Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 761-780

  Wu, Jiahui ^a   Zhang, Dengyou ^a   Chen, Lei ^a   Li, Jianneng ^b   Wang, Jianling ^a   Ning, Chengqing ^c   Yu, Niefang ^c   Zhao, Fei ^a   Chen, Dongying ^a   Chen, Xiaoyan ^a   Chen, Kaixian ^a   Jiang, Hualiang ^a   Liu, Hong ^a   Liu, Dongxiang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b FUDAN UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZO[1,2 B]THIAZOLE DERIVATIVE; SIRTUIN 1; SIRTUIN 3; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL LABELING; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DEACETYLATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG SCREENING; DRUG STABILITY; ENZYME ACTIVATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

ACETYLATION; FLUORESCENT DYES; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SIRTUIN 1; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873906387     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301032j     Document Type: Article

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