메뉴 건너뛰기




Volumn 7, Issue SUPPL. 1, 2010, Pages

Balancing protection and release of DNA: Tools to address a bottleneck of non-viral gene delivery

Author keywords

Biophotonics; Nanomedicine; Nanoparticle; Non viral gene delivery; Polyplex; Responsive delivery

Indexed keywords

DESIGN; DNA; GENE TRANSFER; IMAGING TECHNIQUES; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; OPTIMIZATION; POLYMERS; THREE DIMENSIONAL;

EID: 77951916908     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2009.0260     Document Type: Review
Times cited : (190)

References (111)
  • 1
    • 0025311288 scopus 로고
    • Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (caco-2) cells
    • doi:10.1002/jps.2600790604
    • Artursson, P. 1990 Epithelial transport of drugs in cell culture. I: a model for studying the passive diffusion of drugs over intestinal absorptive (caco-2) cells. J. Pharm. Sci. 79, 476-482. (doi:10.1002/jps.2600790604)
    • (1990) J. Pharm. Sci. , vol.79 , pp. 476-482
    • Artursson, P.1
  • 2
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (caco-2) cells
    • doi:10.1016/0006-291X(91)91647-U
    • Artursson, P. & Karlsson, J. 1991 Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (caco-2) cells. Biochem. Biophys. Res. Commun. 175, 880-885. (doi:10.1016/0006-291X(91)91647-U)
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 3
    • 0037282643 scopus 로고    scopus 로고
    • A dynamic view of cellular processes by in vivo fluorescence auto- And cross-correlation spectroscopy
    • doi:10.1016/S1046-2023(02)00291-8
    • Bacia, K. & Schwille, P. 2003 A dynamic view of cellular processes by in vivo fluorescence auto- and cross-correlation spectroscopy. Methods 29, 74-85. (doi:10.1016/S1046-2023(02)00291-8)
    • (2003) Methods , vol.29 , pp. 74-85
    • Bacia, K.1    Schwille, P.2
  • 4
    • 33646359427 scopus 로고    scopus 로고
    • Temperature-controlled properties of DNA complexes with poly(ethylenimine)-graft-poly(N-isopropylacrylamide)
    • doi:10.1021/bm0509927
    • Bisht, H. S., Manickam, D. S., You, Y. Z. & Oupicky, D. 2006 Temperature-controlled properties of DNA complexes with poly(ethylenimine)- graft-poly(N-isopropylacrylamide). Biomacromolecules 7, 1169-1178. (doi:10.1021/bm0509927)
    • (2006) Biomacromolecules , vol.7 , pp. 1169-1178
    • Bisht, H.S.1    Manickam, D.S.2    You, Y.Z.3    Oupicky, D.4
  • 5
    • 9244227028 scopus 로고    scopus 로고
    • The utility of superparamagnetic contrast agents in MRI: Theoretical consideration and applications in the cardiovascular system
    • doi:10.1002/nbm.904
    • Bjornerud, A. & Johansson, L. 2004 The utility of superparamagnetic contrast agents in MRI: theoretical consideration and applications in the cardiovascular system. NMR Biomed. 17, 465-477. (doi:10.1002/nbm.904)
    • (2004) NMR Biomed. , vol.17 , pp. 465-477
    • Bjornerud, A.1    Johansson, L.2
  • 6
    • 41149086686 scopus 로고    scopus 로고
    • Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver
    • doi:10.1021/bc700388u
    • Burke, R. S. & Pun, S. H. 2008 Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver. Bioconjug. Chem. 19, 693-704. (doi:10.1021/bc700388u)
    • (2008) Bioconjug. Chem. , vol.19 , pp. 693-704
    • Burke, R.S.1    Pun, S.H.2
  • 7
    • 1542319138 scopus 로고    scopus 로고
    • The future of gene therapy
    • doi:10.1038/427779a
    • Cavazzana-Calvo, M., Thrasher, A. & Mavilio, F. 2004 The future of gene therapy. Nature 427, 779-781. (doi:10.1038/427779a)
    • (2004) Nature , vol.427 , pp. 779-781
    • Cavazzana-Calvo, M.1    Thrasher, A.2    Mavilio, F.3
  • 8
    • 0037434649 scopus 로고    scopus 로고
    • Cancer fears cast doubts on future of gene therapy
    • doi:10.1038/421678b
    • Check, E. 2003 Cancer fears cast doubts on future of gene therapy. Nature 421, 678. (doi:10.1038/421678b)
    • (2003) Nature , vol.421 , pp. 678
    • Check, E.1
  • 9
    • 38649099106 scopus 로고    scopus 로고
    • Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET
    • doi:10.1038/sj.mt.6300392
    • Chen, H. H., Ho, Y. P., Jiang, X., Mao, H. Q., Wang, T. H. & Leong, K. W. 2008a Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET. Mol. Ther. 16, 324-332. (doi:10.1038/sj.mt.6300392)
    • (2008) Mol. Ther. , vol.16 , pp. 324-332
    • Chen, H.H.1    Ho, Y.P.2    Jiang, X.3    Mao, H.Q.4    Wang, T.H.5    Leong, K.W.6
  • 10
    • 40549142439 scopus 로고    scopus 로고
    • Intelligent biosynthetic nanobiomaterials (IBNS) for hyperthermic gene delivery
    • doi:10.1007/s11095-007-9382-5
    • Chen, T. H. H., Bae, Y. & Furgeson, D. Y. 2008b Intelligent biosynthetic nanobiomaterials (IBNS) for hyperthermic gene delivery. Pharm. Res. 25, 683-691. (doi:10.1007/s11095-007-9382-5)
    • (2008) Pharm. Res. , vol.25 , pp. 683-691
    • Chen, T.H.H.1    Bae, Y.2    Furgeson, D.Y.3
  • 11
    • 63349092119 scopus 로고    scopus 로고
    • Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET
    • doi:10.1016/j.nantod.2009.02.008
    • Chen, H. H., Ho, Y.-P., Jiang, X., Mao, H.-Q., Wang, T.-H. & Leong, K. W. 2009 Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET. Nano Today 4, 125-134. (doi:10.1016/j.nantod.2009.02.008)
    • (2009) Nano Today , vol.4 , pp. 125-134
    • Chen, H.H.1    Ho, Y.-P.2    Jiang, X.3    Mao, H.-Q.4    Wang, T.-H.5    Leong, K.W.6
  • 12
    • 0037130974 scopus 로고    scopus 로고
    • Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery
    • doi:10.1016/S0169-409X(02)00060-1
    • Chilkoti, A., Dreher, M. R. & Meyer, D. E. 2002 Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Adv. Drug Deliv. Rev. 54, 1093-1111. (doi:10.1016/S0169-409X(02)00060-1)
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1093-1111
    • Chilkoti, A.1    Dreher, M.R.2    Meyer, D.E.3
  • 13
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • doi:10.1038/nature01451
    • Conner, S. D. & Schmid, S. L. 2003 Regulated portals of entry into the cell. Nature 422, 37-44. (doi:10.1038/nature01451)
    • (2003) Nature , vol.422 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 14
    • 39749166238 scopus 로고    scopus 로고
    • Monomolecular assembly of siRNA and poly(ethylene glycol)-peptide copolymers
    • doi:10.1021/bm7011482
    • Derouchey, J., Schmidt, C., Walker, G. F., Koch, C., Plank, C., Wagner, E. & Radler, J. O. 2008 Monomolecular assembly of siRNA and poly(ethylene glycol)-peptide copolymers. Biomacromolecules 9, 724-732. (doi:10.1021/ bm7011482)
