-
2
-
-
0037461806
-
Special report: the birth of biotechnology
-
Russo E. 2003. Special report: the birth of biotechnology. Nature 421:456-457.
-
(2003)
Nature
, vol.421
, pp. 456-457
-
-
Russo, E.1
-
3
-
-
0035468423
-
Making dollars out of DNA: the first major patent in biotechnology and the commercialization of molecular biology, 1974-1980
-
Hughes SS. 2001. Making dollars out of DNA: the first major patent in biotechnology and the commercialization of molecular biology, 1974-1980. Isis 92:541-575.
-
(2001)
Isis
, vol.92
, pp. 541-575
-
-
Hughes, S.S.1
-
4
-
-
0343913079
-
Historical perspective
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley & Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Historical perspective, p 3-34. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley & Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 3-34
-
-
Prazeres, D.M.F.1
-
5
-
-
0025231388
-
Direct gene transfer into mouse muscle in vivo
-
WolffJA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
-
(1990)
Science
, vol.247
, pp. 1465-1468
-
-
Wolff, J.A.1
Malone, R.W.2
Williams, P.3
Chong, W.4
Acsadi, G.5
Jani, A.6
Felgner, P.L.7
-
6
-
-
0028670903
-
Gene expression following direct injection of DNA into liver
-
Hickman MA, Malone RW, Lehmann-Bruinsma K, Sih TR, Knoell D, Szoka FC, Walzem R, Carlson DM, Powell JS. 1994. Gene expression following direct injection of DNA into liver. Hum Gene Ther 5:1477-1483.
-
(1994)
Hum Gene Ther
, vol.5
, pp. 1477-1483
-
-
Hickman, M.A.1
Malone, R.W.2
Lehmann-Bruinsma, K.3
Sih, T.R.4
Knoell, D.5
Szoka, F.C.6
Walzem, R.7
Carlson, D.M.8
Powell, J.S.9
-
7
-
-
0028948817
-
Direct gene transfer into donor hearts at the time of harvest
-
Ardehali A, Fyfe A, Laks H, Drinkwater DC, Qiao J-H, Lusis AJ. 1995. Direct gene transfer into donor hearts at the time of harvest. J Thor Cardiovasc Surg. 109:716-720.
-
(1995)
J Thor Cardiovasc Surg.
, vol.109
, pp. 716-720
-
-
Ardehali, A.1
Fyfe, A.2
Laks, H.3
Drinkwater, D.C.4
Qiao, J.-H.5
Lusis, A.J.6
-
8
-
-
0029998364
-
Gene transfer by naked DNA into adult mouse brain
-
Schwartz B, Benoist C, Abdallah B, Rangara R, Hassan A, Scherman D, Demeneix BA. 1996. Gene transfer by naked DNA into adult mouse brain. Gene Ther 3:405-411.
-
(1996)
Gene Ther
, vol.3
, pp. 405-411
-
-
Schwartz, B.1
Benoist, C.2
Abdallah, B.3
Rangara, R.4
Hassan, A.5
Scherman, D.6
Demeneix, B.A.7
-
9
-
-
0025911805
-
Strong expression of foreign genes following direct injection into fish muscle
-
Hansen E, Fernandes K, Goldspink G, Butterworth P, Umeda PK, Chang KC. 1991. Strong expression of foreign genes following direct injection into fish muscle. FEBS Lett 290:73-76.
-
(1991)
FEBS Lett
, vol.290
, pp. 73-76
-
-
Hansen, E.1
Fernandes, K.2
Goldspink, G.3
Butterworth, P.4
Umeda, P.K.5
Chang, K.C.6
-
10
-
-
0027140509
-
DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations
-
Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. 1993. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 90:11478-11482.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11478-11482
-
-
Fynan, E.F.1
Webster, R.G.2
Fuller, D.H.3
Haynes, J.R.4
Santoro, J.C.5
Robinson, H.L.6
-
11
-
-
0027214439
-
Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA
-
Cox GJ, Zamb TJ, Babiuk LA. 1993. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J Virol 67:5664-5667.
-
(1993)
J Virol
, vol.67
, pp. 5664-5667
-
-
Cox, G.J.1
Zamb, T.J.2
Babiuk, L.A.3
-
12
-
-
0026579897
-
Genetic immunization is a simple method for eliciting an immune response
-
Tang DC, DeVit M, Johnston SA. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356:152-154.
-
(1992)
Nature
, vol.356
, pp. 152-154
-
-
Tang, D.C.1
DeVit, M.2
Johnston, S.A.3
-
13
-
-
0027411456
-
Heterologous protection against influenza by injection of DNA encoding a viral protein
-
Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, Dwarki VJ, Gromkowski SH, Deck RR, Dewitt CM, Friedman A, Hawe LA, Leander KR, Martinez D, Perry HC, Shiver JW, Montgomery DL, Liu MA. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
-
(1993)
Science
, vol.259
, pp. 1745-1749
-
-
Ulmer, J.B.1
Donnelly, J.J.2
Parker, S.E.3
Rhodes, G.H.4
Felgner, P.L.5
Dwarki, V.J.6
Gromkowski, S.H.7
Deck, R.R.8
Dewitt, C.M.9
Friedman, A.10
Hawe, L.A.11
Leander, K.R.12
Martinez, D.13
Perry, H.C.14
Shiver, J.W.15
Montgomery, D.L.16
Liu, M.A.17
-
14
-
-
84959117874
-
Concluding remarks and outlook
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley&Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Concluding remarks and outlook, p 565-578. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley&Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 565-578
-
-
Prazeres, D.M.F.1
-
15
-
-
0025600919
-
In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment
-
Yang NS, Burkholder J, Roberts B, Martinell B, McCabe D. 1990. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 87:9568-9572.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9568-9572
-
-
Yang, N.S.1
Burkholder, J.2
Roberts, B.3
Martinell, B.4
McCabe, D.5
-
16
-
-
0026067889
-
In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA
-
Titomirov AV, Sukharev S, Kistanova E. 1991. In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim Biophys Acta 1088:131-134.
-
(1991)
Biochim Biophys Acta
, vol.1088
, pp. 131-134
-
-
Titomirov, A.V.1
Sukharev, S.2
Kistanova, E.3
-
17
-
-
0028902839
-
Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
-
Xiang Z, Ertl HC. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129-135.
-
(1995)
Immunity
, vol.2
, pp. 129-135
-
-
Xiang, Z.1
Ertl, H.C.2
-
18
-
-
8944253295
-
Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
-
Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, Silverman GJ, Lotz M, Carson DA, Raz E. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352-354.
-
(1996)
Science
, vol.273
, pp. 352-354
-
-
Sato, Y.1
Roman, M.2
Tighe, H.3
Lee, D.4
Corr, M.5
Nguyen, M.D.6
Silverman, G.J.7
Lotz, M.8
Carson, D.A.9
Raz, E.10
-
19
-
-
0030174678
-
DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost
-
Davies HL, Mancini M, Michel M-L, Whalen RG. 1996. DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost. Vaccine 14:910-915.
-
(1996)
Vaccine
, vol.14
, pp. 910-915
-
-
Davies, H.L.1
Mancini, M.2
Michel, M.-L.3
Whalen, R.G.4
-
20
-
-
0029878034
-
Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes
-
Ciernik IF, Berzofsky JA, Carbone DP. 1996. Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J Immunol 156:2369-2375.
-
(1996)
J Immunol
, vol.156
, pp. 2369-2375
-
-
Ciernik, I.F.1
Berzofsky, J.A.2
Carbone, D.P.3
-
21
-
-
0030756172
-
Poly (DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration
-
Jones DH, Corris S, McDonald S, Clegg JCS, Farrar GH. 1997. Poly (DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine 15:814-817.
-
(1997)
Vaccine
, vol.15
, pp. 814-817
-
-
Jones, D.H.1
Corris, S.2
McDonald, S.3
Clegg, J.C.S.4
Farrar, G.H.5
-
22
-
-
0031436820
-
A new DNA vehicle for nonviral gene delivery: supercoiled minicircle
-
Darquet AM, Cameron B, Wils P, Scherman D, Crouzet J. 1997. A new DNA vehicle for nonviral gene delivery: supercoiled minicircle. Gene Ther 4:1341-1349.
-
(1997)
Gene Ther
, vol.4
, pp. 1341-1349
-
-
Darquet, A.M.1
Cameron, B.2
Wils, P.3
Scherman, D.4
Crouzet, J.5
-
23
-
-
0030896557
-
Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asialoglycoprotein receptor
-
Perales JC, Grossmann GA, Molas M, Liu G, Ferkol T, Harpst J, Oda H, Hanson RW. 1997. Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asialoglycoprotein receptor. J Biol Chem 272:7398-7407.
-
(1997)
J Biol Chem
, vol.272
, pp. 7398-7407
-
-
Perales, J.C.1
Grossmann, G.A.2
Molas, M.3
Liu, G.4
Ferkol, T.5
Harpst, J.6
Oda, H.7
Hanson, R.W.8
-
24
-
-
0032805251
-
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
-
Liu F, Song Y, Liu D. 1999. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 6:1258-1266.
-
(1999)
Gene Ther
, vol.6
, pp. 1258-1266
-
-
Liu, F.1
Song, Y.2
Liu, D.3
-
25
-
-
0142089747
-
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
-
Raper SE, Chirmule N, Lee FS, Wivel NA, Bagg A, Gao GP, Wilson JM, Batshaw ML. 2003. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 80:148-158.
-
(2003)
Mol Genet Metab
, vol.80
, pp. 148-158
-
-
Raper, S.E.1
Chirmule, N.2
Lee, F.S.3
Wivel, N.A.4
Bagg, A.5
Gao, G.P.6
Wilson, J.M.7
Batshaw, M.L.8
-
26
-
-
84959134675
-
Gene transfer with plasmid biopharmaceuticals
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley&Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Gene transfer with plasmid biopharmaceuticals, p 35-68. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley&Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 35-68
-
-
Prazeres, D.M.F.1
-
27
-
-
85047694396
-
Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1
-
Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. 2003. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest 112:30-41.
-
(2003)
J Clin Invest
, vol.112
, pp. 30-41
-
-
Zhong, J.1
Eliceiri, B.2
Stupack, D.3
Penta, K.4
Sakamoto, G.5
Quertermous, T.6
Coleman, M.7
Boudreau, N.8
Varner, J.A.9
-
28
-
-
33751181265
-
Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease
-
Koike H, Ishida A, Shimamura M, Mizuno S, Nakamura T, Ogihara T, Kaneda Y, Morishita R. 2006. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease. Gene Ther 13:1639-1644.
-
(2006)
Gene Ther
, vol.13
, pp. 1639-1644
-
-
Koike, H.1
Ishida, A.2
Shimamura, M.3
Mizuno, S.4
Nakamura, T.5
Ogihara, T.6
Kaneda, Y.7
Morishita, R.8
-
29
-
-
0033586375
-
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial
-
Alton EW, Stern M, Farley R, Jaffe A, Chadwick SL, Phillips J, Davies J, Smith SN, Browning J, Davies MG, Hodson ME, Durham SR, Li D, Jeffery PK, Scallan M, Balfour R, Eastman SJ, Cheng SH, Smith AE, Meeker D, Geddes DM. 1999. Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial. Lancet 353:947-954.
-
(1999)
Lancet
, vol.353
, pp. 947-954
-
-
Alton, E.W.1
Stern, M.2
Farley, R.3
Jaffe, A.4
Chadwick, S.L.5
Phillips, J.6
Davies, J.7
Smith, S.N.8
Browning, J.9
Davies, M.G.10
Hodson, M.E.11
Durham, S.R.12
Li, D.13
Jeffery, P.K.14
Scallan, M.15
Balfour, R.16
Eastman, S.J.17
Cheng, S.H.18
Smith, A.E.19
Meeker, D.20
Geddes, D.M.21
more..
