lin SJ. The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 2008; 22:931-44.
-
(2008)
Genes Dev
, vol.22
, pp. 931-944
-
-
Easlon, E.1
Tsang, F.2
Skinner, C.3
Wang, C.4
Lin, S.J.5
-
48
-
-
0016765049
-
Nucleocytoplasmic movement of fluorescent tracers microinjected into living salivary gland cells
-
Paine PL. Nucleocytoplasmic movement of fluorescent tracers microinjected into living salivary gland cells. J Cell Biol 1975;66:652-7.
-
(1975)
J Cell Biol
, vol.66
, pp. 652-657
-
-
Paine, P.L.1
-
49
-
-
0037040581
-
Regulation of corepressor function by nuclear NADH
-
Zhang Q, Piston DW, Goodman RH. Regulation of corepressor function by nuclear NADH. Science 2002; 295:1895-7.
-
(2002)
Science
, vol.295
, pp. 1895-1897
-
-
Zhang, Q.1
Piston, D.W.2
Goodman, R.H.3
-
50
-
-
24344454692
-
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal
-
Kim MY, Zhang T, Kraus WL. Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev 2005; 19:1951-67.
-
(2005)
Genes Dev
, vol.19
, pp. 1951-1967
-
-
Kim, M.Y.1
Zhang, T.2
Kraus, W.L.3
-
51
-
-
77953081730
-
Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span
-
Beneke S, Scherr AL, Ponath V, Popp O, Burkle A. Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span. Mech Ageing Dev 2010; 131:366-9.
-
(2010)
Mech Ageing Dev
, vol.131
, pp. 366-369
-
-
Beneke, S.1
Scherr, A.L.2
Ponath, V.3
Popp, O.4
Burkle, A.5
-
52
-
-
77952573915
-
Deficiency in poly(ADP-ribose) polymerase-1 (PARP-1) accelerates aging and spontaneous carcinogenesis in mice
-
Piskunova TS, Yurova MN, Ovsyannikov AI, Semenchenko AV, Zabezhinski MA, Popovich IG, Wang ZQ, Anisimov VN. Deficiency in poly(ADP-ribose) polymerase-1 (PARP-1) accelerates aging and spontaneous carcinogenesis in mice. Curr Gerontol Geriatr Res 2008; 2008:754190.
-
(2008)
Curr Gerontol Geriatr Res
, vol.2008
, pp. 754190
-
-
Piskunova, T.S.1
Yurova, M.N.2
Ovsyannikov, A.I.3
Semenchenko, A.V.4
Zabezhinski, M.A.5
Popovich, I.G.6
Wang, Z.Q.7
Anisimov, V.N.8
-
53
-
-
84867370386
-
Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation
-
Mangerich A, Burkle A. Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation. Oxid Med Cell Longev 2012; 2012:321653.
-
(2012)
Oxid Med Cell Longev
, vol.2012
, pp. 321653
-
-
Mangerich, A.1
Burkle, A.2
-
54
-
-
70349319371
-
Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes
-
El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U, Schreiber V, McBurney MW, Sassone-Corsi P, Dantzer F. Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. Cell Mol Life Sci 2009; 66:3219-34.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 3219-3234
-
-
El Ramy, R.1
Magroun, N.2
Messadecq, N.3
Gauthier, L.R.4
Boussin, F.D.5
Kolthur-Seetharam, U.6
Schreiber, V.7
McBurney, M.W.8
Sassone-Corsi, P.9
Dantzer, F.10
-
55
-
-
79953761260
-
PARP-2 regulates SIRT1 expression and whole-body energy expenditure
-
Bai P, Canto C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J. PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell metabolism 2011; 13:450-60.
-
(2011)
Cell metabolism
, vol.13
, pp. 450-460
-
-
Bai, P.1
Canto, C.2
Brunyanszki, A.3
Huber, A.4
Szanto, M.5
Cen, Y.6
Yamamoto, H.7
Houten, S.M.8
Kiss, B.9
Oudart, H.10
Gergely, P.11
Menissier-de Murcia, J.12
Schreiber, V.13
Sauve, A.A.14
Auwerx, J.15
-
56
-
-
79953752384
-
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
-
Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab 2011; 13:461-8.