    • (2008) Biomacromolecules , vol.9 , pp. 724-732
    • Derouchey, J.1    Schmidt, C.2    Walker, G.F.3    Koch, C.4    Plank, C.5    Wagner, E.6    Radler, J.O.7
  • 15
    • 33846796031 scopus 로고    scopus 로고
    • Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses
    • doi:10.1529/biophysj.106.095521
    • Dinh, A. T., Pangarkar, C., Theofanous, T. & Mitragotri, S. 2007 Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses. Biophys. J. 92, 831-846. (doi:10.1529/biophysj.106.095521)
    • (2007) Biophys. J. , vol.92 , pp. 831-846
    • Dinh, A.T.1    Pangarkar, C.2    Theofanous, T.3    Mitragotri, S.4
  • 16
    • 0037027911 scopus 로고    scopus 로고
    • Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis
    • doi:10.1016/S0169-409X(02)00145-X
    • Ferrari, S., Geddes, D. M. & Alton, E. W. 2002 Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis. Adv. Drug Deliv. Rev. 54, 1373-1393. (doi:10.1016/S0169-409X(02)00145-X)
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1373-1393
    • Ferrari, S.1    Geddes, D.M.2    Alton, E.W.3
  • 17
    • 4143087473 scopus 로고    scopus 로고
    • Effect of poly(ethylene imine) molecular weight and PEGylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice
    • Fischer, D., Osburg, B., Petersen, H., Kissel, T. & Bickel, U. 2004 Effect of poly(ethylene imine) molecular weight and PEGylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice. Drug Metab. Dispos. 32, 983-992.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 983-992
    • Fischer, D.1    Osburg, B.2    Petersen, H.3    Kissel, T.4    Bickel, U.5
  • 18
    • 0002091096 scopus 로고
    • Intermolecular energy transference and fluorescence
    • Foerster, T. 1948 Intermolecular energy transference and fluorescence. Ann. Phys. 2, 55-75.
    • (1948) Ann. Phys. , vol.2 , pp. 55-75
    • Foerster, T.1
  • 19
    • 1242292220 scopus 로고    scopus 로고
    • Partial acetylation of polyethylenimine enhances in vitro gene delivery
    • doi:10.1023/B:PHAM.0000016251.42392.1e
    • Forrest, M. L., Meister, G. E., Koerber, J. T. & Pack, D. W. 2004 Partial acetylation of polyethylenimine enhances in vitro gene delivery. Pharm. Res. 21, 365-371. (doi:10.1023/B:PHAM.0000016251.42392.1e)
    • (2004) Pharm. Res. , vol.21 , pp. 365-371
    • Forrest, M.L.1    Meister, G.E.2    Koerber, J.T.3    Pack, D.W.4
  • 20
    • 33748374275 scopus 로고    scopus 로고
    • Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions
    • doi:10.1021/bm060300u
    • Gabrielson, N. P. & Pack, D. W. 2006 Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions. Biomacromolecules 7, 2427-2435. (doi:10.1021/bm060300u)
    • (2006) Biomacromolecules , vol.7 , pp. 2427-2435
    • Gabrielson, N.P.1    Pack, D.W.2
  • 21
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • doi:10.1016/j.jconrel.2007.12.017
    • Ganta, S., Devalapally, H., Shahiwala, A. & Amiji, M. 2008 A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Control. Release 126, 187-204. (doi:10.1016/j.jconrel.2007.12.017)
    • (2008) J. Control. Release , vol.126 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 23
    • 0033609001 scopus 로고    scopus 로고
    • Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery
    • doi:10.1073/pnas.96.9.5177
    • Godbey, W. T., Wu, K. K. & Mikos, A. G. 1999 Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc. Natl Acad. Sci. USA 96, 5177-5181. (doi:10.1073/pnas.96.9.5177)
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5177-5181
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 24
    • 42249095831 scopus 로고    scopus 로고
    • Increased nanoparticle penetration in collagenase-treated multicellular spheroids
    • Goodman, T. T., Olive, P. L. & Pun, S. H. 2007 Increased nanoparticle penetration in collagenase-treated multicellular spheroids. Int. J. Nanomed. 2, 265-274.
    • (2007) Int. J. Nanomed. , vol.2 , pp. 265-274
    • Goodman, T.T.1    Olive, P.L.2    Pun, S.H.3
  • 25
    • 55249103122 scopus 로고    scopus 로고
    • 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers
    • doi:10.1021/bc800233a
    • Goodman, T. T., Ng, C. P. & Pun, S. H. 2008 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconjug. Chem. 19, 1951-1959. (doi:10.1021/bc800233a)
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1951-1959
    • Goodman, T.T.1    Ng, C.P.2    Pun, S.H.3
  • 26
    • 0035214028 scopus 로고    scopus 로고
    • Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine
    • doi:10.1021/bc0100455
    • Gosselin, M. A., Guo, W. J. & Lee, R. J. 2001 Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug. Chem. 12, 989-994. (doi:10.1021/bc0100455)
    • (2001) Bioconjug. Chem. , vol.12 , pp. 989-994
    • Gosselin, M.A.1    Guo, W.J.2    Lee, R.J.3
  • 27
    • 0001779594 scopus 로고    scopus 로고
    • Human disc cells in monolayer vs 3D culture: Cell shape, division and matrix formation
    • doi:10.1186/1471-2474-1-1
    • Gruber, H. E. & Hanley Jr, E. N. 2000 Human disc cells in monolayer vs 3D culture: cell shape, division and matrix formation. BMC Musculoskelet. Disord. 1, 1. (doi:10.1186/1471-2474-1-1)
    • (2000) BMC Musculoskelet. Disord. , vol.1 , pp. 1
    • Gruber, H.E.1    Hanley Jr., E.N.2
  • 28
    • 34547221119 scopus 로고    scopus 로고
    • Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies
    • doi:10.1016/j.jconrel.2007.05.012
    • Han, M., Bae, Y., Nishiyama, N., Miyata, K., Oba, M. & Kataoka, K. 2007 Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J. Control. Release 121, 38-48. (doi:10.1016/j.jconrel.2007.05. 012)
    • (2007) J. Control. Release , vol.121 , pp. 38-48
    • Han, M.1    Bae, Y.2    Nishiyama, N.3    Miyata, K.4    Oba, M.5    Kataoka, K.6
  • 29
    • 68249112400 scopus 로고    scopus 로고
    • Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles
    • doi:10.1038/mt.2009.119
    • Han, M., Oba, M., Nishiyama, N., Kano, M. R., Kizaka-Kondoh, S. & Kataoka, K. 2009 Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles. Mol. Ther. 17, 1404-1410. (doi:10.1038/mt.2009.119)
    • (2009) Mol. Ther. , vol.17 , pp. 1404-1410
    • Han, M.1    Oba, M.2    Nishiyama, N.3    Kano, M.R.4    Kizaka-Kondoh, S.5    Kataoka, K.6
  • 30
    • 85020822516 scopus 로고    scopus 로고