-
30
-
-
6344263893
-
Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy
-
Romero NB, Braun S, Benveniste O, Braun S, Benveniste O, Leturcq F, Hogrel JY, Morris GE, Barois A, Eymard B, Payan C, Ortega V, Boch AL, Lejean L, Thioudellet C, Mourot B, Escot C, Choquel A, Recan D, Kaplan JC, Dickson G, Klatzmann D, Molinier-Frenckel V, Guillet JG, Squiban P, Herson S, Fardeau M. 2004. Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy. Hum Gene Ther 15:1065-1076.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 1065-1076
-
-
Romero, N.B.1
Braun, S.2
Benveniste, O.3
Braun, S.4
Benveniste, O.5
Leturcq, F.6
Hogrel, J.Y.7
Morris, G.E.8
Barois, A.9
Eymard, B.10
Payan, C.11
Ortega, V.12
Boch, A.L.13
Lejean, L.14
Thioudellet, C.15
Mourot, B.16
Escot, C.17
Choquel, A.18
Recan, D.19
Kaplan, J.C.20
Dickson, G.21
Klatzmann, D.22
Molinier-Frenckel, V.23
Guillet, J.G.24
Squiban, P.25
Herson, S.26
Fardeau, M.27
more..
-
31
-
-
1542374880
-
Gene therapy of streptozotocininduced diabetes by intramuscular delivery of modified preproinsulin genes
-
Croze F, Prud'homme GJ. 2003. Gene therapy of streptozotocininduced diabetes by intramuscular delivery of modified preproinsulin genes. J Gene Med 5:425-437.
-
(2003)
J Gene Med
, vol.5
, pp. 425-437
-
-
Croze, F.1
Prud'homme, G.J.2
-
32
-
-
34247208149
-
Progress toward a nonviral gene therapy protocol for the treatment of anemia
-
Sebestyén MG, Hegge JO, Noble MA, Lewis DL, Herweijer H, WolffJA. 2007. Progress toward a nonviral gene therapy protocol for the treatment of anemia. Hum Gene Ther 18:269-285.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 269-285
-
-
Sebestyén, M.G.1
Hegge, J.O.2
Noble, M.A.3
Lewis, D.L.4
Herweijer, H.5
Wolff, J.A.6
-
33
-
-
79960750673
-
Clinical applications of DNA vaccines: current progress
-
Ferraro B, Morrow MP, Hutnick NA, Shin TH, Lucke CE, Weiner DB. 2011. Clinical applications of DNA vaccines: current progress. Clin Infect Dis 53:296-302.
-
(2011)
Clin Infect Dis
, vol.53
, pp. 296-302
-
-
Ferraro, B.1
Morrow, M.P.2
Hutnick, N.A.3
Shin, T.H.4
Lucke, C.E.5
Weiner, D.B.6
-
34
-
-
2042522699
-
DNA vaccines against human immunodeficiency virus type 1 in the past decade
-
Giri M, Ugen KE, Weiner DB. 2004. DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clin Microbiol Rev 17:370-389.
-
(2004)
Clin Microbiol Rev
, vol.17
, pp. 370-389
-
-
Giri, M.1
Ugen, K.E.2
Weiner, D.B.3
-
35
-
-
4644274734
-
A bicistronic DNA vaccine containing apical membrane antigen 1 and merozoite surface protein 4/5 can prime humoral and cellular immune responses and partially protect mice against virulent Plasmodium chabaudi adami DS malaria
-
Rainczuk A, Scorza T, Spithill TW, Smooker PM. 2004. A bicistronic DNA vaccine containing apical membrane antigen 1 and merozoite surface protein 4/5 can prime humoral and cellular immune responses and partially protect mice against virulent Plasmodium chabaudi adami DS malaria. Infect Immun 72:5565-5573.
-
(2004)
Infect Immun
, vol.72
, pp. 5565-5573
-
-
Rainczuk, A.1
Scorza, T.2
Spithill, T.W.3
Smooker, P.M.4
-
36
-
-
20044361834
-
Recent developments in tuberculosis vaccines
-
Haile M, Kallenius G. 2005. Recent developments in tuberculosis vaccines. Curr Opin Infect Dis 18:211-215.
-
(2005)
Curr Opin Infect Dis
, vol.18
, pp. 211-215
-
-
Haile, M.1
Kallenius, G.2
-
37
-
-
33646830816
-
Epidermal DNA vaccine for influenza is immunogenic in humans
-
Drape RJ, Macklin MD, Barr LJ, Jones S, Haynes JR, Dean HJ. 2006. Epidermal DNA vaccine for influenza is immunogenic in humans. Vaccine 24:4475-4481.
-
(2006)
Vaccine
, vol.24
, pp. 4475-4481
-
-
Drape, R.J.1
Macklin, M.D.2
Barr, L.J.3
Jones, S.4
Haynes, J.R.5
Dean, H.J.6
-
38
-
-
33646147142
-
DNA vaccines: successes and limitations in cancer and infectious disease
-
Lowe DB, Shearer MH, Kennedy RC. 2006. DNA vaccines: successes and limitations in cancer and infectious disease. J Cell Biochem 98:235-242.
-
(2006)
J Cell Biochem
, vol.98
, pp. 235-242
-
-
Lowe, D.B.1
Shearer, M.H.2
Kennedy, R.C.3
-
39
-
-
10444240021
-
A plasmid-based system for expressing small interfering RNA libraries in mammalian cells
-
Kaykas A, Moon RT. 2004. A plasmid-based system for expressing small interfering RNA libraries in mammalian cells. BMC Cell Biol 5:16. doi:10.1186/1471-2121-5-16.
-
(2004)
BMC Cell Biol
, vol.5
, pp. 16
-
-
Kaykas, A.1
Moon, R.T.2
-
40
-
-
63049087126
-
High-efficiency transfection of short hairpin RNAs-encoding plasmids into primary hippocampal neurons
-
Zeitelhofer M, Karra D, Vessey JP, Jaskic E, Macchi P, Thomas S, Riefler J, Kiebler M, Dahm R. 2009. High-efficiency transfection of short hairpin RNAs-encoding plasmids into primary hippocampal neurons. J Neurosci Res 87:289-300.
-
(2009)
J Neurosci Res
, vol.87
, pp. 289-300
-
-
Zeitelhofer, M.1
Karra, D.2
Vessey, J.P.3
Jaskic, E.4
Macchi, P.5
Thomas, S.6
Riefler, J.7
Kiebler, M.8
Dahm, R.9
-
41
-
-
84862935516
-
Anti-angiogenesis and anticancer effects of a plasmid expressing both ENDO-VEGI151 and small interfering RNA against surviving
-
Li Z, Yang S, Chang T, Cao X, Shi L, Fang G. 2012. Anti-angiogenesis and anticancer effects of a plasmid expressing both ENDO-VEGI151 and small interfering RNA against surviving. Int J Mol Med 29:485-490.
-
(2012)
Int J Mol Med
, vol.29
, pp. 485-490
-
-
Li, Z.1
Yang, S.2
Chang, T.3
Cao, X.4
Shi, L.5
Fang, G.6
-
42
-
-
0034985202
-
Gene therapy for the treatment of hemophilia B using PINC-formulated plasmid delivered to muscle with electroporation
-
Fewell JG, MacLaughlin F, Mehta V, Gondo M, Nicol F, Wilson E, Smith LC. 2001. Gene therapy for the treatment of hemophilia B using PINC-formulated plasmid delivered to muscle with electroporation. Mol Ther 3:574-583.
-
(2001)
Mol Ther
, vol.3
, pp. 574-583
-
-
Fewell, J.G.1
MacLaughlin, F.2
Mehta, V.3
Gondo, M.4
Nicol, F.5
Wilson, E.6
Smith, L.C.7
-
43
-
-
3242698023
-
A new potent hFIX plasmid for hemophilia B gene therapy
-
Lee JS, Lee M, Kim SW. 2004. A new potent hFIX plasmid for hemophilia B gene therapy. Pharm Res 21:1229-1232.
-
(2004)
Pharm Res
, vol.21
, pp. 1229-1232
-
-
Lee, J.S.1
Lee, M.2
Kim, S.W.3
-
44
-
-
84864013836
-
CpG-free plasmid expression cassettes for cystic fibrosis gene therapy
-
Pringle IA, Hyde SC, Connolly MM, Lawton AE, Xu B, Nunez-Alonso G, Davies LA, Sumner-Jones SG, Gill DR. 2012. CpG-free plasmid expression cassettes for cystic fibrosis gene therapy. Biomaterials 33:6833-6842.
-
(2012)
Biomaterials
, vol.33
, pp. 6833-6842
-
-
Pringle, I.A.1
Hyde, S.C.2
Connolly, M.M.3
Lawton, A.E.4
Xu, B.5
Nunez-Alonso, G.6
Davies, L.A.7
Sumner-Jones, S.G.8
Gill, D.R.9
-
45
-
-
31044452085
-
Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration
-
Bertoni C, Jarrahian S, Wheeler TM, Li Y, Olivares EC, Calos MP, Rando TA. 2006. Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration. Proc Natl Acad Sci USA 103:419-424.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 419-424
-
-
Bertoni, C.1
Jarrahian, S.2
Wheeler, T.M.3
Li, Y.4
Olivares, E.C.5
Calos, M.P.6
Rando, T.A.7
-
46
-
-
0036665610
-
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study
-
Makinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E, Ylä-Herttuala S. 2002. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther 6:127-133.
-
(2002)
Mol Ther
, vol.6
, pp. 127-133
-
-
Makinen, K.1
Manninen, H.2
Hedman, M.3
Matsi, P.4
Mussalo, H.5
Alhava, E.6
Ylä-Herttuala, S.7
-
47
-
-
42549140599
-
Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critical limb ischemia
-
Nikol S, Baumgartner I, Van Belle E, Diehm C, Visoná A, Capogrossi MC, Ferreira-Maldent N, Gallino A, Wyatt MG, Wijesinghe LD, Fusari M, Stephan D, Emmerich J, Pompilio G, Vermassen F, Pham E, Grek V, Coleman M, Meyer F. 2008. Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critical limb ischemia. Mol Ther 16:972-978.
-
(2008)
Mol Ther
, vol.16
, pp. 972-978
-
-
Nikol, S.1
Baumgartner, I.2
Van Belle, E.3
Diehm, C.4
Visoná, A.5
Capogrossi, M.C.6
Ferreira-Maldent, N.7
Gallino, A.8
Wyatt, M.G.9
Wijesinghe, L.D.10
Fusari, M.11
Stephan, D.12
Emmerich, J.13
Pompilio, G.14
Vermassen, F.15
Pham, E.16
Grek, V.17
Coleman, M.18
Meyer, F.19
-
48
-
-
33746310019
-
Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep
-
Vera Janavel G, Crottogini A, Cabeza Meckert P, Cuniberti L, Mele A, Papouchado M, Fernández N, Bercovich A, Criscuolo M, Melo C, Laguens R. 2006. Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep. Gene Ther 13:1133-1142.
-
(2006)
Gene Ther
, vol.13
, pp. 1133-1142
-
-
Vera Janavel, G.1
Crottogini, A.2
Cabeza Meckert, P.3
Cuniberti, L.4
Mele, A.5
Papouchado, M.6
Fernández, N.7
Bercovich, A.8
Criscuolo, M.9
Melo, C.10
Laguens, R.11
-
49
-
-
84867869521
-
Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model
-
Lu Q, Yao Y, Yao Y, Liu S, Huang Y, Lu S, Bai Y, Zhou B, Xu Y, Li L, Wang N, Wang L, Zhang J, Cheng X, Qin G, Ma W, Xu C, Tu X, Wang Q. 2012. Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model. PLoS One 7:e46998. doi:10.1371/journal.pone.0046998.
-
(2012)
PLoS One
, vol.7
-
-
Lu, Q.1
Yao, Y.2
Yao, Y.3
Liu, S.4
Huang, Y.5
Lu, S.6
Bai, Y.7
Zhou, B.8
Xu, Y.9
Li, L.10
Wang, N.11
Wang, L.12
Zhang, J.13
Cheng, X.14
Qin, G.15
Ma, W.16
Xu, C.17
Tu, X.18
Wang, Q.19
-
50
-
-
0035816146
-
Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy
-
Xu L, Pirollo KF, Chang EH. 2001. Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy. J Control Release 74:115-128.