-
(2011)
Cell Metab
, vol.13
, pp. 461-468
-
-
Bai, P.1
Canto, C.2
Oudart, H.3
Brunyanszki, A.4
Cen, Y.5
Thomas, C.6
Yamamoto, H.7
Huber, A.8
Kiss, B.9
Houtkooper, R.H.10
Schoonjans, K.11
Schreiber, V.12
Sauve, A.A.13
Menissier-de Murcia, J.14
Auwerx, J.15
-
57
-
-
0034735990
-
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins
-
Landry J, Slama JT, Sternglanz R. Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun 2000; 278:685-90.
-
(2000)
Biochem Biophys Res Commun
, vol.278
, pp. 685-690
-
-
Landry, J.1
Slama, J.T.2
Sternglanz, R.3
-
58
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
-
Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 2002; 277:45099-107.
-
(2002)
J Biol Chem
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
59
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 2003;423:181-5.
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
60
-
-
15244355745
-
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
-
Avalos JL, Bever KM, Wolberger C. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 2005; 17:855-68.
-
(2005)
Mol Cell
, vol.17
, pp. 855-868
-
-
Avalos, J.L.1
Bever, K.M.2
Wolberger, C.3
-
62
-
-
2342550554
-
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
-
Bieganowski P, Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 2004; 117:495-502.
-
(2004)
Cell
, vol.117
, pp. 495-502
-
-
Bieganowski, P.1
Brenner, C.2
-
64
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004; 305:1010-3.
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
65
-
-
0037166274
-
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem 2002; 277:18881-90.
-
(2002)
J Biol Chem
, vol.277
, pp. 18881-18890
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Cohen, H.5
Lin, S.S.6
Manchester, J.K.7
Gordon, J.I.8
Sinclair, D.A.9
-
66
-
-
33747139670
-
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?
-
Yang H, Lavu S, Sinclair DA. Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp Gerontol 2006:41:718-26.
-
(2006)
Exp Gerontol
, vol.41
, pp. 718-726
-
-
Yang, H.1
Lavu, S.2
Sinclair, D.A.3
-
67
-
-
1642580758
-
Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity
-
Gallo CM, Smith DL Jr, Smith JS. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol 2004; 24:1301-12.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1301-1312
-
-
Gallo, C.M.1
Smith Jr., D.L.2
Smith, J.S.3
-
68
-
-
0035917536
-
Crystal structure of a SIR2 homolog-NAD complex
-
Min J, Landry J, Sternglanz R, Xu RM. Crystal structure of a SIR2 homolog-NAD complex. Cell 2001; 105:269-79.
-
(2001)
Cell
, vol.105
, pp. 269-279
-
-
Min, J.1
Landry, J.2
Sternglanz, R.3
Xu, R.M.4
-
69
-
-
2942534101
-
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases
-
Zhao K, Harshaw R, Chai X, Marmorstein R. Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc Natl Acad Sci U S A 2004; 101:8563-8.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8563-8568
-
-
Zhao, K.1
Harshaw, R.2
Chai, X.3
Marmorstein, R.4
-
70
-
-
84870337107
-
The discovery of niacin, biotin, and pantothenic acid
-
Lanska DJ. The discovery of niacin, biotin, and pantothenic acid. Ann Nutr Metab 2012; 61:246-53.
-
(2012)
Ann Nutr Metab
, vol.61
, pp. 246-253
-
-
Lanska, D.J.1
-
71
-
-
33749986033
-
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism
-
Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJ. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact 2006;163:94-112.
-
(2006)
Chem Biol Interact
, vol.163
, pp. 94-112
-
-
Depeint, F.1
Bruce, W.R.2
Shangari, N.3
Mehta, R.4
O'Brien, P.J.5
-
72
-
-
0033610894
-
CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2
-
Tsang AW, Escalante-Semerena JC. CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2. J Biol Chem 1998; 273:31788-94.
-
(1998)
J Biol Chem
, vol.273
, pp. 31788-31794
-
-
Tsang, A.W.1
Escalante-Semerena, J.C.2
|