    • Crosslinked PEI polyplexes for light-triggered DNA release
    • doi:10.1016/j.ymthe.2006.08.1184
    • Handwerger, R. G., Kim, M.-S. & Diamond, S. L. 2006 Crosslinked PEI polyplexes for light-triggered DNA release. Mol. Ther. 13, S415-S416. (doi:10.1016/j.ymthe.2006.08.1184)
    • (2006) Mol. Ther. , vol.13
    • Handwerger, R.G.1    Kim, M.-S.2    Diamond, S.L.3
  • 31
    • 0033973754 scopus 로고    scopus 로고
    • Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: Permeabilities via diffusion, inside- And outside-directed carrier-mediated transport
    • doi:10.1002/(SICI)1520-6017(200001)89:1〈63::AID-JPS7〉3.0.CO;2-6
    • Hilgendorf, C., Spahn-Langguth, H., Regardh, C. G., Lipka, E., Amidon, G. L. & Langguth, P. 2000 Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport. J. Pharm. Sci. 89, 63-75. (doi:10.1002/(SICI)1520- 6017(200001)89:1〈63::AID-JPS7〉3.0.CO;2-6)
    • (2000) J. Pharm. Sci. , vol.89 , pp. 63-75
    • Hilgendorf, C.1    Spahn-Langguth, H.2    Regardh, C.G.3    Lipka, E.4    Amidon, G.L.5    Langguth, P.6
  • 33
    • 33751226915 scopus 로고    scopus 로고
    • Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET
    • doi:10.1016/j.jconrel.2006.09.005
    • Ho, Y. P., Chen, H. H., Leong, K. W. & Wang, T. H. 2006 Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET. J. Control. Release 116, 83-89. (doi:10.1016/j.jconrel.2006.09.005)
    • (2006) J. Control. Release , vol.116 , pp. 83-89
    • Ho, Y.P.1    Chen, H.H.2    Leong, K.W.3    Wang, T.H.4
  • 34
    • 33846027829 scopus 로고    scopus 로고
    • Interaction of polyamine gene vectors with RNA leads to the dissociation of plasmid DNA-carrier complexes
    • doi:10.1002/jgm.975
    • Huth, S., Hoffmann, F., Von Gersdorff, K., Laner, A., Reinhardt, D., Rosenecker, J. & Rudolph, C. 2006 Interaction of polyamine gene vectors with RNA leads to the dissociation of plasmid DNA-carrier complexes. J. Gene Med. 8, 1416-1424. (doi:10.1002/jgm.975)
    • (2006) J. Gene Med. , vol.8 , pp. 1416-1424
    • Huth, S.1    Hoffmann, F.2    Von Gersdorff, K.3    Laner, A.4    Reinhardt, D.5    Rosenecker, J.6    Rudolph, C.7
  • 35
    • 0036057165 scopus 로고    scopus 로고
    • Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions
    • doi:10.1021/bm025527d
    • Itaka, K., Harada, A., Nakamura, K., Kawaguchi, H. & Kataoka, K. 2002 Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. Biomacromolecules 3, 841-845. (doi:10.1021/bm025527d)
    • (2002) Biomacromolecules , vol.3 , pp. 841-845
    • Itaka, K.1    Harada, A.2    Nakamura, K.3    Kawaguchi, H.4    Kataoka, K.5
  • 36
    • 3242707528 scopus 로고    scopus 로고
    • In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine
    • doi:10.1002/jgm.470
    • Itaka, K., Harada, A., Yamasaki, Y., Nakamura, K., Kawaguchi, H. & Kataoka, K. 2004 In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. J. Gene Med. 6, 76-84. (doi:10.1002/jgm.470)
    • (2004) J. Gene Med. , vol.6 , pp. 76-84
    • Itaka, K.1    Harada, A.2    Yamasaki, Y.3    Nakamura, K.4    Kawaguchi, H.5    Kataoka, K.6
  • 38
    • 20444460701 scopus 로고    scopus 로고
    • A new design for light-breakable polymer micelles
    • doi:10.1021/ja0521019
    • Jiang, J. Q., Tong, X. & Zhao, Y. 2005 A new design for light-breakable polymer micelles. J. Am. Chem. Soc. 127, 8290-8291. (doi:10.1021/ja0521019)
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 8290-8291
    • Jiang, J.Q.1    Tong, X.2    Zhao, Y.3
  • 39
    • 0034672649 scopus 로고    scopus 로고
    • Polymer chemical structure is a key determinant of physicochemical and colloidal properties of polymer-DNA complexes for gene delivery
    • doi:10.1016/S0167-781(00)00220-7
    • Jones, N. A., Hill, I. R. C., Stolnik, S., Bignotti, F., Davis, S. S. & Garnett, M. C. 2000 Polymer chemical structure is a key determinant of physicochemical and colloidal properties of polymer-DNA complexes for gene delivery. Biochim. Biophys. Acta Gene Struct. Expr. 1517, 1-18. (doi:10.1016/S0167-781(00)00220-7)
    • (2000) Biochim. Biophys. Acta Gene Struct. Expr. , vol.1517 , pp. 1-18
    • Jones, N.A.1    Hill, I.R.C.2    Stolnik, S.3    Bignotti, F.4    Davis, S.S.5    Garnett, M.C.6
  • 40
    • 2642577464 scopus 로고    scopus 로고
    • Gene therapy. Side effects sideline hemophilia trial
    • doi:10.1126/science.304.5676.1423b
    • Kaiser, J. 2004 Gene therapy. Side effects sideline hemophilia trial. Science 304, 1423-1425. (doi:10.1126/science.304.5676.1423b)
    • (2004) Science , vol.304 , pp. 1423-1425
    • Kaiser, J.1
  • 41
    • 0038946003 scopus 로고    scopus 로고
    • Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria
    • doi:10.1126/science.277.5328.949
    • Kerneis, S., Bogdanova, A., Kraehenbuhl, J. P. & Pringault, E. 1997 Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277, 949-952. (doi:10.1126/science.277.5328.949)
    • (1997) Science , vol.277 , pp. 949-952
    • Kerneis, S.1    Bogdanova, A.2    Kraehenbuhl, J.P.3    Pringault, E.4
  • 42
    • 0033838876 scopus 로고    scopus 로고
    • Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: A technical update
    • doi:10.1016/S1286-4579(00)01266-1
    • Kerneis, S., Caliot, E., Stubbe, H., Bogdanova, A., Kraehenbuhl, J. & Pringault, E. 2000 Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update. Microbes Infect. 2, 1119-1124. (doi:10.1016/S1286-4579(00)01266-1)
    • (2000) Microbes Infect. , vol.2 , pp. 1119-1124
    • Kerneis, S.1    Caliot, E.2    Stubbe, H.3    Bogdanova, A.4    Kraehenbuhl, J.5    Pringault, E.6
  • 43
    • 1942470953 scopus 로고    scopus 로고
    • The effect of the degree of chitosan deacetylation on the efficiency of gene transfection
    • doi:10.1016/j.biomaterials.2003.12.036
    • Kiang, T., Wen, J., Lim, H. W. & Leong, K. W. 2004 The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials 25, 5293-5301. (doi:10.1016/j.biomaterials.2003.12.036)
    • (2004) Biomaterials , vol.25 , pp. 5293-5301
    • Kiang, T.1    Wen, J.2    Lim, H.W.3    Leong, K.W.4
  • 44
    • 33749169797 scopus 로고    scopus 로고
    • Preparation and characterization of mPEG-PCL diblock copolymers with thermo-responsive sol-gel-sol phase transition
    • doi:10.1002/pola.21659
    • Kim, M. S., Hyun, H., Seo, K. S., Cho, Y. H., Lee, J. W., Lee, C. R., Khang, G. & Lee, H. B. 2006 Preparation and characterization of mPEG-PCL diblock copolymers with thermo-responsive sol-gel-sol phase transition. J. Polym. Sci. A Polym. Chem. 44, 5413-5423. (doi:10.1002/pola.21659)