-
(2001)
J Control Release
, vol.74
, pp. 115-128
-
-
Xu, L.1
Pirollo, K.F.2
Chang, E.H.3
-
51
-
-
0038812123
-
Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes
-
Xu L, Huang CC, Huang W, Tang WH, Rait A, Yin YZ, Cruz I, Xiang LM, Pirollo KF, Chang EH. 2002. Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes. Mol Cancer Ther 1:337-346.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 337-346
-
-
Xu, L.1
Huang, C.C.2
Huang, W.3
Tang, W.H.4
Rait, A.5
Yin, Y.Z.6
Cruz, I.7
Xiang, L.M.8
Pirollo, K.F.9
Chang, E.H.10
-
52
-
-
0041622921
-
Enhanced p53 gene transfer to human ovarian cancer cells using the cationic nonviral vector, DDC
-
Kim CK, Choi EJ, Choi SH, Park JS, Haider KH, Ahn WS. 2003. Enhanced p53 gene transfer to human ovarian cancer cells using the cationic nonviral vector, DDC. Gynecol Oncol 90:265-272.
-
(2003)
Gynecol Oncol
, vol.90
, pp. 265-272
-
-
Kim, C.K.1
Choi, E.J.2
Choi, S.H.3
Park, J.S.4
Haider, K.H.5
Ahn, W.S.6
-
53
-
-
18044379986
-
p53 gene therapy of human osteosarcoma using a transferrinmodified cationic liposome
-
Nakase M, Inui M, Okumura K, Kamei T, Nakamura S, Tagawa T. 2005. p53 gene therapy of human osteosarcoma using a transferrinmodified cationic liposome. Mol Cancer Ther 4:625-631.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 625-631
-
-
Nakase, M.1
Inui, M.2
Okumura, K.3
Kamei, T.4
Nakamura, S.5
Tagawa, T.6
-
54
-
-
77649190204
-
Photodynamic therapy-driven induction of suicide cytosine deaminase gene
-
Bil J, Wlodarski P, Winiarska M, Kurzaj Z, Issat T, Jozkowicz A, Wegiel B, Dulak J, Golab J. 2010. Photodynamic therapy-driven induction of suicide cytosine deaminase gene. Cancer Lett 290:216-222.
-
(2010)
Cancer Lett
, vol.290
, pp. 216-222
-
-
Bil, J.1
Wlodarski, P.2
Winiarska, M.3
Kurzaj, Z.4
Issat, T.5
Jozkowicz, A.6
Wegiel, B.7
Dulak, J.8
Golab, J.9
-
55
-
-
0033959448
-
Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer
-
Maruyama-Tabata H, Harada Y, Matsumura T, Satoh E, Cui F, Iwai M, Kita M, Hibi S, Imanishi J, Sawada T, Mazda O. 2000. Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer. Gene Ther 7:53-60.
-
(2000)
Gene Ther
, vol.7
, pp. 53-60
-
-
Maruyama-Tabata, H.1
Harada, Y.2
Matsumura, T.3
Satoh, E.4
Cui, F.5
Iwai, M.6
Kita, M.7
Hibi, S.8
Imanishi, J.9
Sawada, T.10
Mazda, O.11
-
56
-
-
0027421333
-
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
-
Kendall RL, Thomas KA. 1993. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 90:10705-10709.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10705-10709
-
-
Kendall, R.L.1
Thomas, K.A.2
-
57
-
-
70349511935
-
Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally
-
Fewell JG, Matar MM, Rice JS, Brunhoeber E, Slobodkin G, Pence C, Worker M, Lewis DH, Anwer K. 2009. Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally. J Gene Med 11:718-728.
-
(2009)
J Gene Med
, vol.11
, pp. 718-728
-
-
Fewell, J.G.1
Matar, M.M.2
Rice, J.S.3
Brunhoeber, E.4
Slobodkin, G.5
Pence, C.6
Worker, M.7
Lewis, D.H.8
Anwer, K.9
-
58
-
-
44649084951
-
DNA vaccination for prostate cancer
-
Roos AK, King A, Pisa P. 2008. DNA vaccination for prostate cancer. Methods Mol Biol 423:463-472.
-
(2008)
Methods Mol Biol
, vol.423
, pp. 463-472
-
-
Roos, A.K.1
King, A.2
Pisa, P.3
-
59
-
-
35548944929
-
Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma
-
Wolchok JD, Yuan J, Houghton AN, Gallardo HF, Rasalan TS, Wang J, Zhang Y, Ranganathan R, Chapman PB, Krown SE, Livingston PO, Heywood M, Riviere I, Panageas KS, Terzulli SL, Perales MA. 2007. Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma. Mol Ther 5:2044-2050.
-
(2007)
Mol Ther
, vol.5
, pp. 2044-2050
-
-
Wolchok, J.D.1
Yuan, J.2
Houghton, A.N.3
Gallardo, H.F.4
Rasalan, T.S.5
Wang, J.6
Zhang, Y.7
Ranganathan, R.8
Chapman, P.B.9
Krown, S.E.10
Livingston, P.O.11
Heywood, M.12
Riviere, I.13
Panageas, K.S.14
Terzulli, S.L.15
Perales, M.A.16
-
60
-
-
0029820526
-
DNA-based immunization by in vivo transfection of dendritic cells
-
Condon C, Watkins SC, Celluzzi CM, Thompson K, Falo LD. 1996. DNA-based immunization by in vivo transfection of dendritic cells. Nature Med 2:1122-1128.
-
(1996)
Nature Med
, vol.2
, pp. 1122-1128
-
-
Condon, C.1
Watkins, S.C.2
Celluzzi, C.M.3
Thompson, K.4
Falo, L.D.5
-
61
-
-
58049200809
-
Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
-
Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK, Munster PN, Sullivan DM, Ugen KE, Messina JL, Heller R. 2008. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clinic Oncol 26:5896-5903.
-
(2008)
J Clinic Oncol
, vol.26
, pp. 5896-5903
-
-
Daud, A.I.1
DeConti, R.C.2
Andrews, S.3
Urbas, P.4
Riker, A.I.5
Sondak, V.K.6
Munster, P.N.7
Sullivan, D.M.8
Ugen, K.E.9
Messina, J.L.10
Heller, R.11
-
62
-
-
13844262749
-
Intratumoral injection of DNA encoding human interleukin 12 into patients with metastatic melanoma: clinical efficacy
-
Heinzerling L, Burg G, Dummer R, Maier T, Oberholzer PA, Schultz J, Elzaouk L, Pavlovic J, Moelling K. 2005. Intratumoral injection of DNA encoding human interleukin 12 into patients with metastatic melanoma: clinical efficacy. Human Gene Ther 16:35-48.
-
(2005)
Human Gene Ther
, vol.16
, pp. 35-48
-
-
Heinzerling, L.1
Burg, G.2
Dummer, R.3
Maier, T.4
Oberholzer, P.A.5
Schultz, J.6
Elzaouk, L.7
Pavlovic, J.8
Moelling, K.9
-
63
-
-
21044458854
-
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
-
Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. 2005. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nature Med 11:551-555.
-
(2005)
Nature Med
, vol.11
, pp. 551-555
-
-
Tuszynski, M.H.1
Thal, L.2
Pay, M.3
Salmon, D.P.4
Bakay, R.5
Patel, P.6
Blesch, A.7
Vahlsing, H.L.8
Ho, G.9
Tong, G.10
Potkin, S.G.11
Fallon, J.12
Hansen, L.13
Mufson, E.J.14
Kordower, J.H.15
Gall, C.16
Conner, J.17
-
64
-
-
45749097402
-
Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticle containing interleukin-1 receptor antagonist gene in rats with adjuvantinduced arthritis
-
Fernandes JC, Wang H, Jreyssaty C, Benderdour M, Lavigne P, Qiu X, Winnik FM, Zhang X, Dai K, Shi Q. 2008. Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticle containing interleukin-1 receptor antagonist gene in rats with adjuvantinduced arthritis. Mol Ther 16:1243-1251.
-
(2008)
Mol Ther
, vol.16
, pp. 1243-1251
-
-
Fernandes, J.C.1
Wang, H.2
Jreyssaty, C.3
Benderdour, M.4
Lavigne, P.5
Qiu, X.6
Winnik, F.M.7
Zhang, X.8
Dai, K.9
Shi, Q.10
-
65
-
-
36149000959
-
Transient non-viral cutaneous gene delivery in burn wounds
-
Steinstraesser L, Hirsch T, Beller J, Mittler D, Sorkin M, Pazdierny G, Jacobsen F, Eriksson E, Steinau HU. 2007. Transient non-viral cutaneous gene delivery in burn wounds. J Gene Med 9:949-955.
-
(2007)
J Gene Med
, vol.9
, pp. 949-955
-
-
Steinstraesser, L.1
Hirsch, T.2
Beller, J.3
Mittler, D.4
Sorkin, M.5
Pazdierny, G.6
Jacobsen, F.7
Eriksson, E.8
Steinau, H.U.9
-
66
-
-
58149105781
-
Effects of targeted fusion anti-caries DNA vaccine pGJA-P/VAX in rats with caries
-
Liu C, Fan M, Bian Z, Chen Z, Li Y. 2008. Effects of targeted fusion anti-caries DNA vaccine pGJA-P/VAX in rats with caries. Vaccine 26:6685-6689.
-
(2008)
Vaccine
, vol.26
, pp. 6685-6689
-
-
Liu, C.1
Fan, M.2
Bian, Z.3
Chen, Z.4
Li, Y.5
-
67
-
-
14644423897
-
Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode
-
Ishikawa H, Takano M, Matsumoto N, Sawada H, Ide C, Mimura O. 2005. Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode. Gene Ther 12:289-298.
-
(2005)
Gene Ther
, vol.12
, pp. 289-298
-
-
Ishikawa, H.1
Takano, M.2
Matsumoto, N.3
Sawada, H.4
Ide, C.5
Mimura, O.6
-
68
-
-
36749051248
-
Systemic administration of interleukin-4 expressing plasmid DNA delays the development of glomerulonephritis and prolongs survival in lupus-prone female NZB x NZW F1 mice
-
Hayashi T, Hasegawa K, Sasaki Y, Mori T, Adachi C, Maeda K. 2007. Systemic administration of interleukin-4 expressing plasmid DNA delays the development of glomerulonephritis and prolongs survival in lupus-prone female NZB x NZW F1 mice. Nephrol Dial Transplant 22:3131-3138.
-
(2007)
Nephrol Dial Transplant
, vol.22
, pp. 3131-3138
-
-
Hayashi, T.1
Hasegawa, K.2
Sasaki, Y.3
Mori, T.4
Adachi, C.5
Maeda, K.6
-
69
-
-
56349138520
-
A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis
-
Tohyama S, Onodera S, Tohyama H, Yasuda K, Nishihira J, Mizue Y, Hamasaka A, Abe R, Koyama Y. 2008. A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis. Gene Ther 15:1513-1522.
-
(2008)
Gene Ther
, vol.15
, pp. 1513-1522
-
-
Tohyama, S.1
Onodera, S.2
Tohyama, H.3
Yasuda, K.4
Nishihira, J.5
Mizue, Y.6
Hamasaka, A.7
Abe, R.8
Koyama, Y.9
-
70
-
-
63649106581
-
Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury
-
De Laporte L, Yang Y, Zelivyanskaya ML, Cummings BJ, Anderson AJ, Shea LD. 2009. Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury. Mol Ther 17:318-326.
-
(2009)
Mol Ther
, vol.17
, pp. 318-326
-
-
De Laporte, L.1
Yang, Y.2
Zelivyanskaya, M.L.3
Cummings, B.J.4
Anderson, A.J.5
Shea, L.D.6
-
71
-
-
63949086049
-
Intradermal delivery of plasmid VEGF(165) by electroporation promotes wound healing
-
Ferraro B, Cruz YL, Coppola D, Heller R. 2009. Intradermal delivery of plasmid VEGF(165) by electroporation promotes wound healing. Mol Ther 17:651-657.
