Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Nature Communications

Volumn 6, Issue , 2015, Pages

  Dai, Han ^a   Case, April W ^a   Riera, Thomas V ^a   Considine, Thomas ^a   Lee, Jessica E ^b   Hamuro, Yoshitomo ^b   Zhao, Huizhen ^a   Jiang, Yong ^a   Sweitzer, Sharon M ^a   Pietrak, Beth ^a   Schwartz, Benjamin ^a   Blum, Charles A ^a   Disch, Jeremy S ^a   Caldwell, Richard ^a   Szczepankiewicz, Bruce ^a   Oalmann, Christopher ^a   Ng, Pui Yee ^a   White, Brian H ^a   Casaubon, Rebecca ^a   Narayan, Radha ^a   Koppetsch, Karsten ^a   Bourbonais, Francis ^a   Wu, Bo ^c   Wang, Junfeng ^c   Qian, Dongming ^d   Jiang, Fan ^d   Mao, Cheney ^d   Wang, Minghui ^a   Hu, Erding ^a   Wu, Joe C ^a   Perni, Robert B ^a   Vlasuk, George P ^a   Ellis, James L ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b ExSAR Corporation   (United States)

^c HEFEI INSTITUTES OF PHYSICAL SCIENCE   (China)

^d Zhangjiang High Tech Park   (China)

Author keywords

[No Author keywords available]

Indexed keywords

SIRTUIN 1; LYSINE; PROTEIN BINDING; SIRT1 PROTEIN, HUMAN;

AMINO ACID; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DISEASE SEVERITY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; MOLECULAR ANALYSIS; MUTAGENICITY; PUBLIC HEALTH;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; HUMAN; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; PROTEIN DETERMINATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMISTRY; CRYSTALLIZATION; DEUTERIUM HYDROGEN EXCHANGE; ESCHERICHIA COLI; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR DYNAMICS;

MAMMALIA;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; ESCHERICHIA COLI; GENETIC VECTORS; HUMANS; LYSINE; MASS SPECTROMETRY; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SIRTUIN 1; TRANSFECTION;

EID: 84961254101     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8645     Document Type: Article

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