    • (2006) J. Polym. Sci. A Polym. Chem. , vol.44 , pp. 5413-5423
    • Kim, M.S.1    Hyun, H.2    Seo, K.S.3    Cho, Y.H.4    Lee, J.W.5    Lee, C.R.6    Khang, G.7    Lee, H.B.8
  • 45
    • 21144457793 scopus 로고    scopus 로고
    • Polymeric worm micelles as nano-carriers for drug delivery
    • doi:10.1088/0957-4484/16/7/024
    • Kim, Y., Dalhaimer, P., Christian, D. A. & Discher, D. E. 2005a Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology 16, S484-S491. (doi:10.1088/0957-4484/16/7/024)
    • (2005) Nanotechnology , vol.16
    • Kim, Y.1    Dalhaimer, P.2    Christian, D.A.3    Discher, D.E.4
  • 46
    • 13844269030 scopus 로고    scopus 로고
    • Polyethylenimine with acid-labile linkages as a biodegradable gene carrier
    • doi:10.1016/j.jconrel.2004.11.008
    • Kim, Y. H., Park, J. H., Lee, M., Park, T. G. & Kim, S. W. 2005b Polyethylenimine with acid-labile linkages as a biodegradable gene carrier. J. Control. Release 103, 209-219. (doi:10.1016/j.jconrel.2004.11.008)
    • (2005) J. Control. Release , vol.103 , pp. 209-219
    • Kim, Y.H.1    Park, J.H.2    Lee, M.3    Park, T.G.4    Kim, S.W.5
  • 47
    • 20144373766 scopus 로고    scopus 로고
    • Non-viral gene delivery regulated by stiffness of cell adhesion substrates
    • doi:10.1038/nmat1392
    • Kong, H. J., Liu, J. D., Riddle, K., Matsumoto, T., Leach, K. & Mooney, D. J. 2005 Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat. Mater. 4, 460-464. (doi:10.1038/nmat1392)
    • (2005) Nat. Mater. , vol.4 , pp. 460-464
    • Kong, H.J.1    Liu, J.D.2    Riddle, K.3    Matsumoto, T.4    Leach, K.5    Mooney, D.J.6
  • 48
    • 5444267326 scopus 로고    scopus 로고
    • Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers
    • doi:10.1038/sj.gt.3302312
    • Koping-Hoggard, M., Varum, K. M., Issa, M., Danielsen, S., Christensen, B. E., Stokke, B. T. & Artursson, P. 2004 Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther. 11, 1441-1452. (doi:10.1038/sj.gt.3302312)
    • (2004) Gene Ther. , vol.11 , pp. 1441-1452
    • Koping-Hoggard, M.1    Varum, K.M.2    Issa, M.3    Danielsen, S.4    Christensen, B.E.5    Stokke, B.T.6    Artursson, P.7
  • 49
    • 33644888606 scopus 로고    scopus 로고
    • Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix
    • doi:10.1021/nl052241g
    • Kuhn, S. J., Finch, S. K., Hallahan, D. E. & Giorgio, T. D. 2006a Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix. Nano Lett. 6, 306-312. (doi:10.1021/nl052241g)
    • (2006) Nano Lett. , vol.6 , pp. 306-312
    • Kuhn, S.J.1    Finch, S.K.2    Hallahan, D.E.3    Giorgio, T.D.4
  • 50
    • 33645155778 scopus 로고    scopus 로고
    • Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system
    • doi:10.1007/s10439-005-9004-5
    • Kuhn, S. J., Hallahan, D. E. & Giorgio, T. D. 2006b Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system. Ann. Biomed. Eng. 34, 51-58. (doi:10.1007/s10439-005-9004-5)
    • (2006) Ann. Biomed. Eng. , vol.34 , pp. 51-58
    • Kuhn, S.J.1    Hallahan, D.E.2    Giorgio, T.D.3
  • 51
    • 19644388310 scopus 로고    scopus 로고
    • Quantitating intracellular transport of polyplexes by spatio-temporal image correlation spectroscopy
    • doi:10.1073/pnas.0501950102
    • Kulkarni, R. P., Wu, D. D., Davis, M. E. & Fraser, S. E. 2005 Quantitating intracellular transport of polyplexes by spatio-temporal image correlation spectroscopy. Proc. Natl Acad. Sci. USA 102, 7523-7528. (doi:10.1073/pnas.0501950102)
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 7523-7528
    • Kulkarni, R.P.1    Wu, D.D.2    Davis, M.E.3    Fraser, S.E.4
  • 52
    • 0034601880 scopus 로고    scopus 로고
    • Gene expression control by temperature with thermo-responsive polymeric gene carriers
    • doi:10.1016/S0168-3659(00)00297-2
    • Kurisawa, M., Yokoyama, M. & Okano, T. 2000 Gene expression control by temperature with thermo-responsive polymeric gene carriers. J. Control. Release 69, 127-137. (doi:10.1016/S0168-3659(00)00297-2)
    • (2000) J. Control. Release , vol.69 , pp. 127-137
    • Kurisawa, M.1    Yokoyama, M.2    Okano, T.3
  • 54
    • 33846842309 scopus 로고    scopus 로고
    • Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors
    • doi:10.1002/jgm.992
    • Lavigne, M. D., Pennadam, S. S., Ellis, J., Alexander, C. & Gorecki, D. C. 2007 Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors. J. Gene Med. 9, 44-54. (doi:10.1002/jgm.992)
    • (2007) J. Gene Med. , vol.9 , pp. 44-54
    • Lavigne, M.D.1    Pennadam, S.S.2    Ellis, J.3    Alexander, C.4    Gorecki, D.C.5
  • 56
    • 44549088957 scopus 로고    scopus 로고
    • Quantum-dot-assisted fluorescence resonance energy transfer approach for intracellular trafficking of chitosan/DNA complex
    • doi:10.1016/j.actbio.2008.01.010
    • Lee, J. I., Ha, K. S.& Yoo, H. S. 2008 Quantum-dot-assisted fluorescence resonance energy transfer approach for intracellular trafficking of chitosan/DNA complex. Acta Biomater. 4, 791-798. (doi:10.1016/j.actbio.2008.01. 010)
    • (2008) Acta Biomater. , vol.4 , pp. 791-798
    • Lee, J.I.1    Ha, K.S.2    Yoo, H.S.3
  • 57
    • 34248157855 scopus 로고    scopus 로고
    • MRI observation of the light-induced release of a contrast agent from photo-controllable polymer micelles
    • doi:10.1088/0031-9155/52/10/N04
    • Lepage, M., Jiang, J. Q., Babin, J., Qi, B., Tremblay, L. & Zhao, Y. 2007 MRI observation of the light-induced release of a contrast agent from photo-controllable polymer micelles. Phys. Med. Biol. 52, N249-N255. (doi:10.1088/0031-9155/52/10/N04)
    • (2007) Phys. Med. Biol. , vol.52
    • Lepage, M.1    Jiang, J.Q.2    Babin, J.3    Qi, B.4    Tremblay, L.5    Zhao, Y.6
  • 58
    • 33646116051 scopus 로고    scopus 로고
    • Pre-deliver chitosanase to cells: A novel strategy to improve gene expression by endocellular degradation-induced vector unpacking
    • doi:10.1016/j.ijpharm.2006.01.044
    • Liang, D. C., Liu, W. G., Zuo, A. J., Sun, S. J., Cheng, N., Guo, G., Zhang, J. Y. & De Yao, K. 2006 Pre-deliver chitosanase to cells: a novel strategy to improve gene expression by endocellular degradation-induced vector unpacking. Int. J. Pharm. 314, 63-71. (doi:10.1016/j.ijpharm.2006.01.044)
    • (2006) Int. J. Pharm. , vol.314 , pp. 63-71