-
(2009)
Mol Ther
, vol.17
, pp. 651-657
-
-
Ferraro, B.1
Cruz, Y.L.2
Coppola, D.3
Heller, R.4
-
72
-
-
0141606199
-
Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis
-
Dean HJ, Fuller D, Osorio JE. 2003. Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis. Comp Immunol Microbiol Infect Dis 26:373-388.
-
(2003)
Comp Immunol Microbiol Infect Dis
, vol.26
, pp. 373-388
-
-
Dean, H.J.1
Fuller, D.2
Osorio, J.E.3
-
73
-
-
0032533471
-
Optimization of codon usage of plasmid DNA vaccine is required for the effective MHC class I-restricted T cell responses against intracellular bacterium
-
Uchijima M, Yoshida A, Nagata T, Koide Y. 1998. Optimization of codon usage of plasmid DNA vaccine is required for the effective MHC class I-restricted T cell responses against intracellular bacterium. J Immunol 161:5594-5599.
-
(1998)
J Immunol
, vol.161
, pp. 5594-5599
-
-
Uchijima, M.1
Yoshida, A.2
Nagata, T.3
Koide, Y.4
-
75
-
-
0035166836
-
Modulation of immunity against herpes simplex virus infection via mucosal genetic transfer of plasmid DNA encoding chemokines
-
Eo SK, Lee S, Chun S, Rouse BT. 2001. Modulation of immunity against herpes simplex virus infection via mucosal genetic transfer of plasmid DNA encoding chemokines. J Virol 75:569-578.
-
(2001)
J Virol
, vol.75
, pp. 569-578
-
-
Eo, S.K.1
Lee, S.2
Chun, S.3
Rouse, B.T.4
-
77
-
-
77949773004
-
Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity
-
Vaine M, Wang S, Hackett A, Arthos J, Lu S. 2010. Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity. Vaccine 28:2999-3007.
-
(2010)
Vaccine
, vol.28
, pp. 2999-3007
-
-
Vaine, M.1
Wang, S.2
Hackett, A.3
Arthos, J.4
Lu, S.5
-
78
-
-
70249111216
-
Prospects for developing an effective particle-mediated DNA vaccine against influenza
-
Yager EJ, Dean HJ, Fuller DH. 2009. Prospects for developing an effective particle-mediated DNA vaccine against influenza. Expert Rev Vaccines 8:1205-1220.
-
(2009)
Expert Rev Vaccines
, vol.8
, pp. 1205-1220
-
-
Yager, E.J.1
Dean, H.J.2
Fuller, D.H.3
-
79
-
-
33845598030
-
Dengue tetravalent DNA vaccine increases its immunogenicity in mice when mixed with a dengue type 2 subunit vaccine or an inactivated Japanese encephalitis vaccine
-
Imoto J, Konishi E. 2007. Dengue tetravalent DNA vaccine increases its immunogenicity in mice when mixed with a dengue type 2 subunit vaccine or an inactivated Japanese encephalitis vaccine. Vaccine 25:1076-1084.
-
(2007)
Vaccine
, vol.25
, pp. 1076-1084
-
-
Imoto, J.1
Konishi, E.2
-
80
-
-
50849116106
-
Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques
-
Yan J, Harris K, Khan AS, Draghia-Akli R, Sewell D, Weiner DB. 2008. Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques. Vaccine 26:5210-5215.
-
(2008)
Vaccine
, vol.26
, pp. 5210-5215
-
-
Yan, J.1
Harris, K.2
Khan, A.S.3
Draghia-Akli, R.4
Sewell, D.5
Weiner, D.B.6
-
81
-
-
62949237235
-
DNA vaccination protects against an influenza challenge in a double-blind randomized placebo-controlled phase 1b clinical trial
-
Jones S, Evans K, McElwaine-Johnn H, Sharpe M, Oxford J, Lambkin-Williams R, Mant T, Nolan A, Zambon M, Ellis J, Beadle J, Loudon PT. 2009. DNA vaccination protects against an influenza challenge in a double-blind randomized placebo-controlled phase 1b clinical trial. Vaccine 27:2506-2512.
-
(2009)
Vaccine
, vol.27
, pp. 2506-2512
-
-
Jones, S.1
Evans, K.2
McElwaine-Johnn, H.3
Sharpe, M.4
Oxford, J.5
Lambkin-Williams, R.6
Mant, T.7
Nolan, A.8
Zambon, M.9
Ellis, J.10
Beadle, J.11
Loudon, P.T.12
-
82
-
-
70349593708
-
Trans-sialidase from Trypanosoma brucei as a potential target for DNA vaccine development against African trypanosomiasis
-
Silva MS, Prazeres DMF, Lança A, Atouguia J, Monteiro GA. 2009. Trans-sialidase from Trypanosoma brucei as a potential target for DNA vaccine development against African trypanosomiasis. Parasitol Res 105:1223-1229.
-
(2009)
Parasitol Res
, vol.105
, pp. 1223-1229
-
-
Silva, M.S.1
Prazeres, D.M.F.2
Lança, A.3
Atouguia, J.4
Monteiro, G.A.5
-
83
-
-
70149084163
-
Improved cellular immune response elicited by a ubiquitin-fused ESAT-6 DNA vaccine against Mycobacterium tuberculosis
-
Wang QM, Kang L, Wang XH. 2009. Improved cellular immune response elicited by a ubiquitin-fused ESAT-6 DNA vaccine against Mycobacterium tuberculosis. Microbiol Immunol 53:384-390.
-
(2009)
Microbiol Immunol
, vol.53
, pp. 384-390
-
-
Wang, Q.M.1
Kang, L.2
Wang, X.H.3
-
84
-
-
85184725239
-
Structure
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley&Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Structure, p 85-128. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley&Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 85-128
-
-
Prazeres, D.M.F.1
-
85
-
-
77952424081
-
Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection
-
Faurez F, Dory D, Le Moigne V, Gravier R, Jestin A. 2010. Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection. Vaccine 28:3888-3895.
-
(2010)
Vaccine
, vol.28
, pp. 3888-3895
-
-
Faurez, F.1
Dory, D.2
Le Moigne, V.3
Gravier, R.4
Jestin, A.5
-
86
-
-
0032962975
-
Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer
-
Lechardeur D, Sohn KJ, Haardt M, Joshi PB, Monck M, Graham RW, Beatty B, Squire J, O'Brodovich H, Lukacs GL. 1999. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Ther 6:482-497.
-
(1999)
Gene Ther
, vol.6
, pp. 482-497
-
-
Lechardeur, D.1
Sohn, K.J.2
Haardt, M.3
Joshi, P.B.4
Monck, M.5
Graham, R.W.6
Beatty, B.7
Squire, J.8
O'Brodovich, H.9
Lukacs, G.L.10
-
87
-
-
13644257031
-
The role of polyadenylation signal secondary structures on the resistance of plasmid vectors to nucleases
-
Ribeiro SC, Monteiro GA, Prazeres DMF. 2004. The role of polyadenylation signal secondary structures on the resistance of plasmid vectors to nucleases. J Gene Med 6:565-573.
-
(2004)
J Gene Med
, vol.6
, pp. 565-573
-
-
Ribeiro, S.C.1
Monteiro, G.A.2
Prazeres, D.M.F.3
-
88
-
-
34249081884
-
The impact of polyadenylation signals on plasmid nuclease-resistance and transgene expression
-
Azzoni AR, Ribeiro SC, Monteiro GA, Prazeres DMF. 2007. The impact of polyadenylation signals on plasmid nuclease-resistance and transgene expression. J Gene Med 9:392-402.
-
(2007)
J Gene Med
, vol.9
, pp. 392-402
-
-
Azzoni, A.R.1
Ribeiro, S.C.2
Monteiro, G.A.3
Prazeres, D.M.F.4
-
89
-
-
17544372882
-
Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved nonviral intratumoral in vivo gene transfer by jet-injection
-
Walther W, Stein U, Siegel R, Fichtner I, Schlag PM. 2005. Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved nonviral intratumoral in vivo gene transfer by jet-injection. J Gene Med 7:477-485.
-
(2005)
J Gene Med
, vol.7
, pp. 477-485
-
-
Walther, W.1
Stein, U.2
Siegel, R.3
Fichtner, I.4
Schlag, P.M.5
-
90
-
-
0031695499
-
Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor
-
Ross GF, Bruno MD, Uyeda M, Suzuki K, Nagao K, Whitsett JA, Korfhagen TR. 1998. Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor. Gene Ther 5:1244-1250.
-
(1998)
Gene Ther
, vol.5
, pp. 1244-1250
-
-
Ross, G.F.1
Bruno, M.D.2
Uyeda, M.3
Suzuki, K.4
Nagao, K.5
Whitsett, J.A.6
Korfhagen, T.R.7
-
91
-
-
33751510492
-
Identification and characterization of IS1 transposition in plasmid amplification mutants of E. coli clones producing DNA vaccines
-
Prather KL, Edmonds MC, Herod JW. 2006. Identification and characterization of IS1 transposition in plasmid amplification mutants of E. coli clones producing DNA vaccines. Appl Microbiol Biotechnol 73:815-826.
-
(2006)
Appl Microbiol Biotechnol
, vol.73
, pp. 815-826
-
-
Prather, K.L.1
Edmonds, M.C.2
Herod, J.W.3
-
94
-
-
70249151468
-
Deletion formation mutations in plasmid expression vectors are unfavored by runaway amplification conditions and differentially selected under kanamycin stress
-
Oliveira PH, Prazeres DMF, Monteiro GA. 2009. Deletion formation mutations in plasmid expression vectors are unfavored by runaway amplification conditions and differentially selected under kanamycin stress. J Biotechnol 143:231-238.
-
(2009)
J Biotechnol
, vol.143
, pp. 231-238
-
-
Oliveira, P.H.1
Prazeres, D.M.F.2
Monteiro, G.A.3
-
95
-
-
0033868530
-
Stimulatory and inhibitory action of cytokines on the regulation of hCMV-IE promoter activity in human endothelial cells
-
Ritter T, Brandt C, Prösch S, Vergopoulos A, Vogt K, Kolls J, Volk HD. 2000. Stimulatory and inhibitory action of cytokines on the regulation of hCMV-IE promoter activity in human endothelial cells. Cytokine 12:1163-1170.
-
(2000)
Cytokine
, vol.12
, pp. 1163-1170
-
-
Ritter, T.1
Brandt, C.2
Prösch, S.3
Vergopoulos, A.4
Vogt, K.5
Kolls, J.6
Volk, H.D.7
-
96
-
-
84877125846
-
CMV promoter is repressed by p53 and activated by JNK pathway
-
Rodova M, Jayini R, Singasani R, Chipps E, Islam MR. 2013. CMV promoter is repressed by p53 and activated by JNK pathway. Plasmid 69:223-230.
-
(2013)
Plasmid
, vol.69
, pp. 223-230
-
-
Rodova, M.1
Jayini, R.2
Singasani, R.3
Chipps, E.4
Islam, M.R.5
-
97
-
-
0034921775
-
High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter
-
Yew NS, Przybylska M, Ziegler RJ, Liu D, Cheng SH. 2001. High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter. Mol Ther 4:75-82.
-
(2001)
Mol Ther
, vol.4
, pp. 75-82
-
-
Yew, N.S.1
Przybylska, M.2
Ziegler, R.J.3
Liu, D.4
Cheng, S.H.5
-
98
-
-
52449104809
-
DNA vaccines: ready for prime time?
-
Kutzler MA, Weiner DB. 2008. DNA vaccines: ready for prime time? Nat Rev Genet 9:776-788.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 776-788
-
-
Kutzler, M.A.1
Weiner, D.B.2
-
99
-
-
67349156033
-
Plasmid DNA vaccine vector design: Impact on efficacy, safety and upstream production
-
Williams JA, Carnes AE, Hodgson CP. 2009. Plasmid DNA vaccine vector design: Impact on efficacy, safety and upstream production. Biotechnol Adv 27:353-370.
-
(2009)
Biotechnol Adv
, vol.27
, pp. 353-370
-
-
Williams, J.A.1
Carnes, A.E.2
Hodgson, C.P.3
-
100
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi O, Akira S. 2010. Pattern recognition receptors and inflammation. Cell 140:805-820.
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
101
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
-
Kawai T, Akira S. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373-384.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
102
-
-
79951679142
-
Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
-
Barber GN. 2011. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol 23:10-20.
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 10-20
-
-
Barber, G.N.1
-
103
-
-
84876085954
-
STING recognition of cytoplasmic DNA instigates cellular defense
-
Abe T, Harashima A, Xia T, Konno H, Konno K, Morales A, Ahn J, Gutman D, Barber GN. 2013. STING recognition of cytoplasmic DNA instigates cellular defense. Mol Cell 50:5-15.
-
(2013)
Mol Cell
, vol.50
, pp. 5-15
-
-
Abe, T.1
Harashima, A.2
Xia, T.3
Konno, H.4
Konno, K.5
Morales, A.6
Ahn, J.7
Gutman, D.8
Barber, G.N.9
-
104
-
-
79953705058
-
The STING pathway and regulation of innate immune signaling in response to DNA pathogens
-
Ishikawa H, Barber GN. 2011. The STING pathway and regulation of innate immune signaling in response to DNA pathogens. Cell Mol Life Sci 68:1157-1165.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 1157-1165
-
-
Ishikawa, H.1
Barber, G.N.2
-
105
-
-
79955124819
-
CpG DNA as a vaccine adjuvant
-
Bode C, Zhao G, Steinhagen F, Kinjo T, Klinman DM. 2011. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines 10:499-511.
-
(2011)
Expert Rev Vaccines
, vol.10
, pp. 499-511
-
-
Bode, C.1
Zhao, G.2
Steinhagen, F.3
Kinjo, T.4
Klinman, D.M.5
-
106
-
-
0032599950
-
Direct immunologic activities of CpG DNA and implications for gene therapy
-
Krieg AM. 1999. Direct immunologic activities of CpG DNA and implications for gene therapy. J Gene Med 1:56-63.
-
(1999)
J Gene Med
, vol.1
, pp. 56-63
-
-
Krieg, A.M.1
-
107
-
-
0036587573
-
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
-
Gürsel M, Verthelyi D, Gürsel I, Ishii KJ, Klinman DM. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J Leukoc Biol 71:813-820.
-
(2002)
J Leukoc Biol
, vol.71
, pp. 813-820
-
-
Gürsel, M.1
Verthelyi, D.2
Gürsel, I.3
Ishii, K.J.4
Klinman, D.M.5
-
108
-
-
4644330955
-
Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
-
Rutz M, Metzger J, Gellert T, Luppa P, Lipford GB, Wagner H, Bauer S. 2004. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol 34:2541-2550.
-
(2004)
Eur J Immunol
, vol.34
, pp. 2541-2550
-
-
Rutz, M.1
Metzger, J.2
Gellert, T.3
Luppa, P.4
Lipford, G.B.5
Wagner, H.6
Bauer, S.7
-
109
-
-
33745851536
-
Adjuvant activity of CpG oligodeoxynucleotides
-
Klinman DM. 2006. Adjuvant activity of CpG oligodeoxynucleotides. Int Rev Immunol 25:135-154.
-
(2006)
Int Rev Immunol
, vol.25
, pp. 135-154
-
-
Klinman, D.M.1
-
110
-
-
84859489110
-
CpG still rocks! Update on an accidental drug
-
Krieg AM. 2012. CpG still rocks! Update on an accidental drug. Nucleic Acid Ther 22:77-89.
-
(2012)
Nucleic Acid Ther
, vol.22
, pp. 77-89
-
-
Krieg, A.M.1
-
111
-
-
23944484031
-
Studying plasmid horizontal transfer in situ: a critical review
-
Sørensen SJ, Bailey M, Hansen LH, Kroer N, Wuertz S. 2005. Studying plasmid horizontal transfer in situ: a critical review. Nat Rev Microbiol 3:700-710.
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 700-710
-
-
Sørensen, S.J.1
Bailey, M.2
Hansen, L.H.3
Kroer, N.4
Wuertz, S.5
-
112
-
-
84882708788
-
Marker-free plasmids for biotechnological applications - implications and perspectives
-
Oliveira PH, Mairhofer J. 2013. Marker-free plasmids for biotechnological applications - implications and perspectives. Trends Biotechnol 31:539-547.
-
(2013)
Trends Biotechnol
, vol.31
, pp. 539-547
-
-
Oliveira, P.H.1
Mairhofer, J.2
-
113
-
-
84868484767
-
The future of human DNA vaccines
-
Li L, Saade F, Petrovsky N. 2012. The future of human DNA vaccines. J Biotechnol 162:171-182.
-
(2012)
J Biotechnol
, vol.162
, pp. 171-182
-
-
Li, L.1
Saade, F.2
Petrovsky, N.3
-
114
-
-
70350077805
-
Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system
-
Luke J, Carnes AE, Hodgson CP, Williams JA. 2009. Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system. Vaccine 27:6454-6459.
-
(2009)
Vaccine
, vol.27
, pp. 6454-6459
-
-
Luke, J.1
Carnes, A.E.2
Hodgson, C.P.3
Williams, J.A.4
-
115
-
-
77953923884
-
Marker-free plasmids for gene therapeutic applications-lack of antibiotic resistance gene substantially improves the manufacturing process
-
Mairhofer J, Cserjan-Puschmann M, Striedner G, Nöbauer K, Razzazi-Fazeli E, Grabherr R. 2010. Marker-free plasmids for gene therapeutic applications-lack of antibiotic resistance gene substantially improves the manufacturing process. J Biotechnol 146:130-137.
-
(2010)
J Biotechnol
, vol.146
, pp. 130-137
-
-
Mairhofer, J.1
Cserjan-Puschmann, M.2
Striedner, G.3
Nöbauer, K.4
Razzazi-Fazeli, E.5
Grabherr, R.6
-
116
-
-
0032077537
-
Repressor titration: a novel system for selection and stable maintenance of recombinant plasmids
-
Williams SG, Cranenburgh RM, Weiss AM, Wrighton CJ, Sherratt DJ, Hanak JA. 1998. Repressor titration: a novel system for selection and stable maintenance of recombinant plasmids. Nucleic Acids Res 26:2120-2124.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 2120-2124
-
-
Williams, S.G.1
Cranenburgh, R.M.2
Weiss, A.M.3
Wrighton, C.J.4
Sherratt, D.J.5
Hanak, J.A.6
-
117
-
-
84876067752
-
Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
-
Kandimalla ER, Bhagat L, Wang D, Yu D, Sullivan T, La Monica N, Agrawal S. 2013. Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. Nucleic Acids Res 41:3947-3961.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 3947-3961
-
-
Kandimalla, E.R.1
Bhagat, L.2
Wang, D.3
Yu, D.4
Sullivan, T.5
La Monica, N.6
Agrawal, S.7
-
118
-
-
1342332864
-
CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses
-
Reyes-Sandoval A, Ertl HCJ. 2004. CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses. Mol Ther 9:249-261.
-
(2004)
Mol Ther
, vol.9
, pp. 249-261
-
-
Reyes-Sandoval, A.1
Ertl, H.C.J.2
-
119
-
-
43449111490
-
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
-
Hyde SC, Pringle IA, Abdullah S, Lawton AE, Davies L, Varathalingam A, Nunez-Alonso G, Green AM, Bazzani RP, Sumner-Jones SG, Chan M, Li H, Yew NS, Cheng SH, Boyd AC, Davies JC, Griesenbach U, Porteous DJ, Sheppard DN, Munkonge FM, Alton EW, Gill DR. 2008. CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression. Nat Biotechnol 26:549-551.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 549-551
-
-
Hyde, S.C.1
Pringle, I.A.2
Abdullah, S.3
Lawton, A.E.4
Davies, L.5
Varathalingam, A.6
Nunez-Alonso, G.7
Green, A.M.8
Bazzani, R.P.9
Sumner-Jones, S.G.10
Chan, M.11
Li, H.12
Yew, N.S.13
Cheng, S.H.14
Boyd, A.C.15
Davies, J.C.16
Griesenbach, U.17
Porteous, D.J.18
Sheppard, D.N.19
Munkonge, F.M.20
Alton, E.W.21
Gill, D.R.22
more..
-
120
-
-
0026922764
-
Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle
-
WolffJA, Ludtke JJ, Acsadi G, Williams P, Jani A. 1992. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum Mol Genet 1:363-369.
-
(1992)
Hum Mol Genet
, vol.1
, pp. 363-369
-
-
Wolff, J.A.1
Ludtke, J.J.2
Acsadi, G.3
Williams, P.4
Jani, A.5
-
121
-
-
39849089752
-
Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation
-
Chen ZY, Riu E, He CY, Xu H, Kay MA. 2008. Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation. Mol Ther 16:548-556.
-
(2008)
Mol Ther
, vol.16
, pp. 548-556
-
-
Chen, Z.Y.1
Riu, E.2
He, C.Y.3
Xu, H.4
Kay, M.A.5
-
122
-
-
84869086449
-
The extragenic spacer length between the 5' and 3' ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors
-
Lu J, Zhang F, Xu S, Fire AZ, Kay MA. 2012. The extragenic spacer length between the 5' and 3' ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors. Mol Ther 20:2111-2119.
-
(2012)
Mol Ther
, vol.20
, pp. 2111-2119
-
-
Lu, J.1
Zhang, F.2
Xu, S.3
Fire, A.Z.4
Kay, M.A.5
-
123
-
-
33645212833
-
Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin
-
Suzuki M, Kasai K, Saeki Y. 2006. Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin. J Virol 80:3293-3300.
-
(2006)
J Virol
, vol.80
, pp. 3293-3300
-
-
Suzuki, M.1
Kasai, K.2
Saeki, Y.3
-
124
-
-
34250739823
-
Histone modifications are associated with the persistence or silencing of vectormediated transgene expression in vivo
-
Riu E, Chen ZY, Xu H, He CY, Kay MA. 2007. Histone modifications are associated with the persistence or silencing of vectormediated transgene expression in vivo. Mol Ther 15:1348-1355.
-
(2007)
Mol Ther
, vol.15
, pp. 1348-1355
-
-
Riu, E.1
Chen, Z.Y.2
Xu, H.3
He, C.Y.4
Kay, M.A.5
-
125
-
-
84871919467
-
Minicircle DNA vectors achieve sustained expression reflected by active chromatin and transcriptional level
-
Gracey Maniar LE, Maniar JM, Chen ZY, Lu J, Fire AZ, Kay MA. 2013. Minicircle DNA vectors achieve sustained expression reflected by active chromatin and transcriptional level. Mol Ther 21:131-138.
-
(2013)
Mol Ther
, vol.21
, pp. 131-138
-
-
Gracey Maniar, L.E.1
Maniar, J.M.2
Chen, Z.Y.3
Lu, J.4
Fire, A.Z.5
Kay, M.A.6
-
126
-
-
79955705789
-
Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver
-
Argyros O, Wong SP, Fedonidis C, Tolmachov O, Waddington SN, Howe SJ, Niceta M, Coutelle C, Harbottle RP. 2011. Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver. J Mol Med 89:515-529.
-
(2011)
J Mol Med
, vol.89
, pp. 515-529
-
-
Argyros, O.1
Wong, S.P.2
Fedonidis, C.3
Tolmachov, O.4
Waddington, S.N.5
Howe, S.J.6
Niceta, M.7
Coutelle, C.8
Harbottle, R.P.9
-
127
-
-
58149193835
-
Minicircle-DNA production by site specific recombination and protein-DNA interaction chromatography
-
Mayrhofer P, Blaesen M, Schleef M, Jechlinger W. 2008. Minicircle-DNA production by site specific recombination and protein-DNA interaction chromatography. J Gene Med 10:1253-1269.