    • Liang, D.C.1    Liu, W.G.2    Zuo, A.J.3    Sun, S.J.4    Cheng, N.5    Guo, G.6    Zhang, J.Y.7    De Yao, K.8
  • 59
    • 67649135738 scopus 로고    scopus 로고
    • The role of the disulfide group in disulfide-based polymeric gene carriers
    • doi:10.1517/17425240902878010
    • Lin, C. & Engbersen, J. F. 2009 The role of the disulfide group in disulfide-based polymeric gene carriers. Expert Opin. Drug Deliv. 6, 421-439. (doi:10.1517/17425240902878010)
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 421-439
    • Lin, C.1    Engbersen, J.F.2
  • 60
    • 33846452896 scopus 로고    scopus 로고
    • Novel bioreducible poly(amido amine)s for highly efficient gene delivery
    • doi:10.1021/bc060200l
    • Lin, C., Zhong, Z., Lok, M. C., Jiang, X., Hennink, W. E., Feijen, J. & Engbersen, J. F. 2007a Novel bioreducible poly(amido amine)s for highly efficient gene delivery. Bioconjug. Chem. 18, 138-145. (doi:10.1021/bc060200l)
    • (2007) Bioconjug. Chem. , vol.18 , pp. 138-145
    • Lin, C.1    Zhong, Z.2    Lok, M.C.3    Jiang, X.4    Hennink, W.E.5    Feijen, J.6    Engbersen, J.F.7
  • 61
    • 34648843156 scopus 로고    scopus 로고
    • Random and block copolymers of bioreducible poly(amido amine)s with high- And low-basicity amino groups: Study of DNA condensation and buffer capacity on gene transfection
    • doi:10.1016/j.jconrel.2007.07.006
    • Lin, C., Zhong, Z., Lok, M. C., Jiang, X., Hennink, W. E., Feijen, J. & Engbersen, J. F. 2007b Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection. J. Control. Release 123, 67-75. (doi:10.1016/j.jconrel.2007.07.006)
    • (2007) J. Control. Release , vol.123 , pp. 67-75
    • Lin, C.1    Zhong, Z.2    Lok, M.C.3    Jiang, X.4    Hennink, W.E.5    Feijen, J.6    Engbersen, J.F.7
  • 62
    • 48449087647 scopus 로고    scopus 로고
    • Addition of 'Charge-shifting' side chains to linear poly(ethyleneimine) enhances cell transfection efficiency
    • doi:10.1021/bm800291v
    • Liu, X., Yang, J. W. & Lynn, D. M. 2008 Addition of 'Charge-shifting' side chains to linear poly(ethyleneimine) enhances cell transfection efficiency. Biomacromolecules 9, 2063-2071. (doi:10.1021/bm800291v)
    • (2008) Biomacromolecules , vol.9 , pp. 2063-2071
    • Liu, X.1    Yang, J.W.2    Lynn, D.M.3
  • 63
    • 22744456996 scopus 로고    scopus 로고
    • Studying the intracellular dissociation of polymer-oligonucleotide complexes by dual color fluorescence fluctuation spectroscopy and confocal imaging
    • doi:10.1021/bi0476883
    • Lucas, B., Remaut, K., Sanders, N. N., Braeckmans, K., De Smedt, S. C. & Demeester, J. 2005 Studying the intracellular dissociation of polymer-oligonucleotide complexes by dual color fluorescence fluctuation spectroscopy and confocal imaging. Biochemistry 44, 9905-9912. (doi:10.1021/bi0476883)
    • (2005) Biochemistry , vol.44 , pp. 9905-9912
    • Lucas, B.1    Remaut, K.2    Sanders, N.N.3    Braeckmans, K.4    De Smedt, S.C.5    Demeester, J.6
  • 64
    • 33645225035 scopus 로고    scopus 로고
    • Design of polyphosphoester- DNA nanoparticles for non-viral gene delivery
    • doi:10.1016/S0065-2660(05)53011-6
    • Mao, H. Q. & Leong, K. W. 2005 Design of polyphosphoester- DNA nanoparticles for non-viral gene delivery. Adv. Genet. 53, 275-306. (doi:10.1016/S0065-2660(05)53011-6)
    • (2005) Adv. Genet. , vol.53 , pp. 275-306
    • Mao, H.Q.1    Leong, K.W.2
  • 65
    • 27644473227 scopus 로고    scopus 로고
    • Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis
    • doi:10.1242/jcs.02566
    • Mao, Y. & Schwarzbauer, J. E. 2005 Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. J. Cell Sci. 118, 4427-4436. (doi:10.1242/jcs.02566)
    • (2005) J. Cell Sci. , vol.118 , pp. 4427-4436
    • Mao, Y.1    Schwarzbauer, J.E.2
  • 66
    • 51649104683 scopus 로고    scopus 로고
    • Quantum dots as fluorescence resonance energy transfer donors in cells
    • doi:10.1117/1.2939417
    • McGrath, N. & Barroso, M. 2008 Quantum dots as fluorescence resonance energy transfer donors in cells. J. Biomed. Opt. 13, 031210. (doi:10.1117/1.2939417)
    • (2008) J. Biomed. Opt. , vol.13 , pp. 031210
    • McGrath, N.1    Barroso, M.2
  • 68
    • 4344688997 scopus 로고    scopus 로고
    • Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system
    • doi:10.1002/jgm.483
    • Meng, Q. H., Robinson, D., Jenkins, R. G., Mcanulty, R. J. & Hart, S. L. 2004 Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system. J. Gene Med. 6, 210-221. (doi:10.1002/jgm.483)
    • (2004) J. Gene Med. , vol.6 , pp. 210-221
    • Meng, Q.H.1    Robinson, D.2    Jenkins, R.G.3    Mcanulty, R.J.4    Hart, S.L.5
  • 69
    • 22644444670 scopus 로고    scopus 로고
    • PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice
    • doi:10.1021/bc049743q
    • Merdan, T., Kunath, K., Petersen, H., Bakowsky, U., Voigt, K. H., Kopecek, J. & Kissel, T. 2005 PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjug. Chem. 16, 785-792. (doi:10.1021/bc049743q)
    • (2005) Bioconjug. Chem. , vol.16 , pp. 785-792
    • Merdan, T.1    Kunath, K.2    Petersen, H.3    Bakowsky, U.4    Voigt, K.H.5    Kopecek, J.6    Kissel, T.7
  • 70
    • 2942632966 scopus 로고    scopus 로고
    • PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles
    • doi:10.1078/0171-9335-00363
    • Mishra, S., Webster, P. & Davis, M. E. 2004 PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur. J. Cell Biol. 83, 97-111. (doi:10.1078/0171-9335-00363)
    • (2004) Eur. J. Cell Biol. , vol.83 , pp. 97-111
    • Mishra, S.1    Webster, P.2    Davis, M.E.3
  • 71
    • 1542306939 scopus 로고    scopus 로고
    • Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression
    • doi:10.1021/ja0379666
    • Miyata, K., Kakizawa, Y., Nishiyama, N., Harada, A., Yamasaki, Y., Koyama, H. & Kataoka, K. 2004 Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126, 2355-2361. (doi:10.1021/ja0379666)
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 2355-2361
    • Miyata, K.1    Kakizawa, Y.2    Nishiyama, N.3    Harada, A.4    Yamasaki, Y.5    Koyama, H.6    Kataoka, K.7
  • 72
    • 0033020421 scopus 로고    scopus 로고
    • Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes
    • Molestina, R. E., Miller, R. D., Ramirez, J. A. & Summersgill, J. T. 1999 Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes. Infect. Immun. 67, 1323-1330.