-
(2008)
J Gene Med
, vol.10
, pp. 1253-1269
-
-
Mayrhofer, P.1
Blaesen, M.2
Schleef, M.3
Jechlinger, W.4
-
128
-
-
17844404286
-
A novel minimal-size vector (MIDGE) improves transgene expression in colon carcinoma cells and avoids transfection of undesired DNA
-
Schakowski F, Gorschlüter M, Junghans C, SchroffM, Buttgereit P, Ziske C, Schöttker B, König-Merediz SA, Sauerbruch T, Wittig B, Schmidt-Wolf IG. 2001. A novel minimal-size vector (MIDGE) improves transgene expression in colon carcinoma cells and avoids transfection of undesired DNA. Mol Ther 3:793-800.
-
(2001)
Mol Ther
, vol.3
, pp. 793-800
-
-
Schakowski, F.1
Gorschlüter, M.2
Junghans, C.3
Schroff, M.4
Buttgereit, P.5
Ziske, C.6
Schöttker, B.7
König-Merediz, S.A.8
Sauerbruch, T.9
Wittig, B.10
Schmidt-Wolf, I.G.11
-
129
-
-
33847672348
-
Minimal size MIDGE vectors improve transgene expression in vivo
-
Schakowski F, Gorschlüter M, Buttgereit P, Märten A, Lilienfeld-Toal MV, Junghans C, SchroffM, König-Merediz SA, Ziske C, Strehl J, Sauerbruch T, Wittig B, Schmidt-Wolf IG. 2007. Minimal size MIDGE vectors improve transgene expression in vivo. In Vivo 21:17-23.
-
(2007)
In Vivo
, vol.21
, pp. 17-23
-
-
Schakowski, F.1
Gorschlüter, M.2
Buttgereit, P.3
Märten, A.4
Lilienfeld-Toal, M.V.5
Junghans, C.6
Schroff, M.7
König-Merediz, S.A.8
Ziske, C.9
Strehl, J.10
Sauerbruch, T.11
Wittig, B.12
Schmidt-Wolf, I.G.13
-
130
-
-
85184687899
-
Delivery
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley&Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Delivery, p 167-210. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley&Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 167-210
-
-
Prazeres, D.M.F.1
-
131
-
-
0034913116
-
Nonviral vectors in the new millennium: delivery barriers in gene transfer
-
Nishikawa M, Huang L. 2001. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 12:861-870.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 861-870
-
-
Nishikawa, M.1
Huang, L.2
-
132
-
-
77951916908
-
Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery
-
Grigsby CL, Leong KW. 2010. Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery. J R Soc Interface 7:S67-S82.
-
(2010)
J R Soc Interface
, vol.7
, pp. S67-S82
-
-
Grigsby, C.L.1
Leong, K.W.2
-
133
-
-
34447514483
-
Intratumoral injection of IL-12 plasmid DNA-results of a phase I/IB clinical trial
-
Mahvi DM, Henry MB, Albertini MR, Weber S, Meredith K, Schalch H, Rakhmilevich A, Hank J, Sondel P. 2007. Intratumoral injection of IL-12 plasmid DNA-results of a phase I/IB clinical trial. Cancer Gene Ther 14:717-723.
-
(2007)
Cancer Gene Ther
, vol.14
, pp. 717-723
-
-
Mahvi, D.M.1
Henry, M.B.2
Albertini, M.R.3
Weber, S.4
Meredith, K.5
Schalch, H.6
Rakhmilevich, A.7
Hank, J.8
Sondel, P.9
-
134
-
-
19944398726
-
Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution
-
Konstan MW, Davis PB, Wagener JS, Hilliard KA, Stern RC, Milgram LJ, Kowalczyk TH, Hyatt SL, Fink TL, Gedeon CR, Oette SM, Payne JM, Muhammad O, Ziady AG, Moen RC, Cooper MJ. 2004. Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution. Hum Gene Ther 15:1255-1269.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 1255-1269
-
-
Konstan, M.W.1
Davis, P.B.2
Wagener, J.S.3
Hilliard, K.A.4
Stern, R.C.5
Milgram, L.J.6
Kowalczyk, T.H.7
Hyatt, S.L.8
Fink, T.L.9
Gedeon, C.R.10
Oette, S.M.11
Payne, J.M.12
Muhammad, O.13
Ziady, A.G.14
Moen, R.C.15
Cooper, M.J.16
-
135
-
-
33645937646
-
The mechanism of naked DNA uptake and expression
-
WolffJA, Budker V. 2005. The mechanism of naked DNA uptake and expression. Adv Genet 54:3-20.
-
(2005)
Adv Genet
, vol.54
, pp. 3-20
-
-
Wolff, J.A.1
Budker, V.2
-
136
-
-
0034760639
-
Slow accumulation of plasmid in muscle cells: supporting evidence for a mechanism of DNA uptake by receptor-mediated endocytosis
-
Satkauskas S, Bureau MF, Mahfoudi A, Mir LM. 2001. Slow accumulation of plasmid in muscle cells: supporting evidence for a mechanism of DNA uptake by receptor-mediated endocytosis. Mol Ther 4:317-323.
-
(2001)
Mol Ther
, vol.4
, pp. 317-323
-
-
Satkauskas, S.1
Bureau, M.F.2
Mahfoudi, A.3
Mir, L.M.4
-
137
-
-
0034152996
-
Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process
-
Budker V, Budker T, Zhang G, Subbotin VM, Loomis A, WolffJA. 2000. Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process. J Gene Med 2:76-88.
-
(2000)
J Gene Med
, vol.2
, pp. 76-88
-
-
Budker, V.1
Budker, T.2
Zhang, G.3
Subbotin, V.M.4
Loomis, A.5
Wolff, J.A.6
-
138
-
-
33845404380
-
Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import
-
Vaughan EE, DeGiulio JV, Dean DA. 2006. Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import. Curr Gene Ther 6:671-681.
-
(2006)
Curr Gene Ther
, vol.6
, pp. 671-681
-
-
Vaughan, E.E.1
DeGiulio, J.V.2
Dean, D.A.3
-
140
-
-
33644878890
-
The nuclear pore complex: the gateway to successful nonviral gene delivery
-
van der Aa MA, Mastrobattista E, Oosting RS, Hennink WE, Koning GA, Crommelin DJ. 2006. The nuclear pore complex: the gateway to successful nonviral gene delivery. Pharm Res 23:447-459.
-
(2006)
Pharm Res
, vol.23
, pp. 447-459
-
-
van der Aa, M.A.1
Mastrobattista, E.2
Oosting, R.S.3
Hennink, W.E.4
Koning, G.A.5
Crommelin, D.J.6
-
141
-
-
68549132428
-
Physical methods of nucleic acid transfer: general concepts and applications
-
Villemejane J, Mir LM. 2009. Physical methods of nucleic acid transfer: general concepts and applications. Br J Pharmacol 157:207-219.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 207-219
-
-
Villemejane, J.1
Mir, L.M.2
-
142
-
-
44349119297
-
Computer-assisted hydrodynamic gene delivery
-
Suda T, Suda K, Liu D. 2008. Computer-assisted hydrodynamic gene delivery. Mol Ther 16:1098-1104.
-
(2008)
Mol Ther
, vol.16
, pp. 1098-1104
-
-
Suda, T.1
Suda, K.2
Liu, D.3
-
143
-
-
33745646496
-
Current status and future prospects of needle-free liquid jet injectors
-
Mitragotri S. 2006. Current status and future prospects of needle-free liquid jet injectors. Nat Rev Drug Discov 5:543-548.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 543-548
-
-
Mitragotri, S.1
-
144
-
-
1342330352
-
Delivery of DNA to skin by particle bombardment
-
Wang S, Joshi S, Lu S. 2004. Delivery of DNA to skin by particle bombardment. Meth Mol Biol 245:185-193.
-
(2004)
Meth Mol Biol
, vol.245
, pp. 185-193
-
-
Wang, S.1
Joshi, S.2
Lu, S.3
-
145
-
-
20344397680
-
The role of particle-mediated DNA vaccines in biodefense preparedness
-
Dean HJ, Haynes J, Schmaljohn C. 2005. The role of particle-mediated DNA vaccines in biodefense preparedness. Adv Drug Deliv Rev 57:1315-1342.
-
(2005)
Adv Drug Deliv Rev
, vol.57
, pp. 1315-1342
-
-
Dean, H.J.1
Haynes, J.2
Schmaljohn, C.3
-
146
-
-
33748856603
-
Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases
-
Fuller DH, Loudon P, Schmaljohn C. 2006. Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases. Methods 40:86-97.
-
(2006)
Methods
, vol.40
, pp. 86-97
-
-
Fuller, D.H.1
Loudon, P.2
Schmaljohn, C.3
-
147
-
-
63949083280
-
What is (still not) known of the mechanism by which electroporation mediates gene transfer and expression in cells and tissues
-
Escoffre JM, Portet T, Wasungu L, Teissie J, Dean D, Rols MP. 2009. What is (still not) known of the mechanism by which electroporation mediates gene transfer and expression in cells and tissues. Mol Biotechnol 41:286-295.
-
(2009)
Mol Biotechnol
, vol.41
, pp. 286-295
-
-
Escoffre, J.M.1
Portet, T.2
Wasungu, L.3
Teissie, J.4
Dean, D.5
Rols, M.P.6
-
148
-
-
1542328820
-
Skin electroporation for transdermal and topical delivery
-
Denet AR, Vanbever R, Preat V. 2004. Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev 56:659-674.
-
(2004)
Adv Drug Deliv Rev
, vol.56
, pp. 659-674
-
-
Denet, A.R.1
Vanbever, R.2
Preat, V.3
-
149
-
-
56249136280
-
Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration
-
Chiarella P, Massi E, De Robertis M, Sibilio A, Parrella P, Fazio VM, Signori E. 2008. Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration. Expert Opin Biol Ther 8:1645-1657.
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 1645-1657
-
-
Chiarella, P.1
Massi, E.2
De Robertis, M.3
Sibilio, A.4
Parrella, P.5
Fazio, V.M.6
Signori, E.7
-
150
-
-
75449087525
-
Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation
-
Faurie C, Rebersek M, Golzio M, Kanduser M, Escoffre JM, Pavlin M, Teissie J, Miklavcic D, Rols MP. 2010. Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation. J Gene Med 12:117-125.
-
(2010)
J Gene Med
, vol.12
, pp. 117-125
-
-
Faurie, C.1
Rebersek, M.2
Golzio, M.3
Kanduser, M.4
Escoffre, J.M.5
Pavlin, M.6
Teissie, J.7
Miklavcic, D.8
Rols, M.P.9
-
151
-
-
33646849278
-
Enhancement of immune responses to an HBV DNA vaccine by electroporation
-
Luxembourg A, Hannaman D, Ellefsen B, Nakamura G, Bernard R. 2006. Enhancement of immune responses to an HBV DNA vaccine by electroporation. Vaccine 24:4490-4493.
-
(2006)
Vaccine
, vol.24
, pp. 4490-4493
-
-
Luxembourg, A.1
Hannaman, D.2
Ellefsen, B.3
Nakamura, G.4
Bernard, R.5
-
152
-
-
36049015389
-
Electroporation-based DNA immunisation: translation to the clinic
-
Luxembourg A, Evans CF, Hannaman D. 2007. Electroporation-based DNA immunisation: translation to the clinic. Expert Opin Biol Ther 7:1647-1664.
-
(2007)
Expert Opin Biol Ther
, vol.7
, pp. 1647-1664
-
-
Luxembourg, A.1
Evans, C.F.2
Hannaman, D.3
-
153
-
-
33750626735
-
In vivo electroporation for gene therapy
-
Heller LC, Heller R. 2006. In vivo electroporation for gene therapy. Hum Gene Ther 17:890-897.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 890-897
-
-
Heller, L.C.1
Heller, R.2
-
154
-
-
63949088560
-
Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments
-
Bodles-Brakhop AM, Heller R, Draghia-Akli R. 2009. Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments. Mol Ther 17:585-592.
-
(2009)
Mol Ther
, vol.17
, pp. 585-592
-
-
Bodles-Brakhop, A.M.1
Heller, R.2
Draghia-Akli, R.3
-
155
-
-
0030760143
-
Improved DNA: liposome complexes for increased systemic delivery and gene expression
-
Templeton NS, Lasic DD, Frederik PM, Strey HH, Roberts DD, Pavlakis GN. 1997. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol 15:647-652.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 647-652
-
-
Templeton, N.S.1
Lasic, D.D.2
Frederik, P.M.3
Strey, H.H.4
Roberts, D.D.5
Pavlakis, G.N.6
-
156
-
-
33847309821
-
A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC)
-
Farrell LL, Pepin J, Kucharski C, Lin X, Xu Z, Uludag H. 2007. A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC). Eur J Pharm Biopharm 65:388-397.
-
(2007)
Eur J Pharm Biopharm
, vol.65
, pp. 388-397
-
-
Farrell, L.L.1
Pepin, J.2
Kucharski, C.3
Lin, X.4
Xu, Z.5
Uludag, H.6
-
157
-
-
0346670220
-
Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA:poly(L-lysine) complexes
-
Aral C, Akbuga J. 2003. Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA:poly(L-lysine) complexes. J Pharm Pharm Sci 6:321-326.
-
(2003)
J Pharm Pharm Sci
, vol.6
, pp. 321-326
-
-
Aral, C.1
Akbuga, J.2
-
158
-
-
34548324409
-
Preparation, characterization, cytotoxicity and transfection efficiency of poly(DL-lactide-co-glycolide) and poly(DL-lactic acid) cationic nanoparticles for controlled delivery of plasmid DNA
-
Basarkar A, Devineni D, Palaniappan R, Singh J. 2007. Preparation, characterization, cytotoxicity and transfection efficiency of poly(DL-lactide-co-glycolide) and poly(DL-lactic acid) cationic nanoparticles for controlled delivery of plasmid DNA. Int J Pharm 343:247-254.
-
(2007)
Int J Pharm
, vol.343
, pp. 247-254
-
-
Basarkar, A.1
Devineni, D.2
Palaniappan, R.3
Singh, J.4
-
159
-
-
36549051578
-
Direct plasmid DNA encapsulation within PLGA nanospheres by single oil-in-water emulsion method
-
Mok H, Park TG. 2008. Direct plasmid DNA encapsulation within PLGA nanospheres by single oil-in-water emulsion method. Eur J Pharm Biopharm 68:105-111.
-
(2008)
Eur J Pharm Biopharm
, vol.68
, pp. 105-111
-
-
Mok, H.1
Park, T.G.2
-
160
-
-
0034602118
-
Biological potency of microsphere encapsulated plasmid DNA
-
Hao T, McKeever U, Hedley ML. 2000. Biological potency of microsphere encapsulated plasmid DNA. J Control Release 69:249-259.
-
(2000)
J Control Release
, vol.69
, pp. 249-259
-
-
Hao, T.1
McKeever, U.2
Hedley, M.L.3
-
161
-
-
0034681126
-
Cationic microparticles: a potent delivery system for DNA vaccines
-
Singh M, Briones M, Ott G, O'Hagan D. 2000. Cationic microparticles: a potent delivery system for DNA vaccines. Proc Natl Acad Sci USA 97:811-816.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 811-816
-
-
Singh, M.1
Briones, M.2
Ott, G.3
O'Hagan, D.4
-
162
-
-
0037449107
-
Plasmid DNA encoding human carcino-embryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice
-
Luo Y, O'Hagan D, Zhou H, Singh M, Ulmer J, Reisfeld RA, James Primus F, Xiang R. 2003. Plasmid DNA encoding human carcino-embryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. Vaccine 21:1938-1947.
-
(2003)
Vaccine
, vol.21
, pp. 1938-1947
-
-
Luo, Y.1
O'Hagan, D.2
Zhou, H.3
Singh, M.4
Ulmer, J.5
Reisfeld, R.A.6
James Primus, F.7
Xiang, R.8
-
163
-
-
24944567410
-
Augmented humoral and cellular immune responses to hepatitis B DNA vaccine adsorbed onto cationic microparticles
-
He X, Jiang L, Wang F, Xiao Z, Li J, Liu LS, Li D, Ren D, Jin X, Li K, He Y, Shi K, Guo Y, Zhang Y, Sun S. 2005. Augmented humoral and cellular immune responses to hepatitis B DNA vaccine adsorbed onto cationic microparticles. J Control Release 107:357-372.
-
(2005)
J Control Release
, vol.107
, pp. 357-372
-
-
He, X.1
Jiang, L.2
Wang, F.3
Xiao, Z.4
Li, J.5
Liu, L.S.6
Li, D.7
Ren, D.8
Jin, X.9
Li, K.10
He, Y.11
Shi, K.12
Guo, Y.13
Zhang, Y.14
Sun, S.15
-
164
-
-
3142526410
-
Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles
-
Mollenkopf HJ, Dietrich G, Fensterle J, Grode L, Diehl KD, Knapp B, Singh M, O'Hagan DT, Ulmer JB, Kaufmann SH. 2004. Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles. Vaccine 22:2690-2695.
-
(2004)
Vaccine
, vol.22
, pp. 2690-2695
-
-
Mollenkopf, H.J.1
Dietrich, G.2
Fensterle, J.3
Grode, L.4
Diehl, K.D.5
Knapp, B.6
Singh, M.7
O'Hagan, D.T.8
Ulmer, J.B.9
Kaufmann, S.H.10
-
165
-
-
1842434428
-
Chitosan nanoparticles for plasmid DNA delivery: effect of chitosan molecular structure on formulation and release characteristics
-
Bozkir A, Saka OM. 2004. Chitosan nanoparticles for plasmid DNA delivery: effect of chitosan molecular structure on formulation and release characteristics. Drug Deliv 11:2690-2695.
-
(2004)
Drug Deliv
, vol.11
, pp. 2690-2695
-
-
Bozkir, A.1
Saka, O.M.2
-
166
-
-
84893472898
-
Protamine sulfate-calcium carbonate-plasmid DNA ternary nanoparticles for efficient gene delivery
-
Wang C-Q, Wu J-L, Zhuo R-X, Cheng S-X. 2014. Protamine sulfate-calcium carbonate-plasmid DNA ternary nanoparticles for efficient gene delivery. Mol BioSyst 10:672-678.
-
(2014)
Mol BioSyst
, vol.10
, pp. 672-678
-
-
Wang, C.-Q.1
Wu, J.-L.2
Zhuo, R.-X.3
Cheng, S.-X.4
-
168
-
-
0030846040
-
Do DNA vaccines induce autoimmune disease?
-
Mor G, Singla M, Steinberg AD, Hoffman SL, Okuda K, Klinman DM. 1997. Do DNA vaccines induce autoimmune disease? Hum Gene Ther 8:293-300.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 293-300
-
-
Mor, G.1
Singla, M.2
Steinberg, A.D.3
Hoffman, S.L.4
Okuda, K.5
Klinman, D.M.6
-
169
-
-
0003478658
-
Note for guidance on quality, preclinical and clinical aspects of gene transfer medicinal products (CPMP/BWP/3088/99)
-
24 April, European Medicines Agency, London, UK
-
European Agency for the Evaluation Medicinal Products. 24 April 2001. Note for guidance on quality, preclinical and clinical aspects of gene transfer medicinal products (CPMP/BWP/3088/99). European Medicines Agency, London, UK.
-
(2001)
-
-
-
171
-
-
0034467120
-
DNA vaccines: development, standardization and regulation
-
Cichutek K. 2000. DNA vaccines: development, standardization and regulation. Intervirology 43:331-338.
-
(2000)
Intervirology
, vol.43
, pp. 331-338
-
-
Cichutek, K.1
-
172
-
-
0034467028
-
Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice
-
Ledwith BJ, Manam S, Troilo PJ, Barnum AB, Pauley CJ, Griffiths TG, Harper LB, Beare CM, Bagdon WJ, Nichols WW. 2000. Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice. Intervirology 43:258-272.
-
(2000)
Intervirology
, vol.43
, pp. 258-272
-
-
Ledwith, B.J.1
Manam, S.2
Troilo, P.J.3
Barnum, A.B.4
Pauley, C.J.5
Griffiths, T.G.6
Harper, L.B.7
Beare, C.M.8
Bagdon, W.J.9
Nichols, W.W.10
-
173
-
-
11144356610
-
Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation
-
Wang Z, Troilo PJ, Wang X, Griffiths TG, Pacchione SJ, Barnum AB, Harper LB, Pauley CJ, Niu Z, Denisova L, Follmer TT, Rizzuto G, Ciliberto G, Fattori E, Monica NL, Manam S, Ledwith BJ. 2004. Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation. Gene Ther 11:711-721.
-
(2004)
Gene Ther
, vol.11
, pp. 711-721
-
-
Wang, Z.1
Troilo, P.J.2
Wang, X.3
Griffiths, T.G.4
Pacchione, S.J.5
Barnum, A.B.6
Harper, L.B.7
Pauley, C.J.8
Niu, Z.9
Denisova, L.10
Follmer, T.T.11
Rizzuto, G.12
Ciliberto, G.13
Fattori, E.14
Monica, N.L.15
Manam, S.16
Ledwith, B.J.17
-
174
-
-
33744790917
-
Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts
-
Sheets RL, Stein J, Manetz TS, Duffy C, Nason M, Andrews C, Kong WP, Nabel GJ, Gomez PL. 2006. Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts. Toxicol Sci 91:610-619.
-
(2006)
Toxicol Sci
, vol.91
, pp. 610-619
-
-
Sheets, R.L.1
Stein, J.2
Manetz, T.S.3
Duffy, C.4
Nason, M.5
Andrews, C.6
Kong, W.P.7
Nabel, G.J.8
Gomez, P.L.9
-
175
-
-
56049086017
-
Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
-
Iiizumi S, Kurosawa A, So S, Ishii Y, Chikaraishi Y, Ishii A, Koyama H, Adachi N. 2008. Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting. Nucleic Acids Res 36:6333-6342.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 6333-6342
-
-
Iiizumi, S.1
Kurosawa, A.2
So, S.3
Ishii, Y.4
Chikaraishi, Y.5
Ishii, A.6
Koyama, H.7
Adachi, N.8
-
176
-
-
0036001289
-
The assessment of local tolerance, acute toxicity, and DNA biodistribution following particle-mediated delivery of a DNA vaccine to minipigs
-
Pilling AM, Harman RM, Jones SA, McCormack NA, Lavender D, Haworth R. 2002. The assessment of local tolerance, acute toxicity, and DNA biodistribution following particle-mediated delivery of a DNA vaccine to minipigs. Toxicol Pathol 30:298-305.
-
(2002)
Toxicol Pathol
, vol.30
, pp. 298-305
-
-
Pilling, A.M.1
Harman, R.M.2
Jones, S.A.3
McCormack, N.A.4
Lavender, D.5
Haworth, R.6
-
177
-
-
0034469447
-
Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA
-
Manam S, Ledwith BJ, Barnum AB, Troilo PJ, Pauley CJ, Harper LB, Griffiths TG, Niu Z, Denisova L, Follmer TT, Pacchione SJ, Wang Z, Beare CM, Bagdon WJ, Nichols WW. 2000. Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA. Intervirology 43:273-281.
-
(2000)
Intervirology
, vol.43
, pp. 273-281
-
-
Manam, S.1
Ledwith, B.J.2
Barnum, A.B.3
Troilo, P.J.4
Pauley, C.J.5
Harper, L.B.6
Griffiths, T.G.7
Niu, Z.8
Denisova, L.9
Follmer, T.T.10
Pacchione, S.J.11
Wang, Z.12
Beare, C.M.13
Bagdon, W.J.14
Nichols, W.W.15
-
178
-
-
0027031422
-
Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization
-
Nabel EG, Gordon D, Yang ZY, Xu L, San H, Plautz GE, Wu BY, Gao X, Huang L, Nabel GJ. 1992. Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther 3:649-656.
-
(1992)
Hum Gene Ther
, vol.3
, pp. 649-656
-
-
Nabel, E.G.1
Gordon, D.2
Yang, Z.Y.3
Xu, L.4
San, H.5
Plautz, G.E.6
Wu, B.Y.7
Gao, X.8
Huang, L.9
Nabel, G.J.10
-
179
-
-
0035168992
-
Plasmid DNA vaccines. Immunology, tolerance, and autoimmunity
-
Mor G, Eliza M. 2001. Plasmid DNA vaccines. Immunology, tolerance, and autoimmunity. Mol Biotechnol 19:245-250.