    • (1999) Infect. Immun. , vol.67 , pp. 1323-1330
    • Molestina, R.E.1    Miller, R.D.2    Ramirez, J.A.3    Summersgill, J.T.4
  • 73
    • 0034283349 scopus 로고    scopus 로고
    • Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo
    • doi:10.1016/S0304-4165(00)00104-5
    • Mullen, P. M. et al. 2000 Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo. Biochim. Biophys. Acta 1523, 103-110. (doi:10.1016/S0304-4165(00)00104-5)
    • (2000) Biochim. Biophys. Acta , vol.1523 , pp. 103-110
    • Mullen, P.M.1
  • 74
    • 0027595949 scopus 로고
    • The basic science of gene therapy
    • doi:10.1126/science.8493530
    • Mulligan, R. C. 1993 The basic science of gene therapy. Science 260, 926-932. (doi:10.1126/science.8493530)
    • (1993) Science , vol.260 , pp. 926-932
    • Mulligan, R.C.1
  • 75
    • 0038402594 scopus 로고    scopus 로고
    • Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides
    • doi:10.1016/S0168-3659(03)00099-3
    • Murthy, N., Campbell, J., Fausto, N., Hoffman, A. S. & Stayton, P. S. 2003 Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. J. Control. Release 89, 365-374. (doi:10.1016/S0168-3659(03)00099-3)
    • (2003) J. Control. Release , vol.89 , pp. 365-374
    • Murthy, N.1    Campbell, J.2    Fausto, N.3    Hoffman, A.S.4    Stayton, P.S.5
  • 77
    • 0021279687 scopus 로고
    • Demonstration of an extracellular matrix in multicellular tumor spheroids
    • Nederman, T., Norling, B., Glimelius, B., Carlsson, J. & Brunk, U. 1984 Demonstration of an extracellular matrix in multicellular tumor spheroids. Cancer Res. 44, 3090-3097.
    • (1984) Cancer Res. , vol.44 , pp. 3090-3097
    • Nederman, T.1    Norling, B.2    Glimelius, B.3    Carlsson, J.4    Brunk, U.5
  • 78
    • 41049093795 scopus 로고    scopus 로고
    • A perfusable 3D cell-matrix tissue culture chamber for in situ evaluation of nanoparticle vehicle penetration and transport
    • doi:10.1002/bit.21698
    • Ng, C. P. & Pun, S. H. 2008 A perfusable 3D cell-matrix tissue culture chamber for in situ evaluation of nanoparticle vehicle penetration and transport. Biotechnol. Bioeng. 99, 1490-1501. (doi:10.1002/bit.21698)
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 1490-1501
    • Ng, C.P.1    Pun, S.H.2
  • 79
    • 33646946725 scopus 로고    scopus 로고
    • pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector
    • doi:10.1021/bc050364m
    • Oishi, M., Kataoka, K. & Nagasaki, Y. 2006 pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector. Bioconjug. Chem. 17, 677-688. (doi:10.1021/bc050364m)
    • (2006) Bioconjug. Chem. , vol.17 , pp. 677-688
    • Oishi, M.1    Kataoka, K.2    Nagasaki, Y.3
  • 80
    • 0344378203 scopus 로고    scopus 로고
    • Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block
    • doi:10.1021/bc990007+
    • Oupicky, D., Konak, C., Dash, P. R., Seymour, L. W. & Ulbrich, K. 1999 Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block. Bioconjug. Chem. 10, 764-772. (doi:10.1021/bc990007+)
    • (1999) Bioconjug. Chem. , vol.10 , pp. 764-772
    • Oupicky, D.1    Konak, C.2    Dash, P.R.3    Seymour, L.W.4    Ulbrich, K.5
  • 81
    • 0037045229 scopus 로고    scopus 로고
    • Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors
    • doi:10.1021/ja016440n
    • Oupicky, D., Parker, A. L. & Seymour, L. W. 2002 Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors. J. Am. Chem. Soc. 124, 8-9. (doi:10.1021/ja016440n)
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 8-9
    • Oupicky, D.1    Parker, A.L.2    Seymour, L.W.3
  • 82
    • 0042032040 scopus 로고    scopus 로고
    • Temperature-controlled behavior of self-assembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly(N-isopropylacrylamide)
    • doi:10.1021/ma034039a
    • Oupicky, D., Reschel, T., Konak, C. & Oupicka, L. 2003 Temperature-controlled behavior of self-assembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly(N-isopropylacrylamide). Macromolecules 36, 6863-6872. (doi:10.1021/ma034039a)
    • (2003) Macromolecules , vol.36 , pp. 6863-6872
    • Oupicky, D.1    Reschel, T.2    Konak, C.3    Oupicka, L.4
  • 83
    • 22144447455 scopus 로고    scopus 로고
    • Design and development of polymers for gene delivery
    • doi:10.1038/nrd1775
    • Pack, D. W., Hoffman, A. S., Pun, S. & Stayton, P. S. 2005 Design and development of polymers for gene delivery. Nat. Rev. Drug Discov. 4, 581-593. (doi:10.1038/nrd1775)
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 581-593
    • Pack, D.W.1    Hoffman, A.S.2    Pun, S.3    Stayton, P.S.4
  • 84
    • 36549084730 scopus 로고    scopus 로고
    • Determination of nanoparticle vehicle unpackaging by MR imaging of a T2 magnetic relaxation switch
    • doi:10.1016/j.biomaterials.2007.10.018
    • Park, I. K., Ng, C. P., Wang, J., Chu, B., Yuan, C., Zhang, S. & Pun, S. H. 2008 Determination of nanoparticle vehicle unpackaging by MR imaging of a T2 magnetic relaxation switch. Biomaterials 29, 724-732. (doi:10.1016/j. biomaterials.2007.10.018)
    • (2008) Biomaterials , vol.29 , pp. 724-732
    • Park, I.K.1    Ng, C.P.2    Wang, J.3    Chu, B.4    Yuan, C.5    Zhang, S.6    Pun, S.H.7
  • 85
    • 0036022520 scopus 로고    scopus 로고
    • Magnetic relaxation switches capable of sensing molecular interactions
    • doi:10.1038/nbt720
    • Perez, J. M., Josephson, L., O'Loughlin, T., Hogemann, D. & Weissleder, R. 2002 Magnetic relaxation switches capable of sensing molecular interactions. Nat. Biotechnol. 20, 816-820. (doi:10.1038/nbt720)
    • (2002) Nat. Biotechnol. , vol.20 , pp. 816-820