-
(2001)
Mol Biotechnol
, vol.19
, pp. 245-250
-
-
Mor, G.1
Eliza, M.2
-
180
-
-
0142075186
-
Safety evaluation of GX-12. A new DNA vaccine for HIV infection in rodents
-
Choi SM, Lee DS, Son MK, Sohn YS, Kang KK, Kim CY, Kim BM, Kim WB. 2003. Safety evaluation of GX-12. A new DNA vaccine for HIV infection in rodents. Drug Chem Toxicol 26:271-284.
-
(2003)
Drug Chem Toxicol
, vol.26
, pp. 271-284
-
-
Choi, S.M.1
Lee, D.S.2
Son, M.K.3
Sohn, Y.S.4
Kang, K.K.5
Kim, C.Y.6
Kim, B.M.7
Kim, W.B.8
-
181
-
-
33745241077
-
Preclinical and clinical safety studies on DNA vaccines
-
Schalk JAC, Mooi FR, Berbers GAM, van Aerts LAGJM, Ovelgönne H, Kimman TG. 2006. Preclinical and clinical safety studies on DNA vaccines. Hum Vaccines 2:45-53.
-
(2006)
Hum Vaccines
, vol.2
, pp. 45-53
-
-
Schalk, J.A.C.1
Mooi, F.R.2
Berbers, G.A.M.3
van Aerts, L.A.G.J.M.4
Ovelgönne, H.5
Kimman, T.G.6
-
182
-
-
33744792063
-
Toxicological safety evaluation of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar despite differing plasmid backbones or gene-inserts
-
Sheets RL, Stein J, Manetz TS, Andrews C, Bailer R, Rathmann J, Gomez PL. 2006. Toxicological safety evaluation of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar despite differing plasmid backbones or gene-inserts. Toxicol Sci 91:620-630.
-
(2006)
Toxicol Sci
, vol.91
, pp. 620-630
-
-
Sheets, R.L.1
Stein, J.2
Manetz, T.S.3
Andrews, C.4
Bailer, R.5
Rathmann, J.6
Gomez, P.L.7
-
183
-
-
34247144932
-
Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-sero-negative subjects
-
Tavel JA, Martin JE, Kelly GG, Enama ME, Shen JM, Gomez PL, Andrews CA, Koup RA, Bailer RT, Stein JA, Roederer M, Nabel GJ, Graham BS. 2007. Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-sero-negative subjects. J Acquir Immune Defic Syndr 44:601-605.
-
(2007)
J Acquir Immune Defic Syndr
, vol.44
, pp. 601-605
-
-
Tavel, J.A.1
Martin, J.E.2
Kelly, G.G.3
Enama, M.E.4
Shen, J.M.5
Gomez, P.L.6
Andrews, C.A.7
Koup, R.A.8
Bailer, R.T.9
Stein, J.A.10
Roederer, M.11
Nabel, G.J.12
Graham, B.S.13
-
184
-
-
85184674355
-
Product and process development
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley&Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Product and process development, p 69-84. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley&Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 69-84
-
-
Prazeres, D.M.F.1
-
185
-
-
84873993482
-
De Novo Creation of MG1655-derived Escherichia coli strains specifically designed for plasmid DNA production
-
Gonçalves GAL, Prazeres DMF, Monteiro GA, Prather KLJ. 2013. De Novo Creation of MG1655-derived Escherichia coli strains specifically designed for plasmid DNA production. App Microbiol Biotechnol 97:611-620.
-
(2013)
App Microbiol Biotechnol
, vol.97
, pp. 611-620
-
-
Gonçalves, G.A.L.1
Prazeres, D.M.F.2
Monteiro, G.A.3
Prather, K.L.J.4
-
187
-
-
33750018093
-
Development of a highly productive and scalable plasmid DNA production platform
-
Listner K, Bentley L, Okonkowski J, Kistler C, Wnek R, Caparoni A, Junker B, Robinson D, Salmon P, Chartrain M. 2006. Development of a highly productive and scalable plasmid DNA production platform. Biotechnol Prog 22:1335-1345.
-
(2006)
Biotechnol Prog
, vol.22
, pp. 1335-1345
-
-
Listner, K.1
Bentley, L.2
Okonkowski, J.3
Kistler, C.4
Wnek, R.5
Caparoni, A.6
Junker, B.7
Robinson, D.8
Salmon, P.9
Chartrain, M.10
-
188
-
-
33747166436
-
Optimisation of isopropanol and ammonium sulphate precipitation steps in the purification of plasmid DNA
-
Freitas SS, Santos JAL, Prazeres DMF. 2006. Optimisation of isopropanol and ammonium sulphate precipitation steps in the purification of plasmid DNA. Biotechnol Prog 22:1179-1186.
-
(2006)
Biotechnol Prog
, vol.22
, pp. 1179-1186
-
-
Freitas, S.S.1
Santos, J.A.L.2
Prazeres, D.M.F.3
-
189
-
-
77950690475
-
Clearance of host-cell impurities from plasmid-containing lysates by boronate adsorption
-
Gomes GA, Azevedo AM, Aires-Barros MR, Prazeres DMF. 2010. Clearance of host-cell impurities from plasmid-containing lysates by boronate adsorption. J Chromatogr A 1217:2262-2266.
-
(2010)
J Chromatogr A
, vol.1217
, pp. 2262-2266
-
-
Gomes, G.A.1
Azevedo, A.M.2
Aires-Barros, M.R.3
Prazeres, D.M.F.4
-
190
-
-
58149289804
-
Purification of plasmid DNA using aqueous two-phase systems with PEG 600 and sodium citrate/ammonium sulphate
-
Gomes GA, Azevedo AM, Aires-Barros MR, Prazeres DMF. 2009. Purification of plasmid DNA using aqueous two-phase systems with PEG 600 and sodium citrate/ammonium sulphate. Sep Pur Technol 65:22-30.
-
(2009)
Sep Pur Technol
, vol.65
, pp. 22-30
-
-
Gomes, G.A.1
Azevedo, A.M.2
Aires-Barros, M.R.3
Prazeres, D.M.F.4
-
191
-
-
58149295441
-
Plasmid purification by hydrophobic interaction chromatography using sodium citrate in the mobile phase
-
Freitas S, Santos JAL, Prazeres DMF. 2009. Plasmid purification by hydrophobic interaction chromatography using sodium citrate in the mobile phase. Sep Pur Technol 65:95-104.
-
(2009)
Sep Pur Technol
, vol.65
, pp. 95-104
-
-
Freitas, S.1
Santos, J.A.L.2
Prazeres, D.M.F.3
-
192
-
-
33750607427
-
Selective purification of supercoiled plasmid DNA from cell lysates with a single histidine-agarose chromatography step
-
Sousa F, Freitas SS, Azzonni A, Prazeres DMF, Queiroz JA. 2006. Selective purification of supercoiled plasmid DNA from cell lysates with a single histidine-agarose chromatography step. Biotechnol App Biochem 45:131-140.
-
(2006)
Biotechnol App Biochem
, vol.45
, pp. 131-140
-
-
Sousa, F.1
Freitas, S.S.2
Azzonni, A.3
Prazeres, D.M.F.4
Queiroz, J.A.5
-
193
-
-
0037419671
-
Supercoiled plasmid DNA: selective purification by thiophilic/aromatic adsorption
-
Lemmens R, Olsson U, Nyhammar T, Stadler J. 2003. Supercoiled plasmid DNA: selective purification by thiophilic/aromatic adsorption. J Chromatog B 784:291-300.
-
(2003)
J Chromatog B
, vol.784
, pp. 291-300
-
-
Lemmens, R.1
Olsson, U.2
Nyhammar, T.3
Stadler, J.4
-
195
-
-
84959143128
-
Chromatographic separation of plasmid DNA using macroporous beads
-
In Mattiasson B, Kumar A, Galaev IY (ed), CRC Press, New York, NY
-
Prazeres DMF. 2009. Chromatographic separation of plasmid DNA using macroporous beads, p 335-361. In Mattiasson B, Kumar A, Galaev IY (ed), Macroporous Polymers: Production, Properties and Biotechnological/Biomedical Applications. CRC Press, New York, NY.
-
(2009)
Macroporous Polymers: Production, Properties and Biotechnological/Biomedical Applications
, pp. 335-361
-
-
Prazeres, D.M.F.1
-
196
-
-
28144434960
-
Industrial scale cGMP purification of pharmaceutical-grade plasmid DNA
-
Urthaler J, Buchinger W, Necina R. 2005. Industrial scale cGMP purification of pharmaceutical-grade plasmid DNA. Chem Eng Technol 28:1408-1420.
-
(2005)
Chem Eng Technol
, vol.28
, pp. 1408-1420
-
-
Urthaler, J.1
Buchinger, W.2
Necina, R.3
-
197
-
-
33646034034
-
Sterilizing filtration of plasmid DNA: effects of plasmid concentration, molecular weight, and conformation
-
Watson MP, Winters MA, Sagar SL, Konz JO. 2006. Sterilizing filtration of plasmid DNA: effects of plasmid concentration, molecular weight, and conformation. Biotechnol Prog 22:465-470.
-
(2006)
Biotechnol Prog
, vol.22
, pp. 465-470
-
-
Watson, M.P.1
Winters, M.A.2
Sagar, S.L.3
Konz, J.O.4
-
198
-
-
85184703130
-
Veterinary case studies: West Nile, infectious hematopoietic necrosis and melanoma
-
In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing, John Wiley&Sons, Inc., Hoboken, NJ
-
Prazeres DMF. 2011. Veterinary case studies: West Nile, infectious hematopoietic necrosis and melanoma, p 69-84. In Plasmid Biopharmaceuticals: Basics Applications and Manufacturing. John Wiley&Sons, Inc., Hoboken, NJ.
-
(2011)
, pp. 69-84
-
-
Prazeres, D.M.F.1
-
199
-
-
3042786314
-
DNA vaccines-back in the saddle again?
-
Powell K. 2004. DNA vaccines-back in the saddle again? Nat Biotechnol 22:799-801.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 799-801
-
-
Powell, K.1
-
200
-
-
84886562304
-
West Nile-Innovator DNA-The first USDA approved DNA vaccine
-
Fort Dodge Animal Health, Fort Dodge, IA
-
Anonymous. 2008. West Nile-Innovator DNA-The first USDA approved DNA vaccine. Fort Dodge Animal Health, Fort Dodge, IA.
-
(2008)
-
-
-
201
-
-
84886469766
-
Novel Novartis vaccine to protect Canadian salmon farms from devastating viral disease
-
19 July, Novartis Animal Health Inc., Basel, Switzerland
-
Novartis. 19 July 2005. Novel Novartis vaccine to protect Canadian salmon farms from devastating viral disease. Novartis Animal Health Inc., Basel, Switzerland.
-
(2005)
-
-
-
202
-
-
39849090723
-
USDA grants conditional approval for first therapeutic vaccine to treat cancer
-
26 March, Merial Limited, Duluth, GA
-
Merial. 26 March 2007. USDA grants conditional approval for first therapeutic vaccine to treat cancer. Merial Limited, Duluth, GA.
-
(2007)
-
-
-
203
-
-
54949134495
-
Growth hormone-releasing hormone plasmid treatment by electroporation decreases offspring mortality over three pregnancies
-
Person R, Bodles-Brakhop AM, Pope MA, Brown PA, Khan AS, Draghia-Akli R. 2008. Growth hormone-releasing hormone plasmid treatment by electroporation decreases offspring mortality over three pregnancies. Mol Ther 16:1891-1897.
-
(2008)
Mol Ther
, vol.16
, pp. 1891-1897
-
-
Person, R.1
Bodles-Brakhop, A.M.2
Pope, M.A.3
Brown, P.A.4
Khan, A.S.5
Draghia-Akli, R.6
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