    • Perez, J.M.1    Josephson, L.2    O'Loughlin, T.3    Hogemann, D.4    Weissleder, R.5
  • 86
    • 0032571392 scopus 로고    scopus 로고
    • Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells
    • doi:10.1074/jbc.273.13.7507
    • Pollard, H., Remy, J. S., Loussouarn, G., Demolombe, S., Behr, J. P. & Escande, D. 1998 Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J. Biol. Chem. 273, 7507-7511. (doi:10.1074/jbc.273.13.7507)
    • (1998) J. Biol. Chem. , vol.273 , pp. 7507-7511
    • Pollard, H.1    Remy, J.S.2    Loussouarn, G.3    Demolombe, S.4    Behr, J.P.5    Escande, D.6
  • 87
    • 27244457081 scopus 로고    scopus 로고
    • Barriers to gene delivery using synthetic vectors
    • doi:10.1016/S0065-2660(05)53002-5
    • Read, M. L., Logan, A. & Seymour, L. W. 2005 Barriers to gene delivery using synthetic vectors. Adv. Genet. 53, 19-46. (doi:10.1016/S0065- 2660(05)53002-5)
    • (2005) Adv. Genet. , vol.53 , pp. 19-46
    • Read, M.L.1    Logan, A.2    Seymour, L.W.3
  • 88
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin- And caveolae-mediated endocytosis
    • doi:10.1042/BJ20031253
    • Rejman, J., Oberle, V., Zuhorn, I. S. & Hoekstra, D. 2004 Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 377, 159-169. (doi:10.1042/ BJ20031253)
    • (2004) Biochem. J. , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 89
    • 13844274900 scopus 로고    scopus 로고
    • FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery
    • doi:10.1016/j.jconrel.2004.11.019
    • Remaut, K., Lucas, B., Braeckmans, K., Sanders, N. N., De Smedt, S. C. & Demeester, J. 2005 FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery. J. Control. Release 103, 259-271. (doi:10.1016/j.jconrel.2004.11.019)
    • (2005) J. Control. Release , vol.103 , pp. 259-271
    • Remaut, K.1    Lucas, B.2    Braeckmans, K.3    Sanders, N.N.4    De Smedt, S.C.5    Demeester, J.6
  • 90
    • 34547184604 scopus 로고    scopus 로고
    • Can we better understand the intracellular behavior of DNA nanoparticles by fluorescence correlation spectroscopy?
    • doi:10.1016/j.jconrel.2007.04.008
    • Remaut, K., Lucas, B., Raemdonck, K., Braeckmans, K., Demeester, J. & De Smedt, S. C. 2007 Can we better understand the intracellular behavior of DNA nanoparticles by fluorescence correlation spectroscopy? J. Control. Release 121, 49-63. (doi:10.1016/j.jconrel.2007.04.008)
    • (2007) J. Control. Release , vol.121 , pp. 49-63
    • Remaut, K.1    Lucas, B.2    Raemdonck, K.3    Braeckmans, K.4    Demeester, J.5    De Smedt, S.C.6
  • 91
    • 0032958073 scopus 로고    scopus 로고
    • Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
    • doi:10.1038/7385
    • Roy, K., Mao, H. Q., Huang, S. K. & Leong, K. W. 1999 Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. 5, 387-391. (doi:10.1038/7385)
    • (1999) Nat. Med. , vol.5 , pp. 387-391
    • Roy, K.1    Mao, H.Q.2    Huang, S.K.3    Leong, K.W.4
  • 92
    • 0344389048 scopus 로고    scopus 로고
    • Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: Physicochemical and transfection studies
    • doi:10.1016/S0005-2736(98)00199-0
    • Ruponen, M., Yla-Herttuala, S. & Urtti, A. 1999 Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. Biochim. Biophys. Acta 1415, 331-341. (doi:10.1016/S0005-2736(98)00199-0)
    • (1999) Biochim. Biophys. Acta , vol.1415 , pp. 331-341
    • Ruponen, M.1    Yla-Herttuala, S.2    Urtti, A.3
  • 93
    • 0035823546 scopus 로고    scopus 로고
    • Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes
    • doi:10.1074/jbc.M011553200
    • Ruponen, M., Ronkko, S., Honkakoski, P., Pelkonen, J., Tammi, M. & Urtti, A. 2001 Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes. J. Biol. Chem. 276, 33 875-33 880. (doi:10.1074/jbc.M011553200)
    • (2001) J. Biol. Chem. , vol.276 , pp. 33875-33880
    • Ruponen, M.1    Ronkko, S.2    Honkakoski, P.3    Pelkonen, J.4    Tammi, M.5    Urtti, A.6
  • 94
    • 0242494159 scopus 로고    scopus 로고
    • Extracellular and intracellular barriers in non-viral gene delivery
    • doi:10.1016/j.jconrel.2003.08.004
    • Ruponen, M., Honkakoski, P., Ronkko, S., Pelkonen, J., Tammi, M. & Urtti, A. 2003 Extracellular and intracellular barriers in non-viral gene delivery. J. Control. Release 93, 213-217. (doi:10.1016/j.jconrel.2003.08.004)
    • (2003) J. Control. Release , vol.93 , pp. 213-217
    • Ruponen, M.1    Honkakoski, P.2    Ronkko, S.3    Pelkonen, J.4    Tammi, M.5    Urtti, A.6
  • 95
    • 0034607160 scopus 로고    scopus 로고
    • Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery
    • doi:10.1002/(SICI)1097-0290(20000305)67:5〈598::AID-BIT10〉3.0. CO;2-G
    • Schaffer, D. V., Fidelman, N. A., Dan, N. & Lauffenburger, D. A. 2000 Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol. Bioeng. 67, 598-606. (doi:10.1002/(SICI)1097- 0290(20000305)67:5〈598::AID-BIT10〉3.0.CO;2-G)
    • (2000) Biotechnol. Bioeng. , vol.67 , pp. 598-606
    • Schaffer, D.V.1    Fidelman, N.A.2    Dan, N.3    Lauffenburger, D.A.4
  • 96
    • 31544441899 scopus 로고    scopus 로고
    • pH-responsive sulfonamide/PEI system for tumor specific gene delivery: An in vitro study
    • doi:10.1021/bm0503571
    • Sethuraman, V. A., Na, K. & Bae, Y. H. 2006 pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study. Biomacromolecules 7, 64-70. (doi:10.1021/bm0503571)
    • (2006) Biomacromolecules , vol.7 , pp. 64-70
    • Sethuraman, V.A.1    Na, K.2    Bae, Y.H.3
  • 97
    • 0017795758 scopus 로고
    • Fluorescence energy transfer as a spectroscopic ruler
    • doi:10.1146/annurev.bi.47.070178.004131
    • Stryer, L. 1978 Fluorescence energy transfer as a spectroscopic ruler. Annu. Rev. Biochem. 47, 819-846. (doi:10.1146/annurev.bi.47.070178.004131)
    • (1978) Annu. Rev. Biochem. , vol.47 , pp. 819-846
    • Stryer, L.1
  • 98
    • 22644447250 scopus 로고    scopus 로고
    • A thermoresponsive chitosan - NIPAAm/vinyl laurate copolymer vector for gene transfection
    • doi:10.1021/bc0500701
    • Sun, S. J. et al. 2005 A thermoresponsive chitosan - NIPAAm/vinyl laurate copolymer vector for gene transfection. Bioconjug. Chem. 16, 972-980. (doi:10.1021/bc0500701)
    • (2005) Bioconjug. Chem. , vol.16 , pp. 972-980
    • Sun, S.J.1
  • 99
    • 0038574350 scopus 로고    scopus 로고
    • Non-viral gene therapy: Polycation-mediated DNA delivery
    • doi:10.1007/s00253-003-1321-8
    • Thomas, M. & Klibanov, A. M. 2003 Non-viral gene therapy: polycation-mediated DNA delivery. Appl. Microbiol. Biotechnol. 62, 27-34. (doi:10.1007/s00253-003-1321-8)
    • (2003) Appl. Microbiol. Biotechnol. , vol.62 , pp. 27-34
    • Thomas, M.1    Klibanov, A.M.2
  • 100
    • 0034658557 scopus 로고    scopus 로고
    • Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment
    • doi:10.1016/S0378-5173(00)00364-1
    • Torche, A. M., Jouan, H., Le Corre, P., Albina, E., Primault, R., Jestin, A. & Le Verge, R. 2000 Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment. Int. J. Pharm. 201, 15-27. (doi:10.1016/S0378- 5173(00)00364-1)
    • (2000) Int. J. Pharm. , vol.201 , pp. 15-27
    • Torche, A.M.1    Jouan, H.2    Le Corre, P.3    Albina, E.4    Primault, R.5    Jestin, A.6    Le Verge, R.7
  • 102
    • 0035189482 scopus 로고    scopus 로고
    • Quantitative analysis of synthetic gene delivery vector design properties
    • doi:10.1006/mthe.2001.0475
    • Varga, C. M., Hong, K. & Lauffenburger, D. A. 2001 Quantitative analysis of synthetic gene delivery vector design properties. Mol. Ther. 4, 438-446. (doi:10.1006/mthe.2001.0475)
    • (2001) Mol. Ther. , vol.4 , pp. 438-446
    • Varga, C.M.1    Hong, K.2    Lauffenburger, D.A.3
  • 103
    • 0033959447 scopus 로고    scopus 로고
    • Cancer gene therapy: Hard lessons and new courses
    • doi:10.1038/sj.gt.3301084
    • Vile, R. G., Russell, S. J. & Lemoine, N. R. 2000 Cancer gene therapy: hard lessons and new courses. Gene Ther. 7, 2-8. (doi:10.1038/sj.gt. 3301084)
    • (2000) Gene Ther. , vol.7 , pp. 2-8
    • Vile, R.G.1    Russell, S.J.2    Lemoine, N.R.3
  • 104
    • 0038685648 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Gene therapy for the hemophilias
    • doi:10.1038/sj.gt.3302024
    • Walsh, C. E. 2003 Gene therapy progress and prospects: gene therapy for the hemophilias. Gene Ther. 10, 999-1003. (doi:10.1038/sj.gt.3302024)
    • (2003) Gene Ther. , vol.10 , pp. 999-1003
    • Walsh, C.E.1
  • 105
    • 0242367234 scopus 로고    scopus 로고
    • Medicine. Gene therapy - New challenges ahead
    • doi:10.1126/science.1091258
    • Williams, D. A. & Baum, C. 2003 Medicine. Gene therapy - new challenges ahead. Science 302, 400-401. (doi:10.1126/science.1091258)
    • (2003) Science , vol.302 , pp. 400-401
    • Williams, D.A.1    Baum, C.2
  • 106
    • 33645937646 scopus 로고    scopus 로고
    • The mechanism of naked DNA uptake and expression
    • doi:10.1016/S0065-2660(05)54001-X
    • Wolff, J. A. & Budker, V. 2005 The mechanism of naked DNA uptake and expression. Adv. Genet. 54, 1-20. (doi:10.1016/S0065-2660(05)54001-X)
    • (2005) Adv. Genet. , vol.54 , pp. 1-20
    • Wolff, J.A.1    Budker, V.2
  • 107
  • 108
    • 34547572345 scopus 로고    scopus 로고
    • Polymer systems for gene delivery - Past, present, and future
    • doi:10.1016/j.progpolymsci.2007.05.007
    • Wong, S. Y., Pelet, J. M. & Putnam, D. 2007 Polymer systems for gene delivery - past, present, and future. Prog. Polym. Sci. 32, 799-837. (doi:10.1016/j.progpolymsci.2007.05.007)
    • (2007) Prog. Polym. Sci. , vol.32 , pp. 799-837
    • Wong, S.Y.1    Pelet, J.M.2    Putnam, D.3
  • 109
    • 4644286010 scopus 로고    scopus 로고
    • Effective polyethylenimine-mediated gene transfer into human endothelial cells
    • doi:10.1002/jgm.484
    • Zaric, V., Weltin, D., Erbacher, P., Remy, J. S., Behr, J. P. & Stephan, D. 2004 Effective polyethylenimine-mediated gene transfer into human endothelial cells. J. Gene Med. 6, 176-184. (doi:10.1002/jgm.484)
    • (2004) J. Gene Med. , vol.6 , pp. 176-184
    • Zaric, V.1    Weltin, D.2    Erbacher, P.3    Remy, J.S.4    Behr, J.P.5    Stephan, D.6
  • 110
    • 33646902955 scopus 로고    scopus 로고
    • Temperature dependent gene expression induced by PNIPAM-based copolymers: Potential of hyperthermia in gene transfer
    • doi:10.1021/bc050292z
    • Zintchenko, A., Ogris, M. & Wagner, E. 2006 Temperature dependent gene expression induced by PNIPAM-based copolymers: potential of hyperthermia in gene transfer. Bioconjug. Chem. 17, 766-772. (doi:10.1021/bc050292z)
    • (2006) Bioconjug. Chem. , vol.17 , pp. 766-772
    • Zintchenko, A.1    Ogris, M.2    Wagner, E.3
  • 111
    • 39549096259 scopus 로고    scopus 로고
    • Improved transfection efficiency of cs/DNA complex by co-transfected chitosanase gene
    • doi:10.1016/j.ijpharm.2007.10.042
    • Zuo, A., Sun, P., Liang, D., Liu, W., Zhao, R., Guo, G., Cheng, N., Zhang, J. & Yao, K. 2008 Improved transfection efficiency of cs/DNA complex by co-transfected chitosanase gene. Int. J. Pharm. 352, 302-308. (doi:10.1016/j.ijpharm.2007.10.042)
    • (2008) Int. J. Pharm. , vol.352 , pp. 302-308
    • Zuo, A.1    Sun, P.2    Liang, D.3    Liu, W.4    Zhao, R.5    Guo, G.6    Cheng, N.7    Zhang, J.8    Yao, K